Deborah F. Smith

发表

The Genome of the Kinetoplastid Parasite, Leishmania major

Heather J Munden, B. Barrell, A. Goffeau, 2005, Science.

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Edward W. Tate, A. Holder, A. Wilkinson, 2012, PLoS neglected tropical diseases.

The stage-regulated HASPB and SHERP proteins are essential for differentiation of the protozoan parasite Leishmania major in its sand fly vector, Phlebotomus papatasi

P. Volf, Deborah F. Smith, J. Votýpka, 2010, Cellular microbiology.

Reversible Phosphorylation as a Molecular Switch to Regulate Plasma Membrane Targeting of Acylated SH4 Domain Proteins

R. Pepperkok, W. Nickel, Deborah F. Smith, 2009, Traffic.

Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces*

P. Simpson, S. Matthews, B. Wallace, 2010, The Journal of Biological Chemistry.

Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa

Deborah F. Smith, P. Denny, 2004, Molecular microbiology.

Sphingolipid‐free Leishmania are defective in membrane trafficking, differentiation and infectivity

D. Goulding, Deborah F. Smith, P. Denny, 2004, Molecular microbiology.

Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition

D. Depledge, Deborah F. Smith, S. R. Uliana, 2010, PLoS neglected tropical diseases.

Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes

D. Goulding, Deborah F. Smith, H. Price, 2005, Journal of Cell Science.

Comparative expression profiling of Leishmania

A. Ivens, P. Kaye, D. Depledge, 2017 .

Kinetoplastid PPEF phosphatases: Dual acylated proteins expressed in the endomembrane system of Leishmania

Deborah F. Smith, E. Mills, H. Price, 2007, Molecular and biochemical parasitology.

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

Edward W. Tate, A. Wilkinson, J. Brannigan, 2014, IUCrJ.

Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress.

R. Mortara, Deborah F. Smith, J. K. Yokoyama-Yasunaka, 2011, Experimental parasitology.

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

Edward W. Tate, Deborah F. Smith, E. Tate, 2014, PLoS neglected tropical diseases.

The Orthologue of Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1) in Trypanosoma brucei Is an Immunogenic Self-Assembling Molecule

J. Brannigan, M. Carrington, Deborah F. Smith, 2012, PloS one.

The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei

Deborah F. Smith, H. Price, M. Stark, 2010, Molecular and biochemical parasitology.

TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei

Deborah F. Smith, Barbara A. Smith, H. Price, 2007, Molecular and biochemical parasitology.

Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking.

Deborah F. Smith, H. Price, M. Stark, 2007, Molecular biology of the cell.

Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8+ T Cells

P. Kaye, Deborah F. Smith, L. Beattie, 2010, PLoS pathogens.

7 Stress Proteins and Infectious Diseases

Deborah F. Smith, D. Young, A. Mehlert, 1990 .

Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.

Mark C. Field, G. Morgan, Deborah F. Smith, 2005, Experimental parasitology.

The molecular cloning of a dispersed set of developmentally regulated genes which encode the major larval serum protein of D. melanogaster

D. Glover, B. White, Deborah F. Smith, 1981, Cell.

Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8+ T Cells Requires the Presence of Cognate Antigen

P. Kaye, Deborah F. Smith, R. Polley, 2006, Infection and Immunity.

Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan Parasite Leishmania major

Deborah F. Smith, C. Galanos, M. Freudenberg, 2004, Infection and Immunity.

Leishmania major Parasite Control of Infection with the Protozoan Toll-Like Receptor 4 Contributes to Efficient

Deborah F. Smith, C. Galanos, M. Freudenberg, 2004 .

Phenotypic changes associated with deletion and overexpression of a stage‐regulated gene family in Leishmania

Deborah F. Smith, P. Denny, P. McKean, 2001, Cellular microbiology.

Ether Phospholipids and Glycosylinositolphospholipids Are Not Required for Amastigote Virulence or for Inhibition of Macrophage Activation by Leishmania major*

I. C. Almeida, M. Ferguson, Deborah F. Smith, 2003, Journal of Biological Chemistry.

STRUCTURAL BASIS OF MOLECULAR RECOGNITION BY SHERP AT MEMBRANE SURFACES

P. Simpson, S. Matthews, B. Wallace, 2010 .

The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host

Deborah F. Smith, Daniel Paape, H. Price, 2013, Molecular microbiology.

Trafficking and release of Leishmania metacyclic HASPB on macrophage invasion

J. Marrison, Peter J O'Toole, W. Nickel, 2012, Cellular microbiology.

Against Visceral Leishmaniasis Induces Protection Leishmania donovani Stage-Regulated Surface Protein from Immunization with a Recombinant

P. Kaye, Deborah F. Smith, S. Stäger, 2000 .

Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

M. Ferguson, Deborah F. Smith, H. Price, 2010, Molecular and biochemical parasitology.

Functional Analysis of Leishmania Cyclopropane Fatty Acid Synthetase

Terry K. Smith, Paul M. Kaye, Jeremy C. Mottram, 2012, PloS one.

Immunological modulation and evasion by helminth parasites in human populations

R. Maizels, R. Anderson, Deborah F. Smith, 1993, Nature.

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

Katherine A Brown, M. Gelb, F. Buckner, 2003, Molecular and biochemical parasitology.

Immunization with a Recombinant Stage-Regulated Surface Protein from Leishmania donovani Induces Protection Against Visceral Leishmaniasis1

P. Kaye, Deborah F. Smith, S. Stäger, 2000, The Journal of Immunology.

Comparative genomic analysis of three Leishmania species that cause diverse human disease

Brian White, Arnaud Kerhornou, Michael A Quail, 2007, Nature Genetics.

Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

P. Volf, Deborah F. Smith, J. Votýpka, 2017, PLoS pathogens.

Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses

P. Kaye, Deborah F. Smith, N. Rooijen, 2003, Nature Medicine.

Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.

Edward W. Tate, A. Holder, Deborah F. Smith, 2008, Chemical communications.

Regulation of gene expression in trypanosomes

M. Parsons, Deborah F. Smith, L. Vanhamme, 1996 .

Myristoyl-CoA:Protein N-Myristoyltransferase, an Essential Enzyme and Potential Drug Target in Kinetoplastid Parasites*

D. Goulding, Deborah F. Smith, P. McKean, 2003, The Journal of Biological Chemistry.

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

R. Cortese, P. Kaye, Deborah F. Smith, 2017, PLoS neglected tropical diseases.

Therapeutic Vaccination With Recombinant Adenovirus Reduces Splenic Parasite Burden in Experimental Visceral Leishmaniasis

P. Kaye, Deborah F. Smith, T. Aebischer, 2012, The Journal of infectious diseases.

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

Proteomic analysis of Leishmania mexicana differentiation.

S. Karsani, R. Wait, Deborah F. Smith, 2004, Molecular and biochemical parasitology.

Expression profiling of the Leishmania life cycle: cDNA arrays identify developmentally regulated genes present but not annotated in the genome.

D. Vetrie, M. Levick, J. Blackwell, 2004, Molecular and biochemical parasitology.

Analysis of mosquito bloodmeals by DNA profiling

C. Curtis, Deborah F. Smith, S. Gokool, 1993, Medical and veterinary entomology.

Comparative genomics: From genotype to disease phenotype in the leishmaniases

C. Peacock, A. Cruz, Deborah F. Smith, 2007, International journal for parasitology.

Chemokine Gene Expression in Toll-Like Receptor-Competent and -Deficient Mice Infected with Leishmania major

Deborah F. Smith, C. Galanos, M. Freudenberg, 2004, Infection and Immunity.

Leishmania major Infected with Receptor-Competent and-Deficient Mice Chemokine Gene Expression in Toll-Like

Deborah F. Smith, C. Galanos, M. Freudenberg, 2004 .

Gene expression in the infective promastigotes of Leishmania major

R. Coulson, S. Searle, Deborah F. Smith, 1989 .

DNA hybridizations on squash‐blotted sandflies to identify both Phlebotomus papatasi and infecting Leishmania major

Deborah F. Smith, P. Ready, R. Killick-Kendrick, 1988, Medical and veterinary entomology.

Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World

J. Webster, Deborah F. Smith, K. King, 2015, PLoS pathogens.

Squash Blotting Phlebotomus Papatasi to Estimate Rates of Infection by Leishmania Major

Deborah F. Smith, R. Ben-Ismail, P. Ready, 1989 .

Genomic Confirmation of Hybridisation and Recent Inbreeding in a Vector-Isolated Leishmania Population

M. Berriman, J. Cotton, M. Sanders, 2014, PLoS genetics.

Identification of Drosophila Gene Products Required for Phagocytosis of Leishmania donovani

Deborah F. Smith, S. Sweeney, L. Briggs, 2012, PloS one.

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

Edward W. Tate, A. Wilkinson, A. Brzozowski, 2010, Journal of molecular biology.

Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei

K. Wilson, Deborah F. Smith, G. R. Hemsworth, 2013, Protein science : a publication of the Protein Society.

RepSeq – A database of amino acid repeats present in lower eukaryotic pathogens

Daniel P. Depledge, Deborah F. Smith, Ryan P. J. Lower, 2007 .

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.

Pawel Herzyk, Christiane Hertz-Fowler, Hideo Imamura, 2011, Genome research.

N‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites

A. Holder, K. Brown, Deborah F. Smith, 2008, ChemMedChem.

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major.

K. Brown, Deborah F. Smith, R. Leatherbarrow, 2006, The Biochemical journal.

GeneDB—an annotation database for pathogens

Haiming Wang, Andrew Jackson, Brian P. Brunk, 2011, Nucleic Acids Res..

Comparative Expression Profiling of Leishmania: Modulation in Gene Expression between Species and in Different Host Genetic Backgrounds

A. Ivens, P. Kaye, D. Depledge, 2009, PLoS neglected tropical diseases.

In Vivo Recognition of Ovalbumin Expressed by Transgenic Leishmania Is Determined by Its Subcellular Localization1

P. Kaye, Deborah F. Smith, P. Scott, 2006, The Journal of Immunology.

Its Subcellular Localization Is Determined by Leishmania by Transgenic In Vivo Recognition of Ovalbumin Expressed

P. Kaye, Deborah F. Smith, P. Scott, 2006 .

Antigen-Experienced T Cells Limit the Priming of Naive T Cells during Infection with Leishmania major1

P. Kaye, Deborah F. Smith, P. Scott, 2006, The Journal of Immunology.

Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant

Carolin Stegmayer, W. Nickel, B. Schwappach, 2005, Journal of Cell Science.

The Protozoan Inositol Phosphorylceramide Synthase

R. Schwarz, Deborah F. Smith, P. Denny, 2006, Journal of Biological Chemistry.

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

Edward W. Tate, M. Wright, A. Wilkinson, 2020, Journal of medicinal chemistry.

TriTrypDB: a functional genomic resource for the Trypanosomatidae

Eileen Kraemer, Haiming Wang, John A. Miller, 2009, Nucleic Acids Res..

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

Deborah F. Smith, Daniel Paape, H. Price, 2020, Parasites & Vectors.

An Evolutionarily Conserved Coiled-Coil Protein Implicated in Polycystic Kidney Disease Is Involved in Basal Body Duplication and Flagellar Biogenesis in Trypanosoma brucei

Mark C. Field, K. Gull, D. Goulding, 2005, Molecular and Cellular Biology.

Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors

Edward W. Tate, Robin J. Leatherbarrow, Anthony J. Wilkinson, 2014, Journal of medicinal chemistry.

Peptide‐based inhibitors of N‐myristoyl transferase generated from a lipid/combinatorial peptide chimera library

A. Holder, K. Brown, Deborah F. Smith, 2006 .

A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei

Edward W. Tate, M. Wright, M. Carrington, 2012, Biochimica et biophysica acta.

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

Edward W. Tate, M. Grainger, A. Holder, 2007, The Biochemical journal.

Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors Structure-Based of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors.

M. Wright, A. Wilkinson, J. Brannigan, 2018 .

Characterisation of a new Leishmania META gene and genomic analysis of the META cluster.

Deborah F. Smith, S. R. Uliana, F. Franco, 2004, FEMS microbiology letters.

Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite.

Mark C. Field, A. Ivens, D. Goulding, 2002, Molecular and biochemical parasitology.

Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani

Edward W. Tate, M. Wright, Deborah F. Smith, 2015, Chemistry & biology.

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei

Edward W. Tate, M. Wright, Deborah F. Smith, 2016, ACS infectious diseases.

Characterisation of a new gene and genomic analysis of the cluster

Deborah F. Smith, S. R. Uliana, F. Franco, 2004 .

Validation of a new method for immobilising kinetoplastid parasites for live cell imaging

J. Marrison, Deborah F. Smith, H. Price, 2010, Molecular and biochemical parasitology.

Identification and characterisation of a RAD51 gene from Leishmania major.

Deborah F. Smith, P. McKean, J. Keen, 2001, Molecular and biochemical parasitology.

Characterization of a differentially expressed protein that shows an unusual localization to intracellular membranes in Leishmania major.

Deborah F. Smith, Y. Stierhof, P. McKean, 2001, The Biochemical journal.

Expression of a hydrophilic surface protein in infective stages of Leishmania major.

Helen M. Flinn, Deborah F. Smith, D. F. Smith, 1994, Molecular and biochemical parasitology.

Leishmania major: characterisation and expression of a cytoplasmic stress-related protein.

S. Searle, Deborah F. Smith, 1993, Experimental parasitology.

Molecular biology of parasitic protozoa

M. Parsons, Deborah F. Smith, 1996 .

CD36-dependent adhesion and knob expression of the transmission stages of Plasmodium falciparum is stage specific.

R. Hayward, Deborah F. Smith, J. Culvenor, 1998, Molecular and biochemical parasitology.

Isolation of genes showing increased or unique expression in the infective promastigotes of Leishmania major.

R. Coulson, Deborah F. Smith, D. F. Smith, 1990, Molecular and biochemical parasitology.

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

Edward W. Tate, A. Wilkinson, J. Brannigan, 2015, MedChemComm.

Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

M. Ferguson, Deborah F. Smith, H. Price, 2010, Molecular and biochemical parasitology.

N‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites

Edward W. Tate, A. Holder, K. Brown, 2008, ChemMedChem.

Expression of hydrophilic surface proteins in infective stages of Leishmania donovani.

Deborah F. Smith, T. Alce, D. F. Smith, 1999, Molecular and biochemical parasitology.

Diversity in repeat-containing surface proteins of Leishmania major.

Deborah F. Smith, P. McKean, J. Keen, 1997, Molecular and biochemical parasitology.

Transgenic Leishmania and the immune response to infection

P. Kaye, Deborah F. Smith, L. Beattie, 2008, Parasite immunology.

Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8+ T Cells Requires the Presence of Cognate Antigen

P. Kaye, Deborah F. Smith, R. Polley, 2006, Infection and Immunity.