T. Edwards

发表

Helix-mediated protein–protein interactions as targets for intervention using foldamers

Thomas A. Edwards, Andrew J. Wilson, T. Edwards, 2011, Amino Acids.

ATP-Driven Remodeling of the Linker Domain in the Dynein Motor

S. Burgess, M. Walker, P. Knight, 2012, Structure.

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

Rachel L. Dods, J. Éléouët, T. Edwards, 2014, Proceedings of the National Academy of Sciences.

Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL

T. Edwards, Bara Malkova, H. Jenkins, 2011, Proceedings of the National Academy of Sciences.

Modeling of Arylamide Helix Mimetics in the p53 Peptide Binding Site of hDM2 Suggests Parallel and Anti-Parallel Conformations Are Both Stable

Michael R. Shirts, Jonathan C. Fuller, M. Shirts, 2012, PloS one.

Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces

Gail J. Bartlett, R. Sessions, D. Woolfson, 2019, ACS chemical biology.

Hazara nairovirus elicits differential induction of apoptosis and nucleocapsid protein cleavage in mammalian and tick cells.

T. Edwards, J. Fuller, R. Hewson, 2019, Journal of General Virology.

The crystal structure of the Hazara virus nucleocapsid protein

T. Edwards, E. Punch, R. Hewson, 2015, BMC Structural Biology.

Expression, purification and crystallization of the Crimean-Congo haemorrhagic fever virus nucleocapsid protein.

T. Edwards, J. Barr, S. D. Carter, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

A missense variant in specificity protein 6 (SP6) is associated with amelogenesis imperfecta

C. Inglehearn, A. Mighell, T. Edwards, 2020, Human molecular genetics.

Bespoke RNA recognition by Pumilios.

T. Edwards, 2015, Biochemical Society transactions.

Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.

Daniel P. Mulvihill, D. Sousa, T. Edwards, 2011, The Biochemical journal.

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics† †Electronic supplementary information (ESI) available: Detailed experimental procedures and characterisation; additional biophysical data. See DOI: 10.1039/

A. Breeze, S. Warriner, A. Nelson, 2016, Chemical communications.

Cannabinoids modulate potassium current in cultured hippocampal neurons.

R. Hampson, S. Deadwyler, S. Childers, 1993, Receptors & channels.

Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency

R. Sessions, A. Nelson, Andrew J. Wilson, 2020, Chemistry.

Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution.

T. Edwards, H. Jenkins, M. Walden, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture

T. Edwards, Samantha Hover, J. Fontana, 2022, mBio.

Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation

R. Sessions, L. Lian, Andrew J. Wilson, 2020, Chemical science.

Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces

R. Sessions, D. Woolfson, A. Nelson, 2019, ACS chemical biology.

Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein

T. Edwards, J. Barr, J. Hiscox, 2012, Journal of Virology.

Tula orthohantavirus nucleocapsid protein is cleaved in infected cells and may sequester activated caspase-3 during persistent infection to suppress apoptosis.

T. Edwards, R. Hewson, J. Mankouri, 2019, The Journal of general virology.

The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture

T. Edwards, Samantha Hover, J. Fontana, 2022, mBio.

Probing Protein Surfaces: QSAR Analysis with Helix Mimetics

S. Warriner, Andrew J. Wilson, V. Azzarito, 2016, Chembiochem : a European journal of chemical biology.

Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.

A. Brass, Harinder Singh, A. Aggarwal, 2002, Journal of structural biology.

Crystal structure of BstYI at 1.85A resolution: a thermophilic restriction endonuclease with overlapping specificities to BamHI and BglII.

Shuang-yong Xu, A. Aggarwal, C. Escalante, 2004, Journal of molecular biology.

Host switching pathogens, infectious outbreaks and zoonosis: A Marie Skłodowska-Curie innovative training network (HONOURs).

P. Maes, J. Matthijnssens, M. Van Ranst, 2018, Virus research.

Probing Bunyavirus N protein oligomerisation using mass spectrometry

A. Ashcroft, T. Edwards, J. Barr, 2014, Rapid communications in mass spectrometry : RCM.

Structure of Pumilio Reveals Similarity between RNA and Peptide Binding Motifs

A. Aggarwal, T. Edwards, R. Wharton, 2001, Cell.

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6ob00078a Click here for additional data file.

A. Breeze, S. Warriner, A. Nelson, 2016, Organic & biomolecular chemistry.

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics.

Andrew J. Wilson, Kérya Long, T. Edwards, 2013, Bioorganic & medicinal chemistry.

N-alkylated oligoamide alpha-helical proteomimetics.

S. Warriner, Andrew J. Wilson, T. Edwards, 2010, Organic & biomolecular chemistry.

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction

Jeffrey P. Plante, Thomas Burnley, Barbora Malkova, 2009, Chemical communications.

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

A. Nelson, Andrew J. Wilson, T. Edwards, 2017, Chemical science.

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies.

A. Breeze, S. Warriner, A. Nelson, 2015, Molecular bioSystems.

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein–Protein Interactions**

Andrew J. Wilson, Kérya Long, T. Edwards, 2015, Angewandte Chemie.

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03559c Click here for additional data file.

S. Warriner, Andrew J. Wilson, V. Azzarito, 2015, Chemical science.

Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction

A. Breeze, S. Warriner, A. Nelson, 2014, Chembiochem : a European journal of chemical biology.

Aromatic Oligoamide Foldamers with a "Wet Edge" as Inhibitors of the α- Helix-Mediated p53-hDM2 Protein-Protein Interaction

Andrew J. Wilson, N. Murphy, T. Edwards, 2013 .

2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature.

S. Warriner, Andrew J. Wilson, V. Azzarito, 2012, Organic & biomolecular chemistry.

Conformational properties of O-alkylated benzamides

S. Warriner, Andrew J. Wilson, V. Azzarito, 2012 .

Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

M. Rodnina, W. Wintermeyer, S. Homans, 2012, Proceedings of the National Academy of Sciences.

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

T. Edwards, A. O’Neill, Liam K. R. Sharkey, 2016, mBio.

Crystal structure of the SF3 helicase from adeno-associated virus type 2.

A. Aggarwal, C. Escalante, R. Linden, 2003, Structure.

Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.

M. Rosenfeld, A. Aggarwal, D. Rose, 2002, Molecular cell.

Development of a multiplex assay for antibody detection in serum against pathogens affecting ruminants

T. Edwards, J. Barr, A. Brun, 2020, Transboundary and emerging diseases.

Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance[CC-BY]

G. Wong, J. Grimwood, J. Schmutz, 2016, Plant Cell.

Understanding p300-transcription factor interactions using sequence variation and hybridization

R. Sessions, Andrew J. Wilson, T. Edwards, 2021, bioRxiv.

Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics

N. Ranson, T. Edwards, A. O’Neill, 2020, Structure.

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests

P. Millner, T. Edwards, R. Hewson, 2020, PLoS neglected tropical diseases.

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization

M. Luo, N. Ranson, R. Elliott, 2013, Nucleic acids research.

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening

C. Fishwick, T. Edwards, J. Barr, 2018, Antiviral research.

The structure of a native orthobunyavirus ribonucleoprotein reveals a key role for viral RNA in maintaining its helical architecture

T. Edwards, Samantha Hover, J. Fontana, 2021, bioRxiv.

Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle

T. Edwards, R. Hewson, J. Mankouri, 2016, Journal of Virology.

Crystal structure of the catalytic core of human DNA polymerase kappa.

Robert E. Johnson, A. Aggarwal, L. Prakash, 2004, Structure.

Query-guided protein–protein interaction inhibitor discovery†

R. Sessions, D. Woolfson, D. M. Andrews, 2021, Chemical science.

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

M. McPherson, A. Breeze, T. Edwards, 2020, bioRxiv.

Mutagenesis Mapping of the Protein-Protein Interaction Underlying FusB-Type Fusidic Acid Resistance

T. Edwards, A. O’Neill, G. Cox, 2013, Antimicrobial Agents and Chemotherapy.

Crystal Structure of the SF 3 Helicase from Adeno-Associated Virus Type 2

A. Aggarwal, C. Escalante, R. Linden, 2003 .

Crystallization and characterization of Pumilo: a novel RNA binding protein.

A. Aggarwal, C. Escalante, T. Edwards, 2000, Journal of structural biology.

Crystallization and characterization of Smaug: a novel RNA-binding motif.

A. Aggarwal, C. Escalante, T. Edwards, 2002, Biochemical and biophysical research communications.

Cannabinoid receptors: G-protein-mediated signal transduction mechanisms.

R. Hampson, S. Deadwyler, S. Childers, 1993, Biochemical Society symposium.

Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology

D. Hughes, M. McPherson, J. Duan, 2017, Science Signaling.

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci

N. Ranson, G. Atkinson, T. Edwards, 2022, Nucleic acids research.

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex

Rachel L. Dods, J. Éléouët, T. Edwards, 2018, mBio.

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein–Protein Interactions†

Andrew J. Wilson, Kérya Long, T. Edwards, 2015, Angewandte Chemie.

Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation

T. Edwards, M. Peckham, Marcin Wolny, 2016, The Biochemical journal.

Eukaryotic translesion synthesis DNA polymerases: structure and function

Robert E. Johnson, A. Aggarwal, L. Prakash, 2005 .

Model of the brain tumor-Pumilio translation repressor complex.

A. Aggarwal, T. Edwards, R. Wharton, 2003, Genes & development.

Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs**

J. Clarke, Andrew J. Wilson, T. Edwards, 2020, Chembiochem : a European journal of chemical biology.

Structure and Function of the Human Respiratory Syncytial Virus M2-1 Protein.

T. Edwards, J. Barr, Georgia M. Pangratiou, 2018, Sub-cellular biochemistry.

Co-occupancy of two Pumilio molecules on a single hunchback NRE.

A. Aggarwal, C. Escalante, T. Edwards, 2009, RNA.

Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

R. Sessions, D. Woolfson, S. Dutt, 2021, RSC chemical biology.

Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs

J. Clarke, Andrew J. Wilson, T. Edwards, 2019, bioRxiv.

A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain.

S. Carr, A. Baron, T. Edwards, 2007, Journal of molecular biology.

Solution structure of the Vts1 SAM domain in the presence of RNA.

Xin Wang, Lei Zeng, A. Palmer, 2006, Journal of molecular biology.

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

Rachel L. Dods, J. Éléouët, T. Edwards, 2014, Proceedings of the National Academy of Sciences.

Host switching pathogens, infectious outbreaks and zoonosis: A Marie Skłodowska-Curie innovative training network (HONOURs).

P. Maes, J. Matthijnssens, M. Van Ranst, 2018, Virus research.

Held out wings RNA binding activity in the cytoplasm during early spermatogenesis

A. Bretman, T. Edwards, J. Aspden, 2022, bioRxiv.

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

A. Nelson, Andrew J. Wilson, T. Edwards, 2017, Chemical science.

Structure and RNA binding of the mouse Pumilio-2 Puf domain.

T. Edwards, H. Jenkins, Rosanna Baker-Wilding, 2009, Journal of structural biology.

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies.

A. Breeze, S. Warriner, A. Nelson, 2015, Molecular bioSystems.