C. Roberts

发表

Coarse-grained model for colloidal protein interactions, B(22), and protein cluster formation.

Christopher J Roberts, M. Blanco, Erinc Sahin, 2013, The journal of physical chemistry. B.

Protein misfolding and aggregation research: Some thoughts on improving quality and utility

C. Roberts, R. Murphy, 2013, Biotechnology progress.

Nonnative aggregation of an IgG1 antibody in acidic conditions, part 2: nucleation and growth kinetics with competing growth mechanisms.

C. Roberts, R. Brummitt, D. Nesta, 2011, Journal of pharmaceutical sciences.

Non‐native protein aggregation kinetics

Christopher J Roberts, C. Roberts, 2007, Biotechnology and bioengineering.

A Lumry-Eyring nucleated polymerization model of protein aggregation kinetics: 1. Aggregation with pre-equilibrated unfolding.

Christopher J Roberts, C. Roberts, J. Andrews, 2007, The journal of physical chemistry. B.

Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation.

William F. Weiss, M. Ivanova, Erinc Sahin, 2014, Biophysical chemistry.

Connecting high-temperature and low-temperature protein stability and aggregation

C. Roberts, M. Rodrigues, Mónica Rosa, 2017, PloS one.

Modulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutations.

M. Blanco, A. Robinson, C. Roberts, 2016, Protein engineering, design & selection : PEDS.

Folding and aggregation of a multi-domain engineered immunotoxin

Xiangyang Wang, William K. Wang, A. Hunter, 2013 .

Predicting solution aggregation rates for therapeutic proteins: approaches and challenges.

Erinc Sahin, C. Roberts, T. Das, 2011, International journal of pharmaceutics.

Controlling assembly of helical polypeptides via PEGylation strategies.

C. Roberts, D. Pochan, K. Kiick, 2011, Soft matter.

Kinetics of Irreversible Protein Aggregation: Analysis of Extended Lumry−Eyring Models and Implications for Predicting Protein Shelf Life

C. Roberts, 2003 .

Aggregation of poly(acrylic acid)-containing elastin-mimetic copolymers.

Xinqiao Jia, M. Blanco, C. Roberts, 2015, Soft matter.

In Situ Monitoring of Protein Unfolding/Structural States under Cold High-Pressure Stress.

C. Roberts, J. Leão, M. Rodrigues, 2021, Molecular pharmaceutics.

Protein aggregation - Mechanisms, detection, and control.

Wei Wang, Christopher J Roberts, Wei Wang, 2018, International journal of pharmaceutics.

High-Pressure, Low-Temperature Induced Unfolding and Aggregation of Monoclonal Antibodies: Role of the Fc and Fab Fragments.

C. Roberts, V. Razinkov, W. Qi, 2022, The journal of physical chemistry. B.

Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scattering.

Michael F. Drenski, C. Roberts, V. Razinkov, 2016, Analytical biochemistry.

Non-native aggregation of alpha-chymotrypsinogen occurs through nucleation and growth with competing nucleus sizes and negative activation energies.

C. Roberts, J. Andrews, 2007, Biochemistry.

Parallel chromatography and in situ scattering to interrogate competing protein aggregation pathways

C. Roberts, M. Rodrigues, D. Gomes, 2018, Protein science : a publication of the Protein Society.

Aggregation of Therapeutic Proteins: Wang/Protein Aggregation

Wei Wang, Wei Wang, C. Roberts, 2010 .

Predicting High-Concentration Interactions of Monoclonal Antibody Solutions: Comparison of Theoretical Approaches for Strongly Attractive Versus Repulsive Conditions.

Erinc Sahin, C. Roberts, A. Saluja, 2019, The journal of physical chemistry. B.

Non-Arrhenius Protein Aggregation

Wei Wang, Wei Wang, C. Roberts, 2013, The AAPS Journal.

Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics. 2. Competing growth via condensation and chain polymerization.

C. Roberts, Yi Li, 2009, The journal of physical chemistry. B.

Biophysical characterization and molecular simulation of electrostatically driven self‐association of a single‐chain antibody

A. Robinson, C. Roberts, V. Razinkov, 2018, Protein science : a publication of the Protein Society.

Aggregates of α‐chymotrypsinogen anneal to access more stable states

A. Hunter, A. Robinson, C. Roberts, 2014, Biotechnology and bioengineering.

Polyamorphism and density anomalies in network‐forming fluids: Zeroth‐ and first‐order approximations

P. Debenedetti, C. Roberts, 1996 .

Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology.

William F. Weiss, M. Ivanova, C. Roberts, 2010, Biochemistry.

Temperature Dependence of Protein Solution Viscosity and Protein-Protein Interactions: Insights into the Origins of High-Viscosity Protein Solutions.

E. Furst, C. Roberts, V. Razinkov, 2020, Molecular pharmaceutics.

Liquid-liquid immiscibility in single-component network-forming fluids: Model calculations and implications for polyamorphism in water

P. Debenedetti, C. Roberts, George A. Karayiannakis, 1998 .

Predicting unfolding thermodynamics and stable intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation.

Xinqiao Jia, C. Roberts, K. Kiick, 2016, Biophysical chemistry.

Characterization of high-molecular-weight nonnative aggregates and aggregation kinetics by size exclusion chromatography with inline multi-angle laser light scattering.

William F. Weiss, C. Roberts, Yi Li, 2009, Journal of pharmaceutical sciences.

A model to investigate cell surface interactions: PEGylated alkanethiolates on gold - protein resistance and visualization

A. Göpferich, C. Roberts, C. Steinem, 2004 .

Nucleation, Aggregation, and Conformational Distortion

C. Roberts, 2014 .

Predicting Experimental B22 Values and the Effects of Histidine Charge States for Monoclonal Antibodies Using Coarse-Grained Molecular Simulations.

C. Roberts, C. O’Brien, I. Budyak, 2022, Molecular pharmaceutics.

Freezing of Aqueous Solutions and Chemical Stability of Amorphous Pharmaceuticals: Water Clusters Hypothesis.

A. Soper, M. Pikal, C. Roberts, 2019, Journal of pharmaceutical sciences.

Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes.

Steven Blake, Bruce A Kerwin, Christopher J Roberts, 2016, The journal of physical chemistry. B.

Role of Anisotropic Interactions for Proteins and Patchy Nanoparticles

M. Blanco, C. Roberts, 2014, The journal of physical chemistry. B.

Weak IgG self‐ and hetero‐association characterized by fluorescence analytical ultracentrifugation

J. Correia, T. Laue, C. Roberts, 2018, Protein science : a publication of the Protein Society.

Relating particle formation to salt- and pH-dependent phase separation of non-native aggregates of alpha-chymotrypsinogen A.

Erinc Sahin, C. Roberts, Andrew M. Kroetsch, 2012, Journal of pharmaceutical sciences.

Therapeutic protein aggregation: mechanisms, design, and control.

Christopher J Roberts, C. Roberts, 2014, Trends in biotechnology.

Nonnative protein polymers: structure, morphology, and relation to nucleation and growth.

William F. Weiss, C. Roberts, E. Kaler, 2007, Biophysical journal.

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling.

Shiew-Mei Huang, Filippos Kesisoglou, Johannes G Khinast, 2019, Journal of pharmaceutical sciences.

Neutron reflectivity measurement of protein A–antibody complex at the solid-liquid interface

P. Butler, C. Roberts, D. Bracewell, 2017, Journal of chromatography. A.

Reexamining protein-protein and protein-solvent interactions from Kirkwood-Buff analysis of light scattering in multi-component solutions.

Yi Li, Christopher J Roberts, M. Blanco, 2011, The Journal of chemical physics.

Engineering pharmaceutical stability with amorphous solids

Pablo G. Debenedetti, P. Debenedetti, C. Roberts, 2002 .

Nonnative aggregation of an IgG1 antibody in acidic conditions: part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates.

Christopher J Roberts, T. Laue, C. Roberts, 2011, Journal of pharmaceutical sciences.

Multi-variate approach to global protein aggregation behavior and kinetics: effects of pH, NaCl, and temperature for alpha-chymotrypsinogen A.

Babatunde A. Ogunnaike, Yi Li, B. Ogunnaike, 2010, Journal of pharmaceutical sciences.

Nucleation, growth, and activation energies for seeded and unseeded aggregation of alpha-chymotrypsinogen A.

William F. Weiss, C. Roberts, J. Andrews, 2008, Biochemistry.

Conformational and aggregation properties of a PEGylated alanine-rich polypeptide.

C. Roberts, K. Kiick, A. Top, 2011, Biomacromolecules.

Size-exclusion chromatography with multi-angle light scattering for elucidating protein aggregation mechanisms.

Erinc Sahin, Christopher J Roberts, Erinc Sahin, 2012, Methods in molecular biology.

Toward a Suite of Coarse-Grained Models for Molecular Simulation of Monoclonal Antibodies and Therapeutic Proteins.

C. Roberts, J. Forder, Hassan Shahfar, 2021, The journal of physical chemistry. B.

Coarse-Grained Antibody Models for "Weak" Protein-Protein Interactions from Low to High Concentrations.

C. Roberts, A. Saluja, Cesar Calero-Rubio, 2016, The journal of physical chemistry. B.

Protein aggregation, particle formation, characterization & rheology

Prasad Sarangapani, Samiul Amin, C. Roberts, 2014 .

Comparison of Huggins Coefficients and Osmotic Second Virial Coefficients of Buffered Solutions of Monoclonal Antibodies

J. Douglas, C. Roberts, M. Bender, 2021, Polymers.

Coarse-grained modeling of protein second osmotic virial coefficients: sterics and short-ranged attractions.

Alexander Grünberger, Pin-Kuang Lai, M. Blanco, 2013, The journal of physical chemistry. B.

Predicting Protein Interactions of Concentrated Globular Protein Solutions Using Colloidal Models.

E. Furst, C. Roberts, Mahlet A Woldeyes, 2017, The journal of physical chemistry. B.

Protein aggregation and its impact on product quality.

Christopher J Roberts, C. Roberts, 2014, Current opinion in biotechnology.

Specific-ion effects on the aggregation mechanisms and protein-protein interactions for anti-streptavidin immunoglobulin gamma-1.

Bruce A Kerwin, Christopher J Roberts, Vladimir I Razinkov, 2015, The journal of physical chemistry. B.

Conformational stability as a design target to control protein aggregation.

Christopher J Roberts, A. Robinson, C. Roberts, 2014, Protein engineering, design & selection : PEDS.

Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.

William F. Weiss, Andrea Naranjo, Erinc Sahin, 2011, Biochemistry.

IgG cooperativity – Is there allostery? Implications for antibody functions and therapeutic antibody development

T. Laue, C. Roberts, Danlin Yang, 2017, mAbs.

Protein adsorption, desorption, and aggregation mediated by solid-liquid interfaces.

Christopher J Roberts, C. Roberts, D. Nesta, 2015, Journal of pharmaceutical sciences.

Driving Forces for Nonnative Protein Aggregation and Approaches to Predict Aggregation-Prone Regions.

Christopher J Roberts, A. Robinson, C. Roberts, 2017, Annual review of chemical and biomolecular engineering.

Principles, approaches, and challenges for predicting protein aggregation rates and shelf life.

William F Weiss, William F. Weiss, Christopher J Roberts, 2009, Journal of pharmaceutical sciences.

The equation of state of an energy landscape

Thomas M Truskett, F. Stillinger, P. Debenedetti, 1999 .

Low-Temperature Mobility of Water in Sugar Glasses: Insights from Thermally Stimulated Current Study

C. Roberts, G. Collins, Evgenyi Shalaev, 2015 .

Non-Arrhenius Protein Aggregation

Wei Wang, C. Roberts, 2013, The AAPS Journal.

Aggregation of anti-streptavidin immunoglobulin gamma-1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration.

Christopher J Roberts, Vladimir I Razinkov, C. Roberts, 2013, Biophysical chemistry.

Thermodynamics of amyloid dissociation provide insights into aggregate stability regimes.

C. Roberts, R. Brummitt, J. Andrews, 2012, Biophysical chemistry.

Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions.

Christopher J Roberts, C. Roberts, R. Brummitt, 2011, Journal of pharmaceutical sciences.

Protein Aggregation Pathways, Kinetics, and Thermodynamics

C. Roberts, Yi Li, 2010 .

Nonnative Protein Aggregation

C. Roberts, Christopher J. Roberts, 2006 .

Irreversible aggregation of recombinant bovine granulocyte-colony stimulating factor (bG-CSF) and implications for predicting protein shelf life.

Christopher J Roberts, C. Roberts, Richard T Darrington, 2003, Journal of pharmaceutical sciences.

Accelerated storage for shelf-life prediction of lyophiles: temperature dependence of degradation of amorphous small molecular weight drugs and proteins.

C. Roberts, S. Ohtake, Ehab Moussa, 2023, Journal of pharmaceutical sciences.

Solvation in mixed aqueous solvents from a thermodynamic cycle approach.

C. Roberts, P. P. Shah, 2008, The journal of physical chemistry. B.

Competing aggregation pathways for monoclonal antibodies

A. Robinson, C. Roberts, Rachel Kroe-Barrett, 2014, FEBS letters.

Predicting Protein-Protein Interactions of Concentrated Antibody Solutions Using Dilute Solution Data and Coarse-Grained Molecular Models.

Christopher J Roberts, C. Roberts, Atul Saluja, 2018, Journal of pharmaceutical sciences.

A Rapid, Small-Volume Approach to evaluate Protein Aggregation at Air-Water Interfaces.

E. Furst, C. Roberts, V. Razinkov, 2020, Journal of pharmaceutical sciences.

Kinetics and competing mechanisms of antibody aggregation via bulk and surface-mediated pathways.

E. Furst, C. Roberts, V. Razinkov, 2020, Journal of pharmaceutical sciences.

Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations.

C. Roberts, W. Qi, E. Neil Lewis, 2015, Biophysical chemistry.

Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration.

B. Kerwin, C. Roberts, V. Razinkov, 2015, The journal of physical chemistry. B.

Relating Protein-Protein Interactions and Aggregation Rates From Low to High Concentrations.

Christopher J Roberts, C. Roberts, Atul Saluja, 2016, Journal of pharmaceutical sciences.

Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1.

Bruce A Kerwin, Christopher J Roberts, Vladimir I Razinkov, 2016, Journal of pharmaceutical sciences.

Identifying Key Residues That Drive Strong Electrostatic Attractions between Therapeutic Antibodies.

H. Sathish, C. Roberts, R. Remmele, 2019, The journal of physical chemistry. B.

Viscosities and Protein Interactions of Bispecific Antibodies and Their Monospecific Mixtures.

E. Furst, C. Roberts, D. Leiske, 2018, Molecular pharmaceutics.

Protein–Protein Interactions in Dilute to Concentrated Solutions: α-Chymotrypsinogen in Acidic Conditions

Vincenzo Martorana, V. Martorana, M. Blanco, 2014, The journal of physical chemistry. B.

Electrostatically Mediated Protein-Protein Interactions for Monoclonal Antibodies: A Combined Experimental and Coarse-Grained Molecular Modeling Approach.

Hasige A Sathish, Christopher J Roberts, H. Sathish, 2019, Journal of pharmaceutical sciences.

Light Scattering to Quantify Protein-Protein Interactions at High Protein Concentrations.

E. Furst, C. Roberts, Mahlet A Woldeyes, 2019, Methods in molecular biology.

How Well Do Low- and High-Concentration Protein Interactions Predict Solution Viscosities of Monoclonal Antibodies?

Eric M Furst, Christopher J Roberts, Vladimir I Razinkov, 2019, Journal of pharmaceutical sciences.

Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies.

Christopher J Roberts, A. Grillo, Erinc Sahin, 2010, Journal of pharmaceutical sciences.

Aggregation and pH-temperature phase behavior for aggregates of an IgG2 antibody.

William F. Weiss, Kevin R. King, Erinc Sahin, 2012, Journal of pharmaceutical sciences.

Osmotic virial coefficients for model protein and colloidal solutions: importance of ensemble constraints in the analysis of light scattering data.

Vincent K Shen, Daniel W Siderius, Christopher J Roberts, 2012, The Journal of chemical physics.

Antibodies Adsorbed to the Air-Water Interface Form Soft Glasses.

J. Vermant, E. Furst, C. Roberts, 2023, Langmuir : the ACS journal of surfaces and colloids.

Electrostatically Driven Protein-Protein Interactions: Quantitative Prediction of Second Osmotic Virial Coefficients to Aid Antibody Design.

C. Roberts, R. Esfandiary, A. Parupudi, 2022, The journal of physical chemistry letters.

High Pressure Light Scattering of Therapeutic Proteins To Probe Aggregation and Protein-Protein Interactions.

C. Roberts, W. Qi, S. Teixeira, 2023, The journal of physical chemistry. B.

Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1

Christopher J Roberts, A. Robinson, C. Roberts, 2015, mAbs.

Characterizing aggregate growth and morphology of alanine-rich polypeptides as a function of sequence chemistry and solution temperature from scattering, spectroscopy, and microscopy.

Xinqiao Jia, C. Roberts, K. Kiick, 2020, Biophysical chemistry.

Modulation of self-association and subsequent fibril formation in an alanine-rich helical polypeptide.

C. Roberts, K. Kiick, A. Top, 2008, Biomacromolecules.

Equation of State of the Energy Landscape of SPC/E Water

F. Stillinger, C. Roberts, †. A. P. G. Debenedetti, 1999 .

Kinetic folding studies of the P22 tailspike beta-helix domain reveal multiple unfolded states.

A. Robinson, C. Roberts, M. Spatara, 2009, Biophysical chemistry.

Multi-variate approach to global protein aggregation behavior and kinetics: effects of pH, NaCl, and temperature for alpha-chymotrypsinogen A.

B. Ogunnaike, C. Roberts, Yi Li, 2010, Journal of pharmaceutical sciences.

Protein Aggregation, Irreversible: Stabilization Strategies

C. Roberts, 2010 .

A quasichemical approach for protein-cluster free energies in dilute solution.

C. Roberts, T. M. Young, 2007, The Journal of chemical physics.

Effects of temperature and osmolytes on competing degradation routes for an IgG1 antibody.

C. Roberts, D. Nesta, Nayoung Kim, 2013, Journal of pharmaceutical sciences.

Predicting High-Concentration Interactions of Monoclonal Antibody Solutions: Comparison of Theoretical Approaches for Strongly Attractive Versus Repulsive Conditions.

Erinc Sahin, C. Roberts, A. Saluja, 2019, The journal of physical chemistry. B.

Predicting unfolding thermodynamics and stable intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation.

Xinqiao Jia, C. Roberts, K. Kiick, 2016, Biophysical chemistry.