I. Voskoboinik

发表

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

J. Whisstock, B. Hoogenboom, S. Pang, 2019, Nature Communications.

A Common Fold Mediates Vertebrate Defense and Bacterial Attack

Ashley M Buckle, Corrine J Porter, James C Whisstock, 2007, Science.

I. Voskoboinik, J. Camakaris, 2004 .

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

S. E. Stewart, J. Trapani, P. Bird, 2013, Cell Death and Differentiation.

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

J. Trapani, A. Brennan, J. Lopez, 2013, The Journal of Immunology.

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis

J. Trapani, R. Khanna, Corey Smith, 2015, Clinical & translational immunology.

Copper-regulated Trafficking of the Menkes Disease Copper ATPase Is Associated with Formation of a Phosphorylated Catalytic Intermediate*

I. Voskoboinik, J. Camakaris, Byung-Eun Kim, 2002, The Journal of Biological Chemistry.

Neonatal Cytomegalovirus Palatal Ulceration and Bocavirus Pneumonitis Associated With a Defect of Lymphocyte Cytotoxicity Caused by Mutations in UNC13D.

I. Voskoboinik, P. Palasanthiran, R. Mitchell, 2019, Journal of the Pediatric Infectious Diseases Society.

Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D

J. Trapani, I. Voskoboinik, I. Andrews, 2017, Front. Immunol..

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

R. Tothill, J. Trapani, A. Brennan, 2015, Immunology and cell biology.

Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner

Wenbo Yu, I. Voskoboinik, J. Hayball, 2017, Scientific Reports.

Peroxisome proliferators increase the formation of BPDE-DNA adducts in isolated rat hepatocytes.

I. Voskoboinik, J. Ahokas, R. Drew, 1997, Toxicology.

Peroxisome proliferator nafenopin potentiated cytotoxicity and genotoxicity of cyclophosphamide in the liver and bone marrow cells.

I. Voskoboinik, J. Ahokas, R. Drew, 1997, Chemico-biological interactions.

Effect of peroxisome proliferator nafenopin on the cytotoxicity of dihaloalkanes in isolated rat hepatocytes.

I. Voskoboinik, J. Ahokas, R. Drew, 1996, Toxicology in vitro : an international journal published in association with BIBRA.

Differential effect of peroxisome proliferators on rat glutathione S-transferase isoenzymes.

I. Voskoboinik, J. Ahokas, R. Drew, 1996, Toxicology letters.

Antagonism of IAPs Enhances CAR T-cell Efficacy

R. Johnstone, I. Voskoboinik, C. Kearney, 2019, Cancer Immunology Research.

Surprisingly variable "dangers, toils, and snares" faced by humans and mice.

J. Trapani, I. Voskoboinik, 2013, Blood.

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

J. Trapani, I. Voskoboinik, S. Mannering, 2015, The Journal of experimental medicine.

Tumor immune evasion arises through loss of TNF sensitivity

K. Brown, J. Trapani, D. Knight, 2018, Science Immunology.

Lipid order and charge protect killer T cells from accidental death

J. Trapani, B. Hoogenboom, Adrian W Hodel, 2019, Nature Communications.

Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs

A. Brennan, I. Voskoboinik, T. Garrod, 2015, Gene Therapy.

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

J. Trapani, Katherine Baran, I. Voskoboinik, 2008, Methods.

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes*

J. Whisstock, J. Trapani, R. Norton, 2015, The Journal of Biological Chemistry.

Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus

I. Voskoboinik, Z. Mekonnen, E. Gowans, 2020, Vaccines.

Delivery at the Cytotoxic Immune Synapse Rapid and Unidirectional Perforin Pore

J. Trapani, A. Brennan, I. Voskoboinik, 2013 .

The structural basis for membrane binding and pore formation by lymphocyte perforin

J. Whisstock, E. Orlova, H. Saibil, 2010, Nature.

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function.

J. Trapani, I. Voskoboinik, C. House, 2007, Blood.

Menkes Copper-Translocating P-type ATPase (ATP7A): Biochemical and Cell Biology Properties, and Role in Menkes Disease

I. Voskoboinik, J. Camakaris, 2002, Journal of bioenergetics and biomembranes.

Human perforin mutations and susceptibility to multiple primary cancers

J. Trapani, C. Gedye, I. Campbell, 2013, Oncoimmunology.

The complex issue of regulating perforin expression.

J. Trapani, I. Voskoboinik, 2007, Trends in immunology.

facilitate rapid access of granzymes during killer cell attack Perforin forms transient pores on the target cell plasma membrane to

J. Whisstock, H. Saibil, J. Trapani, 2013 .

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing

I. Voskoboinik, C. Kearney, P. Darcy, 2016, Oncoimmunology.

A Method for Detecting Intracellular Perforin in Mouse Lymphocytes

J. Trapani, A. Brennan, I. Voskoboinik, 2014, The Journal of Immunology.

Calcium-dependent Plasma Membrane Binding and Cell Lysis by Perforin Are Mediated through Its C2 Domain

J. Trapani, J. Fletcher, I. Voskoboinik, 2005, Journal of Biological Chemistry.

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

J. A. Spicer, J. Trapani, I. Voskoboinik, 2022, Journal of medicinal chemistry.

Ascorbate and glutathione homeostasis in vascular smooth muscle cells: cooperation with endothelial cells.

I. Voskoboinik, I. Cotgreave, K. Söderholm, 1998, American journal of physiology. Cell physiology.

Ascorbate and glutathione homeostasis in vascular smooth muscle cells: cooperation with endothelial cells.

I. Voskoboinik, I. Cotgreave, K. Söderholm, 1998, The American journal of physiology.

Effects of Diol Epoxide Adducts on Binding of Different Transcription Factors to DNA

I. Voskoboinik, B. Jernström, Å. Persson, 1999 .

Deciphering the syntax of cytotoxic lymphocyte degranulation

I. Voskoboinik, Jamie Lopez, 2013, European journal of immunology.

Immune surveillance of lymphoma in humans

J. Trapani, I. Voskoboinik, M. Smyth, 2005 .

Defining the interaction of perforin with calcium and the phospholipid membrane.

J. Whisstock, J. Trapani, A. Brennan, 2013, The Biochemical journal.

Addressing the mysteries of perforin function

J. Trapani, I. Voskoboinik, 2006, Immunology and cell biology.

The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene

J. Trapani, S. Jane, I. Voskoboinik, 2004, The Journal of experimental medicine.

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death.

J. Whisstock, J. Trapani, A. Brennan, 2012, Trends in immunology.

ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack

H. Hess, J. Trapani, N. Iyer, 2022, Science.

Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions

J. Trapani, P. Ekert, I. Voskoboinik, 2022, bioRxiv.

Infective, neoplastic, and homeostatic sequelae of the loss of perforin function in humans.

J. Trapani, I. Voskoboinik, 2007, Advances in experimental medicine and biology.

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome.

J. Trapani, S. Opat, I. Voskoboinik, 2018, Blood.

Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives

J. Trapani, I. Voskoboinik, K. Thia, 2014, Internal medicine journal.

Molecular mechanisms of copper homeostasis.

I. Voskoboinik, J. Camakaris, J. Mercer, 1999, Biochemical and biophysical research communications.

The MACPF/CDC family of pore-forming toxins

Ashley M Buckle, James C Whisstock, Ruby H P Law, 2008, Cellular microbiology.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Helen R Saibil, Olivia Susanto, James C Whisstock, 2013, Blood.

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

J. A. Spicer, W. Denny, J. Trapani, 2013, Journal of medicinal chemistry.

The molecular basis for perforin oligomerization and transmembrane pore assembly.

J. Whisstock, H. Saibil, J. Trapani, 2009, Immunity.

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

James C. Whisstock, Maya Topf, Tom T. Caradoc-Davies, 2015, PLoS biology.

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

S. Dawson, S. Bloor, P. Lehner, 2017, Nature.

Perforin-mediated target-cell death and immune homeostasis

Mark J. Smyth, J. Trapani, I. Voskoboinik, 2006, Nature Reviews Immunology.

Molecular study of the perforin gene in familial hematological malignancies

L. Huiart, L. Demange, L. Faivre, 2011, Hereditary cancer in clinical practice.

Perforin and granzymes: function, dysfunction and human pathology

James C. Whisstock, J. Whisstock, J. Trapani, 2015, Nature Reviews Immunology.

The battlefield of perforin/granzyme cell death pathways

J. Trapani, I. Voskoboinik, S. Hoves, 2010, Journal of leukocyte biology.

Perforin: structure, function, and role in human immunopathology

J. Whisstock, J. Trapani, Katherine Baran, 2010, Immunological reviews.

Real-time visualization of perforin nanopore assembly.

J. Whisstock, H. Saibil, J. Trapani, 2017, Nature nanotechnology.

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition

J. Trapani, I. Voskoboinik, N. Panoskaltsis, 2016, Oncoimmunology.

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis.

J. Trapani, I. Voskoboinik, Marie-Claude Thia, 2005, Blood.

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin.

J. Trapani, A. Brennan, I. Voskoboinik, 2012, Blood.

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

J. Trapani, Xiaomin Song, A. Roberts, 2020, Haematologica.

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

N. Brown, J. Trapani, I. Voskoboinik, 2018, Front. Immunol..

Perforinopathy: A Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function

J. Trapani, I. Voskoboinik, 2013, Front. Immunol..

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Olivia Susanto, James C Whisstock, Hideo Yagita, 2011, Immunity.

Perforin deficiency and susceptibility to cancer

J. Trapani, A. Brennan, I. Voskoboinik, 2010, Cell Death and Differentiation.

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

J. Whisstock, J. Trapani, I. Voskoboinik, 2009, Proceedings of the National Academy of Sciences.

lymphocyte perforin Fatal immune dysregulation due to a gain of glycosylation mutation in

J. Trapani, A. Brennan, I. Voskoboinik, 2013 .

Dilemmas in the diagnosis and pathogenesis of atypical late‐onset familial haemophagocytic lymphohistiocytosis

I. Voskoboinik, A. Grigg, Adrian Minson, 2021, Clinical & translational immunology.

The Regulation of Catalytic Activity of the Menkes Copper-translocating P-type ATPase

I. Voskoboinik, J. Camakaris, D. Strausak, 2001, The Journal of Biological Chemistry.

Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant.

I. Voskoboinik, J. Camakaris, S. La Fontaine, 2001, Biochemical and biophysical research communications.

Apoptosis induced by the lymphocyte effector molecule perforin.

J. Trapani, I. Voskoboinik, M. Smyth, 2007, Current opinion in immunology.

Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

J. Whisstock, J. Trapani, A. Brennan, 2017, EMBO reports.

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

J. Whisstock, H. Saibil, J. Trapani, 2018, Cell Death & Differentiation.

ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse

Romain F. Laine, A. Brennan, I. Voskoboinik, 2022, Frontiers in Immunology.

The pore conformation of lymphocyte perforin

M. Topf, H. Saibil, J. Trapani, 2021, bioRxiv.

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

J. Trapani, A. Brennan, R. Johnstone, 2016, The FEBS journal.

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.

J. Trapani, I. Voskoboinik, C. House, 2020, Biochimica et biophysica acta. Proteins and proteomics.

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification

J. Whisstock, B. Hoogenboom, S. Pang, 2019, bioRxiv.

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

J. Whisstock, R. Law, I. Voskoboinik, 2010, Tissue antigens.

Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick Syndrome type C1.

J. Trapani, A. Brennan, M. Walterfang, 2022, Blood.

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase.

R. Pearson, I. Voskoboinik, K. Hannan, 2003, Biochemical and biophysical research communications.

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.

I. Voskoboinik, J. Camakaris, M. Petris, 2004, American journal of physiology. Cell physiology.

Understanding the mechanism and function of copper P-type ATPases.

I. Voskoboinik, J. Camakaris, J. Mercer, 2002, Advances in protein chemistry.

Functional Analysis of the N-terminal CXXC Metal-binding Motifs in the Human Menkes Copper-transporting P-type ATPase Expressed in Cultured Mammalian Cells*

I. Voskoboinik, J. Camakaris, J. Mercer, 1999, The Journal of Biological Chemistry.

Lipid specificity of the immune effector perforin

J. Trapani, B. Hoogenboom, Adrian W Hodel, 2020, bioRxiv.

Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A).

Ya Hui Hung, M. Layton, I. Voskoboinik, 2007, The Biochemical journal.

Perforin-A key (shaped) weapon in the immunological arsenal.

J. Whisstock, B. Spicer, R. Law, 2017, Seminars in cell & developmental biology.

Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool.

I. Voskoboinik, J. Camakaris, L. Pase, 2004, The Biochemical journal.

A Multiantigenic DNA Vaccine That Induces Broad Hepatitis C Virus-Specific T-Cell Responses in Mice

A. Brennan, Wenbo Yu, I. Voskoboinik, 2015, Journal of Virology.

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

S. Lewin, J. Trapani, D. Purcell, 2020, Nature Communications.

function polymorphism in perforin results in both pre- and post-synaptic defects in Perforin activity and immune homeostasis: the common A91V

J. Trapani, I. Voskoboinik, P. Darcy, 2013 .

Mutational analysis of the Menkes copper P-type ATPase (ATP7A).

I. Voskoboinik, J. Camakaris, J. Mar, 2003, Biochemical and biophysical research communications.

ATP‐dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured Chinese hamster ovary cells

I. Voskoboinik, J. Camakaris, H. Brooks, 1998, FEBS letters.

Distinguishing perforin-mediated lysis and granzyme-dependent apoptosis.

J. Trapani, I. Voskoboinik, J. Rudd-Schmidt, 2019, Methods in enzymology.

Perforin-dependent cytotoxicity: ‘Kiss of death’ or prolonged embrace with darker elocation-idnseque11es?

J. Trapani, I. Voskoboinik, Misty R. Jenkins, 2015, Oncoimmunology.