T. Roche

发表

α-Keto acid dehydrogenase complexes: XVII. Kinetic and regulatory properties of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase from bovine kidney and heart

F. Hucho, D. Randall, T. Roche, 1972 .

Organization of the Cores of the Mammalian Pyruvate Dehydrogenase Complex Formed by E2 and E2 Plus the E3-binding Protein and Their Capacities to Bind the E1 and E3 Components*

T. Roche, Y. Hiromasa, T. Fujisawa, 2004, Journal of Biological Chemistry.

Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.

T. Roche, Y. Hiromasa, 2008, Biochemistry.

Role of Lipoyl Domains in the Function and Regulation of Mammalian Pyruvate Dehydrogenase Complex

T. Roche, Y. Hiromasa, Haiying Bao, 2008 .

Ligand-induced Effects on Pyruvate Dehydrogenase Kinase Isoform 2*

T. Roche, Y. Hiromasa, Liangyan Hu, 2006, Journal of Biological Chemistry.

Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.

Jianchun Dong, T. Roche, Y. Hiromasa, 2003, European journal of biochemistry.

Facilitated Interaction between the Pyruvate Dehydrogenase Kinase Isoform 2 and the Dihydrolipoyl Acetyltransferase*

T. Roche, Y. Hiromasa, 2003, Journal of Biological Chemistry.

Central Organization of Mammalian Pyruvate Dehydrogenase (PD) Complex and Lipoyl Domain–Mediated Activated Function and Control of PD Kinases and Phosphatase 1

Jianchun Dong, T. Roche, Y. Hiromasa, 2003 .

Critical role of a lipoyl cofactor of the dihydrolipoyl acetyltransferase in the binding and enhanced function of the pyruvate dehydrogenase kinase.

T. Roche, G. Radke, K. Ono, 1993, Biochemical and biophysical research communications.

Binding of the Pyruvate Dehydrogenase Kinase to Recombinant Constructs Containing the Inner Lipoyl Domain of the Dihydrolipoyl Acetyltransferase Component (*)

T. Roche, S. Liu, J. C. Baker, 1995, The Journal of Biological Chemistry.

Lipoyl Domain-based Mechanism for the Integrated Feedback Control of the Pyruvate Dehydrogenase Complex by Enhancement of Pyruvate Dehydrogenase Kinase Activity (*)

T. Roche, J. Guest, G. Radke, 1996, The Journal of Biological Chemistry.

Marked Differences between Two Isoforms of Human Pyruvate Dehydrogenase Kinase*

T. Roche, T. Peng, S. Kasten, 2000, The Journal of Biological Chemistry.

A unifying mechanism for stimulation of mammalian pyruvate dehydrogenase(a) kinase by reduced nicotinamide adenine dinucleotide, dihydrolipoamide, acetyl coenzyme A, or pyruvate.

T. Roche, R. L. Cate, 1978, The Journal of biological chemistry.

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart.

J. R. Brown, D. Watson, T. Roche, 1978, Biochemistry.

Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenasea kinase and synergistic inhibition by pyruvate and ADP.

T. Roche, M. L. Pratt, 1979, The Journal of biological chemistry.

Regulation of fat body pyruvate dehydrogenase complex in the tobacco hornworm, Manduca sexta (L.) (Lepidoptera: Sphingidae).

T. Roche, K. Kramer, D. Dyer, 1980 .

REGULATION OF THE MAMMALIAN PYRUVATE DEHYDROGENASE COMPLEX BY PHOSPHORYLATION AND DEPHOSPHORYLATION

P. Butterworth, T. Roche, L. Reed, 1973 .

Molecular Aspects of the Regulation of the Mammalian Pyruvate Dehydrogenase Complex

F. Hucho, D. Randall, T. Roche, 1972 .

Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis.

E. Keeffe, R. Coppel, J. Lake, 1998, The Journal of clinical investigation.

Arginine-239 in the beta subunit is at or near the active site of bovine pyruvate dehydrogenase.

T. Roche, M. Patel, L. Korotchkina, 1995, Biochimica et biophysica acta.

Function of the nonidentical subunits of mammalian pyruvate dehydrogenase.

T. Roche, L. Reed, Lester J. Reed, 1972, Biochemical and biophysical research communications.

Isocitrate lyase from Pseudomonas indigofera. V. Subunits and terminal residues and the relation to catalytic activity.

T. Roche, B. McFadden, A. Cohen, 1968, Biochemistry.

Function of calcium ions in pyruvate dehydrogenase phosphatase activity.

T. Roche, L. Reed, F. Pettit, 1972, Biochemical and biophysical research communications.

Modification of the active site of isocitrate lyase from Pseudomonas indigofera.

T. Roche, B. McFadden, J. O. Williams, 1971, Archives of biochemistry and biophysics.

Subunit associations in the mammalian pyruvate dehydrogenase complex. Structure and role of protein X and the pyruvate dehydrogenase component binding domain of the dihydrolipoyl transacetylase component.

P. Andrews, T. Roche, M. Rahmatullah, 1989, The Journal of biological chemistry.

Effect of pH and buffer upon Km and inhibition by phosphoenolpyruvate of isocitrate lyase from Pseudomonas indigofera.

T. Roche, B. McFadden, J. O. Williams, 1970, Biochimica et biophysica acta.

Rapid intersite transfer of acetyl groups and movement of pyruvate dehydrogenase component in the kidney pyruvate dehydrogenase complex.

T. Roche, L. Davis, R. L. Cate, 1980, The Journal of biological chemistry.

Enhanced dissociation of pyruvate dehydrogenase from the pyruvate dehydrogenase complex following phosphorylation and regulatory implications.

T. Roche, D. Dyer, R. L. Cate, 1979, Biochemical and biophysical research communications.

Function and regulation of mammalian pyruvate dehydrogenase complex. Acetylation, interlipoyl acetyl transfer, and migration of the pyruvate dehydrogenase component.

T. Roche, R. L. Cate, 1979, The Journal of biological chemistry.

Purification of porcine liver pyruvate dehydrogenase complex and characterization of its catalytic and regulatory properties.

T. Roche, R. L. Cate, Richard L. Cate, 1977, Archives of biochemistry and biophysics.

A kinetic study of dihydrolipoyl transacetylase from bovine kidney.

P. Butterworth, T. Roche, L. Reed, 1975, The Journal of biological chemistry.

Monovalent cation requirement for ADP inhibition of pyruvate dehydrogenase kinase.

T. Roche, L. Reed, 1974, Biochemical and biophysical research communications.

Structure, Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex

P. Butterworth, T. Roche, L. Reed, 1974 .

PYRUVATE DEHYDROGENASE COMPLEX: STRUCTURE, FUNCTION, AND REGULATION

R. M. Oliver, F. Hucho, D. Randall, 1972 .

Formation of a complex of the catalytic subunit of pyruvate dehydrogenase phosphatase isoform 1 (PDP1c) and the L2 domain forms a Ca2+ binding site and captures PDP1c as a monomer.

T. Roche, Y. Hiromasa, A. Turkan, 2004, Biochemistry.

Structural Requirements within the Lipoyl Domain for the Ca2+-dependent Binding and Activation of Pyruvate Dehydrogenase Phosphatase Isoform 1 or Its Catalytic Subunit*

T. Roche, T. Peng, A. Turkan, 2002, The Journal of Biological Chemistry.

Activated Function of the Pyruvate Dehydrogenase Phosphatase through Ca2+-facilitated Binding to the Inner Lipoyl Domain of the Dihydrolipoyl Acetyltransferase*

T. Roche, C. Chuang, G. Chen, 1996, The Journal of Biological Chemistry.

Regulation of bovine kidney alpha-ketoglutarate dehydrogenase complex by calcium ion and adenine nucleotides. Effects on S0.5 for alpha-ketoglutarate.

T. Roche, V. Lawlis, 1981, Biochemistry.

The catalytic requirements for reduction and acetylation of protein X and the related regulation of various forms of resolved pyruvate dehydrogenase kinase.

T. Roche, M. Rahmatullah, 1987, The Journal of biological chemistry.

Purification of bovine kidney and heart pyruvate dehydrogenase phosphatase on Sepharose derivatized with the pyruvate dehydrogenase complex.

T. Roche, M. L. Pratt, J. Maher, 1982, European journal of biochemistry.

A simple, reliable rapid-mixing apparatus for continuous-flow studies.

T. Roche, L. Davis, R. L. Cate, 1979, Analytical biochemistry.

Assembly and Full Functionality of Recombinantly Expressed Dihydrolipoyl Acetyltransferase Component of the Human Pyruvate Dehydrogenase Complex*

T. Wagenknecht, T. Roche, Jiasheng Song, 1997, The Journal of Biological Chemistry.

Role of the E2 core in the dominant mechanisms of regulatory control of mammalian pyruvate dehydrogenase complex

T. Roche, L. Wang, S. Ravindran, 1996 .

Inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5'-diphosphate on reduced nicotinamide adenine dinucleotide inhibition.

T. Roche, V. Lawlis, 1981, Biochemistry.

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

T. Roche, Y. Hiromasa, T. E. Roche, 2007, Cellular and Molecular Life Sciences.

Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.

T. Roche, Y. Hiromasa, Xiaohua Yan, 2004, Biochemistry.

Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.

T. Roche, Xiaohua Yan, Haiying Bao, 2004, Biochemistry.

AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2.

T. Roche, E. Kilgour, J. Orme, 2003, Biochemical Society transactions.

Specificity Determinants for the Pyruvate Dehydrogenase Component Reaction Mapped with Mutated and Prosthetic Group Modified Lipoyl Domains*

M. Zółkiewski, T. Roche, A. Yakhnin, 2000, The Journal of Biological Chemistry.

Requirements for the Adaptor Protein Role of Dihydrolipoyl Acetyltransferase in the Up-regulated Function of the Pyruvate Dehydrogenase Kinase and Pyruvate Dehydrogenase Phosphatase*

T. Roche, A. Yakhnin, D. Yang, 1998, The Journal of Biological Chemistry.

Partial activation of the pyruvate dehydrogenase kinase by the lipoyl domain region of E2 and interchange of the kinase between lipoyl domain regions.

T. Roche, M. Rahmatullah, G. Radke, 1993, The Journal of biological chemistry.

Changes in the core of the mammalian-pyruvate dehydrogenase complex upon selective removal of the lipoyl domain from the transacetylase component but not from the protein X component.

P. Andrews, T. Roche, M. Rahmatullah, 1990, The Journal of biological chemistry.

Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action.

T. Roche, M. Rahmatullah, 1985, The Journal of biological chemistry.

Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis

R. Coppel, T. Roche, M. Gershwin, 1995, The Journal of experimental medicine.

Additional binding sites for the pyruvate dehydrogenase kinase but not for protein X in the assembled core of the mammalian pyruvate dehydrogenase complex: binding region for the kinase.

T. Roche, L. Li, G. Radke, 1992, Archives of biochemistry and biophysics.

Active site modification of isocitrate lyase.

T. Roche, B. McFadden, 1969, Biochemical and biophysical research communications.

Identification of the Tryptophan Residue in the Thiamin Pyrophosphate Binding Site of Mammalian Pyruvate Dehydrogenase (*)

T. Roche, M. Patel, B. Shenoy, 1995, The Journal of Biological Chemistry.

Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.

T. Roche, L. Li, X. Yan, 2001, Archives of biochemistry and biophysics.

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.

Jianchun Dong, J. Dong, T. Roche, 2001, Progress in nucleic acid research and molecular biology.

Molecular biology and biochemistry of pyruvate dehydrogenase complexes 1

T. Roche, M. Patel, 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mechanism of action of isocitrate lyase from Pseudomonas indigofera.

T. Roche, B. McFadden, J. O. Williams, 1971, Biochemistry.

STRUCTURE AND REGULATION OF α‐KETOGLUTARATE DEHYDROGENASE OF BOVINE KIDNEY

T. Roche, V. Lawlis, V. Bryan Lawlis, 1982 .

Alpha-Keto Acid Dehydrogenase Complexes

Robert A. Harris, T. Roche, M. Patel, 1996, MCBU Molecular and Cell Biology Updates.

Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase‐binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis

R. Coppel, T. Roche, A. Tanaka, 1999, Hepatology.

Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme.

R. Coppel, T. Roche, M. Gershwin, 1990, Journal of immunology.

Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross‐reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex

E. Dickson, R. Coppel, T. Roche, 1989, Hepatology.

Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diurnal conditions.

T. Roche, A. Dixit, A. Dixit, 1984, Archives of biochemistry and biophysics.

Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex.

Z. Zhou, Xuekui Yu, W. Hui, 2018, Biochemistry.

Mathematical modeling and simulation of the progression of AIDS

S. Laxminarayan, T. Roche, S. Sofer, 2018 .

Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis.

R. Coppel, T. Roche, C. Quan, 2003, Gastroenterology.

Evidence for lipoic acid mediated NADH and acetyl-CoA stimulation of liver and kidney pyruvate dehydrogenase kinase.

T. Roche, R. L. Cate, 1976, Biochemical and biophysical research communications.

Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis.

M. Kaplan, H. Bonkovsky, R. Coppel, 1991, Journal of immunology.

Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex.

T. Roche, M. Rahmatullah, J. Jilka, 1986, The Journal of biological chemistry.

Properties of the pyruvate dehydrogenase kinase bound to and separated from the dihydrolipoyl transacetylase-protein X subcomplex and evidence for binding of the kinase to protein X.

T. Roche, M. Rahmatullah, J. Jilka, 1986, The Journal of biological chemistry.

Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.

Z. Zhou, Xuekui Yu, T. Roche, 2008, Structure.

Role of protein X in the function of the mammalian pyruvate dehydrogenase complex.

T. Roche, M. Rahmatullah, G. Radke, 1989, Biochemical and biophysical research communications.

Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic.

R. Coppel, Y. Nakanuma, M. Sasaki, 2000, Journal of autoimmunity.

Identification of the essential cysteine residue in the active site of bovine pyruvate dehydrogenase.

T. Roche, M. Patel, M. Ali, 1993, The Journal of biological chemistry.

Recombinant expression and evaluation of the lipoyl domains of the dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.

P. Andrews, T. Roche, J. C. Baker, 1995, Archives of biochemistry and biophysics.

Mechanism of activation of bovine kidney pyruvate dehydrogenase a kinase by malonyl-CoA and enzyme-catalyzed decarboxylation of malonyl-CoA.

T. Roche, M. Rahmatullah, J. Jilka, 1985, European journal of biochemistry.

Specific reactivity of recombinant human PDC-E1α in primary biliary cirrhosis

R. Coppel, T. Roche, M. Gershwin, 1991 .

Specific reactivity of recombinant human PDC-E1 alpha in primary biliary cirrhosis.

R. Coppel, T. Roche, M. Patel, 1991, Journal of autoimmunity.

Domain structures of the dihydrolipoyl transacetylase and the protein X components of mammalian pyruvate dehydrogenase complex. Selective cleavage by protease Arg C.

T. Roche, M. Rahmatullah, G. Radke, 1989, The Journal of biological chemistry.

Sizing of bovine heart and kidney pyruvate dehydrogenase complex and dihydrolipoyl transacetylase core by quasielastic light scattering.

T. Roche, D. Cox, E. Roche, 1993, Biochemistry.

Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase.

T. Roche, Youzhong Guo, M. Hackert, 2020, Acta crystallographica. Section F, Structural biology communications.

Effect of micromolar Ca2+ on NADH inhibition of bovine kidney α-ketoglutarate dehydrogenase complex and possible role of Ca2+ in signal amplification

T. Roche, V. Lawlis, 1980, Molecular and Cellular Biochemistry.

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.

Peter J Bungay, T. Roche, P. Bungay, 2006, Biochemistry.

Lipoyl‐Containing Components of the Pyruvate Dehydrogenase Complex: Roles in Modulating and Anchoring the PDH Kinase and the PDH Phosphatase a

T. Roche, M. Rahmatullah, G. Radke, 1989, Annals of the New York Academy of Sciences.

Separation of protein X from the dihydrolipoyl transacetylase component of the mammalian pyruvate dehydrogenase complex and function of protein X.

T. Roche, M. Rahmatullah, G. Radke, 1989, The Journal of biological chemistry.

Cryoelectron microscopy of mammalian pyruvate dehydrogenase complex.

T. Wagenknecht, R. Grassucci, T. Roche, 1991, The Journal of biological chemistry.

Heterogeneity of autoreactive T cell clones specific for the E2 component of the dehydrogenase complex in primary biliary cirrhosis.

T. Roche, M. Gershwin, T. Prindiville, 2003 .

Dynamics Of Aids Manifestation: A Mathematical Prediction

S. Laxminarayan, T. Roche, S. Sofer, 1990, [1990] Proceedings of the Twelfth Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Component requirements for NADH inhibition and spermine stimulation of pyruvate dehydrogenaseb phosphatase activity.

T. Roche, M. Rahmatullah, 1988, The Journal of biological chemistry.

The Lipoyl‐Containing Components of the Mammalian Pyruvate Dehydrogenase Complex: Structural Comparison and Subdomain Roles a

T. Roche, M. Rahmatullah, G. Radke, 1989, Annals of the New York Academy of Sciences.

Specificity of the pyruvate dehydrogenase kinase for pyruvate dehydrogenase component bound to the surface of the kidney pyruvate dehydrogenase complex and evidence for intracore migration of pyruvate dehydrogenase component.

T. Roche, D. Brandt, 1983, Biochemistry.

Sepharose-insolubilization of the dihydrolipoyl transacetylase core component of the pyruvate dehydrogenase complex: preparation and characterization.

T. Roche, M. L. Pratt, J. C. Gold, 1982, Journal of biochemical and biophysical methods.

Structure and Regulation of the Mammalian Pyruvate Dehydrogenase Complex

P. Butterworth, T. Roche, J. Pelley, 1976 .

Alpha-keto acid dehydrogenase complexes : organization, regulation, and biomedical ramifications : a tribute to Lester J. Reed

T. Roche, L. Reed, M. Patel, 1989 .

Structure, Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex

T. Roche, F. Pettit, C. R. Barrera, 1974 .