D. Haselbach

发表

Conformational dynamics of large proteins and protein complexes.

J. Enderlein, D. Haselbach, K. Tittmann, 2014 .

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

Utz Fischer, Marc Jarvis, Ashwin Chari, 2015, Nature Methods.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

H. Stark, H. Urlaub, B. Kastner, 2018, Cell.

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

D. Haselbach, T. Clausen, A. Schleiffer, 2020, eLife.

Cryo-EM structure of the plant 26S proteasome

H. Tagare, K. Mechtler, Katarina Belacic, 2022, Plant communications.

Quantifying the heterogeneity of macromolecular machines by mass photometry

J. Peters, T. Schwartz, B. Schulman, 2019, bioRxiv.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

H. Stark, H. Urlaub, B. Kastner, 2018, Cell.

HUWE 1 employs a giant substrate-binding ring to feed and regulate its HECT E 3 domain 1 2

O. A. Petrova, R. Kurzbauer, D. Haselbach, 2021 .

Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins

J. Zuber, D. Haselbach, A. Schleiffer, 2022, Science.

Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1

Florian Stengel, Carolin Sailer, A. Warren, 2022, Nature Structural & Molecular Biology.

Cryo-EM structure of the chain-elongating E3 ligase UBR5

D. Haselbach, A. Schleiffer, I. Grishkovskaya, 2022, bioRxiv.

Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.

H. Stark, D. Haselbach, K. Tittmann, 2019, Structure.

Mechanism of APC/CCDC20 activation by mitotic phosphorylation

Karl Mechtler, Jan-Michael Peters, Holger Stark, 2016, Proceedings of the National Academy of Sciences.

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

J. Peters, H. Stark, P. Dube, 2016, Molecular cell.

AKIRIN2 controls the nuclear import of proteasomes in vertebrates

J. Zuber, K. Mechtler, D. Haselbach, 2021, Nature.

A molecular network of conserved factors keeps ribosomes dormant in the egg

K. Mechtler, D. Haselbach, A. Pauli, 2021, bioRxiv.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

Henning Urlaub, Olexandr Dybkov, Holger Stark, 2017, Cell.

Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.

D. Haselbach, Tatyana Bodrug, N. Brown, 2022, Structure.

miR-1 sustains muscle physiology by controlling V-ATPase complex assembly

D. Haselbach, Jingkui Wang, L. Cochella, 2021, Science advances.

A deeply conserved miR-1 dependent regulon supports muscle cell physiology

D. Haselbach, L. Cochella, Thomas Lendl, 2020, bioRxiv.

Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

K. Gruber, D. Haselbach, H. Bergler, 2021, Nature Communications.

Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq

Stefan L Ameres, P. Hufnagl, J. Peters, 2021, Nature Communications.

Cryo-EM ofMitotic Checkpo int Complex-Bound APC / C RevealsReciprocalandConformationalRegulationof Ubiquitin Ligation Graphical

J. Peters, H. Stark, P. Dube, 2016 .

The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains

K. Mechtler, D. Haselbach, T. Clausen, 2021, eLife.

The linear ubiquitin chain assembly complex generates heterotypic ubiquitin chains

K. Mechtler, D. Haselbach, T. Clausen, 2020, bioRxiv.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

B. Kuhlman, M. Kirschner, J. Peters, 2016, Cell.

Dual RING E 3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC / C Graphical

B. Kuhlman, M. Kirschner, J. Peters, 2022 .

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

J. Peters, H. Stark, S. Sidhu, 2019, Proceedings of the National Academy of Sciences.

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

J. Peters, H. Stark, S. Sidhu, 2019, bioRxiv.

BacPROTACs mediate targeted protein degradation in bacteria

R. Kurzbauer, M. Kaiser, D. Haselbach, 2021, Cell.

Structure of the peripheral arm of a minimalistic respiratory complex I.

D. Haselbach, T. Friedrich, P. Hellwig, 2021, Structure.

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

O. A. Petrova, R. Kurzbauer, D. Haselbach, 2021, Nature Chemical Biology.

Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

H. Stark, D. Haselbach, A. Chari, 2017, Nature Communications.

A DNAzyme based label-free detection system for miniaturized assays.

H. Lehrach, D. Haselbach, H. Seitz, 2011, Molecular bioSystems.

Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

D. Haselbach, A. Schleiffer, I. Grishkovskaya, 2023, The EMBO journal.

FakET: Simulating Cryo-Electron Tomograms with Neural Style Transfer

P. Grohs, D. Haselbach, P. Harár, 2023, ArXiv.

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

Ellen D. Zhong, Michael J. Emanuele, D. Haselbach, 2023, Nature Structural & Molecular Biology.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

H. Stark, S. Sidhu, B. Schulman, 2019, Proceedings of the National Academy of Sciences.

Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

H. Stark, D. Haselbach, A. Chari, 2017, Nature Communications.