T. Pijning

发表

A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy

B. Poolman, L. Franken, G. Oostergetel, 2017, Nature Communications.

Just add sugar... : Structural Studies on Glucansucrase and Fructansucrase Enzymes from Lactobacilli

T. Pijning, 2014 .

University of Groningen Biochemical and crystallographic characterization of a glucansucrase from Lactobacillus reuteri 180 Pijning,

L. Dijkhuizen, B. Dijkstra, T. Pijning, 2009 .

Biochemical and crystallographic characterization of a glucansucrase from Lactobacillus reuteri 180

L. Dijkhuizen, B. Dijkstra, T. Pijning, 2008 .

A Novel Genetic Selection System for Improved Enantioselectivity of Bacillus subtilis Lipase A

Tjaard Pijning, B. Dijkstra, W. Quax, 2008, Chembiochem : a European journal of chemical biology.

Mutations in Amino Acid Residues of Limosilactobacillus reuteri 121 GtfB 4,6-α-Glucanotransferase that Affect Reaction and Product Specificity.

L. Dijkhuizen, Yuxiang Bai, Xiaoxiao Li, 2022, Journal of agricultural and food chemistry.

Loop grafting of Bacillus subtilis lipase A: inversion of enantioselectivity.

B. Dijkstra, W. Quax, Y. Boersma, 2008, Chemistry & biology.

Engineering of the Bacillus circulans β-Galactosidase Product Specificity

L. Dijkhuizen, T. Pijning, S. V. van Leeuwen, 2017, Biochemistry.

4,3-α-Glucanotransferase, a novel reaction specificity in glycoside hydrolase family 70 and clan GH-H

L. Dijkhuizen, T. Pijning, G. Gerwig, 2017, Scientific Reports.

Biochemical characterization of a GH70 protein from Lactobacillus kunkeei DSM 12361 with two catalytic domains involving branching sucrase activity

L. Dijkhuizen, T. Pijning, J. Gangoiti, 2018, Applied Microbiology and Biotechnology.

Biochemical characterization of two GH70 family 4,6-α-glucanotransferases with distinct product specificity from Lactobacillus aviarius subsp. aviarius DSM 20655.

L. Dijkhuizen, T. Pijning, Niels A. W. de Kok, 2018, Food chemistry.

Synthesis of New Hyperbranched α-Glucans from Sucrose by Lactobacillus reuteri 180 Glucansucrase Mutants.

L. Dijkhuizen, T. Pijning, G. Gerwig, 2016, Journal of agricultural and food chemistry.

Characterization of the Functional Roles of Amino Acid Residues in Acceptor-binding Subsite +1 in the Active Site of the Glucansucrase GTF180 from Lactobacillus reuteri 180*

L. Dijkhuizen, T. Pijning, G. Gerwig, 2015, The Journal of Biological Chemistry.

The crystal structure of a hyperthermoactive exopolygalacturonase from Thermotoga maritima reveals a unique tetramer

B. Dijkstra, J. van der Oost, T. Pijning, 2009, FEBS letters.

Biochemical Characterization of the Functional Roles of Residues in the Active Site of the β-Galactosidase from Bacillus circulans ATCC 31382

L. Dijkhuizen, T. Pijning, S. V. van Leeuwen, 2017, Biochemistry.

Enzymatic glucosylation of polyphenols using glucansucrases and branching sucrases of glycoside hydrolase family 70

L. Dijkhuizen, T. Pijning, Weifeng Liu, 2021, Critical reviews in food science and nutrition.

The sinusoidal efflux of dibromosulfophthalein from rat liver is stimulated by albumin, ligandin and fatty acid binding protein but not by other dibromosulfophthalein binding proteins.

J. Proost, G. Groothuis, D. Meijer, 1994, Journal of hepatology.

Influence of albumin on the net sinusoidal efflux of the organic anion dibromosulfophthalein from rat liver

G. Groothuis, D. Meijer, T. Pijning, 1992, Hepatology.

Biochemical and genetic characterization of fungal proline hydroxylase in echinocandin biosynthesis

T. Pijning, Liyan Yu, Weifeng Liu, 2018, Applied Microbiology and Biotechnology.

Biotechnological potential of novel glycoside hydrolase family 70 enzymes synthesizing α-glucans from starch and sucrose.

L. Dijkhuizen, T. Pijning, J. Gangoiti, 2017, Biotechnology advances.

Structural determinants of alternating (α1 → 4) and (α1 → 6) linkage specificity in reuteransucrase of Lactobacillus reuteri

L. Dijkhuizen, T. Pijning, G. Gerwig, 2016, Scientific Reports.

Biochemical and genetic characterization of fungal proline hydroxylase in echinocandin biosynthesis

T. Pijning, Liyan Yu, Weifeng Liu, 2018, Applied Microbiology and Biotechnology.

Improved activity and thermostability of Bacillus pumilus lipase by directed evolution.

T. Pijning, Nagihan Akbulut, Merve Tuzlakoğlu Öztürk, 2013, Journal of biotechnology.

Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus.

Tjaard Pijning, K. H. Kalk, B. Dijkstra, 2002, Structure.

Characterization of the (Engineered) Branching Sucrase GtfZ-CD2 from Apilactobacillus kunkeei for Efficient Glucosylation of Benzenediol Compounds

L. Dijkhuizen, T. Pijning, S. V. van Leeuwen, 2022, Applied and environmental microbiology.

Insights into Broad-Specificity Starch Modification from the Crystal Structure of Limosilactobacillus Reuteri NCC 2613 4,6-α-Glucanotransferase GtfB

L. Dijkhuizen, T. Pijning, J. Gangoiti, 2021, Journal of agricultural and food chemistry.

University of Groningen 4 , 3-α-Glucanotransferase , a novel reaction specificity in glycoside hydrolase family 70 and clan

L. Dijkhuizen, T. Pijning, G. Gerwig, 2018 .

Chapter 3 Biochemical characterization of Lactobacillus reuteri Glycoside Hydrolase family 70 GtfB type of 4 , 6-α-glucanotransferase enzymes that synthesize soluble dietary starch fibers

H. Leemhuis, L. Dijkhuizen, Zhengyu Jin, 2018 .

Mining novel starch-converting Glycoside Hydrolase 70 enzymes from the Nestlé Culture Collection genome database: The Lactobacillus reuteri NCC 2613 GtfB

L. Dijkhuizen, T. Pijning, S. V. van Leeuwen, 2017, Scientific Reports.

Crystal Structure of 4,6-α-Glucanotransferase Supports Diet-Driven Evolution of GH70 Enzymes from α-Amylases in Oral Bacteria.

L. Dijkhuizen, B. Dijkstra, Yuxiang Bai, 2016, Structure.

Structure–function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes

L. Dijkhuizen, Yuxiang Bai, T. Pijning, 2016, Cellular and Molecular Life Sciences.

Crystal structure of the 4,6-α-glucanotransferase GtfB: Evidence that dietary changes triggered the evolution of glucansucrases from α-amylases

Joana, Yuxiang, W., 2016 .

Structure-function relationships of family GH 70 glucansucrase and 4 , 6-α-glucanotransferase enzymes , and their evolutionary relationships with family GH 13 enzymes

L. Dijkhuizen, Yuxiang Bai, T. Pijning, 2016 .

Biochemical Characterization of the Lactobacillus reuteri Glycoside Hydrolase Family 70 GTFB Type of 4,6-α-Glucanotransferase Enzymes That Synthesize Soluble Dietary Starch Fibers

H. Leemhuis, L. Dijkhuizen, Zhengyu Jin, 2015, Applied and Environmental Microbiology.

Truncation of domain V of the multidomain glucansucrase GTF180 of Lactobacillus reuteri 180 heavily impairs its polysaccharide-synthesizing ability

L. Dijkhuizen, T. Pijning, G. Gerwig, 2015, Applied Microbiology and Biotechnology.

Biochemical characterization of Lactobacillus reuteri Glycoside Hydrolase family 70 GTFB

H. Leemhuis, L. Dijkhuizen, Zhengyu Jin, 2015 .

Flexibility of truncated and full‐length glucansucrase GTF180 enzymes from Lactobacillus reuteri 180

L. Dijkhuizen, B. Dijkstra, T. Pijning, 2014, The FEBS journal.

Glucansucrases: three-dimensional structures, reactions, mechanism, α-glucan analysis and their implications in biotechnology and food applications.

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2013, Journal of biotechnology.

Structure of the α-1,6/α-1,4-specific glucansucrase GTFA from Lactobacillus reuteri 121.

L. Dijkhuizen, B. Dijkstra, T. Pijning, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Glycosidic bond specificity of glucansucrases: on the role of acceptor substrate binding residues

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2012 .

4,6-α-Glucanotransferase activity occurs more widespread in Lactobacillus strains and constitutes a separate GH70 subfamily

H. Leemhuis, L. Dijkhuizen, T. Pijning, 2012, Applied Microbiology and Biotechnology.

Functional and Structural Characterization of α-(1→2) Branching Sucrase Derived from DSR-E Glucansucrase*

B. Dijkstra, L. Mourey, S. Tranier, 2012, The Journal of Biological Chemistry.

Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes

L. Dijkhuizen, B. Dijkstra, Cesar A. López, 2010, Proceedings of the National Academy of Sciences.

Residue Leu940 Has a Crucial Role in the Linkage and Reaction Specificity of the Glucansucrase GTF180 of the Probiotic Bacterium Lactobacillus reuteri 180*

L. Dijkhuizen, Cesar A. López, T. Pijning, 2014, The Journal of Biological Chemistry.

University of Groningen The structure of an energy-coupling protein from bacteria , IIBcellobiose , reveals similarity to eukaryotic protein tyrosine phosphatases

K. H. Kalk, M. Saier, G. Robillard, 2017 .

The structure of the Escherichia coli phosphotransferase IIAmannitol reveals a novel fold with two conformations of the active site.

K. H. Kalk, G. Robillard, B. Dijkstra, 1998, Structure.

Identification of Thermotoga maritima MSB8 GH57 α-amylase AmyC as a glycogen-branching enzyme with high hydrolytic activity

H. Leemhuis, Š. Janeček, T. Pijning, 2019, Applied Microbiology and Biotechnology.

A new group of glycoside hydrolase family 13 α-amylases with an aberrant catalytic triad

L. Dijkhuizen, Š. Janeček, Ihsanawati, 2017, Scientific Reports.

Thermus thermophilus Glycoside Hydrolase Family 57 Branching Enzyme

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2010, The Journal of Biological Chemistry.

Crystal Structure and Carbohydrate-binding Properties of the Human Cartilage Glycoprotein-39*

K. H. Kalk, B. Dijkstra, T. Pijning, 2003, Journal of Biological Chemistry.

BIOTECHNOLOGICALLY RELEVANT ENZYMES AND PROTEINS Identification of ThermotogamaritimaMSB8 GH57 α-amylase AmyC as a glycogen-branching enzyme with high hydrolytic activity

H. Leemhuis, Š. Janeček, T. Pijning, 2019 .

Mechanistic aspects of uptake and sinusoidal efflux of dibromosulfophthalein in the isolated perfused rat liver.

G. Groothuis, D. Meijer, T. Pijning, 1991, Biochemical pharmacology.

Crystal Structure of Levansucrase from the Gram-Negative Bacterium Brenneria Provides Insights into Its Product Size Specificity.

W. Mu, T. Pijning, A. Guskov, 2022, Journal of agricultural and food chemistry.

Crystal structure of inulosucrase from Lactobacillus: insights into the substrate specificity and product specificity of GH68 fructansucrases.

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2011, Journal of molecular biology.

The role of conserved inulosucrase residues in the reaction and product specificity of Lactobacillus reuteri inulosucrase

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2012, The FEBS journal.

Using Mutability Landscapes To Guide Enzyme Thermostabilization

A. Thunnissen, T. Pijning, G. Poelarends, 2020, Chembiochem : a European journal of chemical biology.

Improved activity and pH stability of E. coli ATCC 11105 penicillin acylase by error-prone PCR

T. Pijning, Huseyin Balci, M. T. Ozturk, 2014, Applied Microbiology and Biotechnology.

The three-dimensional structure of the nitrogen regulatory protein IIANtr from Escherichia coli.

K. H. Kalk, M. Saier, B. Dijkstra, 1998, Journal of molecular biology.

The structure of an energy-coupling protein from bacteria, IIBcellobiose, reveals similarity to eukaryotic protein tyrosine phosphatases.

K. H. Kalk, M. Saier, G. Robillard, 1997, Structure.

Biophysical characterization of mutants of Bacillus subtilis lipase evolved for thermostability: Factors contributing to increased activity retention

R. Boelens, B. Dijkstra, H. Wienk, 2012, Protein science : a publication of the Protein Society.

Lactobacillus reuteri Strains Convert Starch and Maltodextrins into Homoexopolysaccharides Using an Extracellular and Cell-Associated 4,6-α-Glucanotransferase.

L. Dijkhuizen, Yuxiang Bai, T. Pijning, 2016, Journal of agricultural and food chemistry.

4,6-α-Glucanotransferase activity occurs more widespread in Lactobacillus strains and constitutes a separate GH70 subfamily

H. Leemhuis, L. Dijkhuizen, T. Pijning, 2012, Applied Microbiology and Biotechnology.

A crystallographic study of Cys69Ala flavodoxin II from Azotobacter vinelandii: Structural determinants of redox potential

B. Dijkstra, T. Pijning, C. V. van Mierlo, 2005, Protein science : a publication of the Protein Society.

Crystal structure of an inulosucrase from Halalkalicoccus jeotgali B3T, a halophilic archaeal strain

R. Wallis, T. Pijning, M. A. Ghauri, 2021, The FEBS journal.

Crystal Structure of 4,6-α-Glucanotransferase GtfC-ΔC from Thermophilic Geobacillus 12AMOR1: Starch Transglycosylation in Non-Permuted GH70 Enzymes

L. Dijkhuizen, T. Pijning, A. Guskov, 2022, Journal of agricultural and food chemistry.

The Exiguobacterium sibiricum 255-15 GtfC Enzyme Represents a Novel Glycoside Hydrolase 70 Subfamily of 4,6-α-Glucanotransferase Enzymes

L. Dijkhuizen, T. Pijning, J. Gangoiti, 2015, Applied and Environmental Microbiology.

The crystal structure of a hyperthermoactive Exopolygalacturonase from Thermotoga maritima

J. Oost, B. Dijkstra, T. Pijning, 2009 .

Crystal structure of the leucine aminopeptidase from Pseudomonas putida reveals the molecular basis for its enantioselectivity and broad substrate specificity.

B. Dijkstra, A. Thunnissen, T. Pijning, 2010, Journal of molecular biology.

Structure of the complex between trypanosomal triosephosphate isomerase and N‐hydroxy‐4‐phosphono‐butanamide: Binding at the active site despite an “open” flexible loop conformation

C L Verlinde, F. Opperdoes, C. Verlinde, 1992, Protein science : a publication of the Protein Society.

Zonal distribution of the cation lucigenin in rat liver: influence of taurocholate.

G. Groothuis, D. Meijer, T. Pijning, 1989, Molecular pharmacology.

Vesicular uptake system for the cation lucigenin in the rat hepatocyte.

G. Groothuis, D. Meijer, T. Pijning, 1989, Molecular Pharmacology.

Characterization of the glucansucrase GTF180 W1065 mutant enzymes producing polysaccharides and oligosaccharides with altered linkage composition.

L. Dijkhuizen, T. Pijning, S. Kralj, 2017, Food chemistry.

Mutational Analysis of the Role of the Glucansucrase Gtf180-ΔN Active Site Residues in Product and Linkage Specificity with Lactose as Acceptor Substrate

L. Dijkhuizen, T. Pijning, S. V. van Leeuwen, 2018, Journal of agricultural and food chemistry.

Biophysical characterization of mutants of Bacillus subtilis lipase evolved for thermostability: Factors contributing to increased activity retention

R. Boelens, B. Dijkstra, H. Wienk, 2012, Protein science : a publication of the Protein Society.

Glucansucrases: three-dimensional structures, reactions, mechanism, α-glucan analysis and their implications in biotechnology and food applications.

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2013, Journal of biotechnology.

University of Groningen Mutational Analysis of the Role of the Glucansucrase Gtf180-Delta N Active Site Residues in Product and Linkage Specificity with Lactose as Acceptor Substrate Pham,

L. Dijkhuizen, T. Pijning, S. V. Leeuwen, 2018 .

Structure–function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes

L. Dijkhuizen, Yuxiang Bai, T. Pijning, 2016, Cellular and Molecular Life Sciences.

Characterization of the Functional Roles of Amino Acid Residues in Acceptor-binding Subsite +1 in the Active Site of the Glucansucrase GTF180 from Lactobacillus reuteri 180*

L. Dijkhuizen, T. Pijning, G. Gerwig, 2015, The Journal of Biological Chemistry.

Flexibility of truncated and full‐length glucansucrase GTF180 enzymes from Lactobacillus reuteri 180

L. Dijkhuizen, B. Dijkstra, T. Pijning, 2014, The FEBS journal.

University of Groningen Structure-function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes

L. Dijkhuizen, Yuxiang Bai, T. Pijning, 2016 .

Structural and time‐resolved mechanistic investigations of protein hydrolysis by the acidic proline‐specific endoprotease from Aspergillus niger

B. Dijkstra, T. Pijning, A. Vujičić‐Žagar, 2023, Protein science : a publication of the Protein Society.

Crystal structure of inulosucrase from Lactobacillus: insights into the substrate specificity and product specificity of GH68 fructansucrases.

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2011, Journal of molecular biology.

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

T. Saravanan, A. Thunnissen, T. Pijning, 2019, ACS catalysis.

Insights into the Structure-Function Relationship of GH70 GtfB α-Glucanotransferases from the Crystal Structure and Molecular Dynamic Simulation of a Newly Characterized Limosilactobacillus reuteri N1 GtfB Enzyme.

L. Dijkhuizen, Yuxiang Bai, Xiaoxiao Li, 2024, Journal of agricultural and food chemistry.

Polysaccharide utilization loci encoded DUF1735 likely functions as membrane‐bound spacer for carbohydrate active enzymes

T. Pijning, Lisanne Hameleers, Lucie A Gaenssle, 2024, FEBS open bio.