M. McPhillie

发表

The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery.

C. Fishwick, R. Johnson, S. Rawson, 2019, Current medicinal chemistry.

The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design

C. Fishwick, R. Johnson, S. Rawson, 2017, Acta crystallographica. Section D, Structural biology.

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

C. Fishwick, D. Roos, Dhanasekaran Shanmugam, 2018, Front. Cell. Infect. Microbiol..

Computational Methods to Identify New Antibacterial Targets

C. Fishwick, K. Simmons, M. McPhillie, 2015, Chemical biology & drug design.

An in silico structure-based approach to anti-infective drug discovery

C. Fishwick, A. Johnson, Fraser Cunningham, 2013, Parasitology.

Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

C. Fishwick, A. Johnson, I. Chopra, 2011, ACS medicinal chemistry letters.

1,4-Diazepines

M. McPhillie, Andrew N. Boa, 2021, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

Applications of structure-based design to antibacterial drug discovery.

C. Fishwick, K. Simmons, M. McPhillie, 2014, Bioorganic chemistry.

De Novo Design of Type II Topoisomerase Inhibitors as Potential Antimicrobial Agents Targeting a Novel Binding Region

C. Fishwick, M. McPhillie, A. Maxwell, 2021 .

Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.

S. Minucci, M. McPhillie, K. Abouzid, 2021, Bioorganic & medicinal chemistry.

Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?

Jacqueline Farinha Shimizu, M. McPhillie, A. Merits, 2020, Acta tropica.

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

L. Hood, C. Fishwick, J. Dubey, 2016, Scientific Reports.

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators

C. Fishwick, M. Kearney, K. Simmons, 2022, RSC medicinal chemistry.

Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM

D. Rice, P. Baker, S. Sedelnikova, 2018, Proceedings of the National Academy of Sciences.

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening

C. Fishwick, T. Edwards, J. Barr, 2018, Antiviral research.

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

C. Fishwick, M. McPhillie, S. Grossman, 2023, Pharmaceuticals.

A small molecule reveals role of insulin receptor-insulin like growth factor-1 receptor heterodimers

C. Fishwick, M. Kearney, K. Simmons, 2021, bioRxiv.

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

R. Upadhya, Kami Kim, K. El Bissati, 2019, Front. Cell. Infect. Microbiol..

SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria.

P. Imming, M. McPhillie, M. Seleem, 2022, European journal of medicinal chemistry.

Activity of and Development of Resistance to Corallopyronin A, an Inhibitor of RNA Polymerase

C. Fishwick, I. Chopra, M. McPhillie, 2011, Antimicrobial Agents and Chemotherapy.

New Opportunities in the Structure-based Design of Anti-Protozoan Agents.

C. Fishwick, M. McPhillie, Colin W G Fishwick, 2016, Current topics in medicinal chemistry.

Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

L. Hood, C. Fishwick, J. Dubey, 2020, Scientific Reports.

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.

Joel S. Freundlich, D. Rice, C. Fishwick, 2013, Biochemistry.

Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer.

Amr H. Mahmoud, S. Minucci, M. McPhillie, 2021, Bioorganic chemistry.

N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Laura R. Sadofsky, A. Morice, M. McPhillie, 2019, European journal of medicinal chemistry.

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites

C. Fishwick, K. El Bissati, C. Roberts, 2020, Frontiers in Cellular and Infection Microbiology.

Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC2 155 Reveals Sodium-Driven GABA Transport

A. Goldman, M. McPhillie, M. Bartlam, 2020, Journal of Bacteriology.

Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM

D. Rice, P. Baker, S. Sedelnikova, 2018 .

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.

D. Rice, C. Fishwick, S. Prigge, 2014, Bioorganic & medicinal chemistry letters.

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.

D. Rice, S. Prigge, R. McLeod, 2013, Bioorganic & medicinal chemistry letters.

Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

I. Chopra, M. McPhillie, Katherine R. Mariner, 2011, ACS medicinal chemistry letters.