D. Gray

发表

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Ian H. Gilbert, David Horn, Mark C. Field, 2017, Nature Reviews Microbiology.

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

David H. Drewry, Gonzalo Colmenarejo, James R. Brown, 2015, Scientific Reports.

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry

Mark C. Field, David W. Gray, Lauren Webster, 2020, SLAS discovery : advancing life sciences R & D.

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment

M. Ferguson, D. Gray, L. S. Torrie, 2019, Antimicrobial Agents and Chemotherapy.

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity

David W. Gray, S. Schreiber, D. Gray, 2015, PLoS neglected tropical diseases.

Assay donovani Assay with an Axenic Amastigote High-Content Intracellular Leishmania Comparison of a High-Throughput

Lorna, S. Cameron, I. Gilbert, 2013 .

AssayAssay with an Axenic Amastigote High-Content Intracellular Leishmania Comparison of a High-Throughput

S. Cameron, I. Gilbert, D. Gray, 2013 .

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

David W. Gray, A. Hope, D. Gray, 2017, Human reproduction.

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2018, Nature.

Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening

David W. Gray, R. Randall, D. Gray, 2016, Journal of biomolecular screening.

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)

Stuart P. McElroy, J. Arthur, A. Hope, 2017, SLAS discovery : advancing life sciences R & D.

Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

David W. Gray, D. Gray, S. Wyllie, 2021, PLoS neglected tropical diseases.

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry

V. Cowling, D. Gray, D. Lin, 2021, SLAS Discovery.

Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function

David W. Gray, A. Hope, D. Gray, 2019, British journal of pharmacology.

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

David W. Gray, Ignacio Cotillo, D. Gray, 2018, PLoS neglected tropical diseases.

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents

David W. Gray, T. Ioerger, D. Gray, 2021, ACS infectious diseases.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

David W. Gray, K. Read, I. Gilbert, 2016, ACS infectious diseases.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

David W. Gray, E. Winzeler, S. Meister, 2016, Journal of medicinal chemistry.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

E. Winzeler, S. Meister, S. Norval, 2016, Journal of medicinal chemistry.

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

S. Cameron, I. Gilbert, A. Fairlamb, 2013, Antimicrobial Agents and Chemotherapy.

Assessment of Pseudomonas aeruginosa N 5,N 10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

Stuart P. McElroy, David W. Gray, W. Hunter, 2012, PloS one.

Vector-borne diseases series Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need

David W. Gray, K. Read, A. Fairlamb, 2017 .

Drug screening to identify compounds to act as co-therapies for the treatment of pathogenic Burkholderia

David W. Gray, N. Harmer, D. Gray, 2019, bioRxiv.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Juan A. Bueren-Calabuig, David W. Gray, Frederick R. C. Simeons, 2019, Proceedings of the National Academy of Sciences.

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

David W. Gray, A. Hill, G. Drewes, 2018, Journal of medicinal chemistry.

Identification of Small Molecule Inhibitors of Pre-mRNA Splicing

Stuart P. McElroy, David W. Gray, A. Lamond, 2014, The Journal of Biological Chemistry.

Timur of Pre-mRNA Splicing Identification of Small Molecule Inhibitors RNA

Stuart P. McElroy, David W. Gray, A. Lamond, 2014 .

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

David W. Gray, S. Norval, L. Stojanovski, 2015, ChemMedChem.

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

David W. Gray, D. Gray, S. Brough, 2016, PLoS neglected tropical diseases.

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

David W. Gray, Fraser Cunningham, J. Cinatl, 2021, PloS one.

Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species

David W. Gray, N. Harmer, D. Gray, 2021, PloS one.

Targeting N-myristoylation for therapy of B-cell lymphomas

David W. Gray, K. Read, J. Mackey, 2020, Nature Communications.

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

David W. Gray, D. Gray, R. Fedorov, 2019, Molecules.

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Michael D. Urbaniak, G. Drewes, Markus Boesche, 2018, Nature.

High-Throughput Chemical Screening for Antivirulence Developmental Phenotypes in Trypanosoma brucei

David W. Gray, A. Ivens, M. Auer, 2014, Eukaryotic Cell.

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA

David W. Gray, G. Schneider, J. Naismith, 2016, Journal of molecular biology.

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

David W. Gray, G. Schneider, Y. Lindqvist, 2013, ACS chemical biology.

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

David W. Gray, D. Gray, L. S. Torrie, 2019, Antimicrobial Agents and Chemotherapy.

Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies

K. Read, J. Mackey, D. Gray, 2019, Blood.

Characterization of protease activity of Nsp3 from SARS-CoV-2 and its in vitro inhibition by nanobodies

David W. Gray, Fraser Cunningham, A. Hope, 2020, bioRxiv.

Design and Synthesis of Covalent Inhibitors of FabA

David W. Gray, I. Gilbert, Nadine Homeyer, 2023, ACS omega.

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

David W. Gray, A. Fairlamb, D. Gray, 2012, PLoS neglected tropical diseases.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.

Mahavir Singh, R. Brenk, J. Naismith, 2013, ACS chemical biology.

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

David W. Gray, K. Dechering, D. Gray, 2023, Communications Biology.

Burkholderia pseudomallei d‐alanine‐d‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

Stuart P. McElroy, David W. Gray, W. Hunter, 2019, The FEBS journal.

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

David W. Gray, I. Gilbert, A. Fairlamb, 2020, ACS infectious diseases.