D. Dean

发表

The Rb/E2F pathway: expanding roles and emerging paradigms.

J. Harbour, D. Dean, J W Harbour, 2000, Genes & development.

Transcriptional Repression by Rb-E2F and Regulation of Anchorage-Independent Survival

D. Dean, Jennifer T. Yu, R. G. Foster, 2001, Molecular and Cellular Biology.

Corepressors and retinoblastoma protein function.

J. Harbour, D. Dean, 2001, Current topics in microbiology and immunology.

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

J. Harbour, D. Dean, R. Luo, 1999, Cell.

Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis, and a Block in c-Raf Activation

D. Dean, S. El-Naggar, Yongqing Liu, 2009, Molecular and Cellular Biology.

Chromatin remodeling and transcriptional regulation.

D. Dean, R. Luo, Robin X. Luo, 1999, Journal of the National Cancer Institute.

Yap1 is required for maintenance of adult RPE differentiation

H. Kaplan, D. Dean, Qiutang Li, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ZEB represses transcription through interaction with the corepressor CtBP.

D. Dean, A. Postigo, A A Postigo, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa.

H. Kaplan, T. Ezashi, D. Dean, 2016, Cell reports.

Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

D. Dean, A. Postigo, Yongqing Liu, 2018, Nature Communications.

The ZEB1 Transcription Factor Acts in a Negative Feedback Loop with miR200 Downstream of Ras and Rb1 to Regulate Bmi1 Expression*

D. Dean, A. Postigo, Yongqing Liu, 2013, The Journal of Biological Chemistry.

Rod photoreceptor clearance due to misfolded rhodopsin is linked to a DAMP-immune checkpoint switch

H. Kaplan, D. Dean, Yongqing Liu, 2020, The Journal of biological chemistry.

ZEB, a vertebrate homolog of Drosophila Zfh‐1, is a negative regulator of muscle differentiation

D. Dean, A. Postigo, 1997, The EMBO journal.

Domains A and B in the Rb pocket interact to form a transcriptional repressor motif

D. Dean, K. N. Chow, 1996, Molecular and cellular biology.

Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

G. Rosen, J. McQuillan, D. Dean, 1992, The Journal of biological chemistry.

Linking the Rb and polycomb pathways.

S. Gonzalo, D. Dean, A. Dahiya, 2001, Molecular cell.

Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology.

H. Kaplan, D. Dean, Qiutang Li, 2009, Investigative ophthalmology & visual science.

A role for the Rb family of proteins in controlling telomere length

M. Blasco, S. Gonzalo, D. Dean, 2002, Nature Genetics.

ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression

H. Kaplan, D. Dean, Yongqing Liu, 2017, Scientific Reports.

Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells

D. Dean, A. Postigo, Yongqing Liu, 2021, Science Advances.

Tumor initiation via loss of cell contact inhibition versus Ras mutation: Do all roads lead to EMT?

D. Dean, Yongqing Liu, 2010, Cell cycle.

Identification of small Sca-1(+), Lin(-), CD45(-) multipotential cells in the neonatal murine retina.

H. Kaplan, M. Ratajczak, D. Dean, 2009, Experimental hematology.

The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb-E2F1.

D. Dean, Yongqing Liu, D. Darling, 2007, The Biochemical journal.

Repression of Zeb1 and Hypoxia Cause Sequential Mesenchymal‐to‐Epithelial Transition and Induction of Aid, Oct4, and Dnmt1, Leading to Immortalization and Multipotential Reprogramming of Fibroblasts in Spheres

M. Pisano, D. Dean, Qingxian Lu, 2013, Stem cells.

Interferon Regulatory Factor-2 Is a Transcriptional Activator in Muscle Where It Regulates Expression of Vascular Cell Adhesion Molecule-1

D. Dean, M. Iademarco, Traci L. Jesse, 1998, The Journal of cell biology.

Taz-tead1 links cell-cell contact to zeb1 expression, proliferation, and dedifferentiation in retinal pigment epithelial cells.

H. Kaplan, D. Dean, Qingxian Lu, 2010, Investigative ophthalmology & visual science.

Metabolic rescue of cone photoreceptors in retinitis pigmentosa

D. Dean, Wei Wang, Henry J. Kaplan, 2021, Taiwan journal of ophthalmology.

The Integrin α4β1 and Its Counter Receptor VCAM-1 in Development and Immune Function

G. Rosen, D. Dean, M. Iademarco, 1993 .

Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta, and cAMP in human cell lines

D. Dean, S. Bourgeois, R. Newby, 1988, The Journal of cell biology.

Zeb1 mutant mice as a model of posterior corneal dystrophy.

H. Kaplan, D. Dean, Yongqing Liu, 2008, Investigative ophthalmology & visual science.

Vascular cell adhesion molecule 1: contrasting transcriptional control mechanisms in muscle and endothelium.

J. McQuillan, D. Dean, M. Iademarco, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a protein that interacts with the nuclear factor-1 (NF-1) binding site in cells that do not express NF-1: comparison to NF-1, cellular distribution, and effect on transcription.

G. Rosen, J. McQuillan, D. Dean, 1991, Nucleic acids research.

Taz-Tead 1 Links Cell-Cell Contact to Zeb 1 Expression , Proliferation , and Dedifferentiation in Retinal Pigment Epithelial Cells

H. Kaplan, D. Dean, Qingxian Lu, 2010 .

Forskolin inducibility and tissue-specific expression of the fibronectin promoter

P. Ghazal, D. Dean, S. Bourgeois, 1989, Molecular and cellular biology.

An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter.

R. J. Fisher, G. Rosen, D. Dean, 1994, The Journal of biological chemistry.

Expression of Fibronectin and Its Cell Surface Receptors

G. Rosen, S. Weintraub, D. Dean, 1991 .

Glycoprotein synthesis and secretion. Expression of fibronectin and its cell surface receptors.

G. Rosen, S. Weintraub, D. Dean, 1991, The American review of respiratory disease.

A molecular switch between lung development and cancer: is the tumor suppressor Rb turned on during bronchial epithelial cell differentiation and turned off in small cell lung cancer?

S. Weintraub, D. Dean, M. Holtzman, 1994, American journal of respiratory cell and molecular biology.

Expanding Roles for α4 Integrin and its Ligands in Development

D. Dean, M. Onken, P. G. Noakes, 1994 .

Expression of the fibronectin gene.

D. Dean, 1989, American journal of respiratory cell and molecular biology.

Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis

J. Sanes, G. Rosen, D. Dean, 1992, Cell.

The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter.

J. McQuillan, E. Ruoslahti, D. Dean, 1991, The Journal of biological chemistry.

Characterization of the alpha 4 integrin gene promoter.

G. Rosen, D. Dean, T. Birkenmeier, 1991, Proceedings of the National Academy of Sciences of the United States of America.

B. O’Malley, D. Dean, R. Gope, 1984, The Journal of biological chemistry.

Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa (RP): Retinal Cell-Based Therapy

H. Kaplan, D. Dean, Wei Wang, 2019, Stem Cell Biology and Regenerative Medicine.

Opposing roles of ZEB1 in the cytoplasm and nucleus control cytoskeletal assembly and YAP1 activity.

E. Rouchka, D. Dean, A. Postigo, 2022, Cell reports.

Interaction of a common factor with ATF, Sp1, or TATAA promoter elements is required for these sequences to mediate transactivation by the adenoviral oncogene E1a

S. Weintraub, D. Dean, 1992, Molecular and cellular biology.

Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa

H. Kaplan, D. Dean, Wei Wang, 2017, Translational vision science & technology.

Sphere‐Induced Rejuvenation of Swine and Human Müller Glia Is Primarily Caused by Telomere Elongation

H. Kaplan, D. Dean, Yongqing Liu, 2017, Stem cells.

Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells

H. Kaplan, D. Dean, Yongqing Liu, 2020, EBioMedicine.

Swine cone and rod precursors arise sequentially and display sequential and transient integration and differentiation potential following transplantation.

H. Kaplan, D. Dean, Yongqing Liu, 2014, Investigative ophthalmology & visual science.

Role of the LXCXE Binding Site in Rb Function

D. Dean, R. Luo, Douglas C. Dean, 2000, Molecular and Cellular Biology.

Expression and Function of ZEB1 in the Cornea

D. Dean, Yongqing Liu, Yingnan Zhang, 2021, Cells.

Zeb1 promotes corneal neovascularization by regulation of vascular endothelial cell proliferation

H. Kaplan, D. Dean, Yongqing Liu, 2020, Communications Biology.

Active Transcriptional Repression by the Rb–E2F Complex Mediates G1 Arrest Triggered by p16INK4a, TGFβ, and Contact Inhibition

D. Dean, A. Postigo, H.Steven Zhang, 1999, Cell.

Differentiation of Induced Pluripotent Stem Cells of Swine into Rod Photoreceptors and Their Integration into the Retina

R. Roberts, H. Kaplan, T. Ezashi, 2011, Stem cells.

Rb Interacts with Histone Deacetylase to Repress Transcription

D. Dean, R. Luo, A. Postigo, 1998, Cell.

Mechanism of active transcriptional repression by the retinoblastoma protein

S. Weintraub, D. Dean, R. Luo, 1995, Nature.

Chromatin remodeling and Rb activity.

J. Harbour, D. Dean, J William Harbour, 2000, Current opinion in cell biology.

The integrin alpha 4 beta 1 and its counter receptor VCAM-1 in development and immune function.

G. Rosen, D. Dean, M. Iademarco, 1993, The American review of respiratory disease.

Sequential Inductions of the ZEB1 Transcription Factor Caused by Mutation of Rb and Then Ras Proteins Are Required for Tumor Initiation and Progression*

D. Dean, A. Postigo, Yongqing Liu, 2013, The Journal of Biological Chemistry.

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

Manel Esteller, Gunnar Schotta, M. Fraga, 2005, Nature Cell Biology.

The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

P. Starostik, D. Dean, K. N. Chow, 1996, Molecular and cellular biology.

transcriptional repressor motif . cyclin-dependent-kinase-regulated The Rb family contains a conserved

P. Starostik, D. Dean, K. N. Chow, 1996 .

Control of Glutamine Metabolism By the Tumor Suppressor Rb

A. Lane, D. Dean, Yongqing Liu, 2013, Oncogene.

Zeb1 links epithelial-mesenchymal transition and cellular senescence

Douglas S. Darling, D. Dean, S. El-Naggar, 2008, Development.

Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

Duanduan Ma, J. Harbour, D. Dean, 2000, Cell.

Retinoblastoma protein switches the E2F site from positive to negative element

S. Weintraub, D. Dean, C. Prater, 1992, Nature.

Tumor‐associated macrophages (TAMs) depend on ZEB1 for their cancer‐promoting roles

B. Győrffy, T. Lawrence, D. Dean, 2017, The EMBO journal.

A 5′-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene

B. O’Malley, D. Dean, B. Knoll, 1983, Nature.

Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells

Anna V. Taubenberger, W. Enard, Christoph Ziegenhain, 2017, The Journal of experimental medicine.

Rb function in cell-cycle regulation and apoptosis

J. Harbour, D. Dean, 2000, Nature Cell Biology.

ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells

D. Dean, J. Maurel, A. Postigo, 2019, Gut.

EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness

D. Dean, A. Postigo, Yongqing Liu, 2012, Cellular and Molecular Life Sciences.

Cell Anchorage Regulates Apoptosis through the Retinoblastoma Tumor Suppressor/E2F Pathway*

M. Day, D. Dean, R. G. Foster, 1997, The Journal of Biological Chemistry.

c‐Myb and Ets proteins synergize to overcome transcriptional repression by ZEB

D. Dean, A. Postigo, M. Mucenski, 1997, The EMBO journal.

Cloning and analysis of the promotor region of the human fibronectin gene.

D. Dean, S. Bourgeois, C. Bowlus, 1987, Proceedings of the National Academy of Sciences of the United States of America.

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

W. Woodward, Li Ma, M. Hung, 2014, Nature Cell Biology.

miR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13

K. Ang, W. Woodward, Li Ma, 2014, Nature Communications.

Rb-mediated chromatin structure regulation and transcriptional repression

D. Dean, H. S. Zhang, 2001, Oncogene.

EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness

Ester Sánchez-Tilló, Antoni Castells, Douglas S. Darling, 2012, Cellular and Molecular Life Sciences.

14-3-3σ regulates keratinocyte proliferation and differentiation by modulating Yap1 cellular localization

D. Dean, L. Xue, Qiutang Li, 2015, The Journal of investigative dermatology.

14-3-3σ Regulates Keratinocyte Proliferation and Differentiation by Modulating Yap1 Cellular

D. Dean, L. Xue, Qiutang Li, 2015 .

Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.

M. Ratajczak, D. Dean, S. El-Naggar, 2009, Cell stem cell.

Epigenetically distinct sister chromatids and asymmetric generation of tumor initiating cells

D. Dean, A. Postigo, Yongqing Liu, 2018, Cell cycle.

Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas

Wei Wang, D. Dean, Yongqing Liu, 2022, iScience.

Control of Vascular Cell Adhesion Molecule-1 Gene Promoter Activity during Neural Differentiation (*)

J. McQuillan, D. Dean, M. Iademarco, 1995, The Journal of Biological Chemistry.

Independent Repressor Domains in ZEB Regulate Muscle and T-Cell Differentiation

D. Dean, A. Postigo, 1999, Molecular and Cellular Biology.

Mediate Transactivation by the Adenoviral Oncogene Ela

S. Weintraub, D. Dean, 2022 .

Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells.

D. Dean, M. Iademarco, J. Barks, 1995, The Journal of clinical investigation.

The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression.

D. Dean, S. El-Naggar, Yongqing Liu, 2008, The Biochemical journal.

Transcriptional repression and growth suppression by the p107 pocket protein

P. Starostik, D. Dean, K. N. Chow, 1996, Molecular and cellular biology.

zfh-1, the Drosophila Homologue of ZEB, Is a Transcriptional Repressor That Regulates Somatic Myogenesis

James B. Skeath, Ellen Ward, D. Dean, 1999, Molecular and Cellular Biology.

Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors.

D. Dean, A. Postigo, Antonio Postigo, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Expanding roles for alpha 4 integrin and its ligands in development.

G. Rosen, D. Dean, M. Onken, 1994, Cell adhesion and communication.

Zeb1 promotes corneal neovascularization by regulation of vascular endothelial cell proliferation

H. Kaplan, D. Dean, Yongqing Liu, 2020, Communications Biology.

Circulating Reactive Oxidant Causes Apoptosis of Retinal Pigment Epithelium and Cone Photoreceptors in the Mouse Central Retina

H. Kaplan, D. Dean, Jennifer M. Noel, 2011, Ophthalmology and eye diseases.

Selective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of Swine retinal degeneration.

H. Kaplan, P. Demarco, D. Dean, 2011, Investigative ophthalmology & visual science.

Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis

D. Dean, A. Postigo, Yongqing Liu, 2014, Nature Communications.

Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa

H. Kaplan, D. Dean, Qingxian Lu, 2019, Cell reports.

Spheroid-induced heterogeneity and plasticity of uveal melanoma cells

D. Dean, Yongqing Liu, Xiaoqin Lu, 2022, Cellular Oncology.

Synthesis and secretion of hemoglobin by retinal pigment epithelium.

J. Klein, H. Kaplan, D. Dean, 2009, Investigative ophthalmology & visual science.

Paracrine effects of intraocularly implanted cells on degenerating retinas in mice

H. Kaplan, D. Dean, Yongqing Liu, 2020, Stem cell research & therapeutics.

Characterization of three different elements in the 5'-flanking region of the fibronectin gene which mediate a transcriptional response to cAMP.

J. McQuillan, D. Dean, C. Bowlus, 1991, The Journal of biological chemistry.

Rb1 family mutation is sufficient for sarcoma initiation

D. Dean, A. Postigo, Yongqing Liu, 2013, Nature Communications.

Definition of the ovalbumin gene promoter by transfer of an ovalglobin fusion gene into cultured cells.

B. O’Malley, D. Dean, T. Zarucki-Schulz, 1983, Nucleic acids research.

ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression

H. Kaplan, D. Dean, Yongqing Liu, 2017, Scientific Reports.

Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

D. Dean, A. Postigo, Yongqing Liu, 2018, Nature Communications.

Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility

D. Dean, Yongqing Liu, Brian P Ceresa, 2023, Communications biology.

Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa

H. Kaplan, D. Dean, Yongqing Liu, 2023, Cell reports.

Identification of small Sca-1(+), Lin(-), CD45(-) multipotential cells in the neonatal murine retina.

H. Kaplan, M. Ratajczak, D. Dean, 2009, Experimental hematology.

The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression.

D. Dean, S. El-Naggar, Yongqing Liu, 2008, The Biochemical journal.