Hong Lu

发表

An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.

James B. Munro, J. Sodroski, D. Kaufmann, 2019, Cell host & microbe.

5′ Rapid Amplification of cDNA Ends and Illumina MiSeq Reveals B Cell Receptor Features in Healthy Adults, Adults With Chronic HIV-1 Infection, Cord Blood, and Humanized Mice

M. Markowitz, D. Kaufmann, Xueling Wu, 2018, Front. Immunol..

Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors.

Hong Lu, Lu Lu, Shibo Jiang, 2012, Bioorganic & medicinal chemistry letters.

Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).

Hong Lu, Shibo Jiang, Keduo Qian, 2008, Journal of medicinal chemistry.

Different from the HIV Fusion Inhibitor C34, the Anti-HIV Drug Fuzeon (T-20) Inhibits HIV-1 Entry by Targeting Multiple Sites in gp41 and gp120*

Shibo Jiang, Hong Lu, Shibo Jiang, 2005, Journal of Biological Chemistry.

Design of a Protein Surface Antagonist Based on α-Helix Mimicry: Inhibition of gp41 Assembly and Viral Fusion We thank the National Institutes of Health for support of this work and the Deutsche Forschungsgemeinschaft (DFG) for a research fellowship to O.K.

A. Debnath, A. Hamilton, Hong Lu, 2002 .

Combinations of 3-Hydroxyphthalic Anhydride-Modified Ovalbumin With Antiretroviral Drug-Based Microbicide Candidates Display Synergistic and Complementary Effects Against HIV-1 Infection

Hong Lu, Lu Lu, Suiyi Tan, 2011, Journal of acquired immune deficiency syndromes.

Conserved Residue Lys574 in the Cavity of HIV-1 Gp41 Coiled-coil Domain Is Critical for Six-helix Bundle Stability and Virus Entry*

A. Debnath, F. Kirchhoff, Hong Lu, 2007, Journal of Biological Chemistry.

Chemoenzymatic Synthesis of HIV‐1 gp41 Glycopeptides: Effects of Glycosylation on the Anti‐HIV Activity and α‐Helix Bundle‐Forming Ability of Peptide C34

Lai-Xi Wang, Hong Lu, Shibo Jiang, 2005, Chembiochem : a European journal of chemical biology.

Chemically Oversulfated Glycosaminoglycans Are Potent Modulators of Contact System Activation and Different Cell Signaling Pathways*

Hong Lu, E. Ramacciotti, Lijuan Zhang, 2010, The Journal of Biological Chemistry.

Identification of a D-amino acid decapeptide HIV-1 entry inhibitor.

J. Binley, S. Blondelle, Hong Lu, 2006, Biochemical and biophysical research communications.

Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity

Hong Lu, Shibo Jiang, Wu Zhong, 2008 .

Induce Highly Potent Neutralizing Antibodies Conformation-Dependent Epitopes that Protein Contains Multiple Respiratory Syndrome Coronavirus Spike Receptor-Binding Domain of Severe Acute

Hong Lu, Shibo Jiang, Yusen Zhou, 2005 .

Immune Responses and Viral Persistence in Simian/Human Immunodeficiency Virus SHIV.C.CH848-Infected Rhesus Macaques

G. Shaw, R. Veazey, Hui Li, 2021, Journal of Virology.

High Affinity Glycosaminoglycan and Autoantigen Interaction Explains Joint Specificity in a Mouse Model of Rheumatoid Arthritis*

P. Allen, Hong Lu, H. Liapis, 2009, Journal of Biological Chemistry.

ADS-J 1 Inhibits Human Immunodeficiency Virus Type 1 Entry by Interacting with the gp 41 Pocket Region and Blocking Fusion-Active gp 41 Core Formation

A. Debnath, Hong Lu, X. An, 2009 .

Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41.

A. Debnath, Hong Lu, Shibo Jiang, 2005, Biochimica et biophysica acta.

θ-Defensins Prevent HIV-1 Env-mediated Fusion by Binding gp41 and Blocking 6-Helix Bundle Formation*

S. A. Gallo, D. Craik, A. Waring, 2006, Journal of Biological Chemistry.

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Li Huang, 2010, Journal of medicinal chemistry.

Peptides derived from HIV‐1 gp120 co‐receptor binding domain form amyloid fibrils and enhance HIV‐1 infection

Hong Lu, Lu Lu, Suiyi Tan, 2014, FEBS letters.

Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Chin-Ho Chen, 2009, Bioorganic & medicinal chemistry letters.

The RNA/DNA‐binding protein PSF relocates to cell membrane and contributes cells' sensitivity to antitumor drug, doxorubicin

Qi Zhou, Hong Lu, Min Li, 2014, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Combinations of the First and Next Generations of Human Immunodeficiency Virus (HIV) Fusion Inhibitors Exhibit a Highly Potent Synergistic Effect against Enfuvirtide- Sensitive and -Resistant HIV Type 1 Strains

Hong Lu, Shibo Jiang, Lifeng Cai, 2009, Journal of Virology.

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor*

Yonghong Xiao, Linqi Zhang, Hong Lu, 2008, Journal of Biological Chemistry.

Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41.

Qian Zhu, Hong Lu, Shibo Jiang, 2010, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors.

A. Debnath, A. Katritzky, Hong Lu, 2009, Journal of medicinal chemistry.

Synthesis of aromatic-linked polyamine macrocyclic derivatives as HIV-1 entry inhibitors

Hong Lu, Shibo Jiang, Wu Zhong, 2007 .

Automatic quantitation of HIV-1 mediated cell-to-cell fusion with a digital image analysis system (DIAS): application for rapid screening of HIV-1 fusion inhibitors.

Hong Lu, Shibo Jiang, Qian Zhao, 2003, Journal of Virological Methods.

Immune responses and viral persistence in SHIV.C.CH848-infected rhesus macaques.

G. Shaw, R. Veazey, Hui Li, 2021, Journal of virology.

Novel Recombinant Engineered gp41 N-terminal Heptad Repeat Trimers and Their Potential as Anti-HIV-1 Therapeutics or Microbicides*

Hong Lu, Lu Lu, Shibo Jiang, 2010, The Journal of Biological Chemistry.

Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission

Hong Lu, Lu Lu, Suiyi Tan, 2010, Retrovirology.

Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

Shibo Jiang, Zhi Qi, Hong Lu, 2008, Proceedings of the National Academy of Sciences.

Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41.

A. Debnath, A. Katritzky, Hong Lu, 2011, Bioorganic & medicinal chemistry letters.

Identification of a Critical Motif for the Human Immunodeficiency Virus Type 1 (HIV-1) gp41 Core Structure: Implications for Designing Novel Anti-HIV Fusion Inhibitors

Hong Lu, Shibo Jiang, Yuxian He, 2008, Journal of Virology.

A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Hong Lu, Lu Lu, Shibo Jiang, 2012, Retrovirology.

Regulation of Paramyxovirus Fusion Activation: the Hemagglutinin-Neuraminidase Protein Stabilizes the Fusion Protein in a Pretriggered State

Laura M. Palermo, Kelly K. Lee, Hong Lu, 2012, Journal of Virology.

Design, synthesis, and biological activity of novel 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41.

A. Debnath, A. Katritzky, Hong Lu, 2011, Journal of medicinal chemistry.

A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Hong Lu, Lu Lu, Shibo Jiang, 2012, Retrovirology.

[Design, synthesis and biologic evaluation of diarylbenzimidazole derivatives as novel HIV-1 non-nucleoside reverse transcriptase inhibitors].

Hong Lu, Shibo Jiang, Ting Zhou, 2009, Yao xue xue bao = Acta pharmaceutica Sinica.

Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties*

P. Nagarkatti, Mark D. Smith, J. Duan, 2011, The Journal of Biological Chemistry.

Molecular modeling studies of N-substituted pyrrole derivatives--potential HIV-1 gp41 inhibitors.

Joseph Rebehmed, Lan Xie, Shibo Jiang, 2008, Bioorganic & medicinal chemistry.

Advances in the application of 1,2,4-triazole-containing hybrids as anti-tuberculosis agents.

Hong Lu, Yingdong Cao, 2021, Future medicinal chemistry.

N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion

A. Debnath, Hong Lu, Shibo Jiang, 2004, Antimicrobial Agents and Chemotherapy.

Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41.

Hong Lu, Shibo Jiang, Shuwen Liu, 2008, Journal of medicinal chemistry.

3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin Exhibits Potent and Broad Anti-HIV-1 Activity: a Potential Microbicide for Preventing Sexual Transmission of HIV-1

Hong Lu, X. An, Suiyi Tan, 2010, Antimicrobial Agents and Chemotherapy.

ADS-J1 Inhibits Human Immunodeficiency Virus Type 1 Entry by Interacting with the gp41 Pocket Region and Blocking Fusion-Active gp41 Core Formation

A. Debnath, Hong Lu, X. An, 2009, Antimicrobial Agents and Chemotherapy.

Combination of Candidate Microbicides Cellulose Acetate 1,2-Benzenedicarboxylate and UC781 Has Synergistic and Complementary Effects against Human Immunodeficiency Virus Type 1 Infection

Hong Lu, Shibo Jiang, Shuwen Liu, 2005, Antimicrobial Agents and Chemotherapy.

Cellulose acetate 1,2-benzenedicarboxylate inhibits infection by cell-free and cell-associated primary HIV-1 isolates.

Hong Lu, R. Shattock, Shuwen Liu, 2006, AIDS research and human retroviruses.

Receptor-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Contains Multiple Conformation-Dependent Epitopes that Induce Highly Potent Neutralizing Antibodies

Shibo Jiang, Hong Lu, Shibo Jiang, 2005, The Journal of Immunology.

VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA

D. Ho, Yicheng Guo, P. Bieniasz, 2020, Cell host & microbe.

Phosphorothioate Oligonucleotides Inhibit Human Immunodeficiency Virus Type 1 Fusion by Blocking gp41 Core Formation

R. Ptak, Hong Lu, Shibo Jiang, 2006, Antimicrobial Agents and Chemotherapy.

Synthesis and biological activities of O 6 -alkylguanine derivatives

Hong Lu, Ming Lu, Y. Hu, 2010 .

Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.

Long Yu, Xiaodong Pang, Hong Lu, 2011, European journal of medicinal chemistry.

Gp120 V5 Is Targeted by the First Wave of Sequential Neutralizing Antibodies in SHIVSF162P3N-Infected Rhesus Macaques

C. Cheng‐Mayer, Xueling Wu, X. Kong, 2018, Viruses.

Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants

D. Kuritzkes, S. Lockman, Xueling Wu, 2016, EBioMedicine.

Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques

C. Cheng‐Mayer, M. Markowitz, Xueling Wu, 2016, Journal of Virology.

Selection of a novel gp41-specific HIV-1 neutralizing human antibody by competitive antigen panning.

C. Broder, H. Katinger, D. Dimitrov, 2006, Journal of immunological methods.

Early Treatment with Integrase Inhibitor Achieves a Functional Cure for Pediatric SIV Infection

R. Veazey, Xueling Wu, Hong Lu, 2021 .

Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.

Asim Kumar Debnath, Shibo Jiang, Nouri Neamati, 2005, Virology.

Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits

S. Zolla-Pazner, M. Totrov, Xueling Wu, 2016, Journal of Virology.

Structure-based identification of small molecule compounds targeting cell cyclophilin A with anti-HIV-1 activity.

Hualiang Jiang, Qiang Huang, Long Yu, 2007, European journal of pharmacology.

A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1

X. Kong, Hong Lu, Kun-Wei Chan, 2021, Nature Communications.

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion.

Shibo Jiang, Asim K Debnath, A. Debnath, 2002, Angewandte Chemie.

Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents.

Hong Lu, Shibo Jiang, Jian Zhang, 2010, European journal of medicinal chemistry.

Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide

Shibo Jiang, Thomas Peters, Bernd Meyer, 2007, Cell.

Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens

B. Haynes, M. Humbert, C. Broder, 2008, Journal of Virology.

Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition

A. Debnath, Hong Lu, Shibo Jiang, 2008, Journal of Virology.

Identification of the HIV-1 gp41 Core-binding Motif in the Scaffolding Domain of Caveolin-1*

Xi Chen, Lu Lu, Shibo Jiang, 2007, Journal of Biological Chemistry.

Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Xiao‐Feng Wang, 2010, Journal of medicinal chemistry.

HIV gp41 C-terminal Heptad Repeat Contains Multifunctional Domains

Shibo Jiang, Xuxia Yan, Hong Lu, 2007, Journal of Biological Chemistry.

Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation.

J. P. Kennedy, K. Janda, Hong Lu, 2006, Journal of combinatorial chemistry.

Neutralization of HIV-1 primary isolate by ELDKWA-specific murine monoclonal antibodies.

Hong Lu, Shibo Jiang, Ying-hua Chen, 2005, Immunobiology.

A Novel Chimeric Protein-based HIV-1 Fusion Inhibitor Targeting gp41 Glycoprotein with High Potency and Stability*

Hong Lu, Lu Lu, Shibo Jiang, 2011, The Journal of Biological Chemistry.

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Li Huang, 2010, Journal of medicinal chemistry.

Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Xiao‐Feng Wang, 2010, Journal of medicinal chemistry.

Synthesis and anti-HIV-1 activity of 4-[4-(4,6-bisphenylamino-[1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenylazo]- 5-hydroxynaphthalene-2,7-disulfonic acid and its derivatives

A. Debnath, Lai-Xi Wang, Hong Lu, 2004 .

A recombinant mimetics of the HIV-1 gp41 prehairpin fusion intermediate fused with human IgG Fc fragment elicits neutralizing antibody response in the vaccinated mice.

Xue-qing Xu, Hong Lu, Shibo Jiang, 2010, Biochemical and biophysical research communications.

Hong Lu, Shibo Jiang, Lifeng Cai, 2009, Journal of Virology.