D. Wheeler

发表

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Yosef Yarden, Y. Yarden, D. Wheeler, 2015, Springer New York.

Receptor Tyrosine Kinases: Family and Subfamilies

Y. Yarden, D. Wheeler, 2015, Springer International Publishing.

Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma

P. Harari, C. Chung, R. Slebos, 2010, PloS one.

Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition.

J. Kuo, D. Wheeler, H. Kalluri, 2012, Neoplasia.

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck

J. Bussink, P. Span, R. Grenman, 2012, BMC Cancer.

AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer

Peng Liu, R. Salgia, D. Wheeler, 2022, BMC cancer.

AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer

R. Salgia, D. Wheeler, M. Iida, 2021, BMC cancer.

Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab.

D. Wheeler, M. Iida, I. Horak, 2013, Neoplasia.

Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models.

J. Bussink, P. Span, J. Kaanders, 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Protein Kinase C ε Is an Endogenous Photosensitizer That Enhances Ultraviolet Radiation-Induced Cutaneous Damage and Development of Squamous Cell Carcinomas1

H. Ananthaswamy, D. Mitchell, D. Wheeler, 2004, Cancer Research.

Co-targeting mTORC and EGFR signaling as a therapeutic strategy in HNSCC.

Michael M. Fisher, I. Ong, D. Wheeler, 2017 .

Molecular Target Approaches in Head and Neck Cancer: EGFR and Beyond

J. Grandis, P. Harari, D. Wheeler, 2011 .

Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer.

Daniel J. Freeman, P. Harari, D. Wheeler, 2008, International journal of radiation oncology, biology, physics.

ErbB4 targeting approaches for prostate cancer treatment

Vivek M Rangnekar, V. Rangnekar, D. Wheeler, 2008, Cancer biology & therapy.

Protein kinase Cδ-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression

D. Wheeler, M. Leitges, P. Reddig, 2002, Oncogene.

Early Epidermal Destruction with Subsequent Epidermal Hyperplasia Is a Unique Feature of the Papilloma-Independent Squamous Cell Carcinoma Phenotype in PKCε Overexpressing Transgenic Mice

D. Wheeler, A. Verma, T. Oberley, 2005, Toxicologic pathology.

Human epidermal growth factor receptor 3 (HER3) blockade with U3-1287/AMG888 enhances the efficacy of radiation therapy in lung and head and neck carcinoma.

A. J. van der Kogel, D. Wheeler, M. Iida, 2013, Discovery medicine.

Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2.

D. Wheeler, M. Aziz, A. Verma, 2006, Cancer research.

Effect of insulin-like growth factor 1 receptor inhibitor on sensitization of head and neck cancer cells to cetuximab and methotrexate.

P. Harari, D. Wheeler, H. Hatakeyama, 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Targeting HER3-dependent activation of nuclear AKT improves radiotherapy of non-small celllung cancer.

P. Harari, D. Wheeler, M. Iida, 2022, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines

J. Bussink, P. Span, R. Grenman, 2013, Molecular Cancer.

Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals.

KyungMann Kim, D. Wheeler, A. Verma, 2016, Carcinogenesis.

Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism ¶

Y. Li, D. Wheeler, A. Verma, 2005, Photochemistry and photobiology.

Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

D. Wheeler, A. Verma, Y. Li, 2005 .

Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

D. Wheeler, A. Verma, T. Oberley, 2003, Cancer research.

Protein Kinase C Is Linked to 12-O-tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor- Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C Transgenic Mice

D. Wheeler, A. Verma, T. Oberley, 2003 .

Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor–promotion susceptibilities of protein kinase Cα, ‐δ and ‐ϵ transgenic mice

D. Wheeler, A. Verma, N. Dreckschmidt, 2001 .

An Avidity-based PD-L1 Antagonist Using Nanoparticle-Antibody Conjugates for Enhanced Immunotherapy.

Seungpyo Hong, D. Wheeler, M. Iida, 2020, Nano letters.

Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors.

J. Bussink, P. Span, J. Kaanders, 2013, Translational oncology.

Differential Tumor Biology Effects of Double-Initiation in a Mouse Skin Chemical Carcinogenesis Model Comparing Wild Type versus Protein Kinase Cepsilon Overexpression Mice

H. Ananthaswamy, D. Wheeler, A. Verma, 2007, Toxicologic pathology.

Protein Kinase C- e Transgenic Mice: A Unique Model for Metastatic Squamous Cell Carcinoma 1

D. Wheeler, A. Verma, N. Dreckschmidt, 2001 .

Protein Kinase C-ε Transgenic Mice: A Unique Model for Metastatic Squamous Cell Carcinoma

D. Wheeler, A. Verma, N. Dreckschmidt, 2001 .

Establishment and Characterization of a Model of Acquired Resistance to Epidermal Growth Factor Receptor Targeting Agents in Human Cancer Cells

P. Harari, D. Wheeler, E. Armstrong, 2009, Clinical Cancer Research.

Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members

P. Harari, D. Wheeler, T. Kruser, 2008, Oncogene.

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

P. Harari, D. Wheeler, E. F. Dunn, 2010, Nature Reviews Clinical Oncology.

Nuclear Epidermal Growth Factor Receptor Is a Functional Molecular Target in Triple-Negative Breast Cancer

R. Salgia, D. Wheeler, K. Wisinski, 2014, Molecular Cancer Therapeutics.

Adaptive responses to antibody based therapy.

D. Wheeler, M. Iida, T. Brand, 2016, Seminars in cell & developmental biology.

Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

D. Wheeler, A. Verma, T. Oberley, 2003, Cancer research.

AXL mediates resistance to cetuximab therapy.

R. Salgia, D. Wheeler, R. Kimple, 2014, Cancer research.

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab

D. Wheeler, M. Iida, E. Armstrong, 2010, Oncogene.

Nuclear EGFR as a molecular target in cancer.

D. Wheeler, M. Iida, T. Brand, 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma.

D. Wheeler, M. Iida, Chunrong Li, 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas

Prakash Kulkarni, R. Salgia, D. Wheeler, 2020, iScience.

p53 modulates acquired resistance to EGFR inhibitors and radiation.

P. Harari, D. Wheeler, E. Armstrong, 2011, Cancer research.

Therapeutics , Targets , and Chemical Biology p 53 Modulates Acquired Resistance to EGFR Inhibitors and Radiation

P. Harari, D. Wheeler, E. Armstrong, 2011 .

AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma

R. Salgia, B. Bednarz, M. Lingen, 2015, Clinical Cancer Research.

Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells

H. Rodemann, D. Wheeler, A. Grottke, 2017, Cell Death Discovery.

The nuclear epidermal growth factor receptor signaling network and its role in cancer.

D. Wheeler, M. Iida, T. Brand, 2011, Discovery medicine.

Overexpression of Protein Kinase C- (cid:1) in the Mouse Epidermis Leads to a Spontaneous Myeloproliferative-Like Disease

D. Wheeler, P. Reddig, A. Verma, 2004 .

Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond.

J. Grandis, P. Harari, D. Wheeler, 2009, Seminars in radiation oncology.

Treating PIK3CA and EGFR overexpressing breast cancers with lithium citrate

D. Wheeler, T. Brand, 2011, Cancer biology & therapy.

Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics

V. Bindokas, R. Salgia, Frances E. Lennon, 2013, Cancer biology & therapy.

Targeting Nuclear EGFR: Strategies for Improving Cetuximab Therapy in Lung Cancer

D. Wheeler, M. Iida, T. Brand, 2014 .

Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab

D. Wheeler, M. Iida, T. Brand, 2011, Cancer biology & therapy.

Augmentation of Radiation Response by Motesanib, a Multikinase Inhibitor that Targets Vascular Endothelial Growth Factor Receptors

J. Bussink, P. Harari, A. Coxon, 2010, Clinical Cancer Research.

The role of Src in solid tumors.

D. Wheeler, M. Iida, Mari Iida, 2009, The oncologist.

Contributions of Targeted Agents

P. Harari, D. Wheeler, T. Hoang, 2009 .

Mechanisms of resistance to HER family targeting antibodies.

D. Wheeler, T. Kruser, 2010, Experimental cell research.

Nuclear EGFR contributes to acquired resistance to cetuximab

D. Wheeler, C. Li, M. Iida, 2009, Oncogene.

Anti-Trop 2 blockade enhances the therapeutic ef fi cacy of ErbB 3 inhibition in head and neck squamous cell carcinoma

D. Wheeler, B. V. Tine, R. Kimple, 2018 .

Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma

B. V. Van Tine, D. Wheeler, R. Kimple, 2018, Cell Death & Disease.

KRAS mutant colorectal tumors

D. Wheeler, T. Brand, 2012, Small GTPases.

The use of single-agent dasatinib in molecularly unselected non-small-cell lung cancer patients

D. Wheeler, T. Kruser, A. Traynor, 2011, Expert opinion on investigational drugs.

Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab

D. Wheeler, M. Iida, T. Brand, 2013, Cancer biology & therapy.

TAM family proteins and therapy resistance

D. Wheeler, M. Iida, Nellie McDaniel, 2020 .

The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor

R. Salgia, D. Wheeler, R. Kimple, 2017, Science Signaling.

Protein Kinase C Is Linked to 12-O-tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor-Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C Transgenic Mice 1

D. Wheeler, A. Verma, T. Oberley, 2003 .

Yes and Lyn play a role in nuclear translocation of the Epidermal Growth Factor Receptor

D. Wheeler, M. Iida, T. Brand, 2012, Oncogene.

MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents

S. Frye, P. Harari, K. Davies, 2018, Molecular Cancer Therapeutics.

Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol

J. Arbiser, D. Wheeler, R. Kimple, 2017, Molecular Cancer Therapeutics.

Erlotinib is a viable treatment for tumors with acquired resistance to cetuximab

D. Wheeler, M. Iida, T. Brand, 2011, Cancer biology & therapy.

Targeting AKT/PKB to improve treatment outcomes for solid tumors.

P. Harari, D. Wheeler, M. Iida, 2020, Mutation research.

Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

M. Schaller, H. Rodemann, D. Wheeler, 2016, Oncotarget.

Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy

R. Salgia, D. Wheeler, M. Iida, 2014, Molecular Cancer.

Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab

R. Salgia, D. Wheeler, M. Iida, 2016, Molecular Cancer Therapeutics.

Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy

R. Salgia, D. Wheeler, M. Iida, 2014, Molecular Cancer.

Exosomal miRNAs species in the blood of small cell and non-small cell lung cancer patients

R. Salgia, E. Vokes, Xiwei Wu, 2018, Oncotarget.

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients

Jacob G. Scott, A. Baschnagel, D. Wheeler, 2020, Journal of Translational Medicine.

Active recruitment of anti–PD-1–conjugated platelets through tumor-selective thrombosis for enhanced anticancer immunotherapy

D. Wheeler, Quanyin Hu, M. Iida, 2023, Science advances.

Epidermal Growth Factor Receptor cooperates with Src Family Kinases in acquired resistance to cetuximab

P. Harari, D. Wheeler, M. Iida, 2009, Cancer biology & therapy.

Circulating tumor cell abundance in head and neck squamous cell carcinoma decreases with successful chemoradiation and cetuximab treatment.

D. Wheeler, R. Kimple, M. Iida, 2023, Cancer letters.

The Ephrin receptor A2 and Roundabout Guidance Receptor 1 heterodimer: A potential theranostic for squamous cell carcinomas

Prakash Kulkarni, R. Salgia, D. Wheeler, 2020, bioRxiv.

AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer

Seungpyo Hong, R. Salgia, D. Wheeler, 2020, Clinical Cancer Research.

Combined MET Inhibition and Topoisomerase I Inhibition Block Cell Growth of Small Cell Lung Cancer

R. Salgia, E. Vokes, M. Tretiakova, 2013, Molecular Cancer Therapeutics.

Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers

P. Harari, M. Schaller, D. Zips, 2020, Cancers.

Protein kinase Cε and development of squamous cell carcinoma, the nonmelanoma human skin cancer

D. Wheeler, M. Aziz, A. Verma, 2006 .

Feedback regulation of biological networks: Examples relevant to signalling pathways and resistance to pharmacological interceptors.

Y. Yarden, D. Wheeler, 2016, Seminars in cell & developmental biology.

Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.

D. Wheeler, A. Verma, N. Dreckschmidt, 2001, Cancer research.

Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC

Michael M. Fisher, I. Ong, D. Wheeler, 2017, Molecular Cancer Therapeutics.

Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer.

R. Salgia, KyungMann Kim, D. Wheeler, 2013, Lung cancer.

Small Molecule Therapeutics Combined MET Inhibition and Topoisomerase I Inhibition Block Cell Growth of Small Cell Lung Cancer

R. Salgia, E. Vokes, M. Tretiakova, 2014 .

Radiation Sensitivity: The Rise of Predictive Patient-Derived Cancer Models.

D. Wheeler, S. Ramisetty, R. Kimple, 2023, Seminars in radiation oncology.

EPHA2 mutations with oncogenic characteristics in squamous cell lung cancer and malignant pleural mesothelioma

Prakash Kulkarni, N. Vaidehi, R. Salgia, 2019, Oncogenesis.

Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

Yate-Ching Yuan, Xiwei Wu, D. Wheeler, 2023, iScience.

Cancer Biology and Signal Transduction Nuclear Epidermal Growth Factor Receptor Is a Functional Molecular Target in Triple-Negative Breast Cancer

R. Salgia, D. Wheeler, K. Wisinski, 2014 .

Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.

D. Wheeler, M. Aziz, A. Verma, 2006, Molecular carcinogenesis.

Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3

D. Wheeler, M. Iida, T. Brand, 2013, PloS one.

Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti‐PDL1 efficacy in head and neck cancer

P. Harari, R. Birge, Menggang Yu, 2023, Head & neck.

AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma

R. Salgia, B. Bednarz, M. Lingen, 2015, Clinical Cancer Research.

Correction: AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma

R. Salgia, B. Bednarz, M. Lingen, 2018, Clinical Cancer Research.

Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer.

R. Salgia, KyungMann Kim, D. Wheeler, 2013, Lung cancer.

AXL IsaLogicalMolecularTarget inHeadandNeck Squamous Cell Carcinoma

R. Salgia, B. Bednarz, M. Lingen, 2015 .

Immune Escape Strategies in Head and Neck Cancer: Evade, Resist, Inhibit, Recruit

D. Wheeler, M. Iida, Ravi Salgia, 2024, Cancers.

MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer

D. Wheeler, M. Iida, Carlene A. Kranjac, 2024, International journal of molecular sciences.

Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas.

H. Ananthaswamy, D. Mitchell, D. Wheeler, 2004, Cancer research.

Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice.

D. Wheeler, A. Verma, N. Dreckschmidt, 2001, International journal of cancer.