J. Locke

发表

Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy

M. Topf, A. Peña, A. Sweeney, 2020, Structure.

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

J. Diffley, Alessandro Costa, J. Locke, 2021, Nature Structural & Molecular Biology.

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

J. Diffley, Alessandro Costa, J. Locke, 2019, Nature.

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

J. Diffley, Alessandro Costa, J. Locke, 2018, Nature Communications.

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

M. Botchan, J. Berger, Alessandro Costa, 2019, Cell reports.

The mechanism of kinesin inhibition by kinesin-binding protein

C. Hoogenraad, S. Rosenfeld, M. Steinmetz, 2020, eLife.

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

J. Rappsilber, Helen R. Flynn, A. Snijders, 2020, bioRxiv.

A supramolecular assembly mediates lentiviral DNA integration

A. Engelman, Erik Serrao, I. Taylor, 2017, Science.

The mechanism of selective kinesin inhibition by kinesin binding protein

C. Hoogenraad, S. Rosenfeld, M. Steinmetz, 2020, bioRxiv.

Structural basis of human kinesin-8 function and inhibition

M. Topf, A. Joseph, A. Peña, 2017, Proceedings of the National Academy of Sciences.

The polarity sensitivity factor of some fluorescent probe molecules used for studying supramolecular systems and other heterogeneous environments

J. Locke, B. Wagner, Natasha D. Mills, 2018, Canadian Journal of Chemistry.

Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure

Wei Ming Lim, J. Rappsilber, J. Gannon, 2020, Developmental cell.

Microtubule Nucleation by Single Human γTuRC in a Partly Open Asymmetric Conformation

Wei Ming Lim, J. Gannon, J. Locke, 2019, bioRxiv.

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

J. Diffley, Alessandro Costa, J. Locke, 2018, Nature Communications.

Cryo-EM structure of a licensed DNA replication origin

J. Diffley, V. E. Pye, Alessandro Costa, 2017, Nature Communications.

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

J. Diffley, Alessandro Costa, J. Locke, 2019, Nature.

Cryo-EM structure of a licensed DNA replication origin

J. Diffley, V. E. Pye, Alessandro Costa, 2017, Nature Communications.

Structural basis of human kinesin-8 function and inhibition

M. Topf, A. Joseph, A. Peña, 2017, Proceedings of the National Academy of Sciences.

Cryo-EM structure of S. cerevisiae Polymerase epsilon deltacat mutant

J. Diffley, Alessandro Costa, J. Locke, 2018 .