B. Safer

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THE MECHANISM OF TRANSLATIONAL INHIBITION IN HEMIN-DEFICIENT LYSATES

R. Jagus, B. Safer, A. Konieczny, 1982 .

Mitochondrial-cytosolic interactions in perfused rat heart

B. Safer, D. Subbotin, 1973 .

Transcriptional regulation of E2F-1 and eIF-2 genes by alpha-pal: a potential mechanism for coordinated regulation of protein synthesis, growth, and the cell cycle.

B. Safer, B. Efiok, 2000, Biochimica et biophysica acta.

Signal transduction pathways that contribute to increased protein synthesis during T-cell activation.

B. Safer, S. Kimball, S. Miyamoto, 2000, Biochimica et biophysica acta.

Evidence for role of m7G5′-phosphate group in recognition of eukaryotic mRNA by initiation factor IF-M3

B. Safer, W. Merrick, C. Baglioni, 1976, Nature.

Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region.

E. Urcelay, J. Chiorini, B. Safer, 1996, The Biochemical journal.

Regulation of translation initiation factor gene expression during human T cell activation.

N. Sonenberg, C. Thompson, R. Frederickson, 1992, The Journal of biological chemistry.

Effects of acidosis on myocardial contractility and metabolism.

B. Safer, J. Williamson, K. Kobayashi, 2009, Acta medica Scandinavica. Supplementum.

Manometric changes during retrograde biliary infusion in mice.

R. Lutz, B. Safer, J. Owens, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Efficient gene targeting in mouse embryonic stem cells

B. Safer, NS Templeton, DD Roberts, 1997, Gene Therapy.

Mitochondrial-cytosolic interactions in perfused rat heart. Role of coupled transamination in repletion of citric acid cycle intermediates.

B. Safer, J. Williamson, 1973, The Journal of biological chemistry.

Mitochondrial-cytosolic interactions in cardiac tissue: role of the malate-aspartate cycle in the removal of glycolytic NADH from the cytosol.

B. Safer, J. Williamson, K. Lanoue, 1973, Symposia of the Society for Experimental Biology.

Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: indirect mode of action on polypeptide chain initiation.

I. London, W. Anderson, M. Clemens, 1975, Proceedings of the National Academy of Sciences of the United States of America.

High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors.

R. Kotin, M. Hallek, E. Urcelay, 1995, Human gene therapy.

Nomenclature of initiation, elongation and termination factors for translation in eukaryotes. Recommendations 1988. Nomenclature Committee of the International Union of Biochemistry (NC-IUB).

B. Safer, 1989, European journal of biochemistry.

International symposium on translational/transcriptional regulation of gene expression. Highlights of the Fogarty International Center Meeting held in Bethesda, Maryland on 7-9 April, 1982.

M. Grunberg‐Manago, R. Jagus, B. Safer, 1982, FEBS Letters.

Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein

R. Kotin, E. Urcelay, B. Safer, 1995, Journal of virology.

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

M. Katze, B. Safer, D. DeCorato, 1987, The EMBO journal.

An adenovirus mutant unable to express VAI RNA displays different growth responses and sensitivity to interferon in various host cell lines

T. Shenk, B. Safer, R. Schneider, 1986, Molecular and cellular biology.

Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein

R. Kotin, E. Urcelay, B. Safer, 1994, Journal of virology.

Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation.

B. Safer, S. Miyamoto, 1999, The Biochemical journal.

MORPHOLOGICAL AND BIOCHEMICAL STUDIES OF ISOLATED MITOCHONDRIA FROM FETAL, NEONATAL, AND ADULT LIVER AND FROM NEOPLASTIC TISSUES

E. Bresnick, B. Safer, D. Yawn, 1967, The Journal of cell biology.

DNA affinity labeling of adenovirus type 2 upstream promoter sequence-binding factors identifies two distinct proteins

B. Safer, R. Cohen, J. Thompson, 1988, Molecular and cellular biology.

Homologous globin cell-free transcription system with comparison of heterologous factors

W. Anderson, B. Safer, L. Yang, 1984, Molecular and cellular biology.

Formation of α-Pal/Max Heterodimers Synergistically Activates the eIF2-α Promoter*

B. Safer, B. Efiok, Scott T. Shors, 1998, The Journal of Biological Chemistry.

Factors involved in initiation of haemoglobin synthesis can be phosphorylated in vitro

B. Safer, W. Merrick, S. Tahara, 1976, Nature.

Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation

B. Safer, S. Miyamoto, 1999 .

Mode of action of the calcium ionophores X-537A and A23187 on cardiac contractility.

B. Safer, J. Williamson, A. Scarpa, 1974, Biochemical pharmacology.

Polypeptide chain initiation in eukaryotes: mechanism of formation of initiation complex.

S. Ochoa, W. Anderson, C. Nombela, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.

S. Adams, W. Anderson, B. Safer, 1975, The Journal of biological chemistry.

Eukaryotic initiation complex formation. Evidence for two distinct pathways.

S. Adams, W. Anderson, B. Safer, 1975, The Journal of biological chemistry.

Purification and physical properties of homogeneous initiation factor MP from rabbit reticulocytes.

W. Anderson, B. Safer, W. Merrick, 1975, The Journal of biological chemistry.

Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.

B. Safer, W. Merrick, D. T. Peterson, 1979, Journal of Biological Chemistry.

The purification and characterization of subunits α, β, and γ from the rabbit reticulocyte eukaryotic initiation factor 2

W. Anderson, M. Schafer, B. Safer, 1987 .

2B or not 2B: Regulation of the catalytic utilization of elF-2

B. Safer, 1983, Cell.

The protein phosphatases involved in cellular regulation. 4. Classification of two homogeneous myosin light chain phosphatases from smooth muscle as protein phosphatase-2A1 and 2C, and a homogeneous protein phosphatase from reticulocytes active on protein synthesis initiation factor eIF-2 as protein

P. Cohen, B. Safer, D. Crouch, 1983, European journal of biochemistry.

Role of eukaryotic initiation factor 5 in the formation of 80 S initiation complexes.

B. Safer, W. Merrick, D. T. Peterson, 1979, Journal of Biological Chemistry.

Comparison of fMet-tRNAf and Met-tRNAf from Escherichia coli and rabbit liver in initiation of hemoglobin synthesis.

S. Adams, W. Anderson, B. Safer, 1975, The Journal of biological chemistry.

Classification of an eIF‐2 phosphatase as a type‐2 protein phosphatase

P. Cohen, B. Safer, D. Crouch, 1980, FEBS letters.

Purification and properties of eIF-2 phosphatase.

B. Safer, D. Crouch, 1980, The Journal of biological chemistry.

The Metabolic Significance of the Malate-Aspartate Cycle in Heart.

B. Safer, 1975, Circulation research.

Respiratory acidosis and its reversibility in perfused rat heart: regulation of citric acid cycle activity.

B. Safer, J. Williamson, S. Schaffer, 1978, The American journal of physiology.

The regulation of initiation of mammalian protein synthesis.

W. Anderson, R. Jagus, B. Safer, 1981, Progress in nucleic acid research and molecular biology.

DOUBLE-STRANDED RNA AND 2′,5′-OLIGOADENYLATES: COMPANIONS IN INTERFERON ACTION?

H. Sawai, R. Friedman, B. Safer, 1982 .

Identification and characterization of an adenovirus 2 major late promoter CAP sequence DNA-binding protein.

B. Safer, R. Cohen, J. Thompson, 1990, The Journal of biological chemistry.

Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.

C. Samuel, T. Shenk, B. Safer, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

C. Samuel, T. Shenk, B. Safer, 1986, Cell.

Compensatory increase in levels of beta minor globin in murine beta-thalassemia is under translational control.

P. Kantoff, W. Anderson, M. Schafer, 1986, The Journal of biological chemistry.

Reduced activity of the interferon-induced double-stranded RNA-dependent protein kinase during a heat shock stress.

B. Safer, P. Lebon, A. Hovanessian, 1989, The Journal of biological chemistry.

Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner

S. Orkin, N. Andrews, S. Weremowicz, 1993, Molecular and cellular biology.

A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development.

J. Chiorini, B. Safer, B. Efiok, 1994, The Journal of biological chemistry.

Functional dissection of adenovirus VAI RNA

R. Bhat, M. Furtado, D. Fowlkes, 1989, Journal of virology.

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

M. Katze, R. Krug, B. Safer, 1988, Journal of virology.

Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli

M. Weitzman, R. Kotin, E. Urcelay, 1994, Journal of virology.

Use of heparin-Sepharose for the rapid isolation of initiation and elongation factors.

B. Safer, J. Goldstein, 1979, Methods in enzymology.

Investigation of the calcium cycle in perfused rat and frog hearts.

B. Safer, J. Williamson, A. Scarpa, 1974, Recent advances in studies on cardiac structure and metabolism.

EUKARYOTIC INITIATION OF PROTEIN SYNTHESIS

B. Safer, W. Merrick, W. Kemper, 1978 .

Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats

R. Kotin, J. Chiorini, B. Safer, 1994, Journal of virology.

T-cell Activation Leads to Rapid Stimulation of Translation Initiation Factor eIF2B and Inactivation of Glycogen Synthase Kinase-3 (*)

C. Proud, B. Safer, S. Miyamoto, 1996, The Journal of Biological Chemistry.

The molecular mechanism of hemoglobin synthesis and its regulation in the reticulocyte.

W. Anderson, B. Safer, W. Anderson, 1978, CRC critical reviews in biochemistry.

The regulatory element 3' to the A gamma-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein.

S. Jane, A. Nienhuis, J. Cunningham, 1994, Blood.

Regulation of eukaryotic translation initiation factor expression during T-cell activation.

N. Sonenberg, J. Chiorini, R. Frederickson, 1993, Biochimica et biophysica acta.

Increased eIF‐2 alpha expression in mitogen‐activated primary T lymphocytes.

B. Safer, R. Cohen, R. Cohen, 1990, The EMBO journal.

Coordination of Citric Acid Cycle Activity with Electron Transport Flux

B. Safer, J. Williamson, Christopher FordJohn Illingworth, 1976, Circulation research.

Mitochondrial-cytosolic interactions in perfused rat heart

B. Safer, D. Subbotin, 1973 .

Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heart.

B. Safer, J. Williamson, J R Williamson, 1971, Journal of molecular and cellular cardiology.

Identification and characterization of a novel transcription factor participating in the expression of eukaryotic initiation factor 2 alpha.

B. Safer, R. Cohen, W. Jacob, 1989, The Journal of biological chemistry.

Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs

M. Katze, R. Krug, B. Safer, 1986, Molecular and cellular biology.

Isolation and characterization of the promoter and flanking regions of the gene encoding the human protein-synthesis-initiation factor 2α

J. Chiorini, B. Safer, J. Hershey, 1989 .

Contribution of tissue acidosis to ischemic injury in the perfused rat heart.

B. Safer, J. Williamson, S. Schaffer, 1976, Circulation.

Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection

R. Kotin, J. Chiorini, B. Safer, 1995, Journal of virology.

Investigation of the role of mitochondria in the cardiac contraction‐relaxation cycle

B. Safer, J. Williamson, S. Schaffer, 1972, FEBS letters.

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

M. Katze, B. Safer, A. Hovanessian, 1989, Journal of virology.

A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta.

J. Chiorini, B. Safer, S. Miyamoto, 1993, The Journal of biological chemistry.

Isotopic labelling of heart mitochondria as a function of respiratory state

B. Safer, A. Schwartz, C. L. Johnson, 1966 .

Isolation of an active transcription initiation complex from HeLa cell-free extract.

W. Anderson, B. Safer, L. Yang, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles

R. Kotin, J. Chiorini, B. Safer, 1997, Journal of virology.

Role of sequences within the first intron in the regulation of expression of eukaryotic initiation factor 2 alpha.

B. Safer, M. Noguchi, T. A. Silverman, 1992, The Journal of biological chemistry.

Detection of early gene expression changes during activation of human primary lymphocytes by in vitro synthesis of proteins from polysome‐associated mRNAs

B. Safer, S. Miyamoto, J. Qin, 2001, Protein science : a publication of the Protein Society.

The association of eIF-2 with Met-tRNAi or eIF-2B alters the specificity of eIF-2 phosphatase.

B. Safer, D. Crouch, 1984, The Journal of biological chemistry.

Characteristics of eukaryotic initiation factor 2 and its subunits.

J. C. Osborne, B. Safer, W. Merrick, 1980, The Journal of biological chemistry.

Isolation of stable preinitiation, ini from RNA polymerase II-directed t (adenovirus/promoter/HeLa extract/run-off transcript/transcriptio

Linda Yang, B. Safer, H. Tolunay, 2016 .

Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor.

B. Safer, W. Merrick, R. Thach, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Active Transport of Potassium Ion in Heart Mitochondria

B. Safer, A. Schwartz, Brian Safer, 1967, Circulation research.