N. Christensen

发表

Running title: Fab induces conformational changes to HPV16 capsids

A. Makhov, Hyunwook Lee, S. Brendle, 2014 .

Running title : Fab induces conformational changes to HPV 16 capsids 4 5

A. Makhov, Hyunwook Lee, S. Brendle, 2014 .

A Cryo-Electron Microscopy Study Identifies the Complete H16.V5 Epitope and Reveals Global Conformational Changes Initiated by Binding of the Neutralizing Antibody Fragment

Neil D. Christensen, Susan Hafenstein, James F. Conway, 2014, Journal of Virology.

High efficiency induction of papillomas in vivo using recombinant cottontail rabbit papillomavirus DNA.

N. Christensen, J. Kreider, N. Cladel, 1995, Journal of virological methods.

Human Papillomavirus Vaccination Among Adults and Children in 5 US States.

E. Lengerich, N. Christensen, C. Meyers, 2015, Journal of public health management and practice : JPHMP.

Human papillomaviruses bind a basal extracellular matrix component secreted by keratinocytes which is distinct from a membrane-associated receptor.

N. Christensen, T. Culp, L. Budgeon, 2006, Virology.

Multivariate statistical analysis of organ weights in toxicity studies.

N. Christensen, H Spliid, H. Spliid, 1999, Toxicology.

Conserved features in papillomavirus and polyomavirus capsids.

W W Newcomb, T S Baker, T. Baker, 1996, Journal of molecular biology.

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

S. Cho, S. Bywaters, N. Christensen, 2020, eLife.

A small molecule antagonist of the αvβ3 integrin suppresses MDA-MB-435 skeletal metastasis

D. Griggs, N. Christensen, D. Welch, 2004, Clinical & Experimental Metastasis.

Human alpha and beta papillomaviruses use different synonymous codon profiles

N. Christensen, N. Cladel, A. Bertotto, 2010, Virus Genes.

Reactivity pattern of 92 monoclonal antibodies with 15 human papillomavirus types.

M. Pawlita, N. Christensen, T. Waterboer, 2008, The Journal of general virology.

Papillomavirus capsid proteins mutually impact structure.

N. Christensen, S. Alam, C. Meyers, 2011, Virology.

Postattachment neutralization of papillomaviruses by monoclonal and polyclonal antibodies.

N. Christensen, N. Cladel, C. A. Reed, 1995, Virology.

Coinfection of human foreskin fragments with multiple human papillomavirus types (HPV-11, -40, and -LVX82/MM7) produces regionally separate HPV infections within the same athymic mouse xenograft

W. Koltun, N. Christensen, J. Kreider, 1997, Journal of virology.

Immunization with viruslike particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus

N. Christensen, J. Kreider, N. Cladel, 1996, Journal of virology.

Mucosally delivered peptides prime strong immunity in HLA-A2.1 transgenic rabbits.

N. Christensen, N. Cladel, Jiafen Hu, 2010, Vaccine.

Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors

N. Christensen, T. Cooper, T. Schell, 2015, Cancer Immunology, Immunotherapy.

Identification of Two Cross-Neutralizing Linear Epitopes within the L1 Major Capsid Protein of Human Papillomaviruses

P. Coursaget, N. Christensen, A. Touzé, 2002, Journal of Virology.

Protein of HPV-6 and HPV-16 Neutralizing Epitope for the L 2 Minor Capsid Common ( HPV-16 ) L 1 Particles Presenting the Chimeric Human Papillomavirus Type 16

D. Villiers, N. Christensen, E. Rybicki, 2003 .

Chimeric Human Papillomavirus Type 16 (HPV-16) L1 Particles Presenting the Common Neutralizing Epitope for the L2 Minor Capsid Protein of HPV-6 and HPV-16

N. Christensen, E. Rybicki, A. Williamson, 2003, Journal of Virology.

Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11

N. Christensen, J. Kreider, N. Cladel, 1990, Journal of virology.

Assembled baculovirus-expressed human papillomavirus type 11 L1 capsid protein virus-like particles are recognized by neutralizing monoclonal antibodies and induce high titres of neutralizing antibodies.

N. Christensen, J. Kreider, N. Cladel, 1994, The Journal of general virology.

Surface conformational and linear epitopes on HPV-16 and HPV-18 L1 virus-like particles as defined by monoclonal antibodies.

J. Dillner, D. Galloway, N. Christensen, 1996, Virology.

Detection of serologic neutralizing antibodies against HPV-11 in patients with condyloma acuminata and cervical dysplasia using an in vitro assay.

L. Smith, N. Christensen, G. Leiserowitz, 1997, Gynecologic oncology.

Treatment with anti-Pan T-cell antibody did not result in noticeable immune subset depletion. Detection of EBV DNA was higher in PBMCs in rabbits receiving

N. Christensen, T. Whitcomb, Xuwen Peng, 2020 .

DNA Vaccines Delivered By Microneedle and Tattoo Gun Induce Protective Immune Responses to Hla-A2.1 Restricted CRPV E1 and HPV16e7 Epitopes in HLA-A2.1 Transgenic Rabbits

N. Christensen, N. Cladel, L. Budgeon, 2016 .

Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue.

N. Christensen, N. Cladel, T. Cooper, 2016, Virology.

A Novel Pre-Clinical Murine Model to Study the Life Cycle and Progression of Cervical and Anal Papillomavirus Infections

N. Christensen, N. Cladel, T. Cooper, 2015, PloS one.

Gene gun-mediated intracutaneous vaccination with papillomavirus E7 gene delays cancer development of papillomavirus-induced skin papillomas on rabbits.

N. Christensen, N. Cladel, L. Budgeon, 2002, Cancer detection and prevention.

Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer

S. Brendle, N. Christensen, N. Cladel, 2017, Scientific Reports.

Production and characterization of a novel HPV anti-L2 monoclonal antibody panel.

R. Roden, S. Brendle, S. Bywaters, 2018, Virology.

Antibody Competition Reveals Surface Location of HPV L2 Minor Capsid Protein Residues 17–36

S. Brendle, S. Bywaters, N. Christensen, 2017, Viruses.

Kinetics of in vitro adsorption and entry of papillomavirus virions.

N. Christensen, T. Culp, Timothy D. Culp, 2004, Virology.

Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivo.

N. Christensen, N. Cladel, L. Budgeon, 2007, Virology.

Preclinical Model To Test Human Papillomavirus Virus (HPV) Capsid Vaccines In Vivo Using Infectious HPV/Cottontail Rabbit Papillomavirus Chimeric Papillomavirus Particles

N. Christensen, C. Buck, N. Cladel, 2006, Journal of Virology.

RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer

R. Roden, P. Lambert, N. Christensen, 2022, Journal of virology.

Propagation, infection, and neutralization of authentic HPV16 virus.

Margaret E McLaughlin-Drubin, N. Christensen, C. Meyers, 2004, Virology.

Antibodies to human papillomavirus 16 L1 virus-like particles as an independent prognostic marker in cervical cancer.

N. Christensen, C. Marth, A. Bergant, 2002, American journal of obstetrics and gynecology.

Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization.

A. Makhov, Hyunwook Lee, S. Brendle, 2015, Virology.

Binding and neutralization characteristics of a panel of monoclonal antibodies to human papillomavirus 58

S. Brendle, N. Christensen, Tatevik R Broutian, 2010, The Journal of general virology.

Pathogenesis of infection by human papillomavirus.

S. Brendle, S. Bywaters, N. Christensen, 2014, Current problems in dermatology.

Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes.

R. Roden, H. Zayed, S. Brendle, 2015, Vaccine.

Protection of rabbits against cutaneous papillomavirus infection using recombinant tobacco mosaic virus containing L2 capsid epitopes.

A. Benko, N. Christensen, K. Palmer, 2006, Vaccine.

Specific serologic response to genital human papillomavirus types in patients with vulvar precancerous and cancerous lesions.

N. Concin, N. Christensen, A. Bergant, 2005, American journal of obstetrics and gynecology.

Antibody-mediated neutralization in vivo of infectious papillomaviruses

N. Christensen, J. Kreider, Neil D. Christensen, 1990, Journal of virology.

Adaptation-proof SARS-CoV-2 vaccine design

N. Dokholyan, N. Christensen, N. Yennawar, 2022, bioRxiv.

High incidence of spontaneous cataracts in aging laboratory rabbits of an inbred strain.

N. Christensen, T. Cooper, Xuwen Peng, 2015, Veterinary Ophthalmology.

IL-13 R 2 is a Glioma-Restricted Receptor for Interleukin-131

N. Christensen, A. Mintz, W. Debinski, 2002 .

Antibody-Mediated Immune Subset Depletion Modulates the Immune Response in a Rabbit (Oryctolagus cuniculus) Model of Epstein-Barr Virus Infection.

C. Sample, S. Brendle, N. Christensen, 2020, Comparative medicine.

In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance.

Baohua Zhao, N. Christensen, Jianxun Song, 2011, Cancer research.

SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation

N. Christensen, S. Diangelo, P. Silveyra, 2015, PloS one.

Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus

N. Christensen, Zhi-Ming Zheng, N. Cladel, 2022, Viruses.

Differences in N-linked glycosylation between human surfactant protein-B variants of the C or T allele at the single-nucleotide polymorphism at position 1580: implications for disease.

N. Christensen, S. Guttentag, B. Wigdahl, 2003, The Biochemical journal.

Against Ocular Herpes T Cell Epitope-based Vaccines + Human Cd8 Rabbit Model for Preclinical Evaluation of a Novel Hla (hla-a*0201) Transgenic

A. Nesburn, S. Wechsler, G. Dasgupta, 2022 .

A novel human papillomavirus type 6 neutralizing domain comprising two discrete regions of the major capsid protein L1.

W. Mcclements, K. Jansen, N. Christensen, 2001, Virology.

Antibody detection in tear samples as a surrogate to monitor host immunity against papillomavirus infections in vaccinated and naturally infected hosts.

S. Brendle, S. Bywaters, N. Christensen, 2014, The Journal of general virology.

Morphometric analysis and identification of infiltrating leucocytes in regressing and progressing shope rabbit papillomas

N. Christensen, J. Kreider, M. Okabayashi, 1991, International journal of cancer.

Intramuscular injection of plasmid DNA encoding cottontail rabbit papillomavirus E1, E2, E6 and E7 induces T cell-mediated but not humoral immune responses in rabbits.

N. Christensen, N. Cladel, C. A. Reed, 1999, Vaccine.

The U4 Antibody Epitope on Human Papillomavirus 16 Identified by Cryo-electron Microscopy

Hyunwook Lee, S. Brendle, S. Bywaters, 2015, Journal of Virology.

Mapping of human serum-reactive epitopes in virus-like particles of human papillomavirus types 16 and 11.

J. Dillner, N. Christensen, Xiaohong Wang, 2003, Virology.

In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas.

N. Christensen, J. Kreider, L. Budgeon, 2000, Antiviral research.

Animal Models of Papillomavirus Infections

N. Christensen, J. Kreider, 1999 .

High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16

A. Makhov, S. Brendle, S. Bywaters, 2017, Viruses.

Analytical and Preformulation Characterization Studies of Human Papillomavirus Virus-Like Particles to Enable Quadrivalent Multi-Dose Vaccine Formulation Development.

S. Joshi, D. Volkin, S. Brendle, 2022, Journal of pharmaceutical sciences.

IL-13Ralpha2 is a glioma-restricted receptor for interleukin-13.

N. Christensen, A. Mintz, W. Debinski, 2002, Neoplasia.

Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model.

N. Christensen, R. Myers, N. Cladel, 2015, The Journal of general virology.

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

V. Walter, S. Brendle, N. Christensen, 2022, Viruses.

Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes

R. Roden, N. Christensen, Svetlana S. Stegalkina, 2017, Vaccine.

Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes.

R. Roden, J. Schiller, N. Christensen, 2014, Vaccine.

The Viral E4 Protein Is Required for the Completion of the Cottontail Rabbit Papillomavirus Productive Cycle In Vivo

N. Christensen, N. Cladel, J. Doorbar, 2004, Journal of Virology.

Leukocyte proliferation in vitro against cottontail rabbit papillomavirus in rabbits with persisting papillomas/cancer or after regression

N. Christensen, J. Kreider, R. Höpfl, 2004, Archives of Dermatological Research.

Characterization of transformation function of cottontail rabbit papillomavirus E5 and E8 genes.

N. Christensen, N. Cladel, C. A. Reed, 1998, Virology.

Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodies.

D. Galloway, N. Christensen, P. Randhawa, 2009, The Journal of general virology.

Short Communication Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodies

D. Galloway, N. Christensen, P. Randhawa, 2009 .

Maintaining GFP tissue fluorescence through bone decalcification and long-term storage.

N. Christensen, D. Welch, L. Budgeon, 2002, BioTechniques.

Titration of HPV-11 infectivity and antibody neutralization can be measured in vitro.

R. Isseroff, L. Smith, N. Christensen, 1995, The Journal of investigative dermatology.

Comparison of PV Conformational Epitopes Expressed by L1 Proteins in Mammalian (COS) and Insect (SF9) Cells

N. Christensen, R. Schlegel, J. Kreider, 1994 .

The Mouse Papillomavirus Infection Model

N. Christensen, N. Cladel, L. Budgeon, 2017, Viruses.

Formulation of cidofovir improves the anti-papillomaviral activity of topical treatments in the CRPV/rabbit model.

N. Christensen, N. Cladel, Jiafen Hu, 2014, Antiviral research.

Immunological cross-reactivity to laboratory-produced HPV-11 virions of polysera raised against bacterially derived fusion proteins and synthetic peptides of HPV-6b and HPV-16 capsid proteins.

D. Galloway, N. Christensen, J. Kreider, 1990, Virology.

Human papillomavirus type 18 chimeras containing the L2/L1 capsid genes from evolutionarily diverse papillomavirus types generate infectious virus.

N. Christensen, C. Meyers, Horng-Shen Chen, 2011, Virus research.

Further Evidence that Papillomavirus Capsids Exist inTwo DistinctConformations

H. Selinka, N. Christensen, M. Sapp, 2003, Journal of Virology.

Efficient replication of Epstein–Barr virus in stratified epithelium in vitro

C. Sample, N. Christensen, C. Meyers, 2014, Proceedings of the National Academy of Sciences.

A Broad-Spectrum Microbicide with Virucidal Activity against Sexually Transmitted Viruses

F. Krebs, N. Christensen, D. Malamud, 1999, Antimicrobial Agents and Chemotherapy.

Identification of Two Cross-Neutralizing Linear Epitopes within the L1 Major Capsid Protein of Human Papillomaviruses

P. Coursaget, N. Christensen, A. Touzé, 2002, Journal of Virology.

GS-9191 Is a Novel Topical Prodrug of the Nucleotide Analog 9-(2-Phosphonylmethoxyethyl)Guanine with Antiproliferative Activity and Possible Utility in the Treatment of Human Papillomavirus Lesions

William A. Lee, N. Christensen, H. Reiser, 2009, Antimicrobial Agents and Chemotherapy.

Preclinical system for evaluating topical podofilox treatment of papillomas: dose-response and duration of growth prior to treatment.

N. Christensen, J. Kreider, C. Christian, 1992, The Journal of investigative dermatology.

Identification of a Human Papillomavirus Type 16-Specific Epitope on the C-Terminal Arm of the Major Capsid Protein L1

D. Galloway, N. Christensen, J. Carter, 2003, Journal of Virology.

Hybrid papillomavirus L1 molecules assemble into virus-like particles that reconstitute conformational epitopes and induce neutralizing antibodies to distinct HPV types.

W. Mcclements, K. Jansen, N. Christensen, 2001, Virology.

Crystal Structures of Four Types of Human Papillomavirus L1 Capsid Proteins

M. Klein, R. Garcea, N. Christensen, 2007, Journal of Biological Chemistry.

Comparisons of VLP-Based ELISA, Neutralization Assays with Native HPV, and Neutralization Assays with PsV in Detecting HPV Antibody Responses in HIV-Infected Women.

S. Brendle, N. Christensen, C. Meyers, 2015, Journal of AIDS & clinical research.

Expression of HPV-11 L1 protein in transgenic Arabidopsis thaliana and Nicotiana tabacum

N. Christensen, E. Rybicki, I. Hitzeroth, 2007, BMC biotechnology.

Amino Acid Residues in the Carboxy-Terminal Region of Cottontail Rabbit Papillomavirus E6 Influence Spontaneous Regression of Cutaneous Papillomas

N. Christensen, N. Cladel, Jiafen Hu, 2002, Journal of Virology.

Analysis of mechanisms underlying BRMS1 suppression of metastasis

N. Christensen, T. Sakamaki, D. Welch, 2004, Clinical & Experimental Metastasis.

Detection of human serum antibodies that neutralize infectious human papillomavirus type 11 virions.

K. Shah, N. Christensen, J. Kreider, 1992, The Journal of general virology.

The adaptation of the plaque reduction assay for measuring specific cytotoxic cells in limiting dilution cultures.

N. Christensen, T. Ezaki, M. Skinner, 1984, Journal of immunological methods.

Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study

N. Christensen, E. Rybicki, A. Varsani, 2006, Clinical and Vaccine Immunology.

Life Cycle Heterogeneity in Animal Models of Human Papillomavirus-Associated Disease

K. Sotlar, N. Christensen, W. Liu, 2002, Journal of Virology.

Rabbit Genital Tissue Is Susceptible to Infection by Rabbit Oral Papillomavirus: an Animal Model for a Genital Tissue-Targeting Papillomavirus

N. Christensen, N. Cladel, P. Welsh, 1998, Journal of Virology.

Laboratory production of infectious stocks of rabbit oral papillomavirus.

N. Christensen, J. Kreider, N. Cladel, 1996, The Journal of general virology.

Combination Treatment with Intralesional Cidofovir and Viral-DNA Vaccination Cures Large Cottontail Rabbit Papillomavirus-Induced Papillomas and Reduces Recurrences

N. Christensen, N. Cladel, R. Han, 2001, Antimicrobial Agents and Chemotherapy.

Recent advances in preclinical model systems for papillomaviruses.

N. Christensen, N. Cladel, L. Budgeon, 2017, Virus research.

Protective cell-mediated immunity by DNA vaccination against Papillomavirus L1 capsid protein in the Cottontail Rabbit Papillomavirus model.

N. Christensen, N. Cladel, L. Budgeon, 2006, Viral immunology.

Emerging human papillomavirus vaccines

N. Christensen, 2005, Expert opinion on emerging drugs.

Comparison of neutralization of BPV‐1 infection of C127 cells and bovine fetal skin xenografts

N. Christensen, J. Kreider, A. Jenson, 1991, International journal of cancer.

Chimeric L2-Based Virus-Like Particle (VLP) Vaccines Targeting Cutaneous Human Papillomaviruses (HPV)

N. Christensen, S. Shafti-Keramat, R. Kirnbauer, 2017, PloS one.

Protection of Rabbits against Challenge with Rabbit Papillomaviruses by Immunization with the N Terminus of Human Papillomavirus Type 16 Minor Capsid Antigen L2

R. Roden, N. Christensen, B. Karanam, 2007, Journal of Virology.

Bovine papillomavirus type 1 (BPV1) and BPV2 are closely related serotypes.

N. Christensen, Bärbel Reininger, S. Brandt, 2009, Virology.

HPV disease transmission protection and control

N. Christensen, 2016, Microbial cell.

Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2.

D. Lowy, R. Roden, J. Schiller, 2005, Virology.

Tissue xenografts as a model system for study of the pathogenesis of papillomaviruses.

N. Christensen, J. Kreider, M. Howett, 1997, Clinics in dermatology.

Monoclonal antibody neutralization of BPV-1.

N. Christensen, J. Kreider, 1993, Virus research.

Assessment of the serological relatedness of genital human papillomaviruses by hemagglutination inhibition

D. Lowy, R. Roden, J. Schiller, 1996, Journal of virology.

Broad Cross-Protection Is Induced in Preclinical Models by a Human Papillomavirus Vaccine Composed of L1/L2 Chimeric Virus-Like Particles

M. Boxus, S. Brendle, N. Christensen, 2016, Journal of Virology.

A Protective and Broadly Cross-Neutralizing Epitope of Human Papillomavirus L2

I. Bossis, R. Roden, N. Christensen, 2007, Journal of Virology.

Characterization of a human papillomavirus type 16 variant-dependent neutralizing epitope

D. Lowy, R. Roden, J. Schiller, 1997, Journal of virology.

Papillomavirus DNA complementation in vivo.

N. Christensen, N. Cladel, L. Budgeon, 2009, Virus research.

Keratinocyte-Secreted Laminin 5 Can Function as a Transient Receptor for Human Papillomaviruses by Binding Virions and Transferring Them to Adjacent Cells

N. Christensen, M. Marinkovich, L. Budgeon, 2006, Journal of Virology.

A Comparative Study on Delivery of Externally Attached DNA by Papillomavirus VLPs and Pseudoviruses

S. Brendle, N. Christensen, S. Alam, 2021, Vaccines.

Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues

S. Brendle, N. Christensen, N. Cladel, 2021, Viruses.

Cross-Neutralization Potential of Native Human Papillomavirus N-Terminal L2 Epitopes

N. Christensen, S. Alam, C. Meyers, 2011, PloS one.

Overlapping and independent structural roles for human papillomavirus type 16 L2 conserved cysteines.

N. Christensen, S. Alam, C. Meyers, 2009, Virology.

Differential antibody responses to a distinct region of human papillomavirus minor capsid proteins.

N. Christensen, M. Embers, L. Budgeon, 2004, Vaccine.

Protective Immunity to Rabbit Oral and Cutaneous Papillomaviruses by Immunization with Short Peptides of L2, the Minor Capsid Protein

N. Christensen, M. Embers, L. Budgeon, 2002, Journal of Virology.

Skin test to assess immunity against cottontail rabbit papillomavirus antigens in rabbits with progressing papillomas or after papilloma regression.

N. Christensen, J. Kreider, R. Höpfl, 1993, The Journal of investigative dermatology.

The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopes.

N. Christensen, J. Kreider, S. Diangelo, 1991, Virology.

Establishment of a Cottontail Rabbit Papillomavirus/HLA-A2.1 Transgenic Rabbit Model

N. Christensen, N. Cladel, L. Budgeon, 2007, Journal of Virology.

Anti-viral activity of microbicides in model systems. 12th World AIDS Conference

F. Krebs, N. Christensen, D. Malamud, 1998 .

The wide utility of rabbits as models of human diseases

L. BenMohamed, G. Kaplan, G. McFadden, 2018, Experimental & Molecular Medicine.

Helper and suppressor functions of panned populations of immune peritoneal T cells with reactivity to the rat mammary adenocarcinoma 13762A.

N. Christensen, J. Kreider, 1988, Cellular immunology.

Rabbit Genetics and Transgenic Models

N. Christensen, Xuwen Peng, 2012 .

An HLA-A2.1-Transgenic Rabbit Model to Study Immunity to Papillomavirus Infection1

N. Christensen, N. Cladel, T. Schell, 2006, The Journal of Immunology.

A Novel HLA (HLA-A*0201) Transgenic Rabbit Model for Preclinical Evaluation of Human CD8+ T Cell Epitope-Based Vaccines against Ocular Herpes

A. Nesburn, S. Wechsler, L. BenMohamed, 2010, The Journal of Immunology.

Rabbit oral papillomavirus complete genome sequence and immunity following genital infection.

N. Christensen, N. Cladel, C. A. Reed, 2000, Virology.

Wounding prior to challenge substantially improves infectivity of cottontail rabbit papillomavirus and allows for standardization of infection.

N. Christensen, N. Cladel, Jiafen Hu, 2008, Journal of virological methods.

Characterization of immune responses during regression of rabbit oral papillomavirus infections.

N. Christensen, C. Lang, L. Budgeon, 2005, Comparative medicine.

Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids

N. Christensen, S. Hafenstein, C. Bator, 2021, Viruses.

Differences in methodology, but not differences in viral strain, account for variable experimental outcomes in laboratories utilizing the cottontail rabbit papillomavirus model.

N. Christensen, N. Cladel, Jiafen Hu, 2010, Journal of virological methods.

A neutralizing epitope of human papillomavirus type 11 is principally described by a continuous set of residues which overlap a distinct linear, surface-exposed epitope

N. Christensen, G. Mark, S. Ludmerer, 1997, Journal of virology.

Skin Test Reactivity to Papilloma Cells is Long Lasting in Domestic Rabbits after Regression of Cottontail Rabbit Papillomavirus Induced Papillomas

N. Christensen, J. Kreider, R. Höpfl, 1994 .

HPV11 mutant virus-like particles elicit immune responses that neutralize virus and delineate a novel neutralizing domain.

W. Mcclements, K. Jansen, N. Christensen, 2000, Virology.

type 16 variant-dependent neutralizing epitope . Characterization of a human papillomavirus

D. Lowy, R. Roden, J. Schiller, 1997 .

Neutralization of CRPV infectivity by monoclonal antibodies that identify conformational epitopes on intact virions.

N. Christensen, J. Kreider, 1991, Virus research.

Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice.

N. Christensen, D. Welch, N. Cladel, 2003, Virus research.

Vaccine generated immunity targets an HPV16 E7 HLA-A2.1-restricted CD8(+) T cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (CRPV) genome in HLA-A2.1 transgenic rabbits.

N. Christensen, N. Cladel, Callie E Bounds, 2011, Vaccine.

Detection of L1, infectious virions and anti-L1 antibody in domestic rabbits infected with cottontail rabbit papillomavirus.

N. Christensen, N. Cladel, L. Budgeon, 2007, The Journal of general virology.

An in vitro system for studying the initial stages of cottontail rabbit papillomavirus infection.

N. Christensen, J. Kreider, M. Angell, 1992, Journal of virological methods.

Multivalent Human Papillomavirus L1 DNA Vaccination Utilizing Electroporation

R. Roden, N. Christensen, Kihyuck Kwak, 2013, PloS one.

A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11.

R. Roden, N. Christensen, S. Shafti-Keramat, 2007, Vaccine.

The rabbit papillomavirus model: a valuable tool to study viral–host interactions

N. Christensen, N. Cladel, Xuwen Peng, 2019, Philosophical Transactions of the Royal Society B.

Differentiation-Dependent Interpentameric Disulfide Bond Stabilizes Native Human Papillomavirus Type 16

N. Christensen, S. Alam, C. Meyers, 2011, PloS one.

Tissue-Spanning Redox Gradient-Dependent Assembly of Native Human Papillomavirus Type 16 Virions

R. Roden, N. Christensen, S. Alam, 2009, Journal of Virology.

Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections

V. Walter, S. Brendle, N. Christensen, 2022, Journal of virology.

Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy.

D. Gotte, N. Christensen, Zhi-Ming Zheng, 2017, The Journal of general virology.

Secondary Infections, Expanded Tissue Tropism, and Evidence for Malignant Potential in Immunocompromised Mice Infected with Mus musculus Papillomavirus 1 DNA and Virus

N. Christensen, N. Cladel, T. Cooper, 2013, Journal of Virology.

Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site.

A. Makhov, S. Brendle, S. Bywaters, 2017, Structure.

Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L 2 Densities and Heparin Binding Site Highlights

A. Makhov, S. Brendle, S. Bywaters, 2022 .

Neutralization of human papillomavirus (HPV) pseudovirions: a novel and efficient approach to detect and characterize HPV neutralizing antibodies.

K. Jansen, N. Christensen, M. Aste‐Amezaga, 2000, Virology.

Roles for Human Papillomavirus Type 16 L1 Cysteine Residues 161, 229, and 379 in Genome Encapsidation and Capsid Stability

N. Christensen, S. Alam, C. Meyers, 2014, PloS one.

Quantitative RT-PCR assay for HPV infection in cultured cells.

N. Christensen, Timothy D. Culp, 2003, Journal of virological methods.

Papillomavirus Particles Assembled in 293TT Cells Are Infectious In Vivo

N. Christensen, N. Cladel, L. Budgeon, 2006, Journal of Virology.

Cottontail Rabbit Papillomavirus (CRPV) Model System to Test Antiviral and Immunotherapeutic Strategies

N. Christensen, 2005, Antiviral chemistry & chemotherapy.

Inhibition of papilloma progression by antisense oligonucleotides targeted to HPV11 E6/E7 RNA

N. Christensen, G. Clawson, D. Thiboutot, 2004, Gene Therapy.

The U 4 Antibody Epitope on Human Papillomavirus 16 Identified by Cryo-electron Microscopy

S. Brendle, S. Bywaters, Jian Guan, 2015 .

Increased immunity to cottontail rabbit papillomavirus infection in EIII/JC inbred rabbits after vaccination with a mutant E6 that correlates with spontaneous regression.

N. Christensen, N. Cladel, Jiafen Hu, 2007, Viral immunology.

Tumor Challenge : a Proof-of-Concept Study Papillomavirus L 1 Protein Protects against Plant-Produced Cottontail Rabbit

N. Christensen, E. Rybicki, A. Varsani, 2006 .

Immunization of rabbits with cottontail rabbit papillomavirus E1 and E2 genes: protective immunity induced by gene gun-mediated intracutaneous delivery but not by intramuscular injection.

N. Christensen, N. Cladel, C. A. Reed, 2000, Vaccine.

Protection of Rabbits from Viral Challenge by Gene Gun-Based Intracutaneous Vaccination with a Combination of Cottontail Rabbit Papillomavirus E1, E2, E6, and E7 Genes

N. Christensen, N. Cladel, Xuwen Peng, 1999, Journal of Virology.

Significance of papillomavirus conformational itopes in the immunological diagnosis, treatment, and prevention of infections

N. Christensen, J. Kreider, 1992 .

GM-CSF enhances protective immunity to cottontail rabbit papillomavirus E8 genetic vaccination in rabbits.

N. Christensen, N. Cladel, R. Han, 2004, Vaccine.

Intracutaneous DNA Vaccination with the E8 Gene of Cottontail Rabbit Papillomavirus Induces Protective Immunity against Virus Challenge in Rabbits

N. Christensen, N. Cladel, R. Han, 2002, Journal of Virology.

Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7

M. Pawlita, H. Pfister, N. Christensen, 2000, The Lancet.

Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus.

N. Christensen, N. Cladel, L. Budgeon, 2013, Virology.

DNA Vaccination Prevents and/or Delays Carcinoma Development of Papillomavirus-Induced Skin Papillomas on Rabbits

N. Christensen, N. Cladel, L. Budgeon, 2000, Journal of Virology.

Papillomavirus Microbicidal Activities of High-Molecular-Weight Cellulose Sulfate, Dextran Sulfate, and Polystyrene Sulfonate

Robert A. Anderson, P. Hermonat, N. Christensen, 2001, Antimicrobial Agents and Chemotherapy.

Systemic adoptive transfer of immunity and low‐dose irradiation eradicate metastases of 13762a rat mammary adenocarcinoma

N. Christensen, J. Kreider, P. Welsh, 1985, International journal of cancer.

Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part II- Real-time and Accelerated Stability Studies.

S. Joshi, D. Volkin, S. Brendle, 2022, Journal of pharmaceutical sciences.

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

S. Cho, S. Bywaters, N. Christensen, 2020, bioRxiv.

The innate immune adaptor MyD88 is dispensable for spontaneous autoimmune demyelination in a mouse model of multiple sclerosis

N. Christensen, L. Budgeon, H. Waldner, 2013, Journal of Neuroimmunology.

Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research

Y. E. Chen, N. Christensen, Jifeng Zhang, 2021, Frontiers in Genetics.

Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model

G. Gallia, D. Bailey, B. Stillman, 2016, PloS one.

The wide utility of rabbits as models of human diseases

L. BenMohamed, G. Kaplan, G. McFadden, 2018, Experimental & Molecular Medicine.

The type 1 diabetes resistance locus B10 Idd9.3 mediates impaired B‐cell lymphopoiesis and implicates microRNA‐34a in diabetes protection

N. Christensen, T. Cooper, L. Budgeon, 2014, European Journal of Immunology.

Characterization of three rabbit oral papillomavirus oncogenes.

N. Christensen, N. Cladel, L. Budgeon, 2004, Virology.

The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women.

N. Kiviat, D. Galloway, N. Christensen, 1996, The Journal of infectious diseases.

Ranpirnase Eradicates Human Papillomavirus in Cultured Cells and Heals Anogenital Warts in a Phase I Study

T. Hodge, D. Sidransky, S. Brendle, 2017, Antiviral therapy.

CRPV Genomes with Synonymous Codon Optimizations in the CRPV E7 Gene Show Phenotypic Differences in Growth and Altered Immunity upon E7 Vaccination

N. Christensen, N. Cladel, Jiafen Hu, 2008, PloS one.

Suppressor lymphokine produced by rat T-cells in response to syngeneic mammary adenocarcinoma 13762A.

N. Christensen, J. Kreider, R. L. Horetsky, 1988, Cancer research.

Strong and Specific Protective and Therapeutic Immunity Induced by Single HLA-A2.1 Restricted Epitope DNA Vaccine in Rabbits

N. Christensen, N. Cladel, T. Schell, 2009 .

Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression.

N. Christensen, N. Cladel, Xuwen Peng, 2005, The Journal of general virology.

Using HLA-A2.1 Transgenic Rabbit Model to Screen and Characterize New HLA-A2.1 Restricted Epitope DNA Vaccines.

N. Christensen, N. Cladel, T. Schell, 2010, Journal of vaccines & vaccination.

Protein- and DNA-based active immunotherapy targeting interleukin-13 receptor alpha2.

N. Christensen, A. Mintz, N. Cladel, 2008, Cancer biotherapy & radiopharmaceuticals.

Vaccines and immunization against human papillomavirus.

N. Christensen, L. Budgeon, 2014, Current problems in dermatology.

Long-peptide therapeutic vaccination against CRPV-induced papillomas in HLA-A2.1 transgenic rabbits.

N. Christensen, N. Cladel, L. Budgeon, 2014, Trials in vaccinology.

BET bromodomain inhibitors show anti‐papillomavirus activity in vitro and block CRPV wart growth in vivo

R. Prinjha, Kevin Lee, S. Brendle, 2018, Antiviral research.

The expressed L1 proteins of HPV-1, HPV-6, and HPV-11 display type-specific epitopes with native conformation and reactivity with neutralizing and nonneutralizing antibodies.

R. Schlegel, N. Christensen, J. Kreider, 1994, Pathobiology (Basel).

Type-Specific Antiviral Antibodies to Genital Human Papillomavirus Types in Mothers and Newborns

N. Concin, N. Christensen, A. Bergant, 2007, Reproductive Sciences.

Comprehensive Assessment of the Antigenic Impact of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised against Lineage A Major Capsid Proteins of Vaccine-Related Genotypes

N. Christensen, Qinjian Zhao, N. Xia, 2020, Journal of Virology.

Characterization of the binding and neutralizing properties of monoclonal antibodies against JCV

N. Christensen, C. Buck, U. Ray, 2013 .

Binding and neutralization efficiencies of monoclonal antibodies, Fab fragments, and scFv specific for L1 epitopes on the capsid of infectious HPV particles.

N. Christensen, C. A. Reed, Timothy D. Culp, 2007, Virology.

Identification of Two Cross-Neutralizing Linear Epitopes within the L1 Major Capsid Protein of Human Papillomaviruses

P. Coursaget, N. Christensen, A. Touzé, 2002, Journal of Virology.

Immunological analyses of human papillomavirus capsids.

N. Christensen, M. Sapp, R. Rose, 2001, Vaccine.

Monoclonal antibodies to HPV-6 L1 virus-like particles identify conformational and linear neutralizing epitopes on HPV-11 in addition to type-specific epitopes on HPV-6.

N. Christensen, N. Cladel, G. Leiserowitz, 1996, Virology.

Human papillomavirus types 6 and 11 have antigenically distinct strongly immunogenic conformationally dependent neutralizing epitopes.

R. Schlegel, J. Schiller, N. Christensen, 1994, Virology.

An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis

V. Walter, N. Christensen, J. Muscat, 2020, Cancer Prevention Research.

Dextran Sulfate , and Polystyrene Sulfonate High-Molecular-Weight Cellulose Sulfate , Papillomavirus Microbicidal Activities of

N. Christensen, M. Howett, C. A. Reed, 2001 .

A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis.

D. Griggs, N. Christensen, D. Welch, 2004, Clinical & experimental metastasis.

Transmitted Viruses Virucidal Activity against Sexually A Broad-Spectrum Microbicide with

N. Christensen, D. Malamud, S. D. Patrick, 2013 .

Role of conformational epitopes expressed by human papillomavirus major capsid proteins in the serologic detection of infection and prophylactic vaccination.

R. Schlegel, N. Christensen, J. Kreider, 1994, Gynecologic oncology.

The Mouse Papillomavirus Epigenetic Signature Is Characterised by DNA Hypermethylation after Lesion Regression

Euan J. Rodger, N. Christensen, I. Morison, 2021, bioRxiv.

Vital Stain to Study Cell Invasion in Modified Boyden Chamber Assay

N. Christensen, D. Welch, 2003 .

Author Correction: The wide utility of rabbits as models of human diseases

Jia Liu, Shan Lu, Neil Christensen, 2018, Experimental & Molecular Medicine.

HPV binding assay to Laminin-332/integrin α6β4 on human keratinocytes.

S. Brendle, N. Christensen, 2015, Methods in molecular biology.

The environmental pollutant and tobacco smoke constituent Dibenzo[def,p]chrysene is a Co-factor for malignant progression of mouse oral papillomavirus infections.

V. Walter, S. Amin, S. Brendle, 2020, Chemico-biological interactions.

Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part I- Screening of Preservative Combinations.

S. Joshi, D. Volkin, S. Brendle, 2022, Journal of pharmaceutical sciences.

Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types.

S. Brendle, N. Christensen, Tatevik R Broutian, 2010, The Journal of general virology.

Distinct T-cell proliferative responses to 13762A rat mammary adenocarcinoma and derived clones.

N. Christensen, J. Kreider, R. L. Horetsky, 1986, Cellular immunology.

Monoclonal Antibodies to S and N SARS-CoV-2 Proteins as Probes to Assess Structural and Antigenic Properties of Coronaviruses

M. Bewley, V. Kapur, M. Sudoł, 2021, Viruses.

High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility

N. Christensen, S. Hafenstein, C. Bator, 2020, Scientific Reports.

Serum IgG, IgM, and IgA reactivity to human papillomavirus types 11 and 6 virus-like particles in different gynecologic patient groups.

O. Dapunt, Peter Baumgartner, N. Christensen, 1995, The Journal of infectious diseases.

Identification of a Human Papillomavirus Type 16-Specific Epitope on the C-Terminal Arm of the Major Capsid Protein L1

D. Galloway, N. Christensen, J. Carter, 2003, Journal of Virology.

A monoclonal antibody against intact human papillomavirus type 16 capsids blocks the serological reactivity of most human sera.

J. Dillner, J. Schiller, N. Christensen, 1997, The Journal of general virology.

A Novel HLA (HLA-A*0201) Transgenic Rabbit Model for Preclinical Evaluation of Human CD8+ T Cell Epitope-Based Vaccines against Ocular Herpes

A. Nesburn, S. Wechsler, L. BenMohamed, 2010, The Journal of Immunology.