J. Benovic

发表

Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase).

M. Caron, R. Lefkowitz, S. Yang, 1991, Biochemical and biophysical research communications.

Distinct Clathrin‐Coated Pits Sort Different G Protein‐Coupled Receptor Cargo

S. Mundell, J. Benovic, Jiansong Luo, 2006, Traffic.

The ins and outs of G protein-coupled receptor trafficking.

J. Benovic, A. Marchese, Catherine Chen, 2003, Trends in biochemical sciences.

Structure of the human gene encoding the beta-adrenergic receptor kinase.

J. Benovic, R. Penn, 1994, The Journal of biological chemistry.

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

A. Klein-Szanto, H. Yagi, R. Parsons, 2010, Molecular cell.

The role of receptor kinases and arrestins in G protein-coupled receptor regulation.

J. Benovic, J. Krupnick, 1998, Annual review of pharmacology and toxicology.

Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma

J. Swensen, A. Aplin, J. Benovic, 2021, Cancers.

Targeting Oncogenic Gαq/11 in Uveal Melanoma

J. Benovic, Dominic Lapadula, 2021, Cancers.

Homogeneous substrate-labeled fluorescent immunoassay for theophylline in serum.

J. Burd, J. Benovic, R. T. Buckler, 1981, Clinical chemistry.

G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel

J. Benovic, J. Lagman, Paula Sayegh, 2019, Molecular and Cellular Biochemistry.

NMR probes of the spatial arrangement of substrates at the active site of creatine kinase

J. Benovic, Raj K. Gupta, 1981 .

Receptor Docking Sites for G-protein βγ Subunits

J. Benovic, Guangyu Wu, J. Hildebrandt, 1998, The Journal of Biological Chemistry.

l-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain

V. V. Gurevich, E. Bézard, C. Gross, 2005, Neurobiology of Disease.

Molecular and regulatory properties of the adenylyl cyclase-coupled beta-adrenergic receptors.

J. Benovic, J. Gomez, 1992, International review of cytology.

Internalization of the Human Nicotinic Acid Receptor GPR109A Is Regulated by Gi, GRK2, and Arrestin3*

J. Benovic, Yaping Zhang, Ying Shi, 2010, The Journal of Biological Chemistry.

The determination of the free magnesium level in the human red blood cell by 31P NMR.

J. Benovic, R. Gupta, Z. B. Rose, 1978, The Journal of biological chemistry.

G Protein-coupled Receptor Kinase 5 Phosphorylates Nucleophosmin and Regulates Cell Sensitivity to Polo-like Kinase 1 Inhibition*

J. Benovic, Rouzbeh Mashayekhi, C. H. So, 2012, The Journal of Biological Chemistry.

Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms *

J. Benovic, P. Witt-Enderby, R. Pals-Rylaarsdam, 1995, The Journal of Biological Chemistry.

Interleukins impair beta-adrenergic receptor adenylate cyclase (beta AR-AC) system function in human airway epithelial cells.

S. Kelsen, J. Benovic, O. Anakwe, 1995, Chest.

Mechanisms of acute desensitization of the beta2AR-adenylyl cyclase pathway in human airway smooth muscle.

J. Benovic, R. Panettieri, R. Penn, 1998, American journal of respiratory cell and molecular biology.

Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle.

C. Billington, I. Hall, S. Mundell, 1999, American journal of respiratory cell and molecular biology.

Pharmacological inhibition of protein kinases in intact cells: antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness.

J. Benovic, R. Panettieri, A. Pronin, 1999, The Journal of pharmacology and experimental therapeutics.

Binding and Phosphorylation of Tubulin by G Protein-coupled Receptor Kinases*

C. Carman, J. Benovic, T. Som, 1998, The Journal of Biological Chemistry.

Identification and Characterization of Distinct C-Terminal Domains of the Human Hydroxycarboxylic Acid Receptor-2 That Are Essential for Receptor Export, Constitutive Activity, Desensitization, and Internalization

J. Benovic, Qi Zhou, Ying Shi, 2012, Molecular Pharmacology.

Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.

M. Caron, R. Lefkowitz, J. Benovic, 1986, Nature.

G-protein-coupled receptor kinases.

K. Palczewski, J. Benovic, Krzvsztof Palczewskl, 1991, Trends in biochemical sciences.

Arrestin-rhodopsin interaction. Multi-site binding delineated by peptide inhibition.

H. Hamm, J. Benovic, V. Gurevich, 1994, The Journal of biological chemistry.

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor.

J. Benovic, J. Keen, F. Santini, 1996, Nature.

Visualization of Agonist-induced Sequestration and Down-regulation of a Green Fluorescent Protein-tagged β2-Adrenergic Receptor*

J. Benovic, R. Penn, L. Kallal, 1998, The Journal of Biological Chemistry.

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

S. Mundell, J. Benovic, Jiansong Luo, 2005, Blood.

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

S. Mundell, J. Benovic, Jiansong Luo, 2005, Blood.

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.

J. Benovic, R. Penn, G. Kong, 1994, The Journal of biological chemistry.

Internalization of the m2 Muscarinic Acetylcholine Receptor

J. Benovic, V. Gurevich, R. Pals-Rylaarsdam, 1997, The Journal of Biological Chemistry.

Mutation of Individual Serine Residues in the C-terminal Tail of the Lutropin/Choriogonadotropin Receptor Reveal Distinct Structural Requirements for Agonist-induced Uncoupling and Agonist-induced Internalization*

J. Benovic, M. Ascoli, K. Nakamura, 1998, The Journal of Biological Chemistry.

Agonist-Receptor-Arrestin, an Alternative Ternary Complex with High Agonist Affinity*

J L Benovic, J. Benovic, V. Gurevich, 1997, The Journal of Biological Chemistry.

Control of the Cardiac Muscarinic K+ Channel by β-Arrestin 2*

M. Boyett, J. Benovic, T. Haga, 2001, The Journal of Biological Chemistry.

Arrestin Specificity for G Protein-coupled Receptors in Human Airway Smooth Muscle* 210

S. Mundell, J. Benovic, R. Panettieri, 2001, The Journal of Biological Chemistry.

Identification of Gβγ Binding Sites in the Third Intracellular Loop of the M3-muscarinic Receptor and Their Role in Receptor Regulation*

J. Benovic, Guangyu Wu, J. Hildebrandt, 2000, The Journal of Biological Chemistry.

A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes.

K. Palczewski, M. Hunzicker-Dunn, J. Banga, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Molecular events associated with the regulation of signaling by M2 muscarinic receptors.

A. G. Roseberry, J. Benovic, M. Bünemann, 1999, Life sciences.

Characterization of Dominant Negative Arrestins That Inhibit β2-Adrenergic Receptor Internalization by Distinct Mechanisms*

J. Benovic, M. Orsini, 1998, The Journal of Biological Chemistry.

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase.

J. Benovic, C. Kim, R. Richardson, 1993, The Journal of biological chemistry.

Polypeptide variants of beta-arrestin and arrestin3.

C. Sanders, J. Benovic, V. Gurevich, 1993, The Journal of biological chemistry.

Visual Arrestin Binding to Rhodopsin

J. Benovic, V. Gurevich, Jeffrey L. Benovic, 1995, The Journal of Biological Chemistry.

Mechanism of phosphorylation-recognition by visual arrestin and the transition of arrestin into a high affinity binding state.

J. Benovic, V. Gurevich, 1997, Molecular pharmacology.

Arrestin with a single amino acid substitution quenches light-activated rhodopsin in a phosphorylation-independent fashion.

P. Detwiler, J. Benovic, V. Gurevich, 1997, Biochemistry.

Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.

R. Dror, B. Turk, K. Chung, 2020, Molecular cell.

Selective recruitment of arrestin-3 to clathrin coated pits upon stimulation of G protein-coupled receptors.

J. Benovic, J. Keen, F. Santini, 2000, Journal of cell science.

Interaction of Arrestins with Intracellular Domains of Muscarinic and α2-Adrenergic Receptors*

J. Benovic, J. Krupnick, S. Lanier, 1997, The Journal of Biological Chemistry.

Structure and Function of the Third Intracellular Loop of the 5‐Hydroxytryptamine2A Receptor: The Third Intracellular Loop Is α‐Helical and Binds Purified Arrestins

B. Roth, W. Kroeze, J. Benovic, 1999, Journal of neurochemistry.

U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation.

J. Benovic, J. Li, L. Liu-Chen, 1999, The Journal of biological chemistry.

U50,488H-induced Internalization of the Human κ Opioid Receptor Involves a β-Arrestin- and Dynamin-dependent Mechanism

J. Benovic, Jian-guo Li, L. Liu-Chen, 1999, The Journal of Biological Chemistry.

Mechanism of Quenching of Phototransduction

J. Benovic, V. Gurevich, J. Krupnick, 1997, The Journal of Biological Chemistry.

Mapping the Arrestin-Receptor Interface

J. Benovic, V. Gurevich, S. A. Vishnivetskiy, 2004, Journal of Biological Chemistry.

Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways.

D. Sibley, M. Caron, R. Lefkowitz, 1988, Endocrine reviews.

Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase.

M. Caron, K. Palczewski, R. Lefkowitz, 1991, Biochemistry.

CHAPTER 13 – Structure and Function of Adrenergic Receptors: Models for Understanding G Protein-Coupled Receptors

M. Caron, H. Dohlman, B. Kobilka, 1990 .

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma

A. Aplin, J. Benovic, P. Wedegaertner, 2017, Molecular Cancer Research.

The mammalian beta 2-adrenergic receptor: purification and characterization.

M. Caron, R. Lefkowitz, J. Benovic, 1984, Biochemistry.

Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation.

J. Benovic, J. Li, L. Liu-Chen, 2000, Molecular pharmacology.

Title Structure and Function of the Third Intracellular Loop of the 5-Hydroxytryptamine 2 A Receptor : The Third Intracellular Loop Is α-Helical and Binds Purified

B. Roth, W. Kroeze, J. Benovic, 1999 .

Arrestin/Clathrin Interaction

J. Benovic, J. Keen, J. Krupnick, 1997, The Journal of Biological Chemistry.

c‐Src, Insulin‐Like Growth Factor I Receptor, G‐Protein‐Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes

Renato V Iozzo, Lucia R Languino, R. Iozzo, 2017, Journal of cellular biochemistry.

G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression.

J. Benovic, M. D. Meek, S. Ferguson, 2000, Hypertension.

G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

J. Benovic, N. Parameswaran, Jiansong Luo, 2009, The Biochemical journal.

G-protein-coupled receptor kinase activity is increased in hypertension.

J. Benovic, R. Feldman, R. Gros, 1997, The Journal of clinical investigation.

Phenylalanine 193 in Extracellular Loop 2 of the β2-Adrenergic Receptor Coordinates β-Arrestin Interaction

J. Benovic, A. Inoue, Michael Ippolito, 2021, Molecular Pharmacology.

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

A. Aplin, T. Charpentier, J. Benovic, 2018, Molecular Cancer Research.

MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation.

J. Benovic, A. Eszterhas, R. Panettieri, 1999, American journal of physiology. Lung cellular and molecular physiology.

Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin.

A. Gomes, J. Benovic, You-Me Kim, 2003, Biochemistry.

Molecular Basis for Subtype-specific Desensitization of Inhibitory Adenosine Receptors

T. Palmer, G. Stiles, J. Benovic, 1996, The Journal of Biological Chemistry.

A new key in breast cancer metastasis.

J. Benovic, A. Marchese, 2004, Cancer cell.

G protein–coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor–promoted centrosomal separation

J. Benovic, Jiansong Luo, Allison M. Michal, 2013, Molecular biology of the cell.

Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.

J. Benovic, M. Ascoli, K. Nakamura, 1999, Molecular endocrinology.

Ubiquitination of G-protein-coupled receptors.

J. Benovic, A. Marchese, 2004, Methods in molecular biology.

Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors.

J. Benovic, S. Sulon, 2021, Current opinion in endocrine and metabolic research.

Consequence of the tumor-associated conversion to cyclin D1b

S. Tomlins, F. Feng, W. Koch, 2015, EMBO molecular medicine.

Regulation of heterotrimeric G protein signaling in airway smooth muscle.

J. Benovic, R. Penn, 2008, Proceedings of the American Thoracic Society.

Arrestin function in G protein‐coupled receptor endocytosis requires phosphoinositide binding

J. Falck, J. Benovic, I. Gaidarov, 1999, The EMBO journal.

Comparison ofR-, S-, andRS-albuterol interaction with human β1 and β2-adrenergic receptors

J. Benovic, T. Frielle, R. Penn, 1996 .

A technique to harvest viable tracheobronchial epithelial cells from living human donors.

S. Kelsen, J. Benovic, S. Zhou, 1992, American journal of respiratory cell and molecular biology.

Bimodal Regulation of the Human H1 Histamine Receptor by G Protein-coupled Receptor Kinase 2*

J. Benovic, Jiansong Luo, R. Penn, 2005, Journal of Biological Chemistry.

Mechanism of beta-adrenergic receptor kinase activation by G proteins.

J. Benovic, C. M. Kim, S. Dion, 1993, The Journal of biological chemistry.

Molecular and functional characterization of adipokinetic hormone receptor and its peptide ligands in Bombyx mori

J. Benovic, N. Zhou, Jiansong Luo, 2009, FEBS letters.

Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death

J. Benovic, V. Gurevich, W. Cleghorn, 2013, Cell Death and Differentiation.

β -arrestin1 interacts with the G protein subunits β 1 γ 2 and promotes β 1 γ 2-dependent Akt signaling for NF- κ B activation

J. Benovic, R. Ye, Ming Yang, 2009 .

Novel β2-adrenergic receptor signaling pathways

J. Benovic, 2002 .

Differential Roles of Arrestin-2 Interaction with Clathrin and Adaptor Protein 2 in G Protein-coupled Receptor Trafficking*

J. Benovic, You-Me Kim, 2002, The Journal of Biological Chemistry.

Arrestin2 expression selectively increases during neural differentiation

J. Benovic, V. Gurevich, E. Gurevich, 2004, Journal of neurochemistry.

Dual Regulation of EDG1/S1P1 Receptor Phosphorylation and Internalization by Protein Kinase C and G-protein-coupled Receptor Kinase 2*

T. Palmer, S. Cook, J. Benovic, 2002, The Journal of Biological Chemistry.

Phosphorylation-Independent Desensitization of G Protein-Coupled Receptors?

J. Benovic, C. Pao, 2002, Science's STKE.

Historical Perspective of the G Protein-Coupled Receptor Kinase Family

J. Benovic, 2021, Cells.

Arresting Developments in Biased Signaling.

J. Benovic, A. Bhardwaj, Sungsoo M. Yoo, 2020, Trends in pharmacological sciences.

Biased agonism at β-adrenergic receptors.

J. Benovic, Michael Ippolito, 2020, Cellular signalling.

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling

W. Koch, J. Benovic, D. Tilley, 2018, Theranostics.

G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin

J. Benovic, Jiansong Luo, J. Busillo, 2017, Molecular Pharmacology.

Identification of phosphorylation sites in the COOH‐terminal tail of the μ‐opioid receptor

S. Oldfield, A. Tobin, J. Benovic, 2013, Journal of neurochemistry.

Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase.

G. Stiles, J. Benovic, V. Ramkumar, 1993, Biochimica et biophysica acta.

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Brian K. Kobilka, Jeffrey L. Benovic, Henrik G. Dohlman, 1986, Nature.

Synthetic peptides of the hamster P2-adrenoceptor as substrates and inhibitors of the 3-adrenoceptor kinase

M. Caron, H. Dohlman, R. Lefkowitz, 2006 .

Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase.

M. Caron, H. Dohlman, R. Lefkowitz, 1990, British journal of clinical pharmacology.

The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.

M. Caron, R. Lefkowitz, J. Benovic, 1988, Advances in experimental medicine and biology.

f1-ADRENERGIC RECEPTORS

M. Caron, J. Benovic, M. Bouvier, 1988 .

Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains.

M. Caron, R. Lefkowitz, J. Benovic, 1984, The Journal of biological chemistry.

Regulation of G Protein-coupled Receptor Kinases by Caveolin*

C. Carman, M. Lisanti, J. Benovic, 1999, The Journal of Biological Chemistry.

Enhanced expression of G protein‐coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist‐induced desensitization

S. Mundell, J. Benovic, J. Luty, 1998, British journal of pharmacology.

The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by Phospholipids (*)

J. Benovic, Y. Liu, A. Ruoho, 1995, The Journal of Biological Chemistry.

High affinity binding of beta-adrenergic receptor kinase to microsomal membranes. Modulation of the activity of bound kinase by heterotrimeric G protein activation.

I. Garcı́a-Higuera, J. Benovic, C. Murga, 1996, The Journal of biological chemistry.

Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases.

J. Benovic, A. Pronin, V. Slepak, 1998, Biochemistry.

A dominant negative mutant of the G protein-coupled receptor kinase 2 selectively attenuates adenosine A2 receptor desensitization.

S. Mundell, J. Benovic, E. Kelly, 1997, Molecular pharmacology.

Altered Activity of Palmitoylation-deficient and Isoprenylated Forms of the G Protein-coupled Receptor Kinase GRK6*

J. Benovic, R. Loudon, 1997, The Journal of Biological Chemistry.

Differential interaction of GRK2 with members of the Gαqfamily

C. Carman, J. Benovic, P. Wedegaertner, 2003 .

Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation.

J. Benovic, C. Pao, B. Barker, 2009, Biochemistry.

Arrestin isoforms dictate differential kinetics of A2B adenosine receptor trafficking.

S. Mundell, J. Benovic, E. Kelly, 2000, Biochemistry.

Regulation of Arrestin-3 Phosphorylation by Casein Kinase II*

M. Caron, J. Benovic, You-Me Kim, 2002, The Journal of Biological Chemistry.

Biased signaling of the proton‐sensing receptor OGR1 by benzodiazepines

Bin Wang, B. Roth, W. Kroeze, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.

M. Caron, G. Milligan, J. Benovic, 1987, The Journal of biological chemistry.

Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.

J. Benovic, C. M. Kim, J. Onorato, 1993, Receptor.

Arrestin-2 and G Protein-coupled Receptor Kinase 5 Interact with NFκB1 p105 and Negatively Regulate Lipopolysaccharide-stimulated ERK1/2 Activation in Macrophages*

J. Benovic, S. Ley, N. Parameswaran, 2006, Journal of Biological Chemistry.

Differentially regulated expression of the G-protein-coupled receptor kinases, betaARK and GRK6, during myelomonocytic cell development in vitro.

J. Benovic, B. Perussia, R. Loudon, 1996, Blood.

G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein βγ Subunits*

J. Benovic, S. Debburman, M. Hosey, 1996, The Journal of Biological Chemistry.

G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits.

J. Benovic, S. Debburman, M. Hosey, 1996, The Journal of biological chemistry.

Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.

M. Caron, C. Carman, J. Benovic, 2000, The Journal of biological chemistry.

Lipid-mediated Regulation of G Protein-coupled Receptor Kinases 2 and 3 (*)

J. Benovic, J. Lomasney, S. Debburman, 1995, The Journal of Biological Chemistry.

G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.

J. Benovic, A. Pronin, P. Wedegaertner, 2003, The Journal of biological chemistry.

G‐Protein–coupled receptor kinase expression in hypertension

J. Benovic, D. Kelvin, R. Feldman, 1999, Clinical pharmacology and therapeutics.

Development of a Yeast Bioassay to Characterize G Protein-coupled Receptor Kinases

J. Benovic, M. Pausch, B. Noble, 2003, Journal of Biological Chemistry.

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.

J. Benovic, P. Kunapuli, M. Hosey, 1994, The Journal of biological chemistry.

G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells.

A. Malik, J. Benovic, R. Sandoval, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Agonist-dependent Phosphorylation and Desensitization of the Rat A3 Adenosine Receptor

T. Palmer, G. Stiles, J. Benovic, 1995, The Journal of Biological Chemistry.

Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity.

J. Benovic, V. Gurevich, C. M. Kim, 1994, The Journal of biological chemistry.

Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor.

J. Benovic, V. Gurevich, C. M. Kim, 1993, The Journal of biological chemistry.

The Third Intracellular Loop of α2-Adrenergic Receptors Determines Subtype Specificity of Arrestin Interaction*

J. Benovic, V. Gurevich, Jessica L. DeGraff, 2002, The Journal of Biological Chemistry.

Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity.

M. Caron, R. Lefkowitz, J. Benovic, 1983, Biochemical and biophysical research communications.

Kinase 1 Inhibition Regulates Cell Sensitivity to Polo-like Phosphorylates Nucleophosmin and G Protein-coupled Receptor Kinase 5 Cell

J. Benovic, Rouzbeh Mashayekhi, Allison M. Michal, 2012 .

cDNA cloning and chromosomal localization of the human α‐adrenergic receptor kinase

M. Caron, C. Croce, K. Huebner, 1991, FEBS letters.

Purification and characterization of the beta-adrenergic receptor kinase.

M. Caron, R. Lefkowitz, J. Benovic, 1987, The Journal of biological chemistry.

[29] Arrestin: Mutagenesis, expression, purification, and functional characterization

J. Benovic, V. Gurevich, 2000 .

Regulation of beta-agonist- and prostaglandin E2-mediated adenylyl cyclase activity in human airway epithelial cells.

S. Kelsen, J. Benovic, R. Penn, 1994, American journal of respiratory cell and molecular biology.

Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine.

S. Mundell, J. Benovic, R. Panettieri, 2001, American journal of respiratory cell and molecular biology.

Pepducins as a potential treatment strategy for asthma and COPD.

S. Liggett, J. Benovic, R. Panettieri, 2018, Current opinion in pharmacology.

Chronic effects of catecholamines on the beta 2-adrenoreceptor system in cultured human airway epithelial cells.

S. Kelsen, J. Benovic, R. Penn, 1997, The American journal of physiology.

Effects of inflammation and acute beta-agonist inhalation on beta 2-AR signaling in human airways.

S. Peters, J. Benovic, J. Fish, 1996, The American journal of physiology.

Biological actions of formoterol isomers.

J. Benovic, D. Handley, C. Senanayake, 2002, Pulmonary pharmacology & therapeutics.

G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

J. Benovic, R. Al-awar, W. Steyaert, 2022, The Journal of biological chemistry.

Atomic structure of G protein-coupled receptor kinase 5 (GRK5) reveals distinct structural features novel for GRKs

J. Benovic, A. Bhardwaj, K. Komolov, 2015 .

Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.

J. Benovic, C. M. Kim, S. Dion, 1993, The Journal of biological chemistry.

[28] Purification and characterization of β-adrenergic receptor kinase

J. Benovic, 1991 .

Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.

M. Caron, R. Lefkowitz, J. Benovic, 1987, The Journal of biological chemistry.

Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells.

S. Kelsen, J. Benovic, S. Zhou, 1995, American journal of respiratory and critical care medicine.

β2‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2‐adrenoceptor with possible implications for the treatment of asthma

R. Armen, J. Benovic, S. An, 2022, British journal of pharmacology.

Expression of the beta-adrenergic receptor-adenylylcyclase system in basal and columnar airway epithelial cells.

S. Kelsen, J. Benovic, O. Anakwe, 1994, The American journal of physiology.

Modulation of the Arrestin-Clathrin Interaction in Cells

J. Benovic, J. Keen, F. Santini, 1997, The Journal of Biological Chemistry.

Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking.

J. Benovic, X. Tian, D. S. Kang, 2014, Current opinion in cell biology.

β-Arrestins and G protein-coupled receptor trafficking.

J. Benovic, X. Tian, D. S. Kang, 2013, Methods in enzymology.

Sequestration of a G-protein βγ Subunit or ADP-ribosylation of Rho Can Inhibit Thrombin-induced Activation of Platelet Phosphoinositide 3-Kinases (*)

I. Gout, J. Benovic, R. Wetzker, 1995, The Journal of Biological Chemistry.

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5

R. Dror, K. Chung, G. Skiniotis, 2017, Cell.

G Protein-Coupled Receptor Kinases and Arrestins

J. Benovic, 2004 .

Arrestin/Clathrin Interaction LOCALIZATION OF THE ARRESTIN BINDING LOCUS TO THE CLATHRIN TERMINAL DOMAIN*

J. Benovic, J. Keen, V. Gurevich, 1997 .

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

M. Caron, R. Lefkowitz, M. Lohse, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Stereospecificity of the metal--adenosine 5'-triphosphate complex in reactions of muscle pyruvate kinase.

A. Mildvan, W. Cleland, D. Dunaway-Mariano, 1979, Biochemistry.

Structure and Function of the Third Intracellular Loop of the 5-Hydroxytryptamine 2A Receptor: The Third Intracellular Loop Is a -Helical and Binds Puriﬁed Arrestins

B. Roth, W. Kroeze, J. Benovic, 1999 .

G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4.

J. Benovic, B. Barker, 2011, Biochemistry.

Rapid Agonist-induced Desensitization and Internalization of the A2B Adenosine Receptor Is Mediated by a Serine Residue Close to the COOH Terminus*

S. Mundell, J. Benovic, E. Kelly, 2001, The Journal of Biological Chemistry.

Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3.

T. Palmer, J. Pediani, J. Benovic, 2005, Cellular signalling.

Arrestin: mutagenesis, expression, purification, and functional characterization.

J. Benovic, V. Gurevich, 2000, Methods in enzymology.

Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2.

J. Benovic, D. S. Kang, Ronald C Kern, 2009, Biochemistry.

Magnetic resonance studies of the binding of ATP and cations to human hemoglobin.

J. Benovic, R. Gupta, Z. B. Rose, 1978, The Journal of biological chemistry.

Location of the allosteric site for 2,3-bisphosphoglycerate on human oxy- and deoxyhemoglobin as observed by magnetic resonance spectroscopy.

J. Benovic, R. Gupta, Z. B. Rose, 1979, The Journal of biological chemistry.

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets.

Shuchi Gupta, J. Benovic, L. Brass, 2019, Blood advances.

Modulation by GM1 ganglioside of beta 1-adrenergic receptor-induced cyclic AMP formation in Sf9 cells.

J. Benovic, T. Frielle, R. Ledeen, 1995, Biochimica et biophysica acta.

beta-Arrestin: a protein that regulates beta-adrenergic receptor function.

M. Caron, R. Lefkowitz, M. Lohse, 1990, Science.

Characterization of arrestin expression and function.

S. Mundell, J. Benovic, M. Orsini, 2002, Methods in enzymology.

Regulation of G protein-coupled receptors by agonist-dependent phosphorylation.

M. Caron, R. Lefkowitz, J. Benovic, 1990, Society of General Physiologists series.

The β-Adrenergic Receptor-Coupled Adenylate Cyclase: Reconstitution of the Functional Interactions of the Various Purified Components

M. Caron, R. Lefkowitz, L. Birnbaumer, 1986 .

Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization.

J. Benovic, J. Parent, M. Orsini, 1999, The Journal of biological chemistry.

Analysis of G-protein-coupled receptor kinase RGS homology domains.

J. Benovic, P. Wedegaertner, P. Day, 2004, Methods in enzymology.

Characterization of G protein-coupled receptor kinases.

J. Benovic, A. Pronin, R. Loudon, 2002, Methods in enzymology.

Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases.

J. Benovic, P. Kunapuli, S. Debburman, 1995, Molecular pharmacology.

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.

J. Benovic, R. Loudon, 1994, The Journal of biological chemistry.

Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes.

I. Garcı́a-Higuera, J. Benovic, C. Murga, 1994, The Journal of biological chemistry.

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.

M. Caron, R. Lefkowitz, J. Blank, 1993, The Journal of biological chemistry.

Purification, characterization and reconstitution of the adenylate cyclase-coupled β-adrenergic receptor

B. Strulovici, M. Caron, G. Stiles, 1984 .

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

J. B. Higgins, M. Caron, P. Casey, 1992, Science.

The role of G-protein coupled receptor kinases in the regulation of muscarinic cholinergic receptors.

J. Benovic, S. Debburman, R. Richardson, 1996, Progress in brain research.

Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but β-arrestin-independent pathways.

J. Benovic, Xiaoyan Deng, N. Zhou, 2010, Biochemistry.

Identification and chromosomal localization of a processed pseudogene of human GRK6.

J. Benovic, A. Gagnon, 1997, Gene.

Arrestin-2 Interacts with the Ubiquitin-Protein Isopeptide Ligase Atrophin-interacting Protein 4 and Mediates Endosomal Sorting of the Chemokine Receptor CXCR4*

J. Benovic, A. Marchese, J. Trejo, 2007, Journal of Biological Chemistry.

Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors.

N. Aiyar, J. Benovic, P. Nambi, 2000, European journal of pharmacology.

Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2.

D. Sibley, M. Caron, R. Lefkowitz, 1988, The Journal of biological chemistry.

Beta-adrenergic receptor kinase: primary structure delineates a multigene family.

M. Caron, R. Lefkowitz, J. Benovic, 1989, Science.

Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase

B. Strulovici, M. Caron, R. Lefkowitz, 1983, Nature.

Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.

R. Lefkowitz, W. Koch, J. Benovic, 2000, Circulation research.

Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.

J. Benovic, P. Wedegaertner, Xiaoshan Jiang, 2007, Molecular biology of the cell.

Fluorescence microscopy techniques for the study of G protein-coupled receptor trafficking.

J. Benovic, L. Kallal, 2002, Methods in enzymology.

Hypergastrinemia, a clue leading to the identification of an atypical form of diabetes mellitus type 2.

J. Benovic, W. Steyaert, P. Coucke, 2022, Clinica chimica acta; international journal of clinical chemistry.

Inhibition of fi-adrenergic receptor kinase prevents rapid homologous desensitization of f 82-adrenergic receptors ( A 431 celis / permeabilization / receptor phosphorylation / heparin )

M. Caron, R. Lefkowitz, M. Lohse, 2022 .

Deletion of the distal COOH‐terminus of the A2B adenosine receptor switches internalization to an arrestin‐ and clathrin‐independent pathway and inhibits recycling

S. Mundell, T. Palmer, J. Benovic, 2010, British journal of pharmacology.

Comparison of R-, S-, and RS-albuterol interaction with human beta 1- and beta 2-adrenergic receptors.

J. Benovic, T. Frielle, R. Penn, 1996, Clinical reviews in allergy & immunology.

Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system.

B. Strulovici, C. Strader, M. Caron, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Substrate labeled fluorescent immunoassay for quinidine

J. Burd, J. Benovic, R. T. Buckler, 1981 .

Regulation of CXCR4 signaling.

J. Benovic, J. Busillo, Jeffrey L Benovic, 2007, Biochimica et biophysica acta.

Phosphorylation of the N-Formyl Peptide Receptor Carboxyl Terminus by the G Protein-coupled Receptor Kinase, GRK2 (*)

J. Benovic, E. Prossnitz, R. Ye, 1995, The Journal of Biological Chemistry.

Trafficking of the HIV Coreceptor CXCR4

S. Mundell, J. Benovic, J. Parent, 1999, The Journal of Biological Chemistry.

From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins.

J. Benovic, Richard Carr, Jeffrey L Benovic, 2016, Biochemical Society transactions.

Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms

J. Benovic, R. Panettieri, S. An, 2016, Molecular Pharmacology.

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

J. Benovic, J. Keen, F. Santini, 1996, Nature.

Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2*

C. Carman, A. Gilman, J. Benovic, 1999, The Journal of Biological Chemistry.

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the -Adrenergic Receptor (*)

J. Benovic, P. Kunapuli, A. Pronin, 1996, The Journal of Biological Chemistry.

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

M. Caron, R. Lefkowitz, M. Lohse, 1990, The Journal of biological chemistry.

Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein.

M. Caron, R. Lefkowitz, L. Birnbaumer, 1987, Biochemistry.

Magnetic resonance and kinetic studies of the spatial arrangement of phosphoenolpyruvate and chromium (III)-adenosine diphosphate at the catalytic site of pyruvate kinase.

J. Benovic, R. Gupta, 1978, The Journal of biological chemistry.

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

M. Caron, R. Lefkowitz, J. Benovic, 1987, The Journal of biological chemistry.

Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking.

J. Benovic, L. Kallal, 2000, Trends in pharmacological sciences.

Regulation of transmembrane signaling by receptor phosphorylation

D. Sibley, M. Caron, R. Lefkowitz, 1987, Cell.

10 Regulation of Receptor Function

R. Lefkowitz, J. Benovic, 1987 .

β-Adrenergic receptors and rhodopsin: shedding new light on an old subject

M. Caron, B. Kobilka, R. Lefkowitz, 1986 .

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

M. Caron, R. Lefkowitz, J. Benovic, 1986, Nature.

Magnetic resonance studies of the interaction of divalent metal cations with 2,3-bisphosphoglycerate.

J. Benovic, R. Gupta, 1978, Biochemical and biophysical research communications.

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

R. Lefkowitz, L. Birnbaumer, J. Regan, 1986, The Journal of biological chemistry.

Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles.

J. Benovic, R. Cerione, J. Krupinski, 1988, The Journal of biological chemistry.

M3 Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms

Jeffrey L. Benovic, J. Benovic, Jiansong Luo, 2008, Molecular Pharmacology.

Coupling of M2 Muscarinic Receptors to Membrane Ion Channels via Phosphoinositide 3-Kinase γ and Atypical Protein Kinase C*

J. Benovic, Yong-Xiao Wang, M. Kotlikoff, 1999, The Journal of Biological Chemistry.

Arrestin-independent Internalization of the m1, m3, and m4 Subtypes of Muscarinic Cholinergic Receptors*

J. Benovic, M. Hosey, Katharine B. Lee, 1998, The Journal of Biological Chemistry.

Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase.

M. Caron, R. Lefkowitz, J. Benovic, 1989, Biochemistry.

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

M. Caron, R. Lefkowitz, L. Birnbaumer, 1985, The Journal of biological chemistry.

Regulation of receptor trafficking by GRKs and arrestins.

S. Milano, J. Benovic, Jeffrey L Benovic, 2007, Annual review of physiology.

The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs*

J. Benovic, D. Lodowski, V. Tesmer, 2006, Journal of Biological Chemistry.

Suppression of G-protein–Coupled Receptor Kinase 3 Expression Is a Feature of Classical GBM That Is Required for Maximal Growth

P. Mischel, D. Piwnica-Worms, S. Dahiya, 2011, Molecular Cancer Research.

GRK expression in GBM

P. Mischel, D. Piwnica-Worms, S. Dahiya, 2011 .

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

J L Benovic, M. Caron, R. Lefkowitz, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

M. Caron, R. Lefkowitz, J. Benovic, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling*

J. Benovic, O. Meucci, M. Bouvier, 2010, The Journal of Biological Chemistry.

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

J. Benovic, J. Gomez, 1993, The Journal of biological chemistry.

G protein-coupled receptor kinases: Past, present and future.

J. Benovic, K. Komolov, 2018, Cellular signalling.

Regulation of G Protein-coupled Receptor Kinases by Calmodulin and Localization of the Calmodulin Binding Domain*

J. Benovic, A. Pronin, V. Slepak, 1997, The Journal of Biological Chemistry.

Five Members of a Novel Ca2+-binding Protein (CABP) Subfamily with Similarity to Calmodulin*

C. Verlinde, K. Palczewski, H. Erdjument-Bromage, 2000, The Journal of Biological Chemistry.

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.

M. Caron, N. Copeland, D. Gilbert, 1991, The Journal of biological chemistry.

Regulation of G protein-coupled receptors by receptor kinases and arrestins.

J. Benovic, R. Sterne‐Marr, 1995, Vitamins and hormones.

CHAPTER 332 – Signaling Down the Endocytic Pathway

J. Benovic, J. Keen, 2003 .

Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle.

J. Benovic, A. Eszterhas, R. Panettieri, 2000, American journal of respiratory cell and molecular biology.

beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.

M. Caron, R. Lefkowitz, J. Benovic, 1988, The Journal of biological chemistry.

The Dynamin-dependent, Arrestin-independent Internalization of 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptors Reveals Differential Sorting of Arrestins and 5-HT2A Receptors during Endocytosis* 210

B. Roth, J. Benovic, J. A. Gray, 2001, The Journal of Biological Chemistry.

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

M. Caron, R. Lefkowitz, J. Benovic, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of adenylyl cyclase-coupled beta-adrenergic receptors.

M. Caron, R. Lefkowitz, J. Benovic, 1988, Annual review of cell biology.

Inhibition of the beta-adrenergic receptor kinase by polyanions.

M. Caron, R. Lefkowitz, J. Benovic, 1989, The Journal of biological chemistry.

Non-visual Arrestins Are Constitutively Associated with the Centrosome and Regulate Centrosome Function*

J. Benovic, V. Gurevich, H. Shankar, 2010, The Journal of Biological Chemistry.

Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases*♦

J. Benovic, A. Bhardwaj, K. Komolov, 2015, The Journal of Biological Chemistry.

beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation.

J. Benovic, R. Ye, Ming Yang, 2009, The Biochemical journal.

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans

W. Wetsel, J. Benovic, R. Nass, 2017, The Journal of Biological Chemistry.

Arrestin/Clathrin Interaction

J. Benovic, J. Keen, V. Gurevich, 1997, The Journal of Biological Chemistry.

Nonvisual Arrestin Oligomerization and Cellular Localization Are Regulated by Inositol Hexakisphosphate Binding*

C. Brenner, S. Milano, J. Benovic, 2006, Journal of Biological Chemistry.

Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development

J. Benovic, V. Gurevich, E. Gurevich, 2002, Neuroscience.

β-arrestins and G protein-coupled receptor trafficking.

J. Benovic, X. Tian, D. S. Kang, 2014, Handbook of experimental pharmacology.

G Protein-coupled Receptor Kinase Interaction with Hsp90 Mediates Kinase Maturation*

J. Benovic, Jiansong Luo, 2003, Journal of Biological Chemistry.

Safe use of the CXCR4 inhibitor ALX40-4C in humans.

R. Doms, J. Benovic, B. Doranz, 2001, AIDS research and human retroviruses.

Role of the Differentially Spliced Carboxyl Terminus in Thromboxane A2 Receptor Trafficking

J. Benovic, J. Parent, P. Labrecque, 2001, The Journal of Biological Chemistry.

G-protein-coupled receptors: turn-ons and turn-offs

C. Carman, J. Benovic, 1998, Current Opinion in Neurobiology.

Haloperidol and Clozapine Differentially Affect the Expression of Arrestins, Receptor Kinases, and Extracellular Signal-Regulated Kinase Activation

K. Dalby, J. Benovic, V. Gurevich, 2008, Journal of Pharmacology and Experimental Therapeutics.

G Protein-coupled Receptor Kinase 2/Gαq/11Interaction: A NOVEL SURFACE ON A REGULATOR OF G PROTEIN SIGNALING HOMOLOGY DOMAIN FOR BINDING Gα SUBUNITS

J. Benovic, A. Pronin, P. Wedegaertner, 2003 .

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

J. Benovic, P. Kunapuli, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The state of GPCR research in 2004 ( 20 Questions )

J. Benovic, 2004 .

Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.

J. Benovic, T. Reisine, K. Yasuda, 1994, The Journal of pharmacology and experimental therapeutics.

Immunoassayfor Theophyllinein Serum

J. Burd, J. Benovic, Thomas M. Li, 1981 .

Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.

D. Sibley, E. Neer, M. Caron, 1984, The Journal of biological chemistry.

Regulation of G protein-coupled receptor kinases.

J L Benovic, J. Benovic, A. Pronin, 2000, Trends in cardiovascular medicine.

Selective Reduction in A2 Adenosine Receptor Desensitization Following Antisense‐Induced Suppression of G Protein‐Coupled Receptor Kinase 2 Expression

J M Willets, J L Parent, J L Benovic, 1999, Journal of neurochemistry.

Synucleins Are a Novel Class of Substrates for G Protein-coupled Receptor Kinases*

J. Benovic, A. Pronin, A. Morris, 2000, The Journal of Biological Chemistry.

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.

J. Benovic, A. Marchese, H. Stenmark, 2003, Developmental cell.

Novel beta2-adrenergic receptor signaling pathways.

J. Benovic, 2002, Journal of Allergy and Clinical Immunology.

G Protein-coupled Receptor Kinase 5 Is Localized to Centrosomes and Regulates Cell Cycle Progression*

J. Benovic, T. Yen, Rouzbeh Mashayekhi, 2012, The Journal of Biological Chemistry.

Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2*

M. Caron, C. Carman, J. Benovic, 2000, The Journal of Biological Chemistry.

Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors.

M. Caron, B. Kobilka, R. Lefkowitz, 1988, Journal of receptor research.

Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine2A receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells

B. Roth, S. Hufeisen, D. Sheffler, 2001 .

Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells.

B. Roth, S. Hufeisen, D. Sheffler, 2001, Molecular pharmacology.

Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

J. Benovic, P. Kunapuli, V. Gurevich, 1994, The Journal of biological chemistry.

Signaling and Phosphorylation-impaired Mutants of the Rat Follitropin Receptor Reveal an Activation- and Phosphorylation-independent but Arrestin-dependent Pathway for Internalization*

J. Benovic, M. Ascoli, J. Krupnick, 1998, The Journal of Biological Chemistry.

The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system.

M. Caron, R. Lefkowitz, L. Birnbaumer, 1984, Biochemistry.

Regulation of Cysteinyl Leukotriene Type 1 Receptor Internalization and Signaling*

C. Billington, T. Kohout, J. Benovic, 2005, Journal of Biological Chemistry.

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

J L Benovic, M. Caron, H. Dohlman, 1987, The Journal of biological chemistry.

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor*

J L Benovic, J. Benovic, A W Gagnon, 1998, The Journal of Biological Chemistry.

Selective Regulation of Endogenous G Protein-coupled Receptors by Arrestins in HEK293 Cells*

S. Mundell, J. Benovic, 2000, The Journal of Biological Chemistry.

Arrestin Interactions with G Protein-coupled Receptors

J L Benovic, J. Benovic, V. Gurevich, 1995, The Journal of Biological Chemistry.

Differential expression of arrestins is a predictor of breast cancer progression and survival

Amy R. Peck, H. Rui, D. Rimm, 2011, Breast Cancer Research and Treatment.

Purification and characterization of beta-adrenergic receptor kinase.

J. Benovic, 1987, Methods in enzymology.

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

M. Caron, R. Lefkowitz, J. Benovic, 1985, The Journal of biological chemistry.

Beta-adrenergic receptor kinase-1 acutely regulates PTH/PTHrP receptor signalling in human osteoblastlike cells.

J. Benovic, A. Tashjian, G. Kong, 1997, Cellular signalling.

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

J L Benovic, D. Sibley, R. Lefkowitz, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal Sorting*

J. Benovic, A. Marchese, 2001, The Journal of Biological Chemistry.

Cell-free expression of visual arrestin. Truncation mutagenesis identifies multiple domains involved in rhodopsin interaction.

J L Benovic, J. Benovic, V. Gurevich, 1992, The Journal of biological chemistry.

Structural Domains Required for Caenorhabditis elegans G Protein-coupled Receptor Kinase 2 (GRK-2) Function in Vivo*

D. M. Ferkey, J. Benovic, Jianjun Wang, 2012, The Journal of Biological Chemistry.

β-arrestin–biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction

J. Cheung, W. Koch, J. Benovic, 2016, Proceedings of the National Academy of Sciences.

Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization

A. Alcamí, J. Benovic, M. Thelen, 2015, Nature Communications.

A Predicted Amphipathic Helix Mediates Plasma Membrane Localization of GRK5*

D. Evanko, J. Benovic, A. Pronin, 2004, Journal of Biological Chemistry.

Serum theophylline determination by fluorescence polarization immunoassay utilizing an umbelliferone derivative as a fluorescent label.

J. Burd, J. Benovic, T. M. Li, 1981, Analytical Biochemistry.

Internalization of the TXA2 Receptor α and β Isoforms

J. Benovic, J. Parent, M. Orsini, 1999, The Journal of Biological Chemistry.

Structural Basis for β-Arrestins in GPCR Trafficking

J. Benovic, D. S. Kang, Sungsoo M. Yoo, 2017 .

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking*

M. von Zastrow, J. Benovic, M. Puthenveedu, 2009, The Journal of Biological Chemistry.

Caenorhabditus elegans Arrestin Regulates Neural G Protein Signaling and Olfactory Adaptation and Recovery*

J. Benovic, You-Me Kim, H. A. Hess, 2005, Journal of Biological Chemistry.

Role of Arrestins in Endocytosis and Signaling of α2-Adrenergic Receptor Subtypes*

J. Benovic, M. Orsini, A. Gagnon, 1999, Journal of Biological Chemistry.

Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin.

J L Benovic, J. Benovic, V. Gurevich, 1993, The Journal of biological chemistry.

Characterization of the GRK2 Binding Site of Gαq*

J. Benovic, P. Wedegaertner, J. Tesmer, 2004, Journal of Biological Chemistry.

Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia

J. Benovic, J. Joyce, V. Gurevich, 2008, Neurobiology of Aging.

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists*♦

Michel Bouvier, Reynold A Panettieri, B. Kobilka, 2014, The Journal of Biological Chemistry.

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor*

M. von Zastrow, Shanna L. Bowman, J. Benovic, 2016, The Journal of Biological Chemistry.

Identification of βArrestin2 as a corepressor of androgen receptor signaling in prostate cancer

J. Benovic, Y. Daaka, Z. Nie, 2009, Proceedings of the National Academy of Sciences.

Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis.

C. Brenner, S. Milano, H. C. Pace, 2002, Biochemistry.

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.

J. Benovic, M. Bouvier, A. Shukla, 2018, Trends in biochemical sciences.

Regulation of the G Protein-coupled Receptor Kinase GRK5 by Protein Kinase C*

J. Benovic, A. Pronin, 1997, The Journal of Biological Chemistry.

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

J. Benovic, M. Bouvier, V. Lukashova, 2013, Proceedings of the National Academy of Sciences.

Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4

J. Benovic, Jiansong Luo, Francesco De Pascali, 2021, The Journal of biological chemistry.

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder

J. Benovic, V. Gurevich, E. Gurevich, 2011, Neurobiology of Disease.

Characterization of the GRK2 binding site of Galphaq.

J. Benovic, P. Wedegaertner, J. Tesmer, 2004, The Journal of biological chemistry.

Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.

E. Bézard, G. Fisone, B. Bioulac, 2005, Parkinsonism & related disorders.

Characterization of G protein-coupled receptor regulation in antisense mRNA-expressing cells with reduced arrestin levels.

S. Mundell, J. Benovic, R. Loudon, 1999, Biochemistry.

Altered expression and subcellular distribution of GRK subtypes in the dopamine‐depleted rat basal ganglia is not normalized by l‐DOPA treatment

J. Benovic, V. Gurevich, E. Gurevich, 2008, Journal of neurochemistry.

Ischemic Inactivation of G Protein–Coupled Receptor Kinase and Altered Desensitization of Canine Cardiac &bgr;-Adrenergic Receptors

M. Zhang, J. Benovic, D. Kem, 2000, Circulation.

Agonist-dependent phosphorylation of the α2-adrenergic receptor by the β-adrenergic receptor kinase

M. Caron, R. Lefkowitz, J. Regan, 1987 .

Structural biology: Arresting developments in receptor signalling

J. Benovic, 2015, Nature.

1 Structural and Functional Analysis of a β 2-Adrenergic Receptor Complex with GRK 5

R. Dror, K. Chung, G. Skiniotis, 2018 .

JPET #131987 Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and ERK activation

K. Dalby, J. Benovic, V. Gurevich, 2007 .

Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation.

J. Benovic, J. Hildebrandt, G. Bogatkevich, 2000, The Journal of biological chemistry.

Receptor docking sites for G-protein betagamma subunits. Implications for signal regulation.

J. Benovic, J. Hildebrandt, S. Lanier, 1998, Journal of Biological Chemistry.

Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a G_i Protein/ROCK/PKD-Sensitive Manner

J. Cheung, W. Koch, J. Benovic, 2022, Cardiovascular Drugs and Therapy.

Role of arrestins in G-protein-coupled receptor endocytosis.

J. Benovic, J. Keen, F. Santini, 1998, Advances in pharmacology.

Structure/Function Analysis of α2A-Adrenergic Receptor Interaction with G Protein-coupledReceptor Kinase 2*

J. Benovic, C. Pao, 2005, Journal of Biological Chemistry.

Structure-Function Analysis of G Protein-coupled Receptor Kinase-5

C. Carman, J. Benovic, A. Pronin, 1998, The Journal of Biological Chemistry.

Structure/Function Analysis of 2A-Adrenergic Receptor Interaction with G Protein-coupled Receptor Kinase 2*

J. Benovic, C. Pao, 2005 .

The mammalian beta-adrenergic receptor: structural and functional characterization of the carbohydrate moiety.

M. Caron, R. Lefkowitz, J. Benovic, 1987, Journal of receptor research.

β‐arrestin1 phosphorylation by GRK5 regulates G protein‐independent 5‐HT4 receptor signalling

P. Marin, J. Bockaert, J. Benovic, 2009, The EMBO journal.

Desensitization of the β-Adrenergic Coupled Adenylate Cyclase. The β-Adrenergic Receptor Kinase Phosphorylates Agonist-Occupied Cyclase-Coupled Receptors

M. Caron, R. Lefkowitz, J. Benovic, 1987 .

Electrostatic facilitation of the reaction catalyzed by the manganese-containing and the iron-containing superoxide dismutases.

I. Fridovich, J. Benovic, A. Cudd, 1983, Archives of biochemistry and biophysics.

Purification and characterization of beta-adrenergic receptor kinase.

J. Benovic, 1991, Methods in enzymology.

Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C

M. Caron, R. Lefkowitz, J. Benovic, 1988 .

Differential interaction of GRK2 with members of the G alpha q family.

C. Carman, J. Benovic, P. Wedegaertner, 2003, Biochemistry.

Regulation of G protein-coupled receptor function and expression

J. Benovic, 2000 .

Arrestin and the Multi-PDZ Domain-containing Protein MPZ-1 Interact with Phosphatase and Tensin Homolog (PTEN) and Regulate Caenorhabditis elegans Longevity*♦

J. Benovic, A. Palmitessa, 2010, The Journal of Biological Chemistry.

Regulation of g protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain

J. Benovic, A. Pronin, V. Slepak, 1997 .

Molecular mechanisms of beta-adrenergic receptor desensitization.

D. Sibley, R. Lefkowitz, J. Benovic, 1980, Proceedings of the Western Pharmacology Society.

Arrestin/Clathrin Interaction LOCALIZATION OF THE CLATHRIN BINDING DOMAIN OF NONVISUAL ARRESTINS TO THE CARBOXYL TERMINUS*

J. Benovic, J. Keen, J. Krupnick, 1997 .

Faculty Opinions recommendation of Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

J. Benovic, 2010 .

Mechanisms involved in adrenergic receptor desensitization.

M. Caron, R. Lefkowitz, M. Lohse, 1990, Biochemical Society transactions.

Differentially regulated expression of the G-protein-coupled receptor kinases, betaARK and GRK6, during myelomonocytic cell development in vitro.

J. Benovic, R. Loudon, B. Perussia, 1996, Blood.

G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

J. Benovic, N. Parameswaran, Jiansong Luo, 2009, The Biochemical journal.

Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma

A. Aplin, J. Benovic, Donita C. Brady, 2023, The Journal of biological chemistry.

G-proteins | G Protein-Coupled Receptor Kinases and Arrestins

J. Benovic, V. Gurevich, E. Gurevich, 2021, Encyclopedia of Biological Chemistry III.

G-Protein-Coupled Receptor Kinases and Arrestins

J. Benovic, D. S. Kang, N. Zhukovskaya, 2013 .

Haloperidol and Clozapine Differentially Affect the Expression of Arrestins, Receptor Kinases, and Extracellular Signal-Regulated Kinase Activation

K. Dalby, J. Benovic, V. Gurevich, 2008, Journal of Pharmacology and Experimental Therapeutics.

The determination of the free magnesium level in the human red blood cell by 31P NMR.

J. Benovic, R. Gupta, Z. B. Rose, 1978, The Journal of biological chemistry.

How carvedilol does not activate β2-adrenoceptors

J. Benovic, Seungkirl Ahn, H. Rockman, 2023, Nature Communications.

Identification of a β-arrestin-biased negative allosteric modulator for the β2-adrenergic receptor.

Kyle Z. Rajkowski, R. Armen, J. Benovic, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Molecular biology of adrenergic receptors.

M. Caron, H. Dohlman, B. Kobilka, 1988, Cold Spring Harbor symposia on quantitative biology.

Mapping the Arrestin-Receptor Interface STRUCTURAL ELEMENTS RESPONSIBLE FOR RECEPTOR SPECIFICITY OF ARRESTIN PROTEINS*

J. Benovic, V. Gurevich, M. Hosey, 2003 .

The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes

J. Benovic, Matthew J. Varney, 2024, Pharmacological Reviews.

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder

J. Benovic, V. Gurevich, E. Gurevich, 2011, Neurobiology of Disease.