H. Miyoshi

发表

Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation

S. Iwata, B. Byrne, C. Luna-Chavez, 2003, Science.

Quantitative analysis of partition behavior of substituted phenols from aqueous phase into liposomes made of lecithin and various lipids

T. Fujita, H. Miyoshi, H. Maeda, 1987 .

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

S. Dan, H. Miyoshi, E. Kodama, 2020, Nature Communications.

Chemical modifications of respiratory complex I for structural and functional studies

H. Miyoshi, M. Murai, 2014, Journal of Bioenergetics and Biomembranes.

Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II.

H. Miyoshi, K. Kita, M. P. Paranagama, 2010, Mitochondrion.

Mass Spectrometric Analysis of the Ubiquinol-binding Site in Cytochrome bd from Escherichia coli*

Masasuke Yoshida, H. Miyoshi, T. Mogi, 2006, Journal of Biological Chemistry.

Occurrence of a Bound Ubiquinone and Its Function in Escherichia coli Membrane-bound Quinoprotein Glucose Dehydrogenase*

Mamoru Yamada, M. Yamada, H. Miyoshi, 2004, Journal of Biological Chemistry.

Current Topics of the Inhibitors of Mitochondrial Complex I

H. Miyoshi, 2012 .

Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I).

T. Yagi, T. Nishioka, A. Ishihara, 2008, Biochemistry.

Synthesis and inhibition mechanism of Delta lac-acetogenins, a novel type of inhibitor of bovine heart mitochondrial complex I.

T. Nishioka, H. Miyoshi, H. Makabe, 2005, Biochemistry.

Hybrid ubiquinone: novel inhibitor of mitochondrial complex I.

H. Miyoshi, K. Sakamoto, Hiromi Yabunaka, 2002, Biochimica et biophysica acta.

Origin of selective inhibition of mitochondrial complex I by pyridinium-type inhibitor MP-24.

H. Iwamura, H. Miyoshi, J. Iwata, 1999, Biochimica et biophysica acta.

Specificity of Pyridinium Inhibitors of the Ubiquinone Reduction Sites in Mitochondrial Complex I*

H. Iwamura, H. Miyoshi, T. Watanabe, 1998, The Journal of Biological Chemistry.

Probing the Ubiquinone Reduction Site of Mitochondrial Complex I Using Novel Cationic Inhibitors*

H. Iwamura, H. Miyoshi, M. Inoue, 1997, The Journal of Biological Chemistry.

An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria.

S. Ōmura, H. Kölbl, H. Miyoshi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of pyranicin and its deoxygenated analogues and their inhibitory action with bovine heart mitochondrial complex I

H. Miyoshi, Y. Hattori, H. Makabe, 2008 .

Regulation of the Mitochondrial Permeability Transition Pore by Ubiquinone Analogs. A Progress Report

X. Leverve, Ludivine Walter, E. Fontaine, 2002, Free radical research.

Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae

B. Barquera, H. Miyoshi, Takayuki Kato, 2022, Nature Communications.

Molecular mechanisms for the induction of peroxidase activity of the cytochrome c-cardiolipin complex.

H. Miyoshi, Masato Abe, I. Moriyama, 2011, Biochemistry.

Structure-activity relationships of some complex I inhibitors.

H. Miyoshi, 1998, Biochimica et biophysica acta.

Crucial importance of length of fatty-acyl chains bound to the sn-2 position of phosphatidylglycerol for growth and photosynthesis of Synechocystis sp. PCC 6803.

N. Nagata, H. Miyoshi, Tomoko Suzuki, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Quantitative relationship between protonophoric and uncoupling activities of analogs of SF6847 (2,6-di-t-butyl-4-(2',2'-dicyanovinyl)phenol).

T. Fujita, T. Nishioka, H. Miyoshi, 1987, Biochimica et biophysica acta.

Comparison of the structures of the quinone-binding sites in beef heart mitochondria.

H. Miyoshi, R. Ramsay, T. Singer, 1993, The Journal of biological chemistry.

Identification of amino acid residues of mammalian mitochondrial phosphate carrier important for its functional expression in yeast cells, as achieved by PCR-mediated random mutation and gap-repair cloning.

H. Miyoshi, Takenori Yamamoto, Y. Shinohara, 2017, Mitochondrion.

Identification of receptors of main sex‐pheromone components of three Lepidopteran species

T. Yasuda, T. Nishioka, H. Miyoshi, 2008, The European journal of neuroscience.

Two Adenine Nucleotide Translocase Paralogues Involved in Cell Proliferation and Spermatogenesis in the Silkworm Bombyx mori

A. Jouraku, T. Kusakabe, H. Miyoshi, 2015, PloS one.

Specific Methylation of Asp160 (49 kDa subunit) Located inside the Quinone Binding Cavity of Bovine Mitochondrial Complex I.

H. Miyoshi, Takahiro Masuya, W. Aoki, 2016, Biochemistry.

Evaluation of Uncoupling Activities of Phenol Derivatives by using a Lipid Membrane-coated Quartz Crystal Microbalance.

T. Fujita, Y. Okahata, H. Miyoshi, 1993 .

Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system.

S. Ōmura, Yukihiro Asami, H. Miyoshi, 2015, The Journal of general and applied microbiology.

Structural factors of antimycin A molecule required for inhibitory action.

H. Iwamura, H. Miyoshi, N. Tokutake, 1994, Biochimica et biophysica acta.

Biochemical and spectroscopic properties of cyanide-insensitive quinol oxidase from Gluconobacter oxydans.

S. Ōmura, H. Miyoshi, T. Mogi, 2009, Journal of biochemistry.

Mechanism for Remodeling of the Acyl Chain Composition of Cardiolipin Catalyzed by Saccharomyces cerevisiae Tafazzin*

H. Miyoshi, Y. Sakai, Masahide Oku, 2016, The Journal of Biological Chemistry.

Syntheses of photoreactive cardiolipins for a photoaffinity labeling study

H. Miyoshi, Ayumi Kosaka, Masato Abe, 2015 .

Synthetic Ubiquinones Specifically Bind to Mitochondrial Voltage-Dependent Anion Channel 1 (VDAC1) in Saccharomyces cerevisiae Mitochondria.

H. Miyoshi, Takenori Yamamoto, Y. Shinohara, 2017, Biochemistry.

Pinpoint Chemical Modification of the Quinone-Access Channel of Mitochondrial Complex I via a Two-Step Conjugation Reaction.

H. Miyoshi, Takeshi Ito, Takahiro Masuya, 2017, Biochemistry.

Characterization of the reaction of decoupling ubiquinone with bovine mitochondrial respiratory complex I

H. Miyoshi, K. Okuda, Takahiro Masuya, 2016, Bioscience, biotechnology, and biochemistry.

Pinpoint chemical modification of Asp160 in the 49 kDa subunit of bovine mitochondrial complex I via a combination of ligand-directed tosyl chemistry and click chemistry.

H. Miyoshi, Takahiro Masuya, Hironobu Morisaka, 2014, Biochemistry.

Site-specific chemical labeling of mitochondrial respiratory complex I through ligand-directed tosylate chemistry.

H. Miyoshi, K. Ifuku, Takahiro Masuya, 2014, Biochemistry.

Concise procedure for the synthesis of cardiolipins having different fatty acid combinations

H. Miyoshi, M. Murai, Masato Abe, 2010 .

Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK‐1, a product of the longevity gene of the nematode worm

H. Miyoshi, K. Kita, N. Shinjyo, 2003, FEBS letters.

Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases.

S. Ōmura, H. Miyoshi, T. Mogi, 2009, Biochimica et biophysica acta.

Uncoupling action of antibiotic sporaviridins with rat-liver mitochondria.

H. Iwamura, H. Miyoshi, M. Suzuki, 1992, Bioscience, biotechnology, and biochemistry.

Quantitative analyses of uncoupling activity of SF6847 (2,6-di-t-butyl-4-(2,2-dicyanovinyl)phenol) and its analogs with spinach chloroplasts

T. Fujita, H. Miyoshi, 1987 .

Photoaffinity Labeling of Respiratory Complex I in Bovine Heart Submitochondrial Particles by Photoreactive [125I] amilorides.

H. Miyoshi, M. Murai, 2019, Bio-protocol.

Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase.

Shûhei Yamamoto, H. Miyoshi, M. Murai, 2011, Biochimica et biophysica acta.

Exploring the binding site of delta(lac)-acetogenin in bovine heart mitochondrial NADH-ubiquinone oxidoreductase.

H. Miyoshi, Nobuyuki Kakutani, M. Murai, 2010, Biochemistry.

Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae

S. Ōmura, Yukihiro Asami, H. Miyoshi, 2015, The Journal of Antibiotics.

Accumulation of hydroxycinnamic acid amides induced by pathogen infection and identification of agmatine coumaroyltransferase in Arabidopsis thaliana

T. Nishioka, A. Ishihara, H. Miyoshi, 2009, Planta.

Probing the Ubiquinone Reduction Site in Bovine Mitochondrial Complex I Using a Series of Synthetic Ubiquinones and Inhibitors

H. Miyoshi, 2001, Journal of bioenergetics and biomembranes.

Analyses of the Acid Dissociation Constants of Multisubstituted Diarylamines Measured in Solvents and Micellar System

T. Fujita, H. Miyoshi, Ze-jian Guo, 1994 .

Quantitative analysis with physicochemical substituent and molecular parameters of uncoupling activity of substituted diarylamines

T. Fujita, H. Miyoshi, Ze-jian Guo, 1991 .

Quantitative analysis of uncoupling activity of substituted phenols with a physicochemical substituent and molecular parameters.

T. Fujita, H. Miyoshi, N. Tokutake, 1990, Biochimica et biophysica acta.

Quantitative analyses of the uncoupling activity of substituted phenols with mitochondria from flight muscles of house flies.

T. Fujita, H. Miyoshi, 1988, Biochimica et biophysica acta.

Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I

K. Shinzawa-Itoh, H. Miyoshi, Takahiro Masuya, 2022, The Journal of biological chemistry.

Uncoupling mechanism of glycoside antibiotic aculeximycin in isolated rat-liver mitochondria.

H. Iwamura, H. Miyoshi, M. Suzuki, 1996, Journal of biochemistry.

Uncoupling activity of a newly developed fungicide, fluazinam [3-chloro-N-(3-chloro-2,6-dinitro-4-trifluoromethylphenyl)-5-trifluoromethyl-2-pyridinamine]

T. Fujita, H. Miyoshi, Ze-jian Guo, 1991 .

Critical role of a methyl group on the γ-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex I.

H. Miyoshi, M. Yamashita, Tetsuaki Tanaka, 2013, Bioorganic & medicinal chemistry letters.

Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics.

H. Iwamura, H. Miyoshi, K. Sakamoto, 2000, European journal of biochemistry.

The biochemical mode of action of the novel selective fungicide cyazofamid: specific inhibition of mitochondrial complex III in Phythium spinosum

H. Miyoshi, S. Mitani, Araki Satoshi, 2001 .

Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae

S. Ōmura, Yukihiro Asami, H. Miyoshi, 2019, The Journal of Antibiotics.

Quantitative relationship between protonophoric and uncoupling activities of substituted phenols.

T. Fujita, T. Nishioka, H. Miyoshi, 1987, Biochimica et biophysica acta.

Dynamic function of the spacer region of acetogenins in the inhibition of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I).

T. Nishioka, Shûhei Yamamoto, H. Miyoshi, 2008, Biochemistry.

Effect of stereochemistry of Δlac-acetogenins on the inhibition of mitochondrial complex I (NADH-ubiquinone oxidoreductase)

T. Nishioka, N. Yoshinaga, H. Miyoshi, 2007 .

Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I.

H. Iwamura, H. Miyoshi, H. Shimada, 1998, Biochimica et biophysica acta.

Total synthesis of cis-solamin and its inhibitory action with bovine heart mitochondrial complex I

H. Miyoshi, Y. Hattori, H. Makabe, 2004 .

Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I.

H. Iwamura, H. Miyoshi, H. Nakato, 2000, Biochimica et biophysica acta.

Synthesis and inhibitory activity of ubiquinone-acetogenin hybrid inhibitor with bovine mitochondrial complex I.

T. Nishioka, H. Miyoshi, Masato Abe, 2003, Bioorganic & medicinal chemistry letters.

Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I.

H. Miyoshi, Hiromi Yabunaka, T. Motoyama, 2002, Bioorganic & medicinal chemistry letters.

Characterization of the ubiquinol oxidation sites in cytochromes bo and bd from Escherichia coli using aurachin C analogues.

H. Iwamura, H. Miyoshi, T. Mogi, 1999, Journal of biochemistry.

Function of the alkyl side chains of Deltalac-acetogenins in the inhibitory effect on mitochondrial complex I (NADH-ubiquinone oxidoreductase).

T. Nishioka, H. Miyoshi, M. Murai, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of photolabile Δlac-acetogenin for photoaffinity labeling of mitochondrial complex I

T. Nishioka, H. Miyoshi, M. Murai, 2006 .

Synthesis of non-THF analogs of acetogenin toward simplified mimics

T. Nishioka, H. Miyoshi, M. Murai, 2005 .

Essential structural features of acetogenins: role of hydroxy groups adjacent to the bis-THF rings.

T. Nishioka, H. Miyoshi, Naoya Ichimaru, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of 13C-Labeled Ubiquinone-Acetogenin Hybrid Inhibitors of Mitochondrial Complex I

T. Nishioka, H. Miyoshi, Naoya Ichimaru, 2004 .

Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue.

H. Miyoshi, H. Makabe, H. Konno, 2004, Bioorganic & Medicinal Chemistry Letters.

Synthesis of murisolin, (15R, 16R, 19R, 20S)-murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-murisolin and their inhibitory action with bovine heart mitochondrial complex I.

H. Miyoshi, Y. Hattori, H. Makabe, 2006, Chemistry, an Asian journal.

Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I.

H. Miyoshi, H. Makabe, Y. Kimura, 2006, Bioorganic & medicinal chemistry.

Inhibitors of mitochondrial respiratory enzymes

H. Miyoshi, 2005 .

Synthesis of Annonaceous Acetogenins and Their Inhibitory Action with Mitochondrial Complex I

H. Miyoshi, Y. Hattori, H. Makabe, 2011 .

Exploring the binding site of acetogenin in the ND1 subunit of bovine mitochondrial complex I.

H. Miyoshi, M. Murai, K. Sekiguchi, 2009, Biochimica et biophysica acta.

Current topics of organic and biological chemistry of annonaceous acetogenins and their synthetic mimics.

H. Miyoshi, H. Makabe, H. Konno, 2008, Current drug discovery technologies.

Mode of inhibitory action of Deltalac-acetogenins, a new class of inhibitors of bovine heart mitochondrial complex I.

T. Nishioka, H. Miyoshi, M. Murai, 2006, Biochemistry.

Acidity and dynamic structure of the potent uncoupler SF6847 (2,6-di-t-butyl-4-(2,2-dicyanovinyl)phenol) and its derivatives

T. Fujita, H. Iwamura, H. Miyoshi, 1993 .

Correlation of the acid dissociation constants of some multisubstituted diphenyl- and phenylpyridylamines

T. Fujita, H. Miyoshi, Ze-jian Guo, 1991 .

Synthesis of pyranicin and its inhibitory action with bovine heart mitochondrial complex I.

H. Miyoshi, Y. Hattori, H. Makabe, 2008, Organic letters.

Synthesis of two possible diastereomers of reticulatain-1

H. Miyoshi, Y. Hattori, H. Makabe, 2004 .

Synthesis of Murisolin (Ia), (15R, 16R, 19R, 20S)‐Murisolin A (Ib), and (15R, 16R, 19S, 20S)‐16,19‐cis‐Murisolin (Ic) and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I.

H. Miyoshi, Y. Hattori, H. Makabe, 2007 .

Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I.

H. Miyoshi, Y. Hattori, H. Makabe, 2007, Bioorganic & medicinal chemistry.

A γ-Lactone Form Nafuredin, Nafuredin-γ, also Inhibits Helminth Complex I

S. Ōmura, H. Miyoshi, H. Tomoda, 2005, The Journal of Antibiotics.

Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin

H. Miyoshi, H. Makabe, M. Murai, 2005 .

Dynamic function of the alkyl spacer of acetogenins in their inhibitory action with mitochondrial complex I (NADH-ubiquinone oxidoreductase).

T. Nishioka, H. Miyoshi, H. Makabe, 2005, Biochemistry.

Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue.

H. Miyoshi, H. Makabe, H. Konno, 2004, Bioorganic & medicinal chemistry letters.

Defining the mechanism of action of S1QELs, specific suppressors of superoxide production in the quinone-reaction site in mitochondrial complex I

H. Miyoshi, M. Murai, Hironori Kimura, 2019, The Journal of Biological Chemistry.

Reduction of Synthetic Ubiquinone QT Catalyzed by Bovine Mitochondrial Complex I Is Decoupled from Proton Translocation.

H. Miyoshi, K. Okuda, W. Aoki, 2016, Biochemistry.

Identification of the Binding Position of Amilorides in the Quinone Binding Pocket of Mitochondrial Complex I.

H. Miyoshi, Takeshi Ito, Hironobu Morisaka, 2015, Biochemistry.

Amilorides bind to the quinone binding pocket of bovine mitochondrial complex I.

H. Miyoshi, Takeshi Ito, M. Murai, 2015, Biochemistry.

Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I

H. Miyoshi, Takeshi Ito, M. Murai, 2015, Bioscience, biotechnology, and biochemistry.

Exploring interactions between the 49 kDa and ND1 subunits in mitochondrial NADH-ubiquinone oxidoreductase (complex I) by photoaffinity labeling.

H. Miyoshi, J. Hirst, M. Murai, 2011, Biochemistry.

Synthesis and characterization of photoaffinity probe of acetogenin, a strong inhibitor of mitochondrial complex I

Shûhei Yamamoto, H. Miyoshi, M. Murai, 2011 .

Characterization of the binding site of Δlac-acetogenin in bovine mitochondrial complex I by photoaffinity labeling

H. Miyoshi, Nobuyuki Kakutani, M. Murai, 2010 .

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

H. Miyoshi, J. Hirst, Z. Yin, 2022, The Journal of biological chemistry.

Current topics on inhibitors of respiratory complex I.

H. Miyoshi, M. Murai, 2016, Biochimica et biophysica acta.

Conserved Amino Acid Residues of the NuoD Segment Important for Structure and Function of Escherichia coli NDH-1 (Complex I)

T. Yagi, H. Miyoshi, A. Matsuno-Yagi, 2014, Biochemistry.

Fenpyroximate binds to the interface between PSST and 49 kDa subunits in mitochondrial NADH-ubiquinone oxidoreductase.

H. Miyoshi, K. Ifuku, M. Murai, 2012, Biochemistry.

Characterization of the inhibitor binding site in mitochondrial NADH-ubiquinone oxidoreductase by photoaffinity labeling using a quinazoline-type inhibitor.

T. Nishioka, H. Miyoshi, M. Murai, 2009, Biochemistry.

The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I.

T. Yagi, T. Nishioka, A. Ishihara, 2007, Biochemistry.

Role of the isoprenyl tail of ubiquinone in reaction with respiratory enzymes: studies with bovine heart mitochondrial complex I and Escherichia coli bo-type ubiquinol oxidase.

H. Iwamura, H. Miyoshi, K. Kano, 1998, Biochemistry.

Characterization of the ubiquinone reduction site of mitochondrial complex I using bulky synthetic ubiquinones.

H. Iwamura, T. Yagi, H. Miyoshi, 1998, Biochemistry.

Current Topics of Organic and Biological Chemistry of Annonaceous Acetogenins and Their Synthetic Mimics

H. Miyoshi, H. Makabe, H. Konno, 2009 .

Inhibitor Probes of the Quinone Binding Sites of Mammalian Complex II and Escherichia coli Fumarate Reductase*

G. Cecchini, V. Yankovskaya, H. Miyoshi, 1996, The Journal of Biological Chemistry.

Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)

S. Ōmura, H. Miyoshi, H. Tomoda, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Crucial structural factors and mode of action of polyene amides as inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I).

T. Nishioka, H. Miyoshi, Takehiko Yoshida, 2007, Biochemistry.

Structural factors of rotenone required for inhibition of various NADH-ubiquinone oxidoreductases.

H. Iwamura, H. Miyoshi, Y. Niidome, 1996, Biochimica et biophysica acta.

Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases.

H. Iwamura, H. Miyoshi, K. Sakamoto, 1996, Biochimica et biophysica acta.

Comparison of the inhibitory action of natural rotenone and its stereoisomers with various NADH-ubiquinone reductases.

H. Iwamura, H. Miyoshi, K. Ebisui, 1994, European journal of biochemistry.

Structure-function studies on the ubiquinol oxidation site of the cytochrome bo complex from Escherichia coli using p-benzoquinones and substituted phenols.

Y. Anraku, H. Iwamura, H. Miyoshi, 1994, The Journal of biological chemistry.

Comparison of structure of quinone redox site in the mitochondrial cytochrome-bc1 complex and photosystem II (QB site).

H. Iwamura, H. Miyoshi, R. Shimizu, 1992, European journal of biochemistry.

Quinones in long‐lived clk‐1 mutants of Caenorhabditis elegans

H. Miyoshi, K. Kano, N. Ishii, 2002, FEBS letters.

A Tightly Bound Quinone Functions in the Ubiquinone Reaction Sites of Quinoprotein Alcohol Dehydrogenase of an Acetic Acid Bacterium, Gluconobacter suboxydans

H. Miyoshi, K. Matsushita, O. Adachi, 2008, Bioscience, biotechnology, and biochemistry.

The quinohemoprotein alcohol dehydrogenase of Gluconobacter suboxydans has ubiquinol oxidation activity at a site different from the ubiquinone reduction site.

H. Miyoshi, K. Matsushita, O. Adachi, 1999, Biochimica et biophysica acta.

Respiratory Inhibition of Acaricide AKD-2023 and Its Deacetyl Metabolite

H. Miyoshi, S. Matsumoto, S. Kinoshita, 1998 .

Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

S. Ōmura, H. Miyoshi, H. Tomoda, 2006, The Journal of Antibiotics.

Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550

S. Ōmura, H. Miyoshi, H. Tomoda, 2006, The Journal of Antibiotics.

Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II).

S. Ōmura, K. Kawahara, H. Miyoshi, 2009, FEMS microbiology letters.

Comprehensive understanding of multiple actions of anticancer drug tamoxifen in isolated mitochondria

O. Shirai, H. Miyoshi, Takahiro Masuya, 2021, Biochimica et Biophysica Acta (BBA) - Bioenergetics.

The morphogenesis-related NDR kinase pathway of Colletotrichum orbiculare is required for translating plant surface signals into infection-related morphogenesis and pathogenesis

H. Miyoshi, Y. Kubo, Sayo Kodama, 2017, PLoS pathogens.

Inhibition of electron transport of rat-liver mitochondria by synthesized antimycin A analogs.

H. Iwamura, H. Miyoshi, N. Tokutake, 1993, Biochimica et biophysica acta.

Mitochondrial dehydrogenases in the aerobic respiratory chain of the rodent malaria parasite Plasmodium yoelii yoelii.

K. Kawahara, H. Miyoshi, T. Mogi, 2008, Journal of biochemistry.

Kinetic mechanism of quinol oxidation by cytochrome bd studied with ubiquinone-2 analogs.

Masasuke Yoshida, E. Muneyuki, H. Miyoshi, 2006, Journal of biochemistry.

Glutamate 107 in subunit I of the cytochrome bd quinol oxidase from Escherichia coli is protonated and near the heme d/heme b595 binuclear center.

Jie Zhang, James Hemp, R. Gennis, 2007, Biochemistry.

Glutamates 99 and 107 in transmembrane helix III of subunit I of cytochrome bd are critical for binding of the heme b595-d binuclear center and enzyme activity.

S. Akimoto, H. Miyoshi, T. Mogi, 2006, Biochemistry.

Active site rearrangement and structural divergence in prokaryotic respiratory oxidases

R. Gennis, H. Michel, W. Kühlbrandt, 2019, Science.

Properties of cytochrome bd plastoquinol oxidase from the cyanobacterium Synechocystis sp. PCC 6803.

H. Miyoshi, T. Mogi, 2009, Journal of biochemistry.

Probing the ubiquinol-binding site in cytochrome bd by site-directed mutagenesis.

S. Akimoto, H. Miyoshi, T. Mogi, 2006, Biochemistry.

Anaerobic NADH-Fumarate Reductase System Is Predominant in the Respiratory Chain of Echinococcus multilocularis, Providing a Novel Target for the Chemotherapy of Alveolar Echinococcosis

H. Miyoshi, N. Nonaka, K. Katakura, 2007, Antimicrobial Agents and Chemotherapy.

Rhodoquinone reaction site of mitochondrial complex I, in parasitic helminth, Ascaris suum.

H. Miyoshi, K. Kita, K. Sakamoto, 2004, Biochimica et biophysica acta.

Isolation and characterization of the stage-specific cytochrome b small subunit (CybS) of Ascaris suum complex II from the aerobic respiratory chain of larval mitochondria.

K. Murayama, H. Miyoshi, T. Aoki, 2003, Molecular and biochemical parasitology.

Tissue‐specific expression and silencing phenotypes of mitochondrial phosphate carrier paralogues in several insect species

A. Jouraku, H. Miyoshi, Y. Shinohara, 2017, Insect molecular biology.

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

S. Dan, H. Miyoshi, E. Kodama, 2020, Nature Communications.

Antibiotic Korormicin A Kills Bacteria by Producing Reactive Oxygen Species

B. Barquera, M. Koffas, H. Miyoshi, 2019, Journal of bacteriology.

Identification of the binding sites for ubiquinone and inhibitors in the Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae by photoaffinity labeling

B. Barquera, Brady F. Cress, M. Koffas, 2017, The Journal of Biological Chemistry.

Probing Substrate Binding Site of the Escherichia coli Quinol Oxidases Using Synthetic Ubiquinol Analogues*

Y. Anraku, H. Iwamura, H. Miyoshi, 1996, The Journal of Biological Chemistry.

Role of a bound ubiquinone on reactions of the Escherichia coli cytochrome bo with ubiquinol and dioxygen

H. Miyoshi, T. Mogi, Y. Orii, 1999, FEBS Letters.

Isolation and characterizations of quinone analogue-resistant mutants of bo-type ubiquinol oxidase from Escherichia coli.

Y. Anraku, H. Miyoshi, T. Mogi, 1998, Biochemistry.

Characterization and functional role of the QH site of bo-type ubiquinol oxidase from Escherichia coli.

Y. Anraku, H. Miyoshi, T. Mogi, 1998, Biochemistry.

Parasite Mitochondria as a Target for Chemotherapy

H. Miyoshi, K. Kita, H. Miyadera, 2001 .

Complex II from phototrophic purple bacterium Rhodoferax fermentans displays rhodoquinol-fumarate reductase activity.

K. Murayama, H. Miyoshi, A. Hiraishi, 2003, European journal of biochemistry.

Role of a bound ubiquinone on reactions of the Escherichia coli cytochrome bo with ubiquinol and dioxygen

H. Miyoshi, T. Mogi, Y. Orii, 1999, FEBS letters.

Topographical characterization of the ubiquinone reduction site of glucose dehydrogenase in Escherichia coli using depth-dependent fluorescent inhibitors.

H. Iwamura, H. Miyoshi, K. Matsushita, 1999, Biochimica et biophysica acta.

Characterization of the ubiquinone binding site in the alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling.

T. Yagi, H. Miyoshi, H. Kosaka, 2010, Biochemistry.

Complementation of coenzyme Q‐deficient yeast by coenzyme Q analogues requires the isoprenoid side chain

H. Miyoshi, M. Murai, Michael P. Murphy, 2010, The FEBS journal.

Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria

S. Ōmura, Yukihiro Asami, H. Miyoshi, 2021, Journal of industrial microbiology & biotechnology.

Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae

S. Ōmura, Yukihiro Asami, H. Miyoshi, 2019, The Journal of Antibiotics.

IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism

H. Miyoshi, Takahiro Masuya, M. Murai, 2020, The Journal of Biological Chemistry.

Role of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in Liposomes.

H. Miyoshi, Y. Sakai, Masahide Oku, 2017, Biochemistry.

Analysis of revertants from respiratory deficient mutants within the center N of cytochrome b in Saccharomyces cerevisiae

J. Coppee, H. Miyoshi, A. Colson, 1994, FEBS Letters.

A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues.

H. Iwamura, H. Miyoshi, N. Tokutake, 1995, Biochimica et biophysica acta.

Inhibition of electron transport of rat liver mitochondria by unnatural (‐)‐antimycin A3

H. Iwamura, H. Miyoshi, H. Kondo, 1991, FEBS letters.

Asymmetric binding of the high-affinity Q(H)(*)(-) ubisemiquinone in quinol oxidase (bo3) from Escherichia coli studied by multifrequency electron paramagnetic resonance spectroscopy.

H. Michel, H. Miyoshi, T. Mogi, 2003, Biochemistry.

Characterization of the membrane domain subunit NuoJ (ND6) of the NADH-quinone oxidoreductase from Escherichia coli by chromosomal DNA manipulation.

T. Yagi, H. Miyoshi, A. Matsuno-Yagi, 2005, Biochemistry.

The ND5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex I.

T. Yagi, H. Miyoshi, A. Matsuno-Yagi, 2003, Biochemistry.

Roles of Bound Quinone in the Single Subunit NADH-Quinone Oxidoreductase (Ndi1) from Saccharomyces cerevisiae*

T. Yagi, H. Miyoshi, A. Matsuno-Yagi, 2007, Journal of Biological Chemistry.

Identification of a novel quinone-binding site in the cytochrome bo complex from Escherichia coli.

Y. Anraku, H. Iwamura, H. Miyoshi, 1994, Journal of Biological Chemistry.

Reaction Mechanism of Single Subunit NADH-Ubiquinone Oxidoreductase (Ndi1) from Saccharomyces cerevisiae

T. Yagi, H. Miyoshi, H. Kosaka, 2011, The Journal of Biological Chemistry.

Cooperation of Two Quinone-Binding Sites in the Oxidation of Substrates by Cytochrome bo

Y. Anraku, H. Miyoshi, T. Mogi, 1998 .

Stabilization of a semiquinone radical at the high‐affinity quinone‐binding site (QH) of the Escherichia coli bo‐type ubiquinol oxidase

Y. Anraku, H. Miyoshi, T. Mogi, 1995, FEBS letters.

Specific chemical modification explores dynamic structure of the NqrB subunit in Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae.

B. Barquera, H. Miyoshi, Takahiro Masuya, 2021, Biochimica et biophysica acta. Bioenergetics.

Inhibitors of a Na+-pumping NADH-ubiquinone oxidoreductase play multiple roles to block enzyme function

B. Barquera, H. Miyoshi, Takeshi Ito, 2020, The Journal of Biological Chemistry.

The side chain of ubiquinone plays a critical role in Na+ translocation by the NADH-ubiquinone oxidoreductase (Na+-NQR) from Vibrio cholerae.

B. Barquera, H. Miyoshi, Takahiro Masuya, 2022, Biochimica et biophysica acta. Bioenergetics.

Localization of Ubiquinone-8 in the Na+-pumping NADH:Quinone Oxidoreductase from Vibrio cholerae*

U. Gerken, H. Miyoshi, H. Möller, 2011, The Journal of Biological Chemistry.

Electron transport inhibition of the cytochrome bc1 complex of rat-liver mitochondria by phenolic uncouplers.

T. Fujita, H. Miyoshi, N. Tokutake, 1991, Biochimica et biophysica acta.

Direct interaction between mitochondrial succinate-ubiquinone and ubiquinol-cytochrome c oxidoreductases probed by sensitivity to quinone-related inhibitors.

H. Iwamura, H. Miyoshi, A. Yamashita, 1996, Journal of biochemistry.

Characterization of inhibitor binding sites of mitochondrial complex I using fluorescent inhibitor.

T. Nishioka, H. Miyoshi, T. Ino, 2003, Biochimica et biophysica acta.

Comparison of the structural features of ubiquinone reduction sites between glucose dehydrogenase in Escherichia coli and bovine heart mitochondrial complex I.

H. Iwamura, H. Miyoshi, K. Matsushita, 1996, European journal of biochemistry.

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

S. Ōmura, Yukihiro Asami, H. Miyoshi, 2017, The Journal of Antibiotics.

Pinpoint Dual Chemical Cross-Linking Explores the Structural Dynamics of the Ubiquinone Reaction Site in Mitochondrial Complex I.

H. Miyoshi, Takahiro Masuya, M. Murai, 2021, Biochemistry.

Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I

Vivek Sharma, K. Shinzawa-Itoh, H. Miyoshi, 2020, The Journal of Biological Chemistry.

Identification of the binding site of the quinone-head group in mitochondrial Coq10 by photoaffinity labeling.

H. Miyoshi, K. Ifuku, M. Kawamukai, 2014, Biochemistry.

UK-2A,B,C and D, novel antifungal antibiotics from Streptomyces sp.517.02. V. Inhibition mechanism of bovine heart mitochondrial cytochrome bc1 by the novel antibiotic UK-2A.

H. Miyoshi, K. Machida, H. Takimoto, 1999, The Journal of antibiotics.

UK-2A, B, C, and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. Part 5. Inhibition Mechanism of Bovine Heart Mitochondrial Cytochrome bc1 by the Novel Antibiotic UK-2A.

H. Miyoshi, K. Machida, H. Takimoto, 2010 .

Exploring the quinone/inhibitor-binding pocket in mitochondrial respiratory complex I by chemical biology approaches

H. Miyoshi, M. Murai, Hironori Kimura, 2018, The Journal of Biological Chemistry.

Pentenediol-Type Compounds Specifically Bind to Voltage-Dependent Anion Channel 1 in Saccharomyces cerevisiae Mitochondria.

H. Miyoshi, Takenori Yamamoto, Y. Shinohara, 2019, Biochemistry.

Quantitative Analysis of Effects of Substituted Phenols on Membrane Characteristics of Lecithin Liposomes

T. Fujita, T. Nishioka, H. Miyoshi, 1986 .

Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones

K. Shinzawa-Itoh, H. Miyoshi, Takahiro Masuya, 2023, The Journal of biological chemistry.

Identification of amino acid residues of mammalian mitochondrial phosphate carrier important for its functional expression in yeast cells , as achieved by PCR-mediated random mutation and gap-repair cloning

H. Miyoshi, Takenori Yamamoto, Y. Shinohara, 2016 .

IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism.

H. Miyoshi, Takahiro Masuya, M. Murai, 2020, Journal of Biological Chemistry.

Natural tetramic acids elicit multiple inhibitory actions against mitochondrial machineries presiding over oxidative phosphorylation.

Yukihiro Asami, H. Miyoshi, Takenori Yamamoto, 2021, Bioscience, biotechnology, and biochemistry.

Mechanism for Remodeling of the Acyl Chain Composition of Cardiolipin Catalyzed by Saccharomyces cerevisiae Tafazzin*

H. Miyoshi, Y. Sakai, Masahide Oku, 2016, The Journal of Biological Chemistry.

Direct evidence for the interaction of stigmatellin with a protonated acidic group in the bc(1) complex from Saccharomyces cerevisiae as monitored by FTIR difference spectroscopy and 13C specific labeling.

W. Mäntele, C. Hunte, H. Miyoshi, 2004, Biochemistry.

Amilorides bind to the quinone binding pocket of bovine mitochondrial complex I.

H. Miyoshi, Takeshi Ito, M. Murai, 2015, Biochemistry.

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

T. Yagi, S. Iwata, H. Miyoshi, 2018, Scientific Reports.

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

T. Yagi, S. Iwata, H. Miyoshi, 2018 .

A gamma-lactone form nafuredin, nafuredin-gamma, also inhibits helminth complex I.

S. Ōmura, H. Miyoshi, H. Tomoda, 2005, The Journal of antibiotics.

Identification of proteins involved in intracellular ubiquinone trafficking in Saccharomyces cerevisiae using artificial ubiquinone probe.

H. Miyoshi, Takahiro Masuya, M. Murai, 2024, Biochimica et biophysica acta. Bioenergetics.

Identification of the Binding Position of Amilorides in the Quinone Binding Pocket of Mitochondrial Complex I.

H. Miyoshi, Takeshi Ito, Hironobu Morisaka, 2015, Biochemistry.