W. Karthaus

发表

Allosteric interactions prime androgen receptor dimerization and activation.

K. Manova-Todorova, C. Sawyers, D. Matthies, 2022, Molecular cell.

Genome sequencing of normal cells reveals developmental lineages and mutational processes

Asif U. Tamuri, M. Stratton, P. Campbell, 2014, Nature.

Efficient Intracellular Delivery of Native Proteins

Hans Clevers, Niels Geijsen, Vikram Prasad, 2015, Cell.

Regenerative potential of prostate luminal cells revealed by single-cell analysis

D. Pe’er, A. Regev, L. Mazutis, 2020, Science.

A rectal cancer model establishes a platform to study individual responses to chemoradiation

Hans Clevers, Lukas E. Dow, Jinru Shia, 2019, bioRxiv.

A rectal cancer organoid platform to study individual responses to chemoradiation

Jessica A Lavery, Iva Petkovska, Harini Veeraraghavan, 2019, Nature Medicine.

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

M. Rubin, S. Lowe, H. Beltran, 2017, Science.

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

L. Mazutis, M. Setty, M. Morris, 2022, Science.

Strategies to Identify and Target Cells of Origin in Prostate Cancer.

C. Sawyers, W. Karthaus, 2018, Journal of the National Cancer Institute.

Strategies to Identify and Target Cells of Origin in Prostate Cancer

C. Sawyers, W. Karthaus, 2019 .

Organoid culture systems for prostate epithelial tissue and prostate cancer tissue

Hans Clevers, Dong Gao, Else Driehuis, 2016, Nature Protocols.

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

E. Cuppen, H. Clevers, Norman Sachs, 2014, Cell.

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Hans Clevers, Dong Gao, Stephen B. Solomon, 2014, Cell.

Tumor mutational landscape is a record of the pre-malignant state

Lincoln D. Stein, G. Getz, O. Elemento, 2019, bioRxiv.

ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

N. Schultz, D. Zheng, R. Bose, 2017, Nature.

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

H. Clevers, P. Kujala, H. Farin, 2014, The Journal of experimental medicine.

FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.

J. Reis-Filho, J. Baselga, R. Koche, 2020, Cancer cell.

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon

Alexander van Oudenaarden, Hans Clevers, Nobuo Sasaki, 2016, Proceedings of the National Academy of Sciences.

Controlled gene expression in primary Lgr5 organoid cultures

H. Clevers, H. Farin, J. V. Es, 2011, Nature Methods.

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

Hans Clevers, Shabaz Mohammed, S. Ng, 2012, Cell.

Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

Vianne R. Gao, K. Manova-Todorova, A. Gopalan, 2020, Cancer cell.

Author Correction: FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

C. Leslie, A. Sboner, R. Bose, 2020, Nature.

FOXA1 mutations alter pioneering activity, differentiation, and prostate cancer phenotypes

Christina S. Leslie, Zeda Zhang, Andrea Sboner, 2019, Nature.

Patient derived organoids to model rare prostate cancer phenotypes

Dong Gao, Matteo Benelli, Davide Prandi, 2018, Nature Communications.

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.

Paul G. Hynes, H. Clevers, C. Sawyers, 2015, Cell reports.

Allosteric interactions prime androgen receptor dimerization and activation

K. Manova-Todorova, C. Sawyers, D. Matthies, 2022, bioRxiv.

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

Henry W. Long, D. Zheng, B. Bernstein, 2017, eLife.

Multilineage plasticity in prostate cancer through expansion of stem–like luminal epithelial cells with elevated inflammatory signaling

J. Silber, L. Mazutis, M. Morris, 2021 .

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

L. Mazutis, M. Setty, C. Sawyers, 2021, bioRxiv.

Lineage plasticity is a well–established mechanism of resistance to targeted therapies in lung and prostate cancer, where tumors transition from adenocarcinoma to small–cell or neuroendocrine carcinoma. Through single–cell analysis of a cohort of heavily–treated castration–resistant human prostate c

Kristine, J. Silber, L. Mazutis, 2021 .

Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models

J. Schalken, W. Karthaus, C. D. de Ridder, 2021, Cancer gene therapy.

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses.

C. Sawyers, Kyrie Pappas, W. Karthaus, 2019, Journal of visualized experiments : JoVE.

Patient derived organoids to model rare prostate cancer phenotypes

M. Rubin, O. Elemento, A. Sboner, 2018, Nature Communications.

Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers

C. Rudin, U. Bhanot, R. Koche, 2023, Science Translational Medicine.

Single Cell Analysis of Treatment–Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

J. Silber, L. Mazutis, H. Scher, 2024, bioRxiv.