N. Cronin

发表

Structure of the outer membrane complex of a type IV secretion system

Gabriel Waksman, Jorge Navaza, J. Navaza, 2009, Nature.

Zinc Metalloproteases from Myocobacterium leprae and Mycobacterium tuberculosis as Targets for Rational Drug Design

N. Cronin, 2006 .

Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.

R. V. van Montfort, A. Faisal, N. Cronin, 2016, Journal of medicinal chemistry.

Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.

W. Boelens, N. Cronin, N. Keep, 2009, Journal of molecular biology.

Structural basis for translocation by AddAB helicase/nuclease and its arrest at Chi sites

D. Wigley, Xin-Yuan Fu, N. Cronin, 2014, Nature.

Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.

C. Boshoff, G. Waksman, B. Wallace, 2008, Molecular cell.

The three-dimensional structure at 2.4 A resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae.

T. Blundell, M. S. Johnson, J. Cooper, 1997, Journal of molecular biology.

Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome

A. Politis, N. Cronin, F. Beuron, 2019 .

Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain

D. Barford, N. Cronin, Ziguo Zhang, 2015, Journal of molecular biology.

Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10

N. Cronin, Jing Yang, Danni Fan, 2022, bioRxiv.

A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination

M. Malim, V. E. Pye, P. Cherepanov, 2022, Cell Reports.

Tetrameric bacterial sodium channels: characterization of structure, stability, and drug binding.

B. Wallace, N. Cronin, G. Nurani, 2008, Biochemistry.

Do the structures of big ET-1 and big ET-3 adopt a similar overall fold? Consequences for endothelin converting enzyme specificity.

B. Wallace, N. Cronin, 1999, Biochemistry.

The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase

D. Wigley, P. McGlynn, N. Savery, 2017, Nucleic acids research.

Synthesis of a Ribose‐Incorporating Medium Ring Scaffold via a Challenging Ring‐Closing Metathesis Reaction

R. V. van Montfort, N. Cronin, J. Caldwell, 2016, European journal of organic chemistry.

Binding of the Anticonvulsant Drug Lamotrigine and the Neurotoxin Batrachotoxin to Voltage-gated Sodium Channels Induces Conformational Changes Associated with Block and Steady-state Activation*

B. Wallace, N. Cronin, H. Duclohier, 2003, The Journal of Biological Chemistry.

Effects of deglycosylation of sodium channels on their structure and function.

B. Wallace, N. Cronin, H. Duclohier, 2005, Biochemistry.

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

Andy M. Lau, N. Cronin, F. Beuron, 2018, Nature Communications.

Supplemental Data Crystal Structure of a vFlip-IKK γ Complex : Insights into Viral Activation of the IKK Signalosome

Gabriel Waksman, Claire Bagnéris, C. Boshoff, 2008 .

The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.

N. Cronin, S. Djordjević, Snezana Djordjevic, 2011, Acta crystallographica. Section D, Biological crystallography.

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling

N. Cronin, F. Beuron, E. Morris, 2016, Molecular cell.

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

D. Barford, W. Chao, N. Cronin, 2013, Molecular cell.

A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases

Jon R. Wilson, N. Cronin, S. Southall, 2013, Nucleic acids research.

Positive and negative control of helicase recruitment at a bacterial chromosome origin

N. Cronin, H. Murray, P. Soultanas, 2021, bioRxiv.

The DNA replication initiation protein DnaD is recruited to a specific strand of the Bacillus subtilis chromosome origin

N. Cronin, H. Murray, P. Soultanas, 2022, bioRxiv.

Cryo-EM structure of the Smc5/6 holo-complex

A. Oliver, N. Cronin, J. Baxter, 2021, bioRxiv.

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)

R. V. van Montfort, A. Faisal, N. Cronin, 2018, Journal of medicinal chemistry.

The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin

N. Cronin, H. Murray, P. Soultanas, 2023, Nucleic acids research.

Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1

D. Barford, S. Iwata, I. Manolaridis, 2013, Nature.

CryoEM Structure of the Smc5/6 holocomplex

A. Oliver, N. Cronin, J. Baxter, 2022 .

Structural Basis of σ54 Displacement and Promoter Escape in Bacterial Transcription

N. Cronin, M. Buck, Xiaodong Zhang, 2023, bioRxiv.

X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.

J. Cooper, C. Humblet, E. Lunney, 2000, Journal of molecular biology.

TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry

F. Smet, E. Vanstreels, P. Maes, 2023, Cell.

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

S. Hughes, V. E. Pye, P. Cherepanov, 2021, Nature Communications.

Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis

N. Cronin, S. Bhakta, N. Keep, 2010, Protein & Cell.

Characterization of an oxidoreductase from the arylamine N‐acetyltransferase operon in Mycobacterium smegmatis

N. Cronin, S. Bhakta, N. Keep, 2011, The FEBS journal.

TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry

E. Vanstreels, P. Maes, F. De Smet, 2023, Cell.

Corrigendum to Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

W. Boelens, N. Cronin, N. Keep, 2009 .

Characterization of an oxidoreductase from the arylamine N‐acetyltransferase operon in Mycobacterium smegmatis

N. Cronin, S. Bhakta, N. Keep, 2011, The FEBS journal.

Endothelin precursor isoforms: Structural basis for rational drug design of ECE inhibitors

B. Wallace, N. Cronin, Heather Peto, 2002 .