J. Gutiérrez

发表

Backbone flexibility controls the activity and specificity of a protein-protein interface: specificity in snake venom metalloproteases.

Klaus R Liedl, Hannes G. Wallnoefer, Irmgard Merfort, 2010, Journal of the American Chemical Society.

Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom.

J. Gutiérrez, T. Escalante, A. Rucavado, 2009, Toxicon : official journal of the International Society on Toxinology.

Role of TNF-α, IL-1β and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice

J. Gutiérrez, F. Chaves, C. Teixeira, 2005 .

Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms.

J. Gutiérrez, V. Petricevich, C. Teixeira, 2000, Toxicon : official journal of the International Society on Toxinology.

Convergent evolution of pain-inducing defensive venom components in spitting cobras

P. Dorrestein, J. Calvete, I. Vetter, 2020, Science.

Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis

J. Gutiérrez, K. Shea, Jeffrey O’Brien, 2018, PLoS neglected tropical diseases.

Phospholipases A2: unveiling the secrets of a functionally versatile group of snake venom toxins.

J. Gutiérrez, B. Lomonte, 2013, Toxicon : official journal of the International Society on Toxinology.

Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Biochimie.

Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom.

R. Arni, J. Gutiérrez, B. Lomonte, 2000, Archives of biochemistry and biophysics.

Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani.

R. Arni, R. Ward, J. Gutiérrez, 1998, Biochimica et biophysica acta.

Phospholipase A2 myotoxins from Bothrops snake venoms.

J. Gutiérrez, B. Lomonte, 1995, Toxicon : official journal of the International Society on Toxinology.

Autocatalytic acylation of phospholipase-like myotoxins.

J. Gutiérrez, B. Lomonte, J. Pedersen, 1995, Biochemistry.

Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom.

J. Gutiérrez, B. Lomonte, C. Díaz, 1995, Natural toxins.

Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and Bothrops nummifer (jumping viper).

R. Arni, J. Gutiérrez, 1993, Toxicon : official journal of the International Society on Toxinology.

Calcium ion independent membrane leakage induced by phospholipase-like myotoxins.

A. Desideri, J. Gutiérrez, J. Pedersen, 1992, Biochemistry.

Priority Actions and Progress to Substantially and Sustainably Reduce the Mortality, Morbidity and Socioeconomic Burden of Tropical Snakebite

J. Gutiérrez, R. Harrison, 2016, Toxins.

Circumstances and Consequences of Snakebite Envenomings: A Qualitative Study in South-Eastern Costa Rica

J. Gutiérrez, Jazmín Arias-Rodríguez, 2020, Toxins.

Confronting the Neglected Problem of Snake Bite Envenoming: The Need for a Global Partnership

J. Gutiérrez, D. Warrell, R. Theakston, 2006, PLoS medicine.

The Global Snake Bite Initiative: an antidote for snake bite

David J. Williams, P. Gopalakrishnakone, J. Gutiérrez, 2010, The Lancet.

Snakebite envenoming from a global perspective: Towards an integrated approach.

David J. Williams, J. Gutiérrez, D. Warrell, 2010, Toxicon : official journal of the International Society on Toxinology.

The Need for Full Integration of Snakebite Envenoming within a Global Strategy to Combat the Neglected Tropical Diseases: The Way Forward

David J. Williams, J. Calvete, J. Gutiérrez, 2013, PLoS neglected tropical diseases.

Understanding and confronting snakebite envenoming: The harvest of cooperation.

J. Gutiérrez, 2016, Toxicon : official journal of the International Society on Toxinology.

Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase.

J. Rosa, J. Gutiérrez, B. Lomonte, 2013, Journal of proteomics.

An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica.

J. Gutiérrez, C. Avila, E. Rojas, 1988, Toxicon : official journal of the International Society on Toxinology.

Myotoxic phospholipases A(2) in bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.

J. Gutiérrez, B. Lomonte, A. Soares, 2000, Biochimie.

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.

P. Dorrestein, J. Calvete, G. Whiteley, 2018, Journal of proteomics.

Snakebite envenoming

David J. Williams, J. Calvete, J. Gutiérrez, 2017, Nature Reviews Disease Primers.

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.

J. Calvete, L. Sanz, J. Gutiérrez, 2016, Toxicon : official journal of the International Society on Toxinology.

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development.

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2015, Journal of proteomics.

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2016 .

Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2016, Journal of proteomics.

Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening

A. H. Laustsen, C. Workman, K. Kalogeropoulos, 2019, Toxins.

A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa.

J. Gutiérrez, D. Warrell, R. Harrison, 2003, Toxicon : official journal of the International Society on Toxinology.

A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling

J. Gutiérrez, B. Lomonte, C. Montecucco, 2012, Cell Death and Disease.

Defining the pathogenic threat of envenoming by South African shield-nosed and coral snakes (genus Aspidelaps), and revealing the likely efficacy of available antivenom.

J. Calvete, G. Whiteley, J. Gutiérrez, 2019, Journal of proteomics.

Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice

J. Gutiérrez, B. Lomonte, A. Rucavado, 2001, International journal of experimental pathology.

Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom

J. Gutiérrez, F. Chaves, C. Teixeira, 2003, Muscle & nerve.

Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment.

P. Gasque, J. Gutiérrez, A. Rucavado, 2000, Mediators of inflammation.

Appraisal of antivenom production in public laboratories in Latin America during the first semester of 2020: The impact of COVID-19

J. Gutiérrez, H. W. Fan, M. Vigilato, 2021, PLoS neglected tropical diseases.

Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19

J. Gutiérrez, J. Drexler, M. Flores-Díaz, 2021, Frontiers in Medicine.

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

J. Gutiérrez, T. Escalante, A. Rucavado, 2021, Toxins.

An in vitro α-neurotoxin—nAChR binding assay correlates with lethality and in vivo neutralization of a large number of elapid neurotoxic snake venoms from four continents

K. Ratanabanangkoon, J. Gutiérrez, K. Pruksaphon, 2020, PLoS neglected tropical diseases.

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom

M. Lewin, J. Gutiérrez, S. Samuel, 2018, Toxins.

Global Availability of Antivenoms: The Relevance of Public Manufacturing Laboratories

J. Gutiérrez, 2018, Toxins.

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

J. Gutiérrez, A. Arias, S. Ainsworth, 2017, PLoS neglected tropical diseases.

Anticomplementary activity of horse IgG and F(ab')2 antivenoms.

J. Gutiérrez, D. Tambourgi, C. C. Squaiella-Baptistão, 2014, The American journal of tropical medicine and hygiene.

Reducing the impact of snakebite envenoming in Latin America and the Caribbean: achievements and challenges ahead.

J. Gutiérrez, 2014, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Current challenges for confronting the public health problem of snakebite envenoming in Central America

J. Gutiérrez, 2014, Journal of Venomous Animals and Toxins including Tropical Diseases.

New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India

David J. Williams, J. Calvete, J. Gutiérrez, 2013, The Indian journal of medical research.

Preclinical Evaluation of Caprylic Acid-Fractionated IgG Antivenom for the Treatment of Taipan (Oxyuranus scutellatus) Envenoming in Papua New Guinea

David J. Williams, J. Gutiérrez, S. Jensen, 2011, PLoS neglected tropical diseases.

Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Journal of venom research.

[Comparative study of venoms of newborn and adult specimens of Bothrops asper].

J. Gutiérrez, F. Chaves, R. Bolaños, 1980, Revista de biologia tropical.

Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom.

J. Gené, J. Gutiérrez, L. Cerdas, 1985, Toxicon : official journal of the International Society on Toxinology.

Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom.

J. Gené, J. Gutiérrez, L. Cerdas, 1989, Toxicon : official journal of the International Society on Toxinology.

Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes).

J. Gutiérrez, J. Núñez, G. Rojas, 1992, Toxicon : official journal of the International Society on Toxinology.

Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production.

Jose M. Jimenez, J. Gutiérrez, G. Rojas, 1994, Toxicon : official journal of the International Society on Toxinology.

Skeletal muscle necrosis and regeneration after injection of BaH1, a hemorrhagic metalloproteinase isolated from the venom of the snake Bothrops asper (Terciopelo).

J. Gutiérrez, F. Chaves, G. Borkow, 1995, Experimental and molecular pathology.

Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom.

J. Gutiérrez, Y. Angulo, R. Estrada, 1997, Toxicon : official journal of the International Society on Toxinology.

Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom.

J. Gutiérrez, B. Lomonte, A. Rucavado, 1998, Toxicon : official journal of the International Society on Toxinology.

A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms.

J. Gutiérrez, V. Núñez, L. Arenas, 1999, Toxicon : official journal of the International Society on Toxinology.

Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications.

J. Gutiérrez, J. López, E. Rojas, 2002, Revista de biologia tropical.

Pharmacokinetic-Pharmacodynamic Relationships of Immunoglobulin Therapy for Envenomation

J. Gutiérrez, B. Lomonte, G. León, 2003, Clinical pharmacokinetics.

Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment.

J. Gutiérrez, B. Lomonte, E. Rojas, 2005, Acta tropica.

Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa.

J. Gutiérrez, D. Warrell, A. Nasidi, 2005, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of Bothrops asper bites in Colombia.

Juan F. Silva, J. Gutiérrez, D. Warrell, 2006, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management.

J. Calvete, L. Sanz, J. Gutiérrez, 2011, Journal of proteomics.

Second generation snake antivenomics: comparing immunoaffinity and immunodepletion protocols.

J. Calvete, J. Gutiérrez, D. Pla, 2012, Toxicon : official journal of the International Society on Toxinology.

Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A(2): role of negatively charged phospholipids as potential membrane binding sites.

J. Gutiérrez, A. Rucavado, A. Schroit, 2001, Archives of biochemistry and biophysics.

Infectious Complications Following Snakebite by Bothrops lanceolatus in Martinique: A Case Series

R. Neviere, J. Gutiérrez, B. Mégarbane, 2019, The American journal of tropical medicine and hygiene.

Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper

J. Gutiérrez, B. Lomonte, Y. Angulo, 2011, Cell biochemistry and function.

Isolation of a myotoxin from Bothrops asper venom: partial characterization and action on skeletal muscle.

J. Gutiérrez, C. Ownby, G. Odell, 1984, Toxicon : official journal of the International Society on Toxinology.

Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer.

J. Gutiérrez, B. Lomonte, L. Cerdas, 1986, Toxicon : official journal of the International Society on Toxinology.

A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).

J. Gutiérrez, B. Lomonte, 1989, Toxicon : official journal of the International Society on Toxinology.

Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom.

J. Gutiérrez, B. Lomonte, C. Díaz, 1992, Archives of biochemistry and biophysics.

Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica.

J. Gutiérrez, B. Lomonte, A. Rucavado, 1997, Archives of biochemistry and biophysics.

Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro.

J. Gutiérrez, B. Lomonte, W. Cho, 1999, Toxicon : official journal of the International Society on Toxinology.

Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom.

J. Gutiérrez, B. Lomonte, V. Rodrigues, 2000, Archives of biochemistry and biophysics.

Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide

S. Maier, L. Watkins, R. M. Barrientos, 2004, Pain.

Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins.

J. Fox, J. Gutiérrez, T. Escalante, 2009, Journal of proteome research.

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)

M. Lewin, J. Gutiérrez, B. Lomonte, 2019, Scientific Reports.

Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing

A. Conesa, J. Dopazo, J. Calvete, 2011, BMC Genomics.

Why myotoxin-containing snake venoms possess powerful nucleotidases?

F. Di Virgilio, J. Gutiérrez, B. Lomonte, 2013, Biochemical and biophysical research communications.

In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom

A. H. Laustsen, Hanif Ali, M. S. Møller, 2022, mAbs.

Snakebite envenoming from an Ecohealth perspective

J. Gutiérrez, 2020, Toxicon: X.

Efficacy of IgG and F(ab')2 antivenoms to neutralize snake venom-induced local tissue damage as assessed by the proteomic analysis of wound exudate.

J. Fox, J. Gutiérrez, T. Escalante, 2012, Journal of proteome research.

A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

J. Gutiérrez, A. Rucavado, C. Teixeira, 2020, Scientific Reports.

Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes.

J. Gutiérrez, M. C. dos Santos, M. Furtado, 1991, Toxicon : official journal of the International Society on Toxinology.

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage

J. Calvete, L. Sanz, J. Fox, 2015, PLoS neglected tropical diseases.

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

A. H. Laustsen, C. Clouser, J. Gutiérrez, 2017, PeerJ.

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus.

A. H. Laustsen, C. Clouser, J. Gutiérrez, 2017, PeerJ.

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A[sub]2[sub] from the Central American coral snake, [i]Micrurus nigrocinctus[i]

A. H. Laustsen, Vigneault, C. Clouser, 2016 .

Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin.

R. Arni, M. Murakami, J. Gutiérrez, 2005, Journal of molecular biology.

Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis

J. Fox, Jéssica K A Macêdo, J. Gutiérrez, 2016, PLoS neglected tropical diseases.

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

J. Fox, J. Gutiérrez, T. Escalante, 2016, Toxins.

Changes in basement membrane components in an experimental model of skeletal muscle degeneration and regeneration induced by snake venom and myotoxic phospholipase A2.

S. Gastaldello, J. Gutiérrez, T. Escalante, 2021, Toxicon : official journal of the International Society on Toxinology.

Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms?

S. Gastaldello, J. Gutiérrez, T. Escalante, 2018, Toxins.

Polymorphonuclear neutrophil leukocytes in snakebite envenoming.

J. Gutiérrez, A. Soares, J. Zuliani, 2020, Toxicon : official journal of the International Society on Toxinology.

Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture

S. Gastaldello, J. Gutiérrez, B. Lomonte, 2013, Muscle & nerve.

Correction: Poor Regenerative Outcome after Skeletal Muscle Necrosis Induced by Bothrops asper Venom: Alterations in Microvasculature and Nerves

J. Gutiérrez, A. Rucavado, P. Saravia-Otten, 2011, PLoS ONE.

Poor Regenerative Outcome after Skeletal Muscle Necrosis Induced by Bothrops asper Venom: Alterations in Microvasculature and Nerves

J. Gutiérrez, A. Rucavado, P. Saravia-Otten, 2011, PloS one.

Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration.

J. Gutiérrez, J. Zuliani, S. Zamuner, 2005, Toxicon : official journal of the International Society on Toxinology.

Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom.

J. Gutiérrez, A. Rucavado, A. Moura-da-Silva, 2010, Toxicon.

Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies.

J. Gutiérrez, A. Moura-da-Silva, D. Butera, 2003, Toxicon : official journal of the International Society on Toxinology.

Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies.

J. Gutiérrez, B. Lomonte, A. Alape-Girón, 1994, Toxicon : official journal of the International Society on Toxinology.

Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action

J. Gutiérrez, B. Lomonte, C. Montecucco, 2008, Cellular and Molecular Life Sciences.

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

A. H. Laustsen, R. Zenobi, J. Gutiérrez, 2022, bioRxiv.

Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

J. Calvete, L. Sanz, J. Gutiérrez, 2016, Toxins.

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.

J. Gutiérrez, W. Wüster, K. Arbuckle, 2017, Toxicology letters.

Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity.

J. Gutiérrez, C. Ownby, 2003, Toxicon : official journal of the International Society on Toxinology.

Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells

J. Gutiérrez, A. Rucavado, O. Brenes, 2005, Journal of cellular biochemistry.

Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper.

J. Fox, J. Gutiérrez, B. Lomonte, 1997, The Biochemical journal.

A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis

J. Gutiérrez, B. Lomonte, C. Teixeira, 2018, Mediators of inflammation.

A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A2 on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A2α

J. Balsinde, M. Balboa, J. Gutiérrez, 2020, Biomolecules.

Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding

J. Gutiérrez, T. Escalante, A. Rucavado, 2016, Toxins.

Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases.

J. Fox, J. Gutiérrez, T. Escalante, 2011, Journal of proteomics.

Experimental pathology of local tissue damage induced by Bothrops asper snake venom.

J. Gutiérrez, T. Escalante, A. Rucavado, 2009, Toxicon : official journal of the International Society on Toxinology.

Snake venom metalloproteinases. Biological roles and participation in the pathophysiology of envenomation.

J. Gutiérrez, T. Escalante, A. Rucavado, 2009 .

ALOHA: AI-guided tool for the quantification of venom-induced haemorrhage in mice

A. H. Laustsen, William Michael Laprade, J. Gutiérrez, 2022, bioRxiv.

Role of cyclooxygenases in oedema-forming activity of bothropic venoms.

J. Wallace, J. Gutiérrez, C. Teixeira, 2007, Toxicon : official journal of the International Society on Toxinology.

Understanding structural and functional aspects of PII snake venom metalloproteinases: characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis.

J. Calvete, L. Sanz, J. Gutiérrez, 2014, Biochimie.

Snakebite Envenoming: A Public Health Perspective

J. Gutiérrez, 2012 .

Nephrotoxicity induced by the venom of Hypnale hypnale from Sri Lanka: Studies on isolated perfused rat kidney and renal tubular cell lines.

J. Gutiérrez, T. L. Sampaio, K. Maduwage, 2019, Toxicon : official journal of the International Society on Toxinology.

Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteome research.

The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF‐α and PGE2‐dependent mechanisms

J. Gutiérrez, C. M. Fernandes, A. Leite, 2007, British journal of pharmacology.

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).

J. Calvete, L. Sanz, J. Gutiérrez, 2011, Journal of proteome research.

Venoms, venomics, antivenomics

J. Calvete, L. Sanz, J. Gutiérrez, 2009, FEBS letters.

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity.

David J. Williams, J. Calvete, J. Gutiérrez, 2012, Journal of proteomics.

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.

J. Calvete, L. Sanz, J. Gutiérrez, 2009, Journal of proteomics.

Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2.

J. Gutiérrez, B. Lomonte, B. Francis, 1991, Archives of biochemistry and biophysics.

Innovative Immunization Strategies for Antivenom Development

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2018, Toxins.

Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin

J. Gutiérrez, B. Lomonte, M. Sasa, 2016, Toxins.

Two color morphs of the pelagic yellow-bellied sea snake, Pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom.

J. Calvete, L. Sanz, J. Gutiérrez, 2014, Journal of proteomics.

Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom.

J. Calvete, J. Gutiérrez, B. Lomonte, 2011, Toxicon : official journal of the International Society on Toxinology.

Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches.

J. Calvete, L. Sanz, J. Gutiérrez, 2011, Journal of proteome research.

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca.

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2017, Journal of proteomics.

Venom of Bothrops asper from Mexico and Costa Rica: intraspecific variation and cross-neutralization by antivenoms.

J. Gutiérrez, M. Jiménez-Corona, M. Herrera, 2012, Toxicon : official journal of the International Society on Toxinology.

Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: toxicological and taxonomical insights.

J. Calvete, J. Gutiérrez, B. Lomonte, 2012, Journal of proteomics.

Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, The American journal of tropical medicine and hygiene.

Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms.

David J. Williams, J. Calvete, L. Sanz, 2017, Journal of proteomics.

Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays.

J. Calvete, L. Sanz, J. Gutiérrez, 2014, Journal of proteomics.

Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.

J. Gutiérrez, T. Escalante, A. Rucavado, 2002, Mediators of inflammation.

Synergism between Basic Asp49 and Lys49 Phospholipase A2 Myotoxins of Viperid Snake Venom In Vitro and In Vivo

J. Gutiérrez, B. Lomonte, C. Montecucco, 2014, PloS one.

A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming.

David J. Williams, J. Calvete, U. Kuch, 2014, Bulletin of the World Health Organization.

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920).

M. Lewin, J. Gutiérrez, B. Lomonte, 2019 .

DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants.

J. Gutiérrez, A. Sittenfeld, H. Raventos, 1991, Toxicon : official journal of the International Society on Toxinology.

p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities.

J. Gutiérrez, B. Lomonte, C. Díaz, 1993, Toxicon : official journal of the International Society on Toxinology.

Perspectives and recommendations towards evidence-based health care for scorpion sting envenoming in the Brazilian Amazon: A comprehensive review.

W. Monteiro, M. Lacerda, J. Gutiérrez, 2019, Toxicon : official journal of the International Society on Toxinology.

The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms.

J. Gutiérrez, B. Lomonte, T. Escalante, 2001, Toxicon : official journal of the International Society on Toxinology.

Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.

David J. Williams, J. Gutiérrez, S. Serrano, 2014, The American journal of tropical medicine and hygiene.

Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom.

J. Gutiérrez, B. Lomonte, A. Rucavado, 1995, Experimental and molecular pathology.

Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo).

J. Gutiérrez, C. Díaz, G. Borkow, 1995, Toxicon : official journal of the International Society on Toxinology.

Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica.

J. Gutiérrez, B. Lomonte, V. Núñez, 2011, Journal of proteomics.

Characterization of α‐Neurotoxin and Phospholipase A2 Activities from Micrurus Venoms

J. Gutiérrez, P. Bougis, H. Rochat, 1996 .

A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom.

J. Gutiérrez, A. Rucavado, A. Moura-da-Silva, 2014, Toxicon : official journal of the International Society on Toxinology.

Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?

J. Gutiérrez, B. Lomonte, Y. Angulo, 2014, PeerJ.

Role of Collagens and Perlecan in Microvascular Stability: Exploring the Mechanism of Capillary Vessel Damage by Snake Venom Metalloproteinases

J. Fox, J. Gutiérrez, T. Escalante, 2011, PloS one.

Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper.

J. Gutiérrez, A. Rucavado, J. Núñez, 1998, International journal of experimental pathology.

Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice.

J. Gutiérrez, B. Lomonte, F. Chaves, 1986, British journal of experimental pathology.

Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2.

J. Gutiérrez, B. Lomonte, C. Teixeira, 2016, Toxicology letters.

Local effects induced by coral snake venoms: evidence of myonecrosis after experimental inoculations of venoms from five species.

J. Gutiérrez, B. Lomonte, E. Rojas, 1983, Toxicon : official journal of the International Society on Toxinology.

Antibody-mediated neutralization and binding-reversal studies on alpha-neurotoxins from Micrurus nigrocinctus nigrocinctus (coral snake) venom.

J. Gutiérrez, A. Alape-Girón, B. Stiles, 1996, Toxicon : official journal of the International Society on Toxinology.

Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper.

J. Gutiérrez, B. Lomonte, E. Moreno, 1986, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

In Vitro Antiplasmodial Activity of Phospholipases A2 and a Phospholipase Homologue Isolated from the Venom of the Snake Bothrops asper

J. Gutiérrez, J. C. Pérez, L. Vargas, 2012, Toxins.

Critical Role of TLR2 and MyD88 for Functional Response of Macrophages to a Group IIA-Secreted Phospholipase A2 from Snake Venom

J. Balsinde, J. Gutiérrez, B. Lomonte, 2014, PloS one.

Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom.

J. Gutiérrez, A. Rucavado, A. Franceschi, 1999, Toxicon : official journal of the International Society on Toxinology.

Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics.

J. Calvete, L. Sanz, J. Gutiérrez, 2014, Journal of proteomics.

Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom.

J. Gutiérrez, C. Teixeira, Y. Cury, 2001, Toxicon : official journal of the International Society on Toxinology.

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2020, Toxins.

Snakebite envenoming

David J. Williams, J. Calvete, J. Gutiérrez, 2017, Nature Reviews Disease Primers.

Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins.

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2015, Toxicon : official journal of the International Society on Toxinology.

Viperid Envenomation Wound Exudate Contributes to Increased Vascular Permeability via a DAMPs/TLR-4 Mediated Pathway

J. Fox, J. Gutiérrez, T. Escalante, 2016, Toxins.

Effect of the phospholipase A2 inhibitor Varespladib, and its synergism with crotalic antivenom, on the neuromuscular blockade induced by Crotalus durissus terrificus venom (with and without crotamine) in mouse neuromuscular preparations.

J. Gutiérrez, R. S. Floriano, S. Hyslop, 2022, Toxicon : official journal of the International Society on Toxinology.

Varespladib (LY315920) inhibits neuromuscular blockade induced by Oxyuranus scutellatus venom in a nerve-muscle preparation.

M. Lewin, J. Gutiérrez, Y. Oshima-Franco, 2020, Toxicon : official journal of the International Society on Toxinology.

The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom.

J. Gutiérrez, L. Rodrigues-Simioni, M. A. Cruz-Höfling, 1995, Toxicon : official journal of the International Society on Toxinology.

Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo).

J. Gutiérrez, F. Chaves, G. León, 1998, Toxicon : official journal of the International Society on Toxinology.

Longitudinal Metabolomics and Lipidomics Analyses Reveal Alterations Associated with Envenoming by Bothrops asper and Daboia russelii in an Experimental Murine Model

J. Fox, J. Gutiérrez, A. Rucavado, 2022, Toxins.

Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab')2 and whole IgG antivenoms.

David J. Williams, J. Gutiérrez, L. Rodrigues-Simioni, 2016, Toxicology letters.

Inhibition of enzymatic activities of Bothrops asper snake venom and docking analysis of compounds from plants used in Central America to treat snakebite envenoming.

J. Gutiérrez, A. Cáceres, L. Preciado, 2021, Journal of ethnopharmacology.

Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom.

J. Gutiérrez, A. Rucavado, J. A. Pereañez, 2013, Toxicon : official journal of the International Society on Toxinology.

Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Journal of proteome research.

Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Journal of proteome research.

Snakebite envenomation in Central America.

J. Gutiérrez, S. Mackessy, 2009 .

Recovery from the Neuroparalysis Caused by the Micrurus nigrocinctus Venom Is Accelerated by an Agonist of the CXCR4 Receptor

J. Gutiérrez, B. Lomonte, C. Montecucco, 2022, Toxins.

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors

T. Pozzan, J. Gutiérrez, B. Lomonte, 2009, Cellular and Molecular Life Sciences.

Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom.

L. M. Gava, R. Arni, M. Murakami, 2004, Biochimica et biophysica acta.

Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom.

R. Arni, J. Gutiérrez, A. Rucavado, 2002, Acta crystallographica. Section D, Biological crystallography.

Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro.

J. Gutiérrez, C. Teixeira, Vanessa Moreira, 2009, Prostaglandins, leukotrienes, and essential fatty acids.

Role of the animal model on the pharmacokinetics of equine-derived antivenoms.

J. Gutiérrez, A. Rojas, Aarón Gómez, 2013, Toxicon : official journal of the International Society on Toxinology.

Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: report of a workshop.

J. Gutiérrez, Y. Angulo, H. W. Fan, 2009, Toxicon : official journal of the International Society on Toxinology.

A phospholipase A₂ from Bothrops asper snake venom activates neutrophils in culture: expression of cyclooxygenase-2 and PGE₂ biosynthesis.

J. Gutiérrez, B. Lomonte, C. Teixeira, 2011, Toxicon : official journal of the International Society on Toxinology.

Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom.

J. Gutiérrez, M. Herrera, G. León, 2015, Toxicon : official journal of the International Society on Toxinology.

Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties.

J. Gutiérrez, C. Diaz-Oreiro, 1997, Toxicon : official journal of the International Society on Toxinology.

Isolation, characterization and mode of neutralization of a potent antihemorrhagic factor from the serum of the snake Bothrops asper.

J. Gutiérrez, G. Borkow, M. Ovadia, 1995, Biochimica et biophysica acta.

An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages

R. Curi, J. Gutiérrez, B. Lomonte, 2014, Mediators of inflammation.

Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases.

J. Gutiérrez, C. Teixeira, A. Soares, 2008, Toxicon : official journal of the International Society on Toxinology.

Trends in snakebite envenomation therapy: scientific, technological and public health considerations.

J. Gutiérrez, B. Lomonte, A. Rucavado, 2007, Current pharmaceutical design.

Quantitation of myonecrosis induced by myotoxin a from prairie rattlesnake (Crotalus viridis viridis) venom.

J. Gutiérrez, C. Ownby, G. Odell, 1982, Toxicon : official journal of the International Society on Toxinology.

An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies.

J. Gutiérrez, B. Lomonte, A. Tarkowski, 1993, JIM - Journal of Immunological Methods.

Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. and Echis spp. African snakes

J. Gutiérrez, Stephanie Chaves-Araya, Cecilia Díaz, 2022, PLoS neglected tropical diseases.

Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol.

J. Gutiérrez, R. Harrison, M. Herrera, 2017, Toxicon : official journal of the International Society on Toxinology.

Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus).

J. Gutiérrez, Aarón Gómez, M. Herrera, 2017, Journal of proteomics.

Physicochemical characterization of commercial freeze‐dried snake antivenoms

J. Gutiérrez, Aarón Gómez, M. Herrera, 2017, Toxicon : official journal of the International Society on Toxinology.

Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom.

David J. Williams, J. Gutiérrez, Aarón Gómez, 2016, Toxicon : official journal of the International Society on Toxinology.

Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods.

J. Gutiérrez, M. Herrera, G. León, 2013, Biologicals : journal of the International Association of Biological Standardization.

Skin pathology induced by snake venom metalloproteinase: acute damage, revascularization, and re-epithelization in a mouse ear model.

J. Gutiérrez, T. Escalante, A. Rucavado, 2008, The Journal of investigative dermatology.

A Lys49 phospholipase A(2) homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line.

J. Gutiérrez, B. Lomonte, R. Mora, 2005, Toxicon : official journal of the International Society on Toxinology.

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms.

J. Gutiérrez, M. Herrera, G. León, 2013, Toxicon : official journal of the International Society on Toxinology.

Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation.

J. Gutiérrez, B. Lomonte, W. Cho, 2005, Toxicon : official journal of the International Society on Toxinology.

Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia.

J. Gómez, J. Gutiérrez, Y. Angulo, 2012, Toxicon : official journal of the International Society on Toxinology.

Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus.

J. Calvete, J. Gutiérrez, B. Lomonte, 2014, Biochimie.

High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern

J. Gutiérrez, C. Reusken, J. Drexler, 2021, bioRxiv.

12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages.

R. Curi, G. Lambeau, J. Gutiérrez, 2019, Chemico-biological interactions.

Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms.

J. Gutiérrez, B. Lomonte, E. Moreno, 1987, Toxicon : official journal of the International Society on Toxinology.

Cleavage of the NH2-terminal octapeptide of Bothrops asper myotoxic lysine-49 phospholipase A2 reduces its membrane-destabilizing effect.

J. Gutiérrez, B. Lomonte, C. Díaz, 1994, Archives of biochemistry and biophysics.

Comparison between IgG and F(ab')(2) polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions.

J. Gutiérrez, B. Lomonte, E. Rojas, 2001, Toxicon : official journal of the International Society on Toxinology.

Isolation , Characterization and Neutralization of Hemorrhagic Toxins from the Venom of the Snake Bothrops asper

J. Gutiérrez, 2010 .

Web-based snake identification service: A successful model of snake identification in Sri Lanka.

J. Gutiérrez, K. Maduwage, P. Karunathilake, 2021, Toxicon : official journal of the International Society on Toxinology.

Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2

M. Lewin, J. Gutiérrez, B. Lomonte, 2019, Toxicon : official journal of the International Society on Toxinology.

Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

David J. Williams, M. Lewin, J. Gutiérrez, 2018, Toxins.

Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle

S. Nourshargh, J. Gutiérrez, T. Escalante, 2016, PloS one.

First look into the venom of Roatan Island's critically endangered coral snake Micrurus ruatanus: Proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom.

J. Gutiérrez, B. Lomonte, Julián Fernández, 2019, Journal of proteomics.

Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper.

J. Gutiérrez, A. Rucavado, A. Franceschi, 2000, Toxicon : official journal of the International Society on Toxinology.

Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper.

J. Gutiérrez, G. Borkow, M. Ovadia, 1993, Toxicon : official journal of the International Society on Toxinology.

Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia.

J. Gutiérrez, V. Núñez, R. Otero, 2003, Toxicon : official journal of the International Society on Toxinology.

Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom.

J. Gutiérrez, B. Lomonte, A. Rucavado, 2014, Journal of proteomics.

Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins – distinct mechanisms of action

J. Gutiérrez, A. Postle, B. Lomonte, 2013, The FEBS journal.

Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics.

J. Calvete, L. Sanz, J. Gutiérrez, 2013, Toxicon : official journal of the International Society on Toxinology.

Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: keys to understand the variable immune response in horses.

J. Calvete, L. Sanz, J. Gutiérrez, 2012, Journal of proteomics.

Low pH formulation of whole IgG antivenom: impact on quality, safety, neutralizing potency and viral inactivation.

J. Gutiérrez, T. Burnouf, G. León, 2012, Biologicals : journal of the International Association of Biological Standardization.

Antivenoms for snakebite envenomings.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2011, Inflammation & allergy drug targets.

Impact of regional variation in Bothrops asper snake venom on the design of antivenoms: integrating antivenomics and neutralization approaches.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Journal of proteome research.

Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom.

J. Gutiérrez, T. Burnouf, C. Su, 2009, Biologicals : journal of the International Association of Biological Standardization.

High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding.

Torsten Lingott, J. Gutiérrez, I. Merfort, 2009, Biochemistry.

Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature.

J. Gutiérrez, G. Solano, M. Herrera, 2009, Toxicon : official journal of the International Society on Toxinology.

Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management.

J. Calvete, L. Sanz, J. Gutiérrez, 2009, Journal of proteomics.

Citrate inhibition of snake venom proteases.

J. Gutiérrez, C. Ownby, R. Cowell, 1998, Toxicon : official journal of the International Society on Toxinology.

Neutralization of hyaluronidase and indirect hemolytic activities of Costa Rican snake venoms by a polyvalent antivenom.

J. Gené, J. Gutiérrez, L. Cerdas, 1985, Toxicon : official journal of the International Society on Toxinology.

Proteomics and histological assessment of an organotypic model of human skin following exposure to Naja nigricollis venom.

A. H. Laustsen, K. Kalogeropoulos, J. Gutiérrez, 2022, Toxicon : official journal of the International Society on Toxinology.

Epidemiology of snakebites in El Salvador (2014-2019).

J. Gutiérrez, A. Alape-Girón, Luis Castillo, 2020, Toxicon : official journal of the International Society on Toxinology.

Snakebite envenoming in French Guiana: assessment of the preclinical efficacy against the venom of Bothrops atrox of two polyspecific antivenoms.

R. Neviere, J. Gutiérrez, A. Arias, 2019, Toxicon : official journal of the International Society on Toxinology.

Analgesic effect of morphine and tramadol in standard toxicity assays in mice injected with venom of the snake Bothrops asper

J. Gutiérrez, A. Arias, R. Harrison, 2018, Toxicon : official journal of the International Society on Toxinology.

Antivenoms: Life-saving drugs for envenomings by animal bites and stings.

J. Gutiérrez, 2018, Toxicon : official journal of the International Society on Toxinology.

Preclinical assessment of the neutralizing efficacy of snake antivenoms in Latin America and the Caribbean: A review

J. Gutiérrez, 2018, Toxicon : official journal of the International Society on Toxinology.

An improved technique for the assessment of venom‐induced haemorrhage in a murine model

J. Gutiérrez, T. Jenkins, Trenton K Stewart, 2017, Toxicon : official journal of the International Society on Toxinology.

Cross‐reactivity and cross‐immunomodulation between venoms of the snakes Bothrops asper, Crotalus simus and Lachesis stenophrys, and its effect in the production of polyspecific antivenom for Central America

J. Gutiérrez, M. Herrera, G. León, 2017, Toxicon : official journal of the International Society on Toxinology.

Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus)

J. Gutiérrez, M. Montero, M. Herrera, 2017, Toxicon : official journal of the International Society on Toxinology.

Industrial Production and Quality Control of Snake Antivenoms

J. Gutiérrez, Diego A. Navarro, Andrés Hernández, 2016 .

Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms.

J. Gutiérrez, G. Solano, M. Herrera, 2015, Toxicon : official journal of the International Society on Toxinology.

Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria.

J. Calvete, J. Gutiérrez, D. Pla, 2015, Toxicon : official journal of the International Society on Toxinology.

The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay.

J. Gutiérrez, T. Escalante, A. Rucavado, 2015, Toxicon : official journal of the International Society on Toxinology.

Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step.

J. Gutiérrez, M. Herrera, G. León, 2015, Biologicals : journal of the International Association of Biological Standardization.

The analgesics morphine and tramadol do not alter the acute toxicity induced by Bothrops asper snake venom in mice.

J. Gutiérrez, Cristina Herrera, 2014, Toxicon : official journal of the International Society on Toxinology.

Antivenom for snakebite envenoming in Sri Lanka: the need for geographically specific antivenom and improved efficacy.

J. Gutiérrez, I. Gawarammana, D. Keyler, 2013, Toxicon : official journal of the International Society on Toxinology.

Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays.

J. Calvete, L. Sanz, J. Gutiérrez, 2013, Toxicon : official journal of the International Society on Toxinology.

Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: implications for the production of polyspecific snake antivenoms.

J. Gutiérrez, M. C. Dos-Santos, M. Herrera, 2011, Toxicon : official journal of the International Society on Toxinology.

Strengthening antivenom production in Central and South American public laboratories: report of a workshop.

J. Gutiérrez, T. Burnouf, H. G. Higashi, 2007, Toxicon : official journal of the International Society on Toxinology.

Half a century of research on Bothrops asper venom variation: Biological and biomedical implications.

J. Calvete, J. Gutiérrez, B. Lomonte, 2022, Toxicon : official journal of the International Society on Toxinology.

A Lys49 Phospholipase A2, Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region

J. Gutiérrez, B. Lomonte, C. Teixeira, 2012, BioMed research international.

First crotoxin-like phospholipase A(2) complex from a New World non-rattlesnake species: nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis.

J. Calvete, L. Sanz, J. Gutiérrez, 2015, Toxicon : official journal of the International Society on Toxinology.

Purification of IgG and albumin from human plasma by aqueous two phase system fractionation

J. Gutiérrez, Y. Angulo, T. Burnouf, 2012, Biotechnology progress.

Biological and biochemical activities of Vipera berus (European viper) venom.

J. Gutiérrez, B. Lomonte, L. Calderón, 1993, Toxicon : official journal of the International Society on Toxinology.

Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil.

J. Calvete, L. Sanz, J. Gutiérrez, 2015, Journal of proteomics.

Antivenoms for the treatment of snakebite envenomings: the road ahead.

J. Gutiérrez, T. Burnouf, G. León, 2011, Biologicals : journal of the International Association of Biological Standardization.

Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG.

J. Gutiérrez, F. Chaves, G. Loria, 2003, Toxicon : official journal of the International Society on Toxinology.

Snakebites are associated with poverty, weather fluctuations, and El Niño

L. F. Chaves, Ting-Wu Chuang, J. Gutiérrez, 2015, Science Advances.

South and Central American Snakes

J. Gutiérrez, C. Malaque, 2017 .

Snakebite Envenomation in Central and South America

J. Gutiérrez, C. Malaque, 2015 .

Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom.

J. Gutiérrez, G. Solano, Aarón Gómez, 2010, Biologicals : journal of the International Association of Biological Standardization.

MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity

O. Pongs, J. Gutiérrez, M. Kneussel, 2015, Proceedings of the National Academy of Sciences.

Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A2.

J. Gutiérrez, A. Soares, V. Rodrigues, 2000, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

J. Gutiérrez, Charles Bailey, Aarthi Narayanan, 2021, Scientific Reports.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

J. Gutiérrez, Charles Bailey, Aarthi Narayanan, 2020, bioRxiv.

[Neutralization of the hemorrhagic effect induced by Bothrops asper (Serpentes: Viperidae) venom with tropical plant extracts].

J. Gutiérrez, O. Castro, M. Romero, 1999, Revista de biologia tropical.

Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper.

J. Gutiérrez, C. Ownby, G. Odell, 1984, Experimental and molecular pathology.

Neutralization of toxic activities of Bothrops asper snake venom by ethnomedicinal plants used in Central America, with emphasis in Guatemala: a review

J. Gutiérrez, A. Cáceres, P. Saravia-Otten, 2022 .

Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes.

J. Gutiérrez, C. Ownby, E. Rojas, 2003, Toxicon : official journal of the International Society on Toxinology.

Improving antivenom availability and accessibility: science, technology, and beyond.

J. Gutiérrez, 2012, Toxicon : official journal of the International Society on Toxinology.

Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka.

David J. Williams, J. Calvete, L. Sanz, 2014, Journal of proteomics.

Vipera berus berus Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom

J. Calvete, J. Gutiérrez, R. Al-Shekhadat, 2019, Toxins.

Deficient Skeletal Muscle Regeneration after Injury Induced by a Clostridium perfringens Strain Associated with Gas Gangrene

J. Gutiérrez, M. Flores-Díaz, A. Alape-Girón, 2018, Infection and Immunity.

Expanding the neutralization scope of the Central American antivenom (PoliVal-ICP) to include the venom of Crotalus durissus pifanorum.

J. Gutiérrez, Cecilia Díaz, Mauricio Arguedas, 2021, Journal of proteomics.

Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue.

J. Gutiérrez, B. Lomonte, S. Marangoni, 2008, Toxicon : official journal of the International Society on Toxinology.

Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus.

J. Gutiérrez, B. Lomonte, S. Marangoni, 2007, Biochimica et biophysica acta.

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.

M. Gelb, M. Lazdunski, G. Lambeau, 2006, Biochemistry.

Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis.

A. H. Laustsen, J. Gutiérrez, P. Gravlund, 2015, Toxicon : official journal of the International Society on Toxinology.

Immune response towards snake venoms.

J. Gutiérrez, Andrés Hernández, M. Herrera, 2011, Inflammation & allergy drug targets.

Phylovenomics of Daboia russelii across the indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka.

J. Calvete, L. Sanz, U. Kuch, 2019, Journal of proteomics.

Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom.

J. Gutiérrez, A. Alape-Girón, I. Gawarammana, 2016, Toxicon : official journal of the International Society on Toxinology.

Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: identification of directly hemolytic phospholipases A2.

J. Gutiérrez, B. Lomonte, R. Arce-Bejarano, 2014, Toxicon : official journal of the International Society on Toxinology.

Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica.

J. Gutiérrez, B. Lomonte, C. Avila, 1990, Toxicon : official journal of the International Society on Toxinology.

A potent antihemorrhagin in the serum of the non-poisonous water snake Natrix tessellata: isolation, characterization and mechanism of neutralization.

J. Gutiérrez, G. Borkow, M. Ovadia, 1994, Biochimica et biophysica acta.

[Viral hepatitis. Epidemiology, control and prevention].

J. Gutiérrez, 1969, Revista de sanidad e higiene publica.

Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice.

J. Gutiérrez, F. Chaves, M. Barboza, 1995, Toxicon : official journal of the International Society on Toxinology.

A pan-specific antiserum produced by a novel immunization strategy shows a high spectrum of neutralization against neurotoxic snake venoms

K. Ratanabanangkoon, J. Gutiérrez, K. Pruksaphon, 2020, Scientific Reports.

Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus

J. Gutiérrez, B. Lomonte, Julián Fernández, 2021, Scientific Reports.

Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus

J. Calvete, L. Sanz, J. Gutiérrez, 2013, BMC Genomics.

Neutralization of toxic activities of Bothrops asper venom by plants of ethnomedical use in Central America: plants collected in Guatemala

J. Gutiérrez, A. Cáceres, P. Saravia-Otten, 2022, Ciencia, Tecnología y Salud.

Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model.

J. Gutiérrez, A. Rucavado, D. Warrell, 2013, Toxicon : official journal of the International Society on Toxinology.

Characterization of Aspercetin, a Platelet Aggregating Component from the Venom of the Snake Bothrops asper which Induces Thrombocytopenia and Potentiates Metalloproteinase-induced Hemorrhage

J. Fox, J. Gutiérrez, T. Escalante, 2001, Thrombosis and Haemostasis.

Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms.

J. Gutiérrez, A. Yarlequé, I. S. Sano-Martins, 2010, Toxicon : official journal of the International Society on Toxinology.

Effect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative study.

J. Gené, J. Gutiérrez, M. Thelestam, 1992, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa.

J. Calvete, J. Gutiérrez, D. Warrell, 2010, Toxicon : official journal of the International Society on Toxinology.

Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.

J. Gutiérrez, B. Lomonte, C. Teixeira, 2003, Toxicon : official journal of the International Society on Toxinology.

Metalloproteinases in disease: identification of biomarkers of tissue damage through proteomics

J. Fox, J. Gutiérrez, T. Escalante, 2018, Expert review of proteomics.

Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage.

J. Gutiérrez, T. Escalante, A. Rucavado, 2005, Toxicon : official journal of the International Society on Toxinology.

Local tissue damage induced by Bothrops snake venoms - A review

J. Gutiérrez, Bruno Lomonte-Vigliotti, 1989 .

Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations.

J. Gutiérrez, B. Lomonte, A. Rucavado, 2007, Biologicals : journal of the International Association of Biological Standardization.

Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols.

J. Gutiérrez, B. Lomonte, G. León, 2005, Toxicon : official journal of the International Society on Toxinology.

Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration.

J. Gutiérrez, B. Lomonte, K. Barbaro, 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom

Fernando Chaves, Catarina F P Teixeira, Stella R Zamunér, 2005, International journal of experimental pathology.

Venom Composition and Diet of the Cantil Agkistrodon bilineatus howardgloydi (Serpentes: Viperidae)

J. Gutiérrez, M. Sasa, A. Solórzano, 1999 .

Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon.

J. Calvete, L. Sanz, J. Gutiérrez, 2014, Journal of proteomics.

Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies.

J. Gutiérrez, B. Lomonte, A. Alagón, 2013, Journal of Proteomics.

Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom.

J. Gené, J. Gutiérrez, B. Lomonte, 1986, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms

J. Calvete, L. Sanz, J. Gutiérrez, 2017, PLoS neglected tropical diseases.

Epidemiology of snakebites in Colombia (2008-2016).

J. Gutiérrez, L. León-Núñez, Gabriel Camero-Ramos, 2020, Revista de salud publica.

Severe snakebite envenomation in French Guiana: When antivenom is not available

J. Gutiérrez, B. Mégarbane, H. Kallel, 2018, Toxicon : official journal of the International Society on Toxinology.

Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom

J. Gutiérrez, B. Lomonte, M. Salazar, 2017, Toxicon : official journal of the International Society on Toxinology.

Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica.

J. Gutiérrez, M. Herrera, G. León, 2014, Toxicon : official journal of the International Society on Toxinology.

Using Geographical Information Systems to Identify Populations in Need of Improved Accessibility to Antivenom Treatment for Snakebite Envenoming in Costa Rica

J. Gutiérrez, M. Sasa, Erik Hansson, 2013, PLoS neglected tropical diseases.

Snakebite Envenoming in Latin America and the Caribbean

J. Gutiérrez, 2013 .

Neutralization of Bothrops mattogrossensis snake venom from Bolivia: experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation.

J. Gutiérrez, G. Solano, M. Herrera, 2010, Toxicon : official journal of the International Society on Toxinology.

Mortality due to snakebite envenomation in Costa Rica (1993-2006).

J. Gutiérrez, Pablo Fernández, 2008, Toxicon : official journal of the International Society on Toxinology.

BITES AND ENVENOMATIONS BY COLUBRID SNAKES IN MEXICO AND CENTRAL AMERICA

J. Gutiérrez, M. Sasa, 2002 .

Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica.

J. Gutiérrez, M. A. Stephano, H. G. Higashi, 2000, Toxicon : official journal of the International Society on Toxinology.

A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia. The Regional Group on Antivenom Therapy Research (REGATHER).

J. Gutiérrez, V. Núñez, R. Otero, 1996, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia).

J. Gutiérrez, V. Núñez, R. Otero, 1995, Toxicon : official journal of the International Society on Toxinology.

The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2009, Protein and peptide letters.

Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu.

J. Gutiérrez, J. Giglio, A. Cintra, 1991, Experimental and molecular pathology.

Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico.

J. Gutiérrez, M. Herrera, G. León, 2016, Revista de biologia tropical.

Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico.

J. Gutiérrez, B. Lomonte, A. Rucavado, 2013, Toxicon : official journal of the International Society on Toxinology.

Light emitting diode (LED) therapy reduces local pathological changes induced by Bothrops asper snake venom

J. Gutiérrez, S. Zamuner, C. Dale, 2018, Toxicon : official journal of the International Society on Toxinology.

Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms

Juan J. Calvete, Bruno Lomonte, J. Calvete, 2014, Toxins.

Pharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbits.

J. Gutiérrez, B. Lomonte, E. Rojas, 2006, Toxicon : official journal of the International Society on Toxinology.

Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms.

J. J. Chavez, J. Gutiérrez, B. Lomonte, 2001, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.

J. Gutiérrez, B. Lomonte, G. León, 1997, Toxicon : official journal of the International Society on Toxinology.

Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms.

J. Gutiérrez, V. Núñez, R. Otero, 1997, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Production of monovalent anti-Bothrops asper antivenom: development of immune response in horses and neutralizing ability.

J. Gutiérrez, F. Chaves, C. Avila, 1988, Revista de biologia tropical.

Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster.

J. Gutiérrez, L. Cerdas, G. Rojas, 1987, Toxicon : official journal of the International Society on Toxinology.

Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo).

J. Gutiérrez, B. Lomonte, E. Moreno, 1987, Toxicon : official journal of the International Society on Toxinology.

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa.

David J. Williams, J. Calvete, K. Ratanabanangkoon, 2011, Journal of proteomics.

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism.

J. Calvete, L. Sanz, J. Gutiérrez, 2009, Journal of proteomics.

Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.

J. Calvete, J. Gutiérrez, B. Lomonte, 2012, Toxicon : official journal of the International Society on Toxinology.

Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage.

J. Gutiérrez, A. Rucavado, 2000, Biochimie.

Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteome research.

Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia.

J. Gené, J. Gutiérrez, B. Lomonte, 1982, Toxicon : official journal of the International Society on Toxinology.

Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity.

J. Gutiérrez, F. Bolaños, Aldo H Urdaneta, 2004, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Karyotypes of five species of coral snakes (Micrurus)

J. Gutiérrez, L. Cerdas, A. Solórzano, 1988 .

[Bothrops ophryomegas Bocourt (Serpentes: Viperidae) in Costa Rica: distribution, lepidosis, sexual variation and karyotype].

J. Gutiérrez, L. Cerdas, A. Solórzano, 1988, Revista de biologia tropical.

Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom.

J. Gutiérrez, A. Rucavado, M. Henríquez, 2008, Toxicon : official journal of the International Society on Toxinology.

In vitro discovery and optimization of a human monoclonal antibody that neutralizes neurotoxicity and lethality of cobra snake venom

A. H. Laustsen, Hanif Ali, M. S. Møller, 2021 .

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2018, Nature Communications.

Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis.

J. Calvete, L. Sanz, J. Gutiérrez, 2013, Journal of proteomics.

Assessment of the viral safety of antivenoms fractionated from equine plasma

J. Gutiérrez, M. A. Stephano, E. Griffiths, 2004, Biologicals.

Changes in myofibrillar components after skeletal muscle necrosis induced by a myotoxin isolated from the venom of the snake Bothrops asper.

J. Gutiérrez, F. Chaves, V. Arce, 1990, Experimental and molecular pathology.

Skeletal muscle regeneration after myonecrosis induced by crude venom and a myotoxin from the snake Bothrops asper (Fer-de-Lance).

J. Gutiérrez, C. Ownby, G. Odell, 1984, Toxicon : official journal of the International Society on Toxinology.

Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteomics.

Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

J. Gutiérrez, F. Chaves, C. Teixeira, 2006, Inflammation Research.

Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation.

J. Gutiérrez, T. Escalante, A. Rucavado, 2004, Toxicon : official journal of the International Society on Toxinology.

Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom.

M. Nonato, J. Gutiérrez, B. Lomonte, 2012, Toxicon : official journal of the International Society on Toxinology.

Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica.

J. Gutiérrez, V. Núñez, R. Otero, 1998, Toxicon : official journal of the International Society on Toxinology.

Current technology for the industrial manufacture of snake antivenoms

J. Gutiérrez, G. Solano, Aarón Gómez, 2018, Toxicon : official journal of the International Society on Toxinology.

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

A. H. Laustsen, C. Clouser, J. Gutiérrez, 2017, PeerJ.

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy.

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2016, Current pharmaceutical design.

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

David J. Williams, M. Lewin, J. Gutiérrez, 2020, Toxins.

Anticoagulant effect of myotoxic phospholipase A2 isolated from the venom of the snake Bothrops asper (Viperidae).

J. Gutiérrez, J. Alvarado, 2016, Revista de biologia tropical.

Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy.

J. Gutiérrez, T. Escalante, A. Rucavado, 2004, Toxicon : official journal of the International Society on Toxinology.

Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: comparison of their stability in an accelerated test.

José Vega-Baudrit, Guillermo León, J. Gutiérrez, 2014, Toxicon : official journal of the International Society on Toxinology.

Analysis of wound exudates reveals differences in the patterns of tissue damage and inflammation induced by the venoms of Daboia russelii and Bothrops asper in mice.

J. Fox, K. Kalogeropoulos, J. Gutiérrez, 2020, Toxicon : official journal of the International Society on Toxinology.

Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites

H. J. de Silva, J. Gutiérrez, D. Lalloo, 2015, PLoS neglected tropical diseases.

Bothrops (Fer-de-lance) snakebites in the French departments of the Americas (Martinique and Guyana): Clinical and experimental studies and treatment by immunotherapy

R. Neviere, J. Gutiérrez, H. Kallel, 2023, PLoS neglected tropical diseases.

Pan-American Lancehead Pit-Vipers: Coagulotoxic Venom Effects and Antivenom Neutralisation of Bothrops asper and B. atrox Geographical Variants

J. Gutiérrez, B. Fry, A. Alagón, 2021, Toxins.

Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothírops snake venoms.

J. Lang, J. Gutiérrez, R. Otero, 1999, Toxicon : official journal of the International Society on Toxinology.

Snakebite envenoming in different national contexts: Costa Rica, Sri Lanka, and Nigeria

J. Gutiérrez, G. Iliyasu, A. Habib, 2021, Toxicon: X.

Enzyme immunoassays for detection and quantification of venoms of Sri Lankan snakes: Application in the clinical setting

J. Gutiérrez, K. Maduwage, I. Gawarammana, 2020, PLoS neglected tropical diseases.

Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms.

J. Fox, J. Gutiérrez, B. Lomonte, 2018, Toxicon : official journal of the International Society on Toxinology.

Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators

S. Maier, L. Watkins, J. Gutiérrez, 2004, Pain.

Coagulopathy induced by viperid snake venoms in a murine model: Comparison of standard coagulation tests and rotational thromboelastometry.

J. Gutiérrez, T. Escalante, A. Rucavado, 2022, Toxicon : official journal of the International Society on Toxinology.

Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.

J. Gutiérrez, T. Escalante, A. Rucavado, 2000, The American journal of tropical medicine and hygiene.

Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice.

J. Gutiérrez, A. Arias, M. Herrera, 2016, Toxicon : official journal of the International Society on Toxinology.

Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom.

David J. Williams, J. Gutiérrez, K. Arbuckle, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Paediatric snakebite envenoming: recognition and management of cases

J. Gutiérrez, A. Habib, K. Maduwage, 2020, Archives of Disease in Childhood.

High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays

A. H. Laustsen, O. Lund, F. De Masi, 2016, Scientific Reports.

Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation.

J. Gutiérrez, G. Solano, S. Lizano, 2002, Biologicals : journal of the International Association of Biological Standardization.

Understanding and tackling snakebite envenoming with transdisciplinary research

J. Gutiérrez, A. Malhotra, I. Bolon, 2022, PLoS neglected tropical diseases.

Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species).

J. Gutiérrez, B. Lomonte, A. Alape-Girón, 1997, Toxicon : official journal of the International Society on Toxinology.

A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus.

J. Gutiérrez, A. Alape-Girón, B. Stiles, 1997, Toxicon : official journal of the International Society on Toxinology.

Instituto Butantan and Instituto Clodomiro Picado: a long-standing partnership in science, technology, and public health.

J. Gutiérrez, C. Teixeira, H. W. Fan, 2021, Toxicon : official journal of the International Society on Toxinology.

Proteomics of wound exudate in snake venom-induced pathology: search for biomarkers to assess tissue damage and therapeutic success.

J. Fox, J. Gutiérrez, T. Escalante, 2011, Journal of proteome research.

High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry.

J. Fox, J. Gutiérrez, T. Escalante, 2011, Journal of proteomics.

Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2002, Toxicon.

Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice.

J. Gutiérrez, B. Lomonte, F. Chaves, 1989, Toxicon : official journal of the International Society on Toxinology.

Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins

J. Gutiérrez, B. Lomonte, C. Montecucco, 2012, PLoS neglected tropical diseases.

Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu.

J. Gutiérrez, A. Rucavado, A. Soares, 2007, Toxicon : official journal of the International Society on Toxinology.

Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest.

J. Calvete, L. Sanz, J. Gutiérrez, 2016, Journal of proteomics.

Basement membrane degradation and inflammation play a role in the pulmonary hemorrhage induced by a P-III snake venom metalloproteinase.

J. Gutiérrez, T. Escalante, A. Rucavado, 2021, Toxicon : official journal of the International Society on Toxinology.

Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study.

J. Fox, J. Gutiérrez, T. Escalante, 2006, Archives of biochemistry and biophysics.

Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin.

C. Moskaluk, J. Fox, J. Gutiérrez, 2005, Archives of biochemistry and biophysics.

In vitro activity of BaH1, the main hemorrhagic toxin of Bothrops asper snake venom on bovine endothelial cells.

J. Gutiérrez, G. Borkow, M. Ovadia, 1995, Toxicon : official journal of the International Society on Toxinology.

Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels.

J. Gutiérrez, G. Borkow, M. Ovadia, 1994, Toxicon : official journal of the International Society on Toxinology.

Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping

A. H. Laustsen, O. Lund, F. De Masi, 2017, PLoS neglected tropical diseases.

Comparison of the immunogenicity and antigenic composition of ten Central American snake venoms.

J. Gutiérrez, C. Ownby, S. G. Anderson, 1993, Toxicon : official journal of the International Society on Toxinology.

Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro.

J. Gutiérrez, B. Lomonte, A. Tarkowski, 1994, Toxicon : official journal of the International Society on Toxinology.

Biochemical and biological characterization of Bothriechis schlegelii snake venoms from Colombia and Costa Rica

J. Gutiérrez, M. L. Santoro, K. Barbaro, 2016, Experimental biology and medicine.

Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom

J. Gutiérrez, T. Escalante, A. Rucavado, 2005, Thrombosis and Haemostasis.

Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases.

J. Gutiérrez, T. Frisan, M. Thelestam, 2004, Toxicon : official journal of the International Society on Toxinology.

Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo).

J. Gutiérrez, G. Borkow, M. Ovadia, 1992, Experimental and molecular pathology.

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus.

J. Gutiérrez, B. Lomonte, M. Herrera, 2018, Journal of proteomics.

Snake venomics of Central American pitvipers: clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteome research.

Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica.

J. Gutiérrez, A. Moura-da-Silva, I. Tanjoni, 2000, Toxicon : official journal of the International Society on Toxinology.

The Struggle of Neglected Scientific Groups: Ten Years of NeTropica Efforts to Promote Research in Tropical Diseases in Central America

J. Gutiérrez, E. Chaves-Olarte, E. Moreno, 2011, PLoS neglected tropical diseases.

Computational Biology in Costa Rica: The Role of a Small Country in the Global Context of Bioinformatics

José María Gutiérrez, Edgardo Moreno, Bruno Lomonte, 2008, PLoS Comput. Biol..

A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas.

J. Calvete, L. Sanz, J. Gutiérrez, 2018, International journal of biological macromolecules.

A Cellular Deficiency of Gangliosides Causes Hypersensitivity to Clostridium perfringens Phospholipase C*

Yoshio Hirabayashi, J. Gutiérrez, B. Catimel, 2005, Journal of Biological Chemistry.

Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study.

J. Gutiérrez, V. Arce, F. Brenes, 1991, International journal of experimental pathology.

Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: Functional profiles of hemolytic and non-hemolytic isoforms.

J. Gutiérrez, B. Lomonte, Julián Fernández, 2017, Toxicology letters.

Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom.

J. Gutiérrez, T. Escalante, A. Rucavado, 2003, Toxicology and applied pharmacology.

Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom.

J. Gutiérrez, A. Rucavado, A. Soares, 2001, Biochimie.

Signaling pathways involved in zymosan phagocytosis induced by two secreted phospholipases A2 isolated from Bothrops asper snake venom in macrophages.

J. Gutiérrez, C. Teixeira, J. Zuliani, 2018, International journal of biological macromolecules.

Traces of Bothrops snake venoms in necrotic muscle preclude myotube formation in vitro.

J. Gutiérrez, L. Leiva, Luciano S. Fusco, 2022, Toxicon : official journal of the International Society on Toxinology.

Tissue pathology induced by snake venoms: how to understand a complex pattern of alterations from a systems biology perspective?

J. Fox, J. Gutiérrez, B. Lomonte, 2010, Toxicon : official journal of the International Society on Toxinology.

Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper.

J. Gutiérrez, A. Rucavado, G. Borkow, 1995, Toxicon : official journal of the International Society on Toxinology.

The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper.

J. Gutiérrez, I. I. Kaiser, S. Aird, 1990, Archives of biochemistry and biophysics.

Isolation of basic myotoxins from Bothrops moojeni and Bothrops atrox snake venoms.

J. Gutiérrez, B. Lomonte, E. Carmona, 1990, Toxicon : official journal of the International Society on Toxinology.

Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.

J. Gutiérrez, B. Lomonte, G. León, 2000, Toxicon : official journal of the International Society on Toxinology.

[Hematologic values and serum enzymes in horses inoculated with snake venoms for the production of antivenins in Costa Rica].

J. Gutiérrez, F. Chaves, E. Rojas, 1992, Revista de biologia tropical.

Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection

J. Gutiérrez, A. Rucavado, J. Quintana, 2015, Toxins.

Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase.

J. Gutiérrez, T. Escalante, A. Rucavado, 2006, Microvascular research.

Structure of a Lys49-phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper).

W. F. de Azevedo, R. Arni, R. Ward, 1999, Toxicon : official journal of the International Society on Toxinology.

Platelet depletion enhances lethal, hemorrhagic and myotoxic activities of Bothrops asper snake venom in a murine model.

J. Gutiérrez, T. Escalante, A. Rucavado, 2022, Toxicon : official journal of the International Society on Toxinology.

Case Report: Hemothorax in Envenomation by the Viperid Snake Bothrops asper.

J. Gutiérrez, M. Sierra, Luis José Pinto, 2019, The American journal of tropical medicine and hygiene.

Preclinical evaluation of the neutralizing ability of a monospecific antivenom for the treatment of envenomings by Bothrops lanceolatus in Martinique

R. Neviere, R. Césaire, J. Gutiérrez, 2018, Toxicon : official journal of the International Society on Toxinology.

Peptidomimetic hydroxamate metalloproteinase inhibitors abrogate local and systemic toxicity induced by Echis ocellatus (saw‐scaled) snake venom

J. Gutiérrez, A. Rucavado, A. Arias, 2017, Toxicon : official journal of the International Society on Toxinology.

Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines.

J. Gutiérrez, A. Rucavado, C. Teixeira, 2006, Toxicon : official journal of the International Society on Toxinology.

Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum.

J. Gené, J. Gutiérrez, B. Lomonte, 1987, Toxicon : official journal of the International Society on Toxinology.

Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity.

J. Gutiérrez, C. Teixeira, J. Zuliani, 2005, Toxicon : official journal of the International Society on Toxinology.

Immunohistochemical demonstration of the binding of Bothrops asper myotoxin to skeletal muscle sarcolemma.

J. Gutiérrez, B. Lomonte, F. Brenes, 1987, Toxicon : official journal of the International Society on Toxinology.

Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics.

J. Calvete, J. Gutiérrez, A. Arias, 2016, Toxicon : official journal of the International Society on Toxinology.

Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo).

J. Gutiérrez, F. Chaves, F. Brenes, 1992, Toxicon : official journal of the International Society on Toxinology.

Preliminary studies on different modes of interaction between hemorrhagic and non-hemorrhagic p-i snake venom metalloproteinases with basement membrane substrates: insights from an In silico approach

J. Gutiérrez, A. Patiño, A. Pereañez, 2018 .

Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue‐damaging activities

J. Fox, J. Gutiérrez, A. Rucavado, 2003, Protein science : a publication of the Protein Society.

Site mutation of residues in a loop surrounding the active site of a PI snake venom metalloproteinase abrogates its hemorrhagic activity.

J. Gutiérrez, T. Escalante, A. Rucavado, 2019, Biochemical and biophysical research communications.

Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii.

J. Calvete, L. Sanz, J. Gutiérrez, 2016, Biochimie.

Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica.

J. Gené, J. Gutiérrez, B. Lomonte, 1989, Toxicon : official journal of the International Society on Toxinology.

Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus.

J. Gutiérrez, L. Cerdas, J. Rosso, 1987, Comparative biochemistry and physiology. B, Comparative biochemistry.

Mapping the Immune Cell Microenvironment with Spatial Profiling in Muscle Tissue Injected with the Venom of Daboia russelii

C. Moskaluk, J. Gutiérrez, T. Escalante, 2023, Toxins.

Snakebite Envenomation as a Neglected Tropical Disease

J. Gutiérrez, 2021 .

A group IIA‐secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways

J. Gutiérrez, C. Teixeira, J. Zuliani, 2011, Journal of leukocyte biology.

Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A(2).

J. Gutiérrez, B. Lomonte, J. Zuliani, 2005, Toxicon : official journal of the International Society on Toxinology.

Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom.

J. Gutiérrez, F. Chaves, L. Cerdas, 2016, Revista de biologia tropical.

In Vitro Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles

J. Gutiérrez, G. Solano, M. Herrera, 2021, Frontiers in Immunology.

Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.

J. Gutiérrez, C. Teixeira, M. Muscará, 2001, Toxicon : official journal of the International Society on Toxinology.

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

G. Carmignoto, J. Gutiérrez, A. Chiavegato, 2010, Proceedings of the National Academy of Sciences.

Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms.

J. Gutiérrez, C. Teixeira, Y. Cury, 2002, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[Understanding snake venoms: 50 years of research in Latin America].

J. Gutiérrez, 2002, Revista de biologia tropical.

Bothrops Snakebite Envenomings in the Amazon Region

R. Neviere, W. Monteiro, J. Gutiérrez, 2020, Current Tropical Medicine Reports.

Effects of Bothrops asper Snake Venom on Lymphatic Vessels: Insights into a Hidden Aspect of Envenomation

J. Gutiérrez, B. Lomonte, R. Mora, 2008, PLoS neglected tropical diseases.

Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper.

J. Calvete, L. Sanz, J. Gutiérrez, 2007, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture.

J. Gutiérrez, G. Borkow, M. Ovadia, 1997, Toxicology and applied pharmacology.

The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes.

J. Gutiérrez, B. Lomonte, C. Montecucco, 2010, Toxicon : official journal of the International Society on Toxinology.

Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage.

J. Gutiérrez, S. Arvidson, M. Thelestam, 2007, The Journal of infectious diseases.

Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: evidence of rapid plasma membrane damage and a dual role for extracellular calcium.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2007, Toxicology in vitro : an international journal published in association with BIBRA.

Effects of Bothrops asper (terciopelo) myotoxin III, a basic phospholipase A2, on liposomes and mouse gastrocnemius muscle.

J. Gutiérrez, M. Thelestam, E. Bultrón, 1993, Toxicon : official journal of the International Society on Toxinology.

Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom.

R. Arni, R. Ward, J. Gutiérrez, 2001, Archives of biochemistry and biophysics.

Snakebite mortality in Costa Rica.

J. Gutiérrez, G. Rojas, G. Bogarín, 1997, Toxicon : official journal of the International Society on Toxinology.

A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia. The Regional Group on Antivenom Therapy Research (REGATHER).

J. Gutiérrez, V. Núñez, R. Otero, 1996, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[Neutralization of local effects of Bothrops asper venom by polyvalent antivenin].

J. Gutiérrez, F. Chaves, L. Cerdas, 1981, Toxicon.

Systemic vascular leakage induced in mice by Russell’s viper venom from Pakistan

J. Fox, J. Gutiérrez, T. Escalante, 2018, Scientific Reports.

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms

J. Calvete, J. Gutiérrez, J. Kool, 2018, Communications Biology.

Antibiotic therapy for snakebite envenoming

R. Neviere, J. Gutiérrez, H. Kallel, 2020, The journal of venomous animals and toxins including tropical diseases.

“Bad things come in small packages”: predicting venom-induced coagulopathy in Bothrops atrox bites using snake ontogenetic parameters

W. Monteiro, M. Lacerda, J. Gutiérrez, 2020, Clinical toxicology.

Oral Microbiota of the Snake Bothrops lanceolatus in Martinique

R. Neviere, J. Gutiérrez, B. Mégarbane, 2018, International journal of environmental research and public health.

Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.

J. Fox, J. Gutiérrez, A. Rucavado, 2003, Archives of biochemistry and biophysics.

Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake bothrops asper.

J. Gutiérrez, T. Escalante, A. Rucavado, 2000, Biochemical pharmacology.

Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids.

J. Calvete, L. Sanz, J. Gutiérrez, 2015, Toxicon : official journal of the International Society on Toxinology.

Systemic cytokine response in children bitten by snakes in Costa Rica

J. Gutiérrez, B. Lomonte, Shuxian Hu, 2001, Pediatric emergency care.

Venomous snakebites in children and adolescents: a 12-year retrospective review

J. Gutiérrez, I. Faingezicht, M. París, 2001 .

Toxicological, enzymatic, and immunochemical characterization of Bothrops asper (Serpentes: Viperidae) reference venom from Panama

J. Gutiérrez, R. Otero-Patiño, N. Vega, 2020 .

Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead

J. Calvete, L. Sanz, J. Gutiérrez, 2017, Toxins.

Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: an antivenomics and neutralization study.

David J. Williams, J. Calvete, L. Sanz, 2014, Journal of proteomics.

Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: application in horse immunization for antivenom production.

J. Gutiérrez, F. Chaves, M. Ovadia, 1998, Toxicon : official journal of the International Society on Toxinology.

Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies.

J. Gutiérrez, B. Lomonte, C. Díaz, 1992, Toxicon : official journal of the International Society on Toxinology.

Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability.

J. Gutiérrez, B. Lomonte, E. Carmona, 1990, Toxicon : official journal of the International Society on Toxinology.

Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms.

J. Gutiérrez, B. Lomonte, L. Calderón, 1991, Toxicon : official journal of the International Society on Toxinology.

Isolation from a polyvalent antivenom of antibodies to a myotoxin in Bothrops asper snake venom.

J. Gutiérrez, B. Lomonte, E. Mata, 1985, Toxicon : official journal of the International Society on Toxinology.

Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture.

J. Gutiérrez, G. Borkow, M. Ovadia, 1997, Toxicon : official journal of the International Society on Toxinology.

Chapter 208 – Bothrops asper Hemorrhagic Proteinases

J. Gutiérrez, 2013 .

Bothrops asper Hemorrhagic Proteinases

J. Gutiérrez, A. Rucavado, M. Ovadia, 2004 .

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.

M. Lazdunski, J. Fox, J. Gutiérrez, 2000, The Biochemical journal.

Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests.

G. Neshich, L. Borro, J. Gutiérrez, 2017, Bioorganic & medicinal chemistry letters.

Identification of new snake venom metalloproteinase inhibitors using compound screening and rational Peptide design.

E. Pérez-Payá, J. Calvete, J. Gutiérrez, 2012, ACS medicinal chemistry letters.

Effects on cultured mammalian cells of myotoxin III, a phospholipase A2 isolated from Bothrops asper (terciopelo) venom.

J. Gutiérrez, E. Butrón, M. Ghelestam, 1993, Biochimica et biophysica acta.

The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities.

J. Gené, J. Gutiérrez, B. Lomonte, 1991, Biochimica et biophysica acta.

Preliminary assessment of antivenom availability and management in the public health system of Costa Rica: An analysis based on a survey to pharmacists in public health facilities

J. Gutiérrez, Angie Leon-Salas, C. Rojas, 2022, Toxicon: X.

Snakebite Envenoming in Children: a Neglected Tropical Disease in a Costa Rican Pediatric Tertiary Care Center.

J. Gutiérrez, M. L. Avila-Agüero, K. Camacho-Badilla, 2019, Acta tropica.

Paediatric snakebite envenoming: the world’s most neglected ‘Neglected Tropical Disease’?

J. Gutiérrez, A. Habib, K. Maduwage, 2020, Archives of Disease in Childhood.

A Call for Incorporating Social Research in the Global Struggle against Snakebite

David J. Williams, J. Calvete, J. Gutiérrez, 2015, PLoS neglected tropical diseases.

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

J. Gutiérrez, B. Lomonte, F. Cunha, 2017, Journal of Venomous Animals and Toxins including Tropical Diseases.

Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro.

J. Gutiérrez, B. Lomonte, H. Selistre‐de‐Araujo, 2006, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line.

J. Gutiérrez, R. Mora, B. Valverde, 2006, Toxicon : official journal of the International Society on Toxinology.

Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox.

J. Gutiérrez, B. Lomonte, V. Núñez, 2004, Toxicon : official journal of the International Society on Toxinology.

Biochemical and Molecular Identification of Type V MRSA among Students at a Small Southern University

J. Gutiérrez, J. Escudero, Stacy Vasquez, 2015 .

Biochemical and biological characterization of Ecuadorian pitviper venoms (genera Bothriechis, Bothriopsis, Bothrops and Lachesis).

U. Kuch, J. Gutiérrez, D. Mebs, 1996, Toxicon : official journal of the International Society on Toxinology.

South American snake venom proteins antigenically related to Bothrops asper myotoxins.

J. Gutiérrez, B. Lomonte, E. Carmona, 1990, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Application of the Amide Test to Differentiation of Species of the Genus Cryptococcus

J. Gutiérrez, S. Pérez-Ramos, 1983 .

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

A. H. Laustsen, B. Voldborg, R. Zenobi, 2023, Nature Communications.

Comparative venomics and preclinical efficacy evaluation of a monospecific Hemachatus antivenom towards sub-Saharan Africa cobra venoms.

J. Calvete, J. Gutiérrez, D. Pla, 2021, Journal of proteomics.

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

Ole Lund, Bruno Lomonte, Kamille E Krause, 2020, PLoS neglected tropical diseases.

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2018, Nature Communications.

Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms

J. Gutiérrez, Cecilia Díaz, G. Solano, 2021, Toxicon: X.

Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?

J. Gutiérrez, B. Lomonte, 2011, Acta chimica Slovenica.

Steps to overcome the North–South divide in research relevant to climate change policy and practice

H. Mshinda, S. Huq, R. Smithers, 2017 .

Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.

J. Gutiérrez, A. Machado, G. Solano, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows.

J. Gutiérrez, M. Herrera, G. León, 2010, Biologicals (Print).

The application of laboratory-based analytical tools and techniques for the quality assessment and improvement of commercial antivenoms used in the treatment of snakebite envenomation.

A. Mukherjee, J. Gutiérrez, Aparup Patra, 2021, Drug testing and analysis.

A pan-specific antiserum produced by a novel immunization strategy shows a high spectrum of neutralization against neurotoxic snake venoms

K. Ratanabanangkoon, J. Gutiérrez, K. Pruksaphon, 2020, Scientific Reports.

A synthetic biology approach for consistent production of plant‐made recombinant polyclonal antibodies against snake venom toxins

J. Forment, J. Calvete, J. Gutiérrez, 2017, Plant biotechnology journal.

Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs.

J. Gutiérrez, B. Lomonte, J. Chippaux, 2005, Toxicon : official journal of the International Society on Toxinology.

Understanding the Snake Venom Metalloproteinases: An Interview with Jay Fox and José María Gutiérrez

J. Fox, J. Gutiérrez, 2017, Toxins.

Clinical Toxicology of Snakebite in Central America

J. Gutiérrez, 2017 .

Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom

J. Calvete, J. Gutiérrez, D. Pla, 2018, Toxicon: X.

231. Second Generation Antivenomics: Comparing Immunoaffinity and Immunodepletion Protocols

Juan J. Calvete, Davinia Pla, José María Gutiérrez, 2012 .

Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities.

A. Cecchini, J. Gutiérrez, A. Soares, 2001, The international journal of biochemistry & cell biology.

Effects of bleeding in horses iÍnmunized with snake venoms for antivenom production

J. Gutiérrez, Y. Angulo, R. Estrada, 1997 .

A Biomimetic of Endogenous Tissue Inhibitors of Metalloproteinases: Inhibition Mechanism and Contribution of Composition, Polymer Size, and Shape to the Inhibitory Effect.

J. Gutiérrez, T. Escalante, M. Nakamoto, 2021, Nano letters.

Standardization of assays for testing the neutralizing ability of antivenoms.

J. Gené, J. Gutiérrez, B. Lomonte, 1990, Toxicon : official journal of the International Society on Toxinology.

Dissociation of enzymatic and toxic activities by the use of antibodies.

J. Gutiérrez, B. Lomonte, 1990, Toxicon : official journal of the International Society on Toxinology.

Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.

J. Gutiérrez, B. Stiles, G. León, 1999, The American journal of tropical medicine and hygiene.

Clinical effects of immunization, bleeding, and albumin-based fluid therapy in horses used as immunoglobulin source to produce a polyspecific antivenom (Echitab-plus-ICP) towards venoms of African snakes

J. Gutiérrez, J. M. Estrada, G. Solano, 2023, Toxicon: X.

Improving the control of snakebite envenomation in Latin America and the Caribbean: a discussion on pending issues.

J. Gutiérrez, H. W. Fan, 2018, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

A. H. Laustsen, J. Gutiérrez, T. Jenkins, 2023, bioRxiv.

Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis.

J. Gutiérrez, B. Lomonte, O. Acosta, 2015, Chemico-biological interactions.

Bothrops asper bite and post-traumatic stress disorder in Costa Rica: Report of two cases.

J. Gutiérrez, Fabián Bonilla-Murillo, Ricardo Millán-González, 2023, Toxicon : official journal of the International Society on Toxinology.

Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production.

J. Gutiérrez, M. Herrera, G. León, 2009, Biologicals : journal of the International Association of Biological Standardization.

Peripheral Arterial Thrombosis following Russell's Viper Bites

S. Miller, J. Gutiérrez, A. Rucavado, 2022, TH Open.

Inhibiting necrosis caused by spitting cobra venom Authors

J. Gutiérrez, T. Jenkins, Laura-Oana Albulescu, 2023 .

Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom.

A. Tulinsky, R. Arni, R. Ward, 1994, Acta crystallographica. Section D, Biological crystallography.

Ten Simple Rules for Aspiring Scientists in a Low-Income Country

José María Gutiérrez, Edgardo Moreno, J. Gutiérrez, 2008, PLoS Comput. Biol..

Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani.

R. Arni, R. Ward, C. Barberato, 1999, Archives of biochemistry and biophysics.

Biochemical and Molecular Identification of Type V MRSA among Students at a Small Southern University

J. Gutiérrez, J. Escudero, Stacy Vasquez, 2015 .

Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Naja spp. African snakes

J. Gutiérrez, Aarón Gómez, M. Herrera, 2023, PLoS neglected tropical diseases.

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms

J. Calvete, J. Gutiérrez, J. Kool, 2018, Communications Biology.

Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus

J. Gutiérrez, B. Lomonte, T. Thum, 2023, Pflügers Archiv - European Journal of Physiology.

Snakebite envenoming

David J. Williams, J. Calvete, J. Gutiérrez, 2017, Nature Reviews Disease Primers.

Physicochemical and immunological effects of adjuvant formulations with snake venom antigens for immunization of horses for antivenom production.

J. Gutiérrez, A. Khandhar, C. Fox, 2023, Toxicon.

A multi-sectorial approach for addressing the problem of snakebite envenoming in Honduras.

J. Gutiérrez, J. Alger, E. Boza-Oviedo, 2019, Toxicon.

Snakebite envenomation in the Caribbean: The role of medical and scientific cooperation

J. Gutiérrez, H. Mehdaoui, D. Résière, 2018, PLoS neglected tropical diseases.

Using Geographical Information Systems to Identify Populations in Need of Improved Accessibility to Antivenom Treatment for Snakebite Envenoming in Costa Rica

J. Gutiérrez, M. Sasa, Erik Hansson, 2013, PLoS neglected tropical diseases.

Venomous animals in a changing world

P. Martinez, J. Gutiérrez, T. Amado, 2022, Global change biology.

In Vivo Neutralization of Myotoxin II, a Phospholipase A2 Homologue from Bothrops asper Venom, Using Peptides Discovered via Phage Display Technology

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2022, ACS Omega.

Long-term sequelae secondary to snakebite envenoming: a single centre retrospective study in a Costa Rican paediatric hospital

J. Gutiérrez, M. Avila-Aguero, K. Camacho-Badilla, 2020, BMJ Paediatrics Open.

Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom

J. Gutiérrez, C. Teixeira, M. Montero, 2014, Journal of immunotoxicology.

Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment.

P. Gasque, J. Gutiérrez, A. Rucavado, 2000 .

Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro.

J. Gutiérrez, B. Lomonte, G. Borkow, 1994, Toxicon.

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms.

J. Gutiérrez, M. Herrera, G. León, 2013, Toxicon : official journal of the International Society on Toxinology.

Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom.

J. Gutiérrez, A. Rucavado, J. A. Pereañez, 2013, Toxicon : official journal of the International Society on Toxinology.

Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening

A. H. Laustsen, C. Workman, K. Kalogeropoulos, 2019, Toxins.

Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice.

J. Gutiérrez, B. Lomonte, F. Chaves, 1986, British journal of experimental pathology.

Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes.

J. Gutiérrez, E. Moreno, 1988, Toxicon : official journal of the International Society on Toxinology.

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca.

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2017, Journal of proteomics.

Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2016, Journal of Proteomics.

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

A. H. Laustsen, J. Gutiérrez, B. Lomonte, 2016 .

Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays.

J. Calvete, L. Sanz, J. Gutiérrez, 2014, Journal of proteomics.

Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches.

J. Calvete, L. Sanz, J. Gutiérrez, 2011, Journal of proteome research.

Proteomic and toxicological analysis of the venom of Micrurus yatesi and its neutralization by an antivenom

J. Gutiérrez, B. Lomonte, Stephanie Chaves-Araya, 2022, Toxicon: X.

Characterization of alpha-neurotoxin and phospholipase A2 activities from Micrurus venoms. Determination of the amino acid sequence and receptor-binding ability of the major alpha-neurotoxin from Micrurus nigrocinctus nigrocinctus.

J. Gutiérrez, P. Bougis, H. Rochat, 1996, European journal of biochemistry.

Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom.

M. Nonato, J. Gutiérrez, B. Lomonte, 2012, Toxicon : official journal of the International Society on Toxinology.

Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii.

J. Calvete, L. Sanz, J. Gutiérrez, 2016, Biochimie.

Skeletal muscle regeneration after myonecrosis induced by Bothrops asper (terciopelo) venom.

J. Gutiérrez, F. Chaves, L. Cerdas, 1986, Toxicon : official journal of the International Society on Toxinology.

Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom.

J. Gutiérrez, B. Lomonte, G. Rojas, 1991, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Hemorrhagic and procoagulant P-III snake venom metalloproteinases differ in their binding to the microvasculature of mouse cremaster muscle.

J. Gutiérrez, T. Escalante, A. Rucavado, 2020, Toxicon : official journal of the International Society on Toxinology.

Proteomic Analysis of Human Blister Fluids Following Envenomation by Three Snake Species in India: Differential Markers for Venom Mechanisms of Action

J. Fox, Jéssica K A Macêdo, J. Gutiérrez, 2019, Toxins.

Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom.

J. Gutiérrez, A. Rucavado, M. Henríquez, 2008, Toxicon : official journal of the International Society on Toxinology.

16th Annual Scientific Congress of Asia Pacific Association of Medical Toxicology (APAMT) 8–10 November 2017, Kandy, Sri Lanka

S. Lanka, J. Gutiérrez, N. Nguyen, 2018, Clinical toxicology.

Anticomplementary activity of horse IgG and F(ab')2 antivenoms.

J. Gutiérrez, D. Tambourgi, C. C. Squaiella-Baptistão, 2012, The American journal of tropical medicine and hygiene.

Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature.

J. Gutiérrez, G. Solano, M. Herrera, 2009, Toxicon : official journal of the International Society on Toxinology.

Bothrops asper Metalloproteinase BaP1

J. Gutiérrez, T. Escalante, A. Rucavado, 2013 .

Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.

J. Calvete, J. Gutiérrez, B. Lomonte, 2012, Toxicon : official journal of the International Society on Toxinology.