L. S. Torrie

发表

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Ian H. Gilbert, David Horn, Mark C. Field, 2017, Nature Reviews Microbiology.

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

Stuart P. McElroy, L. S. Torrie, W. McLean, 2013, PLoS biology.

IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening

R. Brenk, W. Hunter, L. S. Torrie, 2012, PloS one.

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Ian H Gilbert, Paul G Wyatt, Torsten Luksch, 2011, ChemMedChem.

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment

M. Ferguson, D. Gray, L. S. Torrie, 2019, Antimicrobial Agents and Chemotherapy.

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

L. Stojanovski, K. Read, I. Gilbert, 2018, ACS infectious diseases.

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease

I. Gilbert, D. Horn, L. S. Torrie, 2021, Antimicrobial agents and chemotherapy.

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

I. Gilbert, D. Robinson, L. S. Torrie, 2022, ACS infectious diseases.

University of Dundee Chemical Validation of Methionyl tRNA Synthetase ( MetRS ) as a Druggable Target in Leishmania donovani

Frederick R. C. Simeons, L. Stojanovski, K. Read, 2017 .

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Vector-borne diseases series Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need

David W. Gray, K. Read, A. Fairlamb, 2017 .

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

Resolution of the insect ouabain paradox.

J. Dow, L. S. Torrie, T. Southall, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

D. Robertson, J. Hughes, D. Alessi, 2021, PLoS biology.

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014, Journal of medicinal chemistry.

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

G. F. Ruda, I. Gilbert, D. V. van Aalten, 2015, ACS chemical biology.

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2018, Journal of medicinal chemistry.

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

Stuart P. McElroy, S. Norval, L. Stojanovski, 2015, ChemMedChem.

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

Ian H Gilbert, Manu De Rycker, Sujatha Manthri, 2017, ACS infectious diseases.

Chemical Validation of Trypanothione Synthetase

I. Gilbert, A. Fairlamb, L. S. Torrie, 2009, The Journal of Biological Chemistry.

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Stuart P. McElroy, S. Norval, L. Stojanovski, 2017, Journal of medicinal chemistry.

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

A. Fairlamb, L. S. Torrie, S. Wyllie, 2014, The Biochemical journal.

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Ian H. Gilbert, Irene Hallyburton, Alan H. Fairlamb, 2011, Journal of medicinal chemistry.

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

David W. Gray, D. Gray, L. S. Torrie, 2019, Antimicrobial Agents and Chemotherapy.

Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N myristoyltransferase inhibitors

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014 .

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.

Mahavir Singh, R. Brenk, J. Naismith, 2013, ACS chemical biology.

Burkholderia pseudomallei d‐alanine‐d‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

Stuart P. McElroy, David W. Gray, W. Hunter, 2019, The FEBS journal.

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

David W. Gray, I. Gilbert, A. Fairlamb, 2020, ACS infectious diseases.

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

K. Read, I. Gilbert, A. Fairlamb, 2011, ChemMedChem.

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

David W. Gray, I. Gilbert, D. Robinson, 2019, PloS one.

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Mark C. Field, David W. Gray, K. Read, 2017, Nature Reviews Microbiology.

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Mark C. Field, David W. Gray, K. Read, 2018, Nature Reviews Microbiology.

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.

L. S. Torrie, S. Shepherd, M. De Rycker, 2024, The Journal of biological chemistry.