J. Nakae

发表

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

Y. Kido, D. Accili, W. Biggs, 2021 .

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

R. DePinho, J. Nakae, J. Paik, 2010, Circulation research.

The FoxO transcription factors and metabolic regulation

J. Nakae, Miyo Oki, Yongheng Cao, 2008, FEBS letters.

The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.

A. Fukamizu, J. Nakae, H. Daitoku, 2006, The Journal of clinical investigation.

Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors

D. Accili, T. Kitamura, J. Nakae, 2003, The Journal of cell biology.

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.

D. Accili, J. Nakae, J. Altomonte, 2003, American journal of physiology. Endocrinology and metabolism.

Differential regulation of gene expression by insulin and IGF‐1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

D. Accili, V. Barr, J. Nakae, 2000, The EMBO journal.

Long-term effect of recombinant human insulin-like growth factor I on metabolic and growth control in a patient with leprechaunism.

J. Nakae, M. Kato, M. Murashita, 1998, The Journal of clinical endocrinology and metabolism.

Replacements of Leucine 87 in Human Insulin Receptor Alter Affinity for Insulin (*)

E. Ohtsuka, J. Nakae, K. Fujieda, 1995, The Journal of Biological Chemistry.

Two novel aquaporin-2 mutations in a sporadic Japanese patient with autosomal recessive nephrogenic diabetes insipidus.

J. Nakae, K. Fujieda, T. Tajima, 2003, Endocrine journal.

Near-Normal Linear Growth in the Setting of Markedly Reduced Growth Hormone and IGF-1

J. Nakae, M. Murashita, N. Shinohara, 1999, Hormone Research in Paediatrics.

Clinical and Basic Aspects of Intrauterine Growth Retardation

J. Nakae, M. Murashita, N. Shinohara, 1997 .

Hyperthyroidism in Growth Hormone Deficient Children Treated with Human Growth Hormone

J. Nakae, M. Murashita, N. Shinohara, 1995 .

Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes

M. Suematsu, J. Nakae, Masaya Nakamura, 2020, Communications Biology.

Glucose homeostasis: lessons from knockout mice

Y. Kido, D. Accili, T. Kitamura, 2001 .

Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance

T. Noda, M. Kasuga, A. Yoshimura, 2012, Diabetes.

Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity.

Y. Matsuki, R. Hiramatsu, H. Okamura, 2009, Endocrinology.

Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and β-Cell Compensation to Insulin Resistance*

Y. Kido, S. Xuan, D. Accili, 2002, The Journal of Biological Chemistry.

Pathogenesis of insulin resistance: who wields the baton?

Y. Kido, D. Accili, T. Kitamura, 2001 .

PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis

J. Nakae, M. Nakata, T. Yada, 2017, Molecular metabolism.

Three Novel AVPR2 Mutations in Three Japanese Families with X-Linked Nephrogenic Diabetes Insipidus

J. Nakae, K. Fujieda, K. Yuri, 1996, Pediatric Research.

Genetics of type 2 diabetes: insight from targeted mouse mutants.

Y. Kido, D. Accili, J. Nakae, 2001, Current molecular medicine.

The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B4 axis

D. Accili, M. Kasuga, S. Seino, 2020, Proceedings of the National Academy of Sciences.

Protective role of AgRP neuron's PDK1 against salt-induced hypertension.

J. Nakae, W. Ogawa, M. Nakata, 2018, Biochemical and biophysical research communications.

Novel repressor regulates insulin sensitivity through interaction with Foxo1

T. Abe, H. Kiyonari, H. Itoh, 2012, The EMBO journal.

Mosaic analysis of insulin receptor function.

C. Kahn, D. Accili, T. Kitamura, 2004, The Journal of clinical investigation.

Islet β-cell-produced NUCB2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing UCP-2 in β-cells

M. Mori, J. Nakae, M. Nakata, 2019, The Journal of Physiological Sciences.

Supplemental Information Colonic Pro-in fl ammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl 2 / Ccr 2-Dependent Manner

T. Abe, Tetsuhiro Kikuchi, H. Itoh, 2016 .

PDK1/FoxO1 pathway in POMC neurons regulates Pomc expression and 1 food intake 2

T. Noda, J. Nakae, W. Ogawa, 2010 .

Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance.

T. Kitamura, J. Nakae, Y. Kitamura, 2012, Endocrinology.

Overexpression of FoxO 1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance

T. Kitamura, J. Nakae, Y. Kitamura, 2012 .

A Novel Mutation in the V2 Vasopressin Receptor Gene in Two Siblings with Nephrogenic Diabetes Insipidus

J. Nakae, M. Murashita, N. Shinohara, 1995 .

Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation

J. Nakae, W. Ogawa, M. Nakata, 2018, Scientific Reports.

Three novel mutations and a de novo deletion mutation of the DAX-1 gene in patients with X-linked adrenal hypoplasia congenita.

J. Nakae, M. Murashita, N. Shinohara, 1997, The Journal of clinical endocrinology and metabolism.

Three Novel PHEX Gene Mutations in Japanese Patients with X-Linked Hypophosphatemic Rickets

K. Tachibana, J. Nakae, M. Murashita, 2000, Pediatric Research.

A Case of Congenital Lipoid Adrenal Hyperplasia Associated with Dilated Cardiomyopathy

J. Nakae, K. Fujieda, M. Kaji, 1998 .

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

D. Accili, W. Biggs, W. Cavenee, 2002, Nature Genetics.

A novel mutation localized in the 3' non-HMG box region of the SRY gene in 46,XY gonadal dysgenesis.

J. Nakae, N. Shinohara, T. Tajima, 1994, Human molecular genetics.

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Y. Kido, D. Accili, W. Biggs, 2002, The Journal of clinical investigation.

Clinical review 125: The insulin receptor and its cellular targets.

Y. Kido, D. Accili, J. Nakae, 2001, The Journal of clinical endocrinology and metabolism.

Truncation at the C-terminus of the DAX-1 protein impairs its biological actions in patients with X-linked adrenal hypoplasia congenita.

J. Nakae, M. Kato, M. Murashita, 1996, The Journal of clinical endocrinology and metabolism.

Turner Syndrome with Crohn Disease

J. Nakae, K. Fujieda, T. Tajima, 2001 .

Molecular basis of nonclassical steroid 21-hydroxylase deficiency detected by neonatal mass screening in Japan.

J. Nakae, T. Tajima, K. Fujieda, 1997, The Journal of clinical endocrinology and metabolism.

Spontaneous puberty in 46,XX subjects with congenital lipoid adrenal hyperplasia. Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic acute regulatory protein (StAR) gene.

K. Tachibana, J. Nakae, T. Tajima, 1997, The Journal of clinical investigation.

Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia.

K. Tachibana, Y. Takeshima, J. Nakae, 1997, Human molecular genetics.

Compound heterozygous mutations in the gamma subunit gene of ENaC (1627delG and 1570-1G-->A) in one sporadic Japanese patient with a systemic form of pseudohypoaldosteronism type 1.

K. Tachibana, J. Nakae, T. Tajima, 2001, The Journal of clinical endocrinology and metabolism.

The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society A Novel Missense Mutation of Mineralocorticoid Receptor Gene in One Japanese Family with a Renal

J. Nakae, T. Tajima, K. Fujieda, 2022 .

Molecular pathogenesis of lipoid adrenal hyperplasia and adrenal hypoplasia congenita

J. Nakae, K. Fujieda, T. Tajima, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice

A. Hamsten, A. Silveira, K. Kitagawa, 2012, PloS one.

Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts.

E. Olson, J. Nakae, M. Okamoto, 2009, Endocrine journal.

Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.

J. Nakae, T. Tajima, K. Fujieda, 2001, The Journal of clinical endocrinology and metabolism.

A novel missense mutation in the HMG box region of the SRY gene in a Japanese patient with an XY sex reversal

J. Nakae, K. Fujieda, T. Tajima, 2000, Journal of Human Genetics.

Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity*

P. Froguel, D. Accili, M. Kasuga, 2004, Journal of Biological Chemistry.

Zfp238 Regulates the Thermogenic Program in Cooperation with Foxo1

H. Itoh, J. Nakae, H. Okado, 2019, iScience.

The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

D. Accili, W. Biggs, K. Arden, 2003, Developmental cell.

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression.

D. Accili, T. Kitamura, J. Nakae, 2001, The Journal of clinical investigation.

Distinct and overlapping functions of insulin and IGF-I receptors.

Y. Kido, D. Accili, J. Nakae, 2001, Endocrine reviews.

The Insulin Receptor and Its Cellular Targets

Y. Kido, D. Accili, J. Nakae, 2001 .

Targeted Gene Mutations Define the Roles of Insulin and IGF-I Receptors in Mouse Embryonic Development

D. Accili, K. Rother, J. Nakae, 1999, Journal of pediatric endocrinology & metabolism : JPEM.

Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure

H. Kiyonari, M. Lombès, J. Nakae, 2008, Diabetes.

PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.

T. Noda, M. Kasuga, S. Chua, 2010, American journal of physiology. Endocrinology and metabolism.

Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR

D. Accili, J. Nakae, M. Rechler, 2000, The Journal of Biological Chemistry.

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway*

D. Accili, J. Nakae, B. Park, 1999, The Journal of Biological Chemistry.

Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner.

T. Abe, Tetsuhiro Kikuchi, H. Itoh, 2016, Cell metabolism.

FOXO1 represses lymphatic valve formation and maintenance via PRDM1.

T. Furuyama, J. Nakae, Kenta Niimi, 2021, Cell reports.

Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.

Keiichi Fukuda, Makoto Suematsu, Hirotoshi Tanaka, 2011, Cell metabolism.

Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt.

D. Accili, M. Kasuga, T. Kitamura, 2001, Biochemistry.

Interaction of FoxO1 and TSC2 Induces Insulin Resistance through Activation of the Mammalian Target of Rapamycin/p70 S6K Pathway*

N. Mochizuki, J. Nakae, Yongheng Cao, 2006, Journal of Biological Chemistry.

Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient.

J. Nakae, K. Fujieda, T. Tajima, 2003, The Journal of clinical endocrinology and metabolism.

The mechanism of insulin action.

D. Accili, J. Nakae, 1999, Journal of pediatric endocrinology & metabolism : JPEM.

Two mutations of the Gsα gene in two Japanese patients with sporadic pseudohypoparathyroidism type Ia

Y. Ishikawa, J. Nakae, K. Fujieda, 2001, Journal of Human Genetics.

Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22 Axis

Tetsuhiro Kikuchi, H. Itoh, J. Nakae, 2019, iScience.

Molecular analysis of type II 3β-hydroxysteroid dehydrogenase gene in Japanese patients with classical 3β-hydroxysteroid dehydrogenase deficiency

J. Nakae, N. Shinohara, K. Fujieda, 1995 .

Constitutive Expression of Insulin Receptor Substrate (IRS)-1 Inhibits Myogenic Differentiation through Nuclear Exclusion of Foxo1 in L6 Myoblasts

J. Nakae, F. Hakuno, Shin-ichiro Takahashi, 2011, PloS one.

No genetic mutation in type II 3 beta-hydroxysteroid dehydrogenase gene in patients with biochemical evidence of enzyme deficiency.

J. Nakae, M. Murashita, T. Tajima, 1997, Hormone research.

Mutations of the CYP21 gene in nonclassical steroid 21-hydroxylase deficiency in Japan.

J. Nakae, T. Tajima, K. Fujieda, 1998, Endocrine journal.

Hydrochlorothiazide effectively reduces urinary calcium excretion in two Japanese patients with gain-of-function mutations of the calcium-sensing receptor gene.

J. Nakae, N. Shinohara, K. Fujieda, 2002, The Journal of clinical endocrinology and metabolism.

Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation

J. Nakae, W. Ogawa, M. Nakata, 2018, Scientific Reports.

Posterior Hypothalamic Astrocytoma Mimicking Hamartoma, Causing Precocious Puberty

J. Nakae, K. Fujieda, T. Tajima, 1993 .

Gonadotropin-Releasing Hormone Improve Predicted Final Height in Central Precocious Puberty and M Analog Therapy Fai Two Children with icrocephalus led to

J. Nakae, N. Shinohara, T. Tajima, 2006 .

Gonadotropin-releasing hormone analog therapy failed to improve predicted final height in two children with central precocious puberty and microcephalus.

J. Nakae, N. Shinohara, T. Tajima, 2000, Endocrine journal.

Final Height of Patients with Idiopathic Precocious Puberty Treated with Cyproterone Acetate

J. Nakae, N. Shinohara, K. Fujieda, 1993 .

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

Y. Kido, S. Xuan, D. Accili, 2002, The Journal of clinical investigation.

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

Y. Kido, S. Xuan, D. Accili, 2002, The Journal of clinical investigation.

Transgenic rescue of insulin receptor-deficient mice.

D. Accili, H. Okamoto, T. Kitamura, 2004, The Journal of clinical investigation.

Tissue-Specific Metabolic Regulation of FOXO-Binding Protein: FOXO Does Not Act Alone

J. Nakae, N. Kodani, 2020, Cells.

Experience with GH Therapy in a Patient with Osteogenesis Imperfecta

J. Nakae, M. Murashita, N. Shinohara, 1997 .

FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression

H. Itoh, T. Kitamura, J. Nakae, 2019, iScience.

Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice

Y. Kido, D. Accili, J. Nakae, 2001, Annals of medicine.

Two novel mutations of thiazide-sensitive Na-Cl cotrans porter (TSC) gene in two sporadic Japanese patients with Gitelman syndrome.

J. Nakae, K. Fujieda, Yuichi Kobayashi, 2002, Endocrine journal.

PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure

G. Barsh, T. Noda, M. Kasuga, 2011, PloS one.

A Boy without Growth Hormone is Growing Normally

J. Nakae, M. Murashita, N. Shinohara, 1996 .

Predominance of the mutation at 1138 of the cDNA for the fibroblast growth factor receptor 3 in Japanese patients with achondroplasia

H. Tonoki, J. Nakae, N. Shinohara, 1995, Japanese Journal of Human Genetics.

A Japanese Case with Frasier Syndrome Splice Junction Mutation of WT 1 Gene Caused by the

Toshihiro, Tajima, Hiroyuki, 2006 .

Two heterozygous mutations of CLDN16 in a Japanese patient with FHHNC

J. Nakae, K. Fujieda, T. Tajima, 2003, Pediatric Nephrology.

Prenatal diagnosis of steroid 21-hydroxylase deficiency by the modified polymerase chain reaction to detect splice site mutation in the CYP21 gene.

J. Nakae, T. Tajima, K. Fujieda, 1998, Endocrine journal.

Conventional molecular diagnosis of steroid 21-hydroxylase deficiency using mismatched primers and polymerase chain reaction.

J. Nakae, T. Tajima, K. Fujieda, 1997, Endocrine research.

Mutations of the 21-Hydroxylase CYP 21 Gene Deficiency in in Nonclassical Steroid Japan

J. Nakae, K. Fujieda, G. Cutler, 2006 .

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

R. DePinho, J. Nakae, J. Paik, 2010, Circulation research.

Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance.

T. Kitamura, J. Nakae, Y. Kitamura, 2012, Endocrinology.

Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner.

T. Abe, Tetsuhiro Kikuchi, H. Itoh, 2016, Cell metabolism.

Effect of Human Growth Hormone (hGH) Treatment on Growth Rate and Obesity in Prader-Willi Syndrome

J. Nakae, N. Shinohara, K. Fujieda, 1994 .

PDK-1 / FoxO 1 pathway in POMC neurons regulates Pomc expression and food intake

T. Noda, M. Kasuga, S. Chua, 2010 .

3β-Hydroxysteroid Dehydrogenase Deficiency

J. Nakae, K. Fujieda, T. Mukai, 2004 .

Novel missense mutation (Leu466Arg) of the DAX1 gene in a patient with X-linked congenital adrenal hypoplasia.

J. Nakae, M. Murashita, N. Shinohara, 1999, American journal of medical genetics.