M. Szewczyk

发表

Phage display: concept, innovations, applications and future.

Jyoti Pande, J. Pande, M. Szewczyk, 2010, Biotechnology advances.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, eLife.

Caloxins: a novel class of selective plasma membrane Ca2+ pump inhibitors obtained using biotechnology

J. Pande, M. Szewczyk, A. Grover, 2008, Pflügers Archiv - European Journal of Physiology.

Ca2+‐mediated ascorbate release from coronary artery endothelial cells

M. Szewczyk, A. Grover, C. Kwan, 2006, British journal of pharmacology.

Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening

Clara D. Christ, C. Arrowsmith, A. Haegebarth, 2021, SLAS discovery : advancing life sciences R & D.

Discovery of a chemical probe for PRDM9

E. Guccione, C. Arrowsmith, M. Schapira, 2019, Nature Communications.

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

Kyle V. Butler, C. Arrowsmith, M. Schapira, 2016, ACS chemical biology.

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

B. Haibe-Kains, K. Massirer, D. Cescon, 2022, Nature Chemical Biology.

Chemical Biology Approaches for Characterization of Epigenetic Regulators.

C. Arrowsmith, P. Prinos, M. Szewczyk, 2016, Methods in enzymology.

Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.

C. Arrowsmith, M. Vedadi, M. Szewczyk, 2020, Journal of medicinal chemistry.

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Julian E. Fuchs, O. Fedorov, C. Arrowsmith, 2019, Nature Chemical Biology.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress responses

Amber L. Couzens, M. Tyers, A. Gingras, 2018, bioRxiv.

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

B. Haibe-Kains, K. Massirer, D. Cescon, 2022, Nature Chemical Biology.

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

M. Minden, M. Lupien, C. Arrowsmith, 2022, bioRxiv.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

Anne E Carpenter, Jayme L. Dahlin, Bruce K. Hua, 2022, bioRxiv.

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

Xi-Ping Huang, B. Roth, P. Atadja, 2015, Angewandte Chemie.

Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca2+-pump isoform 4, on coronary artery

J. Pande, M. Szewczyk, A. Grover, 2008, Journal of cellular and molecular medicine.

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

P. Atadja, E. Li, F. Liu, 2017, Journal of medicinal chemistry.

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

R. Aebersold, C. Arrowsmith, M. Vedadi, 2022, Biochimica et biophysica acta. Gene regulatory mechanisms.

A First-in-class, Highly Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

R. Campbell, C. Arrowsmith, M. Schapira, 2020, bioRxiv.

Ca2+-pumps and Na+–Ca2+-exchangers in coronary artery endothelium versus smooth muscle

M. Szewczyk, A. Grover, P. Rangachari, 2007, Journal of cellular and molecular medicine.

Caloxin 1b3: a novel plasma membrane Ca(2+)-pump isoform 1 selective inhibitor that increases cytosolic Ca(2+) in endothelial cells.

J. Pande, M. Szewczyk, A. Grover, 2010, Cell calcium.

extracellular inhibitor caloxin 1b1 pump isoforms are inhibited differently by the 2+ Casmooth muscle and endothelial plasma membrane

J. Pande, M. Szewczyk, A. Grover, 2016 .

Allosteric inhibitors of plasma membrane Ca pumps: Invention and applications of caloxins.

J. Pande, M. Szewczyk, A. Grover, 2011, World journal of biological chemistry.

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics

C. Arrowsmith, M. Vedadi, M. Szewczyk, 2020, bioRxiv.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, bioRxiv.

l-Proline derived arylmethanamine ligands and their application in the copper-catalyzed asymmetric Henry reaction: a rare example of a Cu-complex with a dicopper tetraacetate core

M. Szewczyk, Z. Kałuża, Piotr Niedziejko, 2015 .

L‐Proline Derived Arylmethanamine Ligands and Their Application in the Copper‐Catalyzed Asymmetric Henry Reaction: A Rare Example of a Cu‐Complex with a Dicopper Tetraacetate Core.

M. Szewczyk, Z. Kałuża, Piotr Niedziejko, 2016 .

Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid

Simon S. Woo, M. Vedadi, S. LaPlante, 2021, ChemMedChem.

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.

Cheryl H Arrowsmith, Peter J Brown, Mary M Mader, 2018, ACS medicinal chemistry letters.

Preparation of NiCuGO composite and investigation of its electrocatalytic properties in methanol oxidation

M. Szewczyk, W. Simka, A. Kazek-Kęsik, 2022, Electrochimica Acta.

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

K. Saikatendu, C. Arrowsmith, M. Schapira, 2018, Oncotarget.

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, Journal of medicinal chemistry.

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.

Matthieu Schapira, Cheryl H Arrowsmith, Peter J Brown, 2016, Journal of medicinal chemistry.

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

A. Fox-Robichaud, M. Szewczyk, B. Trigatti, 2018, The Journal of Biological Chemistry.

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Bas J. Wouters, M. Minden, O. Abdel-Wahab, 2019, Cancer cell.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Jun Guo, Kenneth M Comess, Haizhong Zhu, 2017, Nature chemical biology.

Role of lysine 173 in heparin binding to heparin cofactor II.

M. Szewczyk, D. Tollefsen, F. Church, 1991, The Journal of biological chemistry.

Discovery of a Dual PRMT5-PRMT7 Inhibitor.

Matthieu Schapira, Cheryl H Arrowsmith, Peter J Brown, 2015, ACS medicinal chemistry letters.

Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.

J. Dick, M. Minden, M. Lupien, 2019, Experimental hematology.

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

Matthew J. Meiners, J. Greenblatt, J. Min, 2021, Nature Chemical Biology.

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

Matthew J. Meiners, J. Greenblatt, J. Min, 2021, bioRxiv.

Altered RNA splicing initiates the viral mimicry response from inverted SINEs following type I PRMT inhibition in Triple-Negative Breast Cancer

Benjamin Haibe-Kains, D. Cescon, M. Lupien, 2021 .

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

Clara D. Christ, C. Arrowsmith, H. Weinmann, 2016, Journal of medicinal chemistry.

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, Communications Biology.

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, bioRxiv.

Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.

Laura E. Herring, J. Licht, C. Arrowsmith, 2023, Journal of the American Chemical Society.

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

J. Min, C. Arrowsmith, M. Schapira, 2020, bioRxiv.

Validating Small Molecule Chemical Probes for Biological Discovery.

C. Arrowsmith, M. Szewczyk, D. Barsyte-Lovejoy, 2022, Annual review of biochemistry.

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.

B. Kuster, S. Knapp, C. Sotriffer, 2021, Journal of medicinal chemistry.

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

B. Kuster, S. Knapp, C. Sotriffer, 2021, bioRxiv.

Aortic smooth muscle and endothelial plasma membrane Ca2+ pump isoforms are inhibited differently by the extracellular inhibitor caloxin 1b1.

J. Pande, M. Szewczyk, A. Grover, 2006, American journal of physiology. Cell physiology.

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Jayme L. Dahlin, J. Baell, M. Walters, 2017, Nature Communications.

Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor

Clara D. Christ, C. Arrowsmith, A. Haegebarth, 2018, Cancer Chemistry.

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics **

C. Arrowsmith, M. Vedadi, M. Szewczyk, 2021, ChemMedChem.

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

C. Arrowsmith, M. Schapira, M. Szewczyk, 2023, bioRxiv.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Amber L. Couzens, M. Tyers, A. Gingras, 2020, Nature Communications.

Photoswitchable Catalysis by a Small Swinging Molecule Confined on the Surface of a Colloidal Particle

M. Szewczyk, G. Sobczak, V. Sashuk, 2018 .

A chemical probe to modulate human GID4 Pro/N-degron interactions

S. Knapp, J. Min, C. Arrowsmith, 2023, bioRxiv.

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, Journal of medicinal chemistry.

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Anthony D. Keefe, Christopher J. Mulhern, A. Keefe, 2023, Journal of medicinal chemistry.