P. Wyatt

发表

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Ian H. Gilbert, David Horn, Mark C. Field, 2017, Nature Reviews Microbiology.

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

Paul G Wyatt, Valerio Berdini, V. Berdini, 2008, Journal of medicinal chemistry.

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

Daniel James, Agata Krasowski, Ruth Brenk, 2007, ChemMedChem.

Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

P. Wyatt, J. Frearson, Jiangtao Ma, 2010, The Journal of Biological Chemistry.

Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis

Tom L. Blundell, Bernardo Ochoa-Montaño, Clifton E. Barry, 2014, Antimicrobial Agents and Chemotherapy.

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Ian H Gilbert, Paul G Wyatt, Torsten Luksch, 2011, ChemMedChem.

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA

Robert H Bates, David Barros, C. Chung, 2018, ChemMedChem.

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics.

P. Woollard, P. Wyatt, F. Nerozzi, 2005, Journal of medicinal chemistry.

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR.

P. Wyatt, F. Nerozzi, A. Szardenings, 2005, Bioorganic & Medicinal Chemistry Letters.

Assay donovani Assay with an Axenic Amastigote High-Content Intracellular Leishmania Comparison of a High-Throughput

Lorna, S. Cameron, I. Gilbert, 2013 .

AssayAssay with an Axenic Amastigote High-Content Intracellular Leishmania Comparison of a High-Throughput

S. Cameron, I. Gilbert, D. Gray, 2013 .

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

I. Gilbert, A. Fairlamb, P. Wyatt, 2009, ChemMedChem.

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

Glycosyl Phosphates: A New Latent-Active Anomeric Phosphorylation Strategy

P. Wyatt, G. Boons, A. Burton, 1996 .

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

L. Stojanovski, K. Read, I. Gilbert, 2018, ACS infectious diseases.

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

David W. Gray, A. Hope, D. Gray, 2017, Human reproduction.

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2018, Nature.

The Tuberculosis Drug Accelerator at year 10: what have we learned?

H. M. Petrassi, Christopher B. Cooper, Robert H Bates, 2021, Nature Medicine.

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

K. Read, P. Wyatt, W. McLean, 2018, Bioorganic & medicinal chemistry letters.

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Robert H Bates, L. Stojanovski, K. Read, 2022, Nature Communications.

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity

Magdalena Pachota, K. Pyrć, G. Dubin, 2022, bioRxiv.

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020, Journal of medicinal chemistry.

University of Dundee Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020 .

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017 .

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents

David W. Gray, T. Ioerger, D. Gray, 2021, ACS infectious diseases.

Discovery of pro-soft drug modulators of sphingosine-1-phosphate receptor 1 (S1PR1)

K. Read, P. Wyatt, W. McLean, 2020 .

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

P. Wyatt, S. Green, C. Barry, 2020, Science.

Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug-Discovery Campaigns.

P. Wyatt, Nicola Luise, 2018, Chemistry.

Self‐Assembling Cyclophanes and Catenanes Possessing Elements of Planar Chirality

David J. Williams, J. F. Stoddart, F. Raymo, 1998 .

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2022, European journal of medicinal chemistry.

Preparation of fluorinated galactosyl nucleoside diphosphates to study the mechanism of the enzyme galactopyranose mutase

P. Wyatt, G. Boons, A. Burton, 1997 .

Comprar Organic Synthesis: The Disconnection Approach | Stuart Warren | 9780470712368 | Wiley

P. Wyatt, S. Warren, 2008 .

Diversity-oriented synthesis of bicyclic fragments containing privileged azines.

P. Wyatt, Nicola Luise, 2019, Bioorganic & medicinal chemistry letters.

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.

A Merritt, I. D. Starkey, A. Beresford, 1998, Journal of medicinal chemistry.

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

Mladen Vinković, Paul G Wyatt, Jayne Curry, 2009, Journal of medicinal chemistry.

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Ian H. Gilbert, Alan H. Fairlamb, Paul G. Wyatt, 2011, Journal of medicinal chemistry.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

Marcel Kaiser, Susan A Charman, Ian H Gilbert, 2013, ChemMedChem.

Organic Synthesis: Strategy and Control

P. Wyatt, S. Warren, 2007 .

Chapter 15. Antiviral Agents

P. Wyatt, R. Boehme, A. D. Borthwick, 1994 .

Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.

Michael J Allen, Paul G Wyatt, Mamta Patel, 2002, Bioorganic & medicinal chemistry letters.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

David W. Gray, E. Winzeler, S. Meister, 2016, Journal of medicinal chemistry.

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.

P. Colman, J. Varghese, A. Wonacott, 2001, Bioorganic & medicinal chemistry letters.

Synthesis, X-ray structures and chemistry of enantiomerically pure 10,11-dihydro-5-phenyl-5H-dibenzo[b,f ]phosphepine 5-oxides

M. Mcpartlin, P. Wyatt, Thomas M. Woodroffe, 2001 .

Identification of inhibitors of protein kinase B using fragment-based lead discovery.

Marcel L Verdonk, Paul G Wyatt, Michelle D Garrett, 2007, Journal of medicinal chemistry.

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules

I. Gilbert, R. Brenk, P. Wyatt, 2013, ChemMedChem.

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Ian H. Gilbert, Chidochangu P. Mpamhanga, William N. Hunter, 2009, Journal of medicinal chemistry.

Synthesis of Racemic and Enantiomerically Pure (R*,R*,R*)‐Tris(α‐methylbenzyl)phosphane − X‐ray Crystal Structures of the Phosphane Oxides and Borane Complexes

P. Wyatt, H. Eley, J. Charmant, 2003 .

Quinol derivatives as potential trypanocidal agents

I. Gilbert, A. Fairlamb, P. Wyatt, 2012, Bioorganic & medicinal chemistry.

Axially Chiral Catenanes and π‐Electron‐Deficient Receptors

Christopher L. Brown, Andrew J. P. White, David J. Williams, 2006 .

Synthesis of 9-(3-hydroxypropoxy)guanine, a novel antiviral acyclonucleoside

P. Wyatt, A. Parkin, M. R. Harnden, 1988 .

Synthesis and chemistry of enantiomerically pure 10,11-dihydrodibenzo[b,f]thiepines.

A. Orpen, P. Wyatt, J. Charmant, 2006, Organic & biomolecular chemistry.

Synthesis of novel C2 symmetrical and enantiomerically pure thiepines

A. Orpen, P. Wyatt, A. Hudson, 1999 .

The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

R. Brenk, P. Wyatt, J. Frearson, 2014, Journal of medicinal chemistry.

Detection of ligands from a dynamic combinatorial library by X-ray crystallography.

Paul G Wyatt, M. Congreve, H. Jhoti, 2003, Angewandte Chemie.

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

P. Wyatt, L. Lefièvre, Sean G Brown, 2014, Human reproduction.

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

S. Cameron, I. Gilbert, A. Fairlamb, 2013, Antimicrobial Agents and Chemotherapy.

Fragment-based hit identification: thinking in 3D.

Nathan Brown, Steven V Ley, Kristian Birchall, 2013, Drug discovery today.

Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy]purines

P. Wyatt, D. Sutton, M. R. Harnden, 1990 .

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

A. Korkegian, K. Read, P. Hipskind, 2018, Journal of medicinal chemistry.

Solution structures of some ‘uridine dialdehyde’ derivatives

R. T. Walker, P. Wyatt, O. Howarth, 1984 .

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2015, Journal of medicinal chemistry.

Vector-borne diseases series Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need

David W. Gray, K. Read, A. Fairlamb, 2017 .

SYNTHESIS OF ACHIRAL AND HOMOCHIRAL DIBENZOB.FPHOSPHEPIN 5-OXIDES USING BROMINE/LITHIUM EXCHANGE. X-RAY STRUCTURE OF (10R, 11R)-10,11-DIHYDROXY-10,11- DIHYDRO-5-PHENYL-5H-DIBENZOB,FPHOSPHEPIN 5-OXIDE

M. Mcpartlin, P. Wyatt, Thomas M. Woodroffe, 1996 .

Synthesis of homochiral dibenzo[b,f]phosphepin 5-oxides using a double ortho-lithiation strategy

P. Wyatt, S. Warren, 1996 .

Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism*

A. Fairlamb, J. König, P. Wyatt, 2011, The Journal of Biological Chemistry.

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2021, Journal of medicinal chemistry.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Juan A. Bueren-Calabuig, David W. Gray, Frederick R. C. Simeons, 2019, Proceedings of the National Academy of Sciences.

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

David W. Gray, A. Hill, G. Drewes, 2018, Journal of medicinal chemistry.

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

A Short High Yielding Synthesis of the Potent Anti-VZV Carbocyclic Nucleoside Analogue Carba-BVDU

P. Wyatt, R. Cousins, S. Sollis, 1995 .

A Short High Yielding Synthesis of the Potent anti‐VZV Carbocyclic Nucleoside Analogue Carba‐BVDU.

P. Wyatt, R. Cousins, S. Sollis, 1996 .

An efficient protocol for Sharpless-style racemic dihydroxylation

A. Nelson, P. Wyatt, P. O’Brien, 1995 .

An Efficient Protocol for a Sharpless Style Racemic Dihydroxylation.

A. Nelson, P. Wyatt, P. O’Brien, 2010 .

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

David W. Gray, S. Norval, L. Stojanovski, 2015, ChemMedChem.

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Daniel Rauh, Brad Sherborne, Michael Kiczun, 2013, ACS chemical biology.

Drug discovery in academia: the third way?

P. Wyatt, J. Frearson, Paul Wyatt, 2010, Expert opinion on drug discovery.

Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives.

Alison C. Foster, Michael J Allen, Paul G Wyatt, 2002, Bioorganic & medicinal chemistry letters.

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017, Journal of medicinal chemistry.

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

David W. Gray, Fraser Cunningham, J. Cinatl, 2021, PloS one.

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

D. Robertson, J. Hughes, D. Alessi, 2021, PLoS biology.

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

A. Korkegian, L. Stojanovski, K. Read, 2021, ACS omega.

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.

T. Myers, C. Eyermann, K. Chibale, 2021, Journal of medicinal chemistry.

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014, Journal of medicinal chemistry.

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

Michael D. Urbaniak, G. Drewes, M. Bantscheff, 2012, ACS chemical biology.

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Thomas R. Ioerger, Travis Hartman, Tom L. Blundell, 2017, ACS infectious diseases.

Targeting N-myristoylation for therapy of B-cell lymphomas

David W. Gray, K. Read, J. Mackey, 2020, Nature Communications.

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

G. F. Ruda, I. Gilbert, D. V. van Aalten, 2015, ACS chemical biology.

Setting Our Sights on Infectious Diseases

John P. Overington, P. Herrling, J. McCarthy, 2019, ACS infectious diseases.

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2018, Journal of medicinal chemistry.

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

Stuart P. McElroy, S. Norval, L. Stojanovski, 2015, ChemMedChem.

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

K. Read, I. Gilbert, A. Fairlamb, 2010, ChemMedChem.

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Michael D. Urbaniak, G. Drewes, Markus Boesche, 2018, Nature.

Chemical Validation of Trypanothione Synthetase

I. Gilbert, A. Fairlamb, L. S. Torrie, 2009, The Journal of Biological Chemistry.

A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

P. Wyatt, C. Carlow, C. Poole, 2014, PLoS neglected tropical diseases.

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

K. Read, K. Chibale, T. Ioerger, 2018, ACS infectious diseases.

Target assessment for antiparasitic drug discovery.

I. Gilbert, A. Fairlamb, P. Wyatt, 2007, Trends in parasitology.

Synthesis and Structure Activity Relationships of a Series of Penicillin-Derived Pseudosymmetric Inhibitors of HIV-1 Proteinase

P. Wyatt, R. Bethell, N. Cammack, 1994 .

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

Ian H Gilbert, Paul G Wyatt, K. Read, 2011, Current topics in medicinal chemistry.

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Stuart P. McElroy, S. Norval, L. Stojanovski, 2017, Journal of medicinal chemistry.

Structure-activity relationship investigations of a potent and selective benzodiazepine oxytocin antagonist.

P. Woollard, P. Wyatt, M. J. Allen, 2001, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Ian H. Gilbert, Irene Hallyburton, Alan H. Fairlamb, 2011, Journal of medicinal chemistry.

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Stuart P. McElroy, I. Gilbert, A. Fairlamb, 2009, ChemMedChem.

Approaches to carbocyclic analogues of the potent neuraminidase inhibitor 4-guanidino-Neu5Ac2en. X-Ray molecular structure of N-[(1S,2S,6R)-2-azido-6-benzyloxymethyl-4-formylcyclohex-3-enyl]acetamide

P. Wyatt, J. Scicinski, R. Storer, 1995 .

Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies

K. Read, J. Mackey, D. Gray, 2019, Blood.

Characterization of protease activity of Nsp3 from SARS-CoV-2 and its in vitro inhibition by nanobodies

David W. Gray, Fraser Cunningham, A. Hope, 2020, bioRxiv.

Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method

Ian H. Gilbert, Fabio Zuccotto, Paul G. Wyatt, 2021, Journal of Computer-Aided Molecular Design.

Prediction of Drug Penetration in Tuberculosis Lesions.

P. Wyatt, L. Via, V. Dartois, 2016, ACS infectious diseases.

Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis

Julia M. Fisher, T. Ioerger, P. Wyatt, 2019, Antimicrobial Agents and Chemotherapy.

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

S. Norval, K. Read, I. Gilbert, 2011, ChemMedChem.

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Robert H Bates, L. Stojanovski, K. Read, 2021, Journal of medicinal chemistry.

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.

Peter C Ray, Michael Kiczun, Margaret Huggett, 2017, Drug discovery today.

Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N myristoyltransferase inhibitors

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014 .

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.

Ian Collins, Paul Workman, Edward McDonald, 2006, Bioorganic & medicinal chemistry.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

I. Gilbert, M. Ferguson, A. Wernimont, 2013, PLoS neglected tropical diseases.

Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

K. Read, P. Wyatt, W. McLean, 2019, ACS medicinal chemistry letters.

Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

T. Ioerger, P. Wyatt, S. Green, 2021, Cell chemical biology.

Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity

T. Blundell, C. Spry, V. Mizrahi, 2021, ACS infectious diseases.

Screening a protein kinase inhibitor library against Plasmodium falciparum

I. Gilbert, A. Fairlamb, P. Wyatt, 2017, Malaria Journal.

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

K. Read, I. Gilbert, A. Fairlamb, 2011, ChemMedChem.

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

D. Robinson, P. Wyatt, 2015, Acta crystallographica. Section F, Structural biology communications.

287 POSTER Fragment-based discovery of AT9283; a multi-targeted kinase inhibitor with potent Aurora kinase activity

V. Berdini, P. Wyatt, L. Fazal, 2008 .

Synthesis, Oral Bioavailability and in vivo Activity of Acetal Derivatives of the Selective Antiherpesvirus Agent 9-(3-hydroxypropoxy) Guanine (BRL 44385)

P. Wyatt, M. R. Boyd, L. Jennings, 1994 .

Synthesis of 9-hydroxypurines: Intermediates to novel antiviral acyclonucleosides

P. Wyatt, M. R. Harnden, 1990 .

Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxymethyl)propoxy]purines.

P. Wyatt, D. Sutton, M. R. Harnden, 1990, Journal of Medicinal Chemistry.

Synthesis of 9-Hydroxypurines: Intermediates to Novel Antiviral Acyclonucleosides.

P. Wyatt, M. R. Harnden, 1991 .

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2023, Journal of Medicinal Chemistry.

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

T. Blundell, D. Chan, V. Mizrahi, 2021, Nature Communications.

Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site

T. Blundell, D. Chan, V. Mizrahi, 2019, bioRxiv.

Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2023, Nature.

Setting Our Sights on Infectious Diseases

John P. Overington, P. Herrling, J. McCarthy, 2019, ACS infectious diseases.

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.

I. Gilbert, P. Wyatt, Andrew S. T. Lim, 2017, Drug discovery today.

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

David W. Gray, S. Cameron, I. Gilbert, 2013, Antimicrobial Agents and Chemotherapy.

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0md00203h

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020, RSC medicinal chemistry.

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

V. Berdini, P. Wyatt, L. Fazal, 2009, Journal of medicinal chemistry.

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2018, Nature.

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Mark C. Field, David W. Gray, K. Read, 2017, Nature Reviews Microbiology.

Benzophenone derivatives: a novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

D. Green, P. Wyatt, R. Bethell, 1995, Journal of medicinal chemistry.

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Mark C. Field, David W. Gray, K. Read, 2018, Nature Reviews Microbiology.