M. Welcker

发表

Rapid destruction of human Cdc25A in response to DNA damage.

N. Mailand, J. Bartek, J. Lukas, 2000, Science.

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.

James M. Roberts, B. Clurman, K. Loeb, 2003, Molecular cell.

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Rob Pieters, Christopher Winter, Giulio Draetta, 2007, The Journal of experimental medicine.

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

B. Clurman, M. Welcker, Markus Welcker, 2008, Nature Reviews Cancer.

Phosphorylation of Eukaryotic Elongation Factor 2 (eEF2) by Cyclin A–Cyclin-Dependent Kinase 2 Regulates Its Inhibition by eEF2 Kinase

B. Clurman, M. Welcker, A. Ryazanov, 2012, Molecular and Cellular Biology.

Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor

B. Clurman, N. Zheng, M. Welcker, 2022, Science advances.

Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP

B. Clurman, D. Galloway, M. Welcker, 2019, PLoS pathogens.

Fbw7 dimerization determines the specificity and robustness of substrate degradation

B. Clurman, N. Zheng, M. Welcker, 2013, Genes & development.

Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

B. Clurman, D. Russell, M. Welcker, 2008, The Journal of cell biology.

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.

James M. Roberts, I. Bernstein, B. Clurman, 2008, Genes & development.

Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma

B. Clurman, Jing Huang, M. Slovak, 2008, The Journal of experimental medicine.

Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma

B. Clurman, Jing Huang, M. Slovak, 2008, The Journal of experimental medicine.

A Novel Function for Cyclin E in Cell Cycle Progression

James M. Roberts, B. Clurman, P. Kaldis, 2008 .

Kinase-independent function of cyclin E.

James M. Roberts, B. Clurman, P. Kaldis, 2007, Molecular cell.

Fbw7/hCDC4 dimerization regulates its substrate interactions

B. Clurman, M. Welcker, 2007, Cell Division.

Ras activity regulates cyclin E degradation by the Fbw7 pathway.

B. Clurman, M. Welcker, A. Minella, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase*

S. Elledge, B. Clurman, J. Qin, 2004, Journal of Biological Chemistry.

Oncoprotein ubiquitylation

B. Clurman, M. Welcker, 2014, Cell cycle.

p21/WAF1/Cip1 expression in invasive ductal breast carcinoma: relationship to p53, proliferation rate, and survival at 5 years

J. Bartek, J. Bártková, M. Welcker, 2001, Virchows Archiv.

Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types.

J. Bartek, J. Lukas, G. Peters, 1995, Oncogene.

Enhanced protein stability: a novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells.

J. Bartek, J. Lukas, M. Strauss, 1996, Oncogene.

Monoclonal antibody probes for p21WAF1/CIP1 and the INK4 family of cyclin-dependent kinase inhibitors.

J. Bartek, J. Lukas, J. Bártková, 2000, Hybridoma.

The SV 40 Large T Antigen Contains a Decoy Phosphodegron That Mediates Its Interactions with Fbw 7 / hCdc 4 *

B. Clurman, M. Welcker, 2005 .

A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size

B. Clurman, R. Eisenman, A. Orian, 2004, Current Biology.

The SV40 Large T Antigen Contains a Decoy Phosphodegron That Mediates Its Interactions with Fbw7/hCdc4*♦

B. Clurman, M. Welcker, 2005, Journal of Biological Chemistry.

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.

B. Clurman, M. Welcker, Ryan J. Davis, 2014, Cancer cell.

Identification of CDK2 substrates in human cell lysates

Ruedi Aebersold, R. Aebersold, B. Clurman, 2008, Genome Biology.

p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability

B. Clurman, M. Welcker, J. Grim, 2007, Oncogene.

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

B. Clurman, J. Harper, R. Eisenman, 2004, Proceedings of the National Academy of Sciences of the United States of America.

p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation

B. Clurman, M. Welcker, H. Hwang, 2002, Current Biology.

p21WAF1/CIP1 mutants deficient in inhibiting cyclin-dependent kinases (CDKs) can promote assembly of active cyclin D/CDK4(6) complexes in human tumor cells.

M. Strauss, J. Bartek, J. Lukas, 1998, Cancer research.

Nucleolar Targeting of the Fbw7 Ubiquitin Ligase by a Pseudosubstrate and Glycogen Synthase Kinase 3

B. Clurman, L. Frappier, M. Welcker, 2011, Molecular and Cellular Biology.

Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins.

B. Clurman, M. Welcker, M. Gustafson, 2005, Biochemical and biophysical research communications.

Cell Cycle: How Cyclin E Got Its Groove Back

B. Clurman, M. Welcker, 2005, Current Biology.

p21wAFi/c//v Mutants Deficient in Inhibiting Cyclin-dependent Kinases (CDKs) Can Promote Assembly of Active Cyclin D/CDK4(6) Complexes in Human Tumor Cells1

J. Bartek, J. Lukas, M. Strauss, 2006 .

Mutants Deficient in Inhibiting Cyclin-dependent Kinases ( CDKs ) Can Promote Assembly of Active Cyclin D / CDK 4 ( 6 ) Complexes in Human Tumor Cells 1

J. Bartek, J. Lukas, M. Strauss, 2006 .

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.

B. Clurman, M. Welcker, Ryan J. Davis, 2014, Cancer cell.

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

B. Clurman, R. Sears, R. Pieters, 2007, The Journal of experimental medicine.