D. Vatner

发表

Healthful aging mediated by inhibition of oxidative stress

S. Vatner, Jie Zhang, Marko Oydanich, 2020, Ageing Research Reviews.

Myocardial apoptosis in heart disease: does the emperor have clothes?

S. Vatner, D. Vatner, J. Corbalan, 2016, Basic Research in Cardiology.

Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade.

S. Vatner, D. Vatner, Lin Yan, 2014, American journal of physiology. Heart and circulatory physiology.

Apoptosis predominates in nonmyocytes in heart failure.

F. Natividad, S. Vatner, R. Kitsis, 2009, American journal of physiology. Heart and circulatory physiology.

MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths.

Danish Sayed, M. Abdellatif, Jacqueline Lypowy, 2008, Molecular biology of the cell.

Gene program for cardiac cell survival induced by transient ischemia in conscious pigs

S. Vatner, D. Vatner, C. Depré, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Antioxidant defense and protection against cardiac arrhythmias: lessons from a mammalian hibernator (the woodchuck)

S. Vatner, Lai-Hua Xie, D. Vatner, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism.

W. Hunter, S. Vatner, D. Vatner, 2008, American journal of physiology. Heart and circulatory physiology.

Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance

S. Vatner, D. Vatner, Lin Yan, 2015, Diabetes.

Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus.

S. Vatner, B. Trimarco, D. Vatner, 2003, American journal of physiology. Heart and circulatory physiology.

Myocardial ischemic protection in natural mammalian hibernation

S. Vatner, D. Vatner, Lin Yan, 2015, Basic Research in Cardiology.

Metabolomic analysis of two different models of delayed preconditioning.

S. Vatner, D. Vatner, Ji Yeon Park, 2013, Journal of molecular and cellular cardiology.

Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia.

S. Vatner, E. Lewandowski, D. Vatner, 2011, Cardiovascular research.

An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p.

Danish Sayed, M. Abdellatif, D. Vatner, 2010, Cellular signalling.

Repetitive Ischemia by Coronary Stenosis Induces a Novel Window of Ischemic Preconditioning

S. Vatner, D. Vatner, J. Sadoshima, 2008, Circulation.

Obligatory Role of Cardiac Nerves and α1-Adrenergic Receptors for the Second Window of Ischemic Preconditioning in Conscious Pigs

S. Vatner, D. Vatner, Lin Yan, 2006, Circulation research.

Program of Cell Survival Underlying Human and Experimental Hibernating Myocardium

J. Pepper, D. Pennell, S. Vatner, 2004, Circulation research.

Blockade of EMAP II protects cardiac function after chronic myocardial infarction by inducing angiogenesis.

S. Vatner, D. Vatner, Lin Yan, 2015, Journal of molecular and cellular cardiology.

Species differences in regulation of alpha-adrenergic receptor function.

S. Vatner, D. Vatner, Y. Shen, 1989, The American journal of physiology.

Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart.

S. Vatner, Y. Ishikawa, D. Vatner, 1999, The American journal of cardiology.

Inhibition of p38α MAPK rescues cardiomyopathy induced by overexpressed β2-adrenergic receptor, but not β1-adrenergic receptor

S. Vatner, D. Vatner, J. Sadoshima, 2007 .

Depressed 3-Adrenergic Receptor- and Endothelium-Mediated Vasodilation in Conscious Dogs With Heart Failure

S. Vatner, D. Vatner, R. Shannon, 2005 .

Initial Changes in β-Adrenergic Receptor Function during Development of Rapid Ventricular Pacing-Induced Heart Failure

S. Vatner, D. Vatner, R. Shannon, 1996 .

Abnormalities in β-Adrenergic Signal Transduction with Myocardial Decompensation and Failure

D. Vatner, 1994 .

Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.

S. Vatner, D. Cohen, D. Vatner, 1993, The Journal of clinical investigation.

Depressed beta-adrenergic receptor- and endothelium-mediated vasodilation in conscious dogs with heart failure.

S. Vatner, D. Vatner, R. Shannon, 1993, Circulation research.

Common Genomic Response in Different Mouse Models of &bgr;-Adrenergic–Induced Cardiomyopathy

S. Liggett, E. Olson, M. Lohse, 2003, Circulation.

Cardiomyopathy Induced −-Adrenergic β Common Genomic Response in Different Mouse Models of Print

S. Liggett, E. Olson, M. Lohse, 2003 .

beta-adrenergic receptor signaling: an acute compensatory adjustment-inappropriate for the chronic stress of heart failure? Insights from Gsalpha overexpression and other genetically engineered animal models.

S. Vatner, D. Vatner, C. Homcy, 2000, Circulation research.

Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart.

F. Natividad, S. Vatner, D. Vatner, 2007, Journal of molecular and cellular cardiology.

Consequences of Growth Hormone Deficiency on Cardiac Structure, Function, and β-Adrenergic Pathway: Studies in Mutant Dwarf Rats.

P. Douglas, D. Vatner, R. Clark, 1997, Endocrinology.

Caloric restriction reduces growth of mammary tumors and metastases.

S. Vatner, P. Abarzúa, D. Vatner, 2011, Carcinogenesis.

A Novel Mechanism for Myocardial Stunning Involving Impaired Ca2+ Handling

S. Vatner, J. V. Van Eyk, D. Vatner, 2001, Circulation research.

Mechanisms of Increased Vascular Stiffness Down the Aortic Tree in Aging, Pre-Menopausal Female Monkeys.

S. Vatner, Jie Zhang, Marko Oydanich, 2020, American journal of physiology. Heart and circulatory physiology.

Subtypes of β‐Adrenergic Receptors in Bovine Coronary Arteries

S. Vatner, D. Vatner, D. Knight, 1986 .

Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans.

P. Douglas, D. Vatner, E. Gervino, 1996, Journal of applied physiology.

Propranolol prevents enhanced stress signaling in Gsα cardiomyopathy: potential mechanism for β-blockade in heart failure

S. Vatner, D. Vatner, J. Sadoshima, 2004 .

Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.

S. Vatner, J. Ingwall, D. Vatner, 2010, Journal of molecular and cellular cardiology.

Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice.

Ryan T. Strachan, P. Ernsberger, B. Hoit, 2005, American journal of physiology. Heart and circulatory physiology.

Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis

S. Vatner, Jie Zhang, Marko Oydanich, 2020, Basic Research in Cardiology.

Best Anesthetics for Assessing Left Ventricular Systolic Function by Echocardiography in Mice

S. Vatner, D. Vatner, Lin Yan, 2015, American journal of physiology. Heart and circulatory physiology.

Cardiomyocyte overexpression of the α1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning.

S. Vatner, R. Graham, D. Vatner, 2012, American journal of physiology. Heart and circulatory physiology.

Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload.

S. Vatner, Y. Ishikawa, T. Wagner, 2010, American Journal of Physiology. Heart and Circulatory Physiology.

Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.

S. Vatner, Y. Ishikawa, T. Wagner, 1998, The Journal of clinical investigation.

Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac Gsα Overexpression

S. Vatner, Y. Ishikawa, T. Wagner, 1996 .

Decrease in Myocardial Ryanodine Receptors and Altered Excitation‐Contraction Coupling Early in the Development of Heart Failure

S. Vatner, D. Vatner, R. Shannon, 1994, Circulation.

NADP improves the efficiency of cholera toxin catalyzed ADP-ribosylation in liver and heart membranes.

R. Graham, D. Vatner, C. Homcy, 1986, Biochemical and biophysical research communications.

Preemptive conditioning of the swine heart by H11 kinase/Hsp22 provides cardiac protection through inducible nitric oxide synthase.

S. Vatner, D. Vatner, C. Depré, 2011, American Journal of Physiology. Heart and Circulatory Physiology.

One hour of myocardial ischemia in conscious dogs increases beta-adrenergic receptors, but decreases adenylate cyclase activity.

S. Vatner, D. Vatner, Y. Shen, 1988, Journal of molecular and cellular cardiology.

Effects of cardiac denervation on development of heart failure and catecholamine desensitization.

S. Vatner, I. Mirsky, D. Vatner, 1997, Circulation.

Role of intact cardiac nerves and reflex mechanisms in desensitization to catecholamines in conscious dogs.

S. Vatner, D. Vatner, T. Hintze, 1990, The Journal of clinical investigation.

Characterization of a Novel Cardiac Isoform of the Cell Cycle-related Kinase That Is Regulated during Heart Failure*

S. Vatner, D. Vatner, C. Depré, 2008, Journal of Biological Chemistry.

β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse

S. Vatner, Y. Ishikawa, T. Wagner, 1999 .

Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice

S. Vatner, Y. Ishikawa, T. Wagner, 1999 .

Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax.

S. Vatner, D. Vatner, M. Jain, 2013, Journal of proteome research.

Stimulating G protein-coupled receptors: cure or cause for heart failure?

D. Vatner, 2001, Circulation research.

Decreased adenylate cyclase activity and expression of Gs alpha in human myocardium after orthotopic cardiac transplantation.

G. Couper, D. Vatner, A. Feldman, 1995, Circulation research.

One Hour of Myocardial Ischemia Decreases the Activity of the Stimulatory Guanine-Nucleotide Regulatory Protein Gs

S. Vatner, D. Vatner, D. Knight, 1989, Circulation research.

Decreased stimulatory guanosine triphosphate binding protein in dogs with pressure-overload left ventricular failure.

S. Vatner, D. Vatner, C. Homcy, 1988, The Journal of clinical investigation.

Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.

S. Vatner, D. Vatner, L. Hittinger, 1991, The Journal of clinical investigation.

Impaired cardiac muscarinic receptor function in dogs with heart failure.

S. Vatner, D. Vatner, C. Homcy, 1988, The Journal of clinical investigation.

Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure.

S. Vatner, D. Vatner, C. Homcy, 1985, The Journal of clinical investigation.

Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase.

S. Vatner, S. Okumura, Y. Ishikawa, 2012, American journal of physiology. Heart and circulatory physiology.

Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.

S. Vatner, D. Vatner, J. Sadoshima, 2008, Cardiovascular research.

β-adrenergic cardiac hypertrophy is mediated primarily by the β1-subtype in the rat heart

S. Vatner, D. Vatner, J. Sadoshima, 2001 .

Reduced subendocardial ryanodine receptors and consequent effects on cardiac function in conscious dogs with left ventricular hypertrophy.

S. Vatner, D. Vatner, L. Hittinger, 1999, Circulation research.

Function in Conscious Dogs With Left Ventricular Hypertrophy Reduced Subendocardial Ryanodine Receptors and Consequent Effects on Cardiac

S. Vatner, D. Vatner, L. Hittinger, 1999 .

Paradoxical Cellular Ca 2 (cid:1) Signaling in Severe but Compensated Canine Left Ventricular Hypertrophy

S. Vatner, W. Lederer, Heping Cheng, 2005 .

Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts.

F. Natividad, S. Vatner, E. Lewandowski, 2004, Journal of molecular and cellular cardiology.

Differential regulation of inotropy and lusitropy in overexpressed Gsalpha myocytes through cAMP and Ca2+ channel pathways.

S. Vatner, Y. Ishikawa, S. Yamamoto, 1999, The Journal of clinical investigation.

Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure.

S. Vatner, D. Vatner, J. Galper, 1996, Circulation.

Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure.

S. Vatner, S. Okumura, Y. Ishikawa, 1999, American journal of physiology. Heart and circulatory physiology.

Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure.

S. Vatner, S. Okumura, Y. Ishikawa, 1999, The American journal of physiology.

Increased alpha 1-adrenergic vascular sensitivity during development of hypertension in conscious dogs.

S. Vatner, D. Vatner, Y. Shen, 1993, The American journal of physiology.

Effects of Moderate Pressure Overload Cardiac Hypertrophy on The Distribution of Creatine Kinase Isozymes 1

J. Ingwall, D. Vatner, 1984, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Determinants of the cardiomyopathic phenotype in chimeric mice overexpressing cardiac Gsalpha.

S. Vatner, Y. Ishikawa, T. Wagner, 2000, Circulation research.

Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload

S. Vatner, Lai-Hua Xie, R. Kitsis, 2012, Basic Research in Cardiology.

Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse.

S. Vatner, Y. Ishikawa, T. Wagner, 1999, The Journal of clinical investigation.

Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis.

S. Vatner, D. Vatner, J. Sadoshima, 2001, Journal of molecular and cellular cardiology.

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the SIRT1/FoxO3a Pathway

J. Auwerx, D. Sinclair, S. Vatner, 2013 .

Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function.

S. Vatner, D. Vatner, Misun Park, 2011, American journal of physiology. Heart and circulatory physiology.

Rats are Protected from the Stress of Chronic Pressure Overload as Compared with Mice.

S. Vatner, D. Fraidenraich, Jie Zhang, 2020, American journal of physiology. Regulatory, integrative and comparative physiology.

Effects of chronic beta-adrenergic receptor stimulation in mice.

S. Vatner, Y. Ishikawa, D. Vatner, 1997, Journal of molecular and cellular cardiology.

Overexpression of Gs alpha protein in the hearts of transgenic mice.

Y. Ishikawa, T. Wagner, D. Vatner, 1995, The Journal of clinical investigation.

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.

S. Vatner, D. Vatner, J. Sadoshima, 2002, The Journal of clinical investigation.

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

D. Roden, S. Vatner, D. Vatner, 2005, The Journal of clinical investigation.

Cardiomyopathy induced by cardiac Gs alpha overexpression.

S. Vatner, Y. Ishikawa, T. Wagner, 1997, The American journal of physiology.

Downregulation of caveolin by chronic beta-adrenergic receptor stimulation in mice.

S. Vatner, Y. Toya, Y. Ishikawa, 1997, American Journal of Physiology.

Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression.

S. Vatner, Y. Ishikawa, T. Wagner, 1996, Circulation research.

Alpha-adrenergic vasoconstriction and receptor subtypes in large coronary arteries of calves.

S. Vatner, R. Graham, D. Vatner, 1988, The American journal of physiology.

Physiological and biochemical adrenergic regulation of the stunned myocardium

S. Vatner, D. Vatner, 1998, Molecular and Cellular Biochemistry.

Smooth Muscle Myosin Inhibition: A Novel Therapeutic Approach for Pulmonary Hypertension

S. Vatner, D. Vatner, You-tang Shen, 2012, PloS one.

Enhanced cAMP-induced nitric oxide-dependent coronary dilation during myocardial stunning in conscious pigs.

S. Vatner, N. Sato, D. Vatner, 2000, American journal of physiology. Heart and circulatory physiology.

Aging Increases Aortic MMP‐2 Activity and Angiotensin II in Nonhuman Primates

E. Lakatta, F. Natividad, S. Vatner, 2003, Hypertension.

Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor.

S. Vatner, D. Vatner, T. Hintze, 1989, The Journal of clinical investigation.

Myocardial B-adrenergic receptor function during the development of pacing-induced heart failure

S. Vatner, D. Vatner, H. Hayakawa, 1994 .

Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats.

P. Douglas, D. Vatner, R. Clark, 1997, Endocrinology.

Apoptosis of cardiac myocytes in Gsalpha transgenic mice.

S. Vatner, Y. Ishikawa, T. Wagner, 1999, Circulation research.

Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart.

S. Vatner, D. Vatner, J. Sadoshima, 2001, Journal of molecular and cellular cardiology.

β‐ADRENOCEPTOR DESENSITIZATION DURING THE DEVELOPMENT OF CANINE PACING‐INDUCED HEART FAILURE

Y. Ishikawa, D. Vatner, R. Shannon, 1996, Clinical and experimental pharmacology & physiology.

Effects of pressure overload, left ventricular hypertrophy on beta-adrenergic receptors, and responsiveness to catecholamines.

S. Vatner, D. Vatner, C. Homcy, 1984, The Journal of clinical investigation.

Mechanisms mediating responsiveness to beta-adrenergic stimulation after coronary reperfusion in conscious dogs.

S. Vatner, D. Vatner, Y. Shen, 1994, The American journal of physiology.

Insights into cardioprotection obtained from study of cellular Ca 2+ handling in true hibernating myocardium

Qian Wang, S. Vatner, D. Vatner, 2004 .

Accelerated Cardiomyopathy in Mice With Overexpression of Cardiac Gsα and a Missense Mutation in the α-Myosin Heavy Chain

J. Seidman, S. Vatner, C. Seidman, 2002 .

Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.

J. Seidman, S. Vatner, C. Seidman, 2002, Circulation.

Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.

S. Vatner, D. Vatner, J. Sadoshima, 2007, The Journal of clinical investigation.

Beta-receptors and adenylate cyclase: comparison of nonischemic, ischemic, and postmortem tissue.

S. Vatner, D. Vatner, D. Knight, 1990, The American journal of physiology.

Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.

S. Vatner, D. Vatner, J. Sadoshima, 2004, Journal of molecular and cellular cardiology.

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

S. Vatner, D. Vatner, Lin Yan, 2013, AGE.

Apoptosis of Cardiac Myocytes in Gs (cid:97) Transgenic Mice

S. Vatner, Y. Ishikawa, T. Wagner, 1999 .

Accelerated Cardiomyopathy in Mice With Overexpression of Cardiac G s (cid:1) and a Missense Mutation in the (cid:1) -Myosin Heavy Chain

J. Seidman, S. Vatner, C. Seidman, 2002 .

Mechanisms of a1-Adrenergic Vascular Desensitization in Conscious Dogs

S. Vatner, R. Graham, N. Hasebe, 2005 .

Mechanisms of alpha 1-adrenergic vascular desensitization in conscious dogs.

S. Vatner, R. Graham, N. Hasebe, 1992, Circulation Research.

Uncoupling of the β-Adrenergic Receptor by Myocardial Ischemia

D. Vatner, 1989 .

Reduced3H-ouabain binding site (Na,K-ATPase) concentration in ventricular myocardium of dogs with tachycardia induced heart failure

K. Kjeldsen, D. Vatner, R. Shannon, 1993, Basic Research in Cardiology.

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.

S. Vatner, G. Yehia, C. Molina, 2003, The Journal of clinical investigation.

Mechanisms of Supersensitivity to Sympathomimetic Amines in the Chronically Denervated Heart of the Conscious Dog

S. Vatner, D. Vatner, J. Amano, 1985, Circulation research.

Sex differences in myocardial infarction and rupture.

S. Vatner, D. Vatner, C. Depré, 2007, Journal of molecular and cellular cardiology.

Reply to "Letter to the editor: When what you see may not be what you get: prudent considerations of anesthetics for murine echocardiography".

S. Vatner, D. Vatner, R. Pachon, 2015, American journal of physiology. Heart and circulatory physiology.

A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion.

S. Vatner, Jie Zhang, Marko Oydanich, 2018, Journal of molecular and cellular cardiology.

α- and β-Adrenergic Control of Large Coronary Arteries in Conscious Calves

S. Vatner, D. Vatner, M. Young, 1990 .

Modulation of β-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5

S. Vatner, K. Iwatsubo, D. Vatner, 2010, Heart Failure Reviews.

Autophagy: a Novel Protective Mechanism in Chronic Ischemia

S. Vatner, D. Vatner, J. Sadoshima, 2006, Cell cycle.

(3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors.

R. Lefkowitz, D. Vatner, 1974, Molecular pharmacology.

β-Adrenergic Receptor Signaling in Heart Failure

S. Vatner, D. Vatner, Lin Yan, 2013 .

Sex-specific regulation of gene expression in the aging monkey aorta.

F. Natividad, S. Vatner, D. Vatner, 2007, Physiological genomics.

‘Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption’

S. Vatner, K. L. La Perle, T. Wagner, 2013, Aging cell.

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload

Jing Liu, Guiping Yang, Yoshihiro Ishikawa, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction.

S. Vatner, D. Vatner, J. Sadoshima, 2009, American journal of physiology. Cell physiology.

Autophagy in chronically ischemic myocardium.

Lin Yan, Guiping Yang, S. Vatner, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Type 5 Adenylyl Cyclase Disruption Alters Not Only Sympathetic But Also Parasympathetic and Calcium-Mediated Cardiac Regulation

S. Vatner, S. Okumura, J. Kawabe, 2003, Circulation research.

Abstract 3672: Seasonal Variation in Ischemia Tolerance in a True Mammalian Hibernator

S. Vatner, D. Vatner, Lin Yan, 2009 .

Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress

Lin Yan, Wei Chen, Stephen F. Vatner, 2007, Cell.

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

J. Auwerx, D. Sinclair, S. Vatner, 2018, Aging cell.

Cardiovascular Effects of Aging in Primates—Gender Differences

S. Vatner, D. Vatner, C. Depré, 2011 .

Heart Rate and Electrocardiography Monitoring in Mice.

S. Vatner, D. Vatner, C. Hong, 2011, Current protocols in mouse biology.

Disruption of Type 5 Adenylyl Cyclase Enhances Desensitization of Cyclic Adenosine Monophosphate Signal and Increases Akt Signal With Chronic Catecholamine Stress

Reiko Kurotani, Stephen F. Vatner, Yoshihiro Ishikawa, 2007, Circulation.

Beta-adrenergic receptor regulation in the heart in pathophysiologic states: abnormal adrenergic responsiveness in cardiac disease.

S. Vatner, D. Vatner, C. Homcy, 1991, Annual review of physiology.

Disruption of adenylyl cyclase type 5 mimics exercise training

S. Vatner, Jie Zhang, Marko Oydanich, 2016, Basic Research in Cardiology.

Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.

S. Vatner, D. Vatner, J. Sadoshima, 2009, American journal of physiology. Heart and circulatory physiology.

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

J. Auwerx, D. Sinclair, S. Vatner, 2013, Circulation.

Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging.

S. Vatner, K. Iwatsubo, Y. Ishikawa, 2013, American journal of physiology. Heart and circulatory physiology.

Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis

S. Vatner, D. Vatner, Lin Yan, 2015, Basic Research in Cardiology.

Overexpression of Cardiomyocyte &agr;1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling

S. Vatner, R. Graham, D. Vatner, 2015, Arteriosclerosis, thrombosis, and vascular biology.

Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress.

S. Vatner, D. Vatner, C. Depré, 2019, Free radical biology & medicine.

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

S. Vatner, Danish Sayed, M. Abdellatif, 2009, Circulation research.

Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging

Zhongkui Hong, Zhaohui Li, S. Vatner, 2012, Aging cell.

Temporal Analysis of Vascular Smooth Muscle Cell Elasticity and Adhesion Reveals Oscillation Wave Forms that Differ with Aging

Zhongkui Hong, W. Hunter, S. Vatner, 2012 .

Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress.

S. Vatner, Y. Ishikawa, D. Vatner, 2008, Circulation journal : official journal of the Japanese Circulation Society.

Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart against Stress(Special Lecture 2,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

S. Vatner, Y. Ishikawa, D. Vatner, 2008 .

Persistent Stunning Induces Myocardial Hibernation and Protection: Flow/Function and Metabolic Mechanisms

S. Vatner, D. Vatner, J. Sadoshima, 2003, Circulation research.

Mechanism of Enhanced Cardiac Function in Mice with Hypertrophy Induced by Overexpressed Akt*

C. Croce, G. Condorelli, A. Drusco, 2003, Journal of Biological Chemistry.

Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy

S. Vatner, D. Vatner, J. Sadoshima, 2006, Circulation.

Overexpressed cardiac Gsα in rabbits

S. Vatner, Y. Ishikawa, D. Vatner, 2006 .

Downregulation of caveolin by chronic β-adrenergic receptor stimulation in mice.

S. Vatner, Y. Toya, Y. Ishikawa, 1997, American journal of physiology. Cell physiology.

Echocardiography in Mice.

S. Vatner, D. Vatner, David Ho, 2011, Current protocols in mouse biology.

Reply to: "Letter to the editor: Ketamine-only versus isoflurane effects on murine cardiac function: comparison at similar depths of anesthesia?".

S. Vatner, D. Vatner, R. Pachon, 2015, American journal of physiology. Heart and circulatory physiology.

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

J. Auwerx, S. Vatner, R. Houtkooper, 2015, Aging cell.

Subtypes of beta-adrenergic receptors in bovine coronary arteries.

S. Vatner, D. Vatner, D. Knight, 1986, Circulation research.

Peripheral vascular endothelial dysfunction and apoptosis in old monkeys.

F. Natividad, S. Vatner, D. Vatner, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha.

S. Vatner, Y. Ishikawa, M. Osaka, 1998, Circulation research.

Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice

D. Roden, S. Vatner, T. Wagner, 2005 .

Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart.

S. Vatner, D. Vatner, Lin Yan, 2006, Journal of molecular and cellular cardiology.

Models of longevity (Calorie Restriction and AC5 KO): Result of three bad hypotheses

S. Vatner, D. Vatner, Lin Yan, 2012, Aging.

Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.

S. Vatner, D. Vatner, J. Sadoshima, 2006, Journal of molecular and cellular cardiology.

Cardiac Gsalpha overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway.

H. Cantiello, S. Vatner, Y. Ishikawa, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Localisation of Cardiac GSαin Transgenic Mice Overexpressing GSα

S. Vatner, Y. Ishikawa, T. Wagner, 1997 .

Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging

Elliot L Elson, Guy M Genin, Zhe Sun, 2010, Circulation research.

Vascular Stiffness in Aging and Disease

S. Vatner, R. Graham, Jie Zhang, 2021, Frontiers in Physiology.

Gender differences on the effects of aging on cardiac and peripheral adrenergic stimulation in old conscious monkeys.

F. Natividad, S. Vatner, D. Vatner, 2003, American journal of physiology. Heart and circulatory physiology.

Characterization of subfractions from purified sarcolemma of canine left ventricle.

D. Vatner, 1990, Journal of molecular and cellular cardiology.

Arterial Pressure Monitoring in Mice.

S. Vatner, D. Vatner, C. Hong, 2011, Current protocols in mouse biology.

Inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension.

S. Vatner, R. Graham, D. Vatner, 1991, Circulation research.

Reduced Oxidative Stress as a Mechanism for Increased Longevity, Exercise and Heart Failure Protection with Adenylyl Cyclase Type 5 Inhibition

S. Vatner, Jie Zhang, D. Vatner, 2016 .

Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection

S. Vatner, D. Vatner, R. Pachon, 2015, Oxidative medicine and cellular longevity.

β‐Adrenergic and Cholinergic Receptors in Hypertension‐Induced Hypertrophy

S. Vatner, D. Vatner, C. Homcy, 1985, Hypertension.

Altered excitation-contraction coupling in myocytes from remodeled myocardium after chronic myocardial infarction.

C. Kramer, S. Vatner, G. Szigeti, 2002, Journal of molecular and cellular cardiology.

Reply to "Letter to the Editor: Mechanisms of sex differences in exercise capacity".

S. Vatner, Jie Zhang, Marko Oydanich, 2020, American journal of physiology. Regulatory, integrative and comparative physiology.

Differential regulation of G protein expression in rat hearts exposed to chronic hypoxia.

J. Richalet, D. Vatner, J. Moalic, 1995, The American journal of physiology.

Large Coronary Artery Regulation by α- and β-Adrenergic Receptors in Conscious Calves

S. Vatner, D. Vatner, M. Young, 1991 .

Augmented Vascular Smooth Muscle Cell Stiffness and Adhesion When Hypertension Is Superimposed on Aging

Zhongkui Hong, W. Hunter, S. Vatner, 2015, Hypertension.

Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart.

S. Vatner, Lai-Hua Xie, D. Vatner, 2015, American journal of physiology. Heart and circulatory physiology.

Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension.

Zhongkui Hong, W. Hunter, S. Vatner, 2013, American journal of physiology. Heart and circulatory physiology.

Paradoxical Cellular Ca2+ Signaling in Severe but Compensated Canine Left Ventricular Hypertrophy

S. Vatner, W. Lederer, Heping Cheng, 2005, Circulation research.

Identification and Functional Role ofβ-adrenergic Receptor Subtypes in Primate and Rodent:In Vivoversus Isolated Myocytes

S. Vatner, D. Vatner, M. Iwase, 1996 .

Identification and functional role of beta-adrenergic receptor subtypes in primate and rodent: in vivo versus isolated myocytes.

S. Vatner, Y. Cui, D. Vatner, 1996, Journal of Molecular and Cellular Cardiology.

Exercise enhancement by RGS14 disruption is mediated by brown adipose tissue

S. Vatner, Jie Zhang, Marko Oydanich, 2023, Aging cell.

Mechanisms of sex differences in exercise capacity.

S. Vatner, Jie Zhang, Marko Oydanich, 2019, American journal of physiology. Regulatory, integrative and comparative physiology.

Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha.

S. Vatner, Y. Ishikawa, D. Vatner, 2007, American journal of physiology. Heart and circulatory physiology.

Abstract 17173: Caloric Restriction Protects Against Aging Cardiomyopathy, But Not Longevity

S. Vatner, D. Vatner, Lin Yan, 2011 .

Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window.

S. Vatner, D. Vatner, C. Depré, 2010, American journal of physiology. Heart and circulatory physiology.

Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in Primates

S. Vatner, Jie Zhang, D. Vatner, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Adenylyl cyclase type 5 protein expression during cardiac development and stress.

S. Vatner, K. Iwatsubo, Y. Ishikawa, 2009, American journal of physiology. Heart and circulatory physiology.

Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs.

S. Vatner, Y. Ishikawa, D. Vatner, 1994, The Journal of clinical investigation.

Two Mechanisms Mediating Enhanced Glucose Tolerance with Regulator of GS Protein 14 Disruption; Increased Exercise Capacity and Increased Brown Adipose Tissue

S. Vatner, Jie Zhang, Marko Oydanich, 2018, Diabetes.

Abstract 18790: Brown Adipose Tissue Enhances Exercise Performance

S. Vatner, Jie Zhang, Marko Oydanich, 2017 .

Abstract 18750: Increased Brown Adipose Tissue as a Novel Mechanism Mediating Cardioprotection

S. Vatner, Jie Zhang, D. Vatner, 2016 .

A Food and Drug Administration–Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion

S. Vatner, Jie Zhang, D. Vatner, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

S. Vatner, D. Vatner, Lin Yan, 2013, AGE.

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

J. Auwerx, S. Vatner, D. Vatner, 2012, Aging cell.

Mechanism of Gender-Specific Differences in Aortic Stiffness With Aging in Nonhuman Primates

F. Natividad, S. Vatner, D. Vatner, 2007, Circulation.

Abstract 1673: Enhanced Coronary Reserve Mediated by Nitric Oxide in Adenylyl Cyclase Type 5 Knockout

S. Vatner, D. Vatner, C. Hong, 2008 .

Abstract 5501: Reduced Coronary Reserve as a Mechanism in Beta-Adrenergic Receptor Mediated Cardiomyopathy and its Rescue by Adenylyl Cyclase Type 5 Knockout

S. Vatner, D. Vatner, C. Hong, 2008 .

Paradoxically Enhanced Endothelin-B Receptor—Mediated Vasoconstriction in Conscious Old Monkeys

F. Natividad, S. Vatner, D. Vatner, 2001, Circulation.

Adrenergic responsiveness is reduced, while baseline cardiac function is preserved in old adult conscious monkeys.

S. Vatner, D. Vatner, Y. Shen, 1995, The American journal of physiology.

Beta-adrenergic receptor signalling in stunned myocardium of conscious pigs.

S. Vatner, Y. Ishikawa, D. Vatner, 1997, Journal of molecular and cellular cardiology.

Effects of coronary arterial reperfusion on beta-adrenergic receptor-adenylyl cyclase coupling.

S. Vatner, D. Vatner, W. Manders, 1993, The American journal of physiology.

Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals.

S. Vatner, D. Vatner, E. Kranias, 2004, American journal of physiology. Heart and circulatory physiology.

Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy.

S. Vatner, D. Vatner, J. Sadoshima, 2003, Cardiovascular research.

Abstract 1625: Type 5 Adenylyl Cyclase Disruption Enhances Exercise Capacity Not Due to Improved Cardiac Output, but Rather to Resistance to Oxidative Stress in Skeletal Muscle

S. Vatner, Jeffrey G. Williams, D. Vatner, 2009 .

Abstract 5936: Inhibition of Type 5 Adenylyl Cyclase Rescues Cardiomyopathy Induced by Overexpressed beta2-Adrenergic Receptors in the Heart

S. Vatner, Jeffrey G. Williams, D. Vatner, 2009 .

Effect of post-mortem time on. beta. -adrenergic receptor binding and adenylate cyclase activity

D. Vatner, D. Knight, C. Homcy, 1986 .

Adenylylcyclase: Characterization in the Heart and Its Regulation in Heart Failure

S. Vatner, J. Kawabe, Y. Ishikawa, 1993 .

Abstract 17445: Overexpression of Adenylyl Cyclase Type 5 (AC5) in the Heart Predisposes to Cardiac Arrhythmias

S. Vatner, K. Iwatsubo, Y. Ishikawa, 2010 .

Response to Letter to the Editor on “Does Vidarabine Mediate Cardioprotection via Inhibition of AC5?”

S. Vatner, D. Vatner, Claudio A Bravo, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Abstract 2664: Arrhythmia Protection Insights From a Hibernating Animal

S. Vatner, Lai-Hua Xie, D. Vatner, 2009 .

Abstract 19323: Disruption of Adenylyl Cyclase Type 5, a Novel Target for Obesity, Diabetes and Diabetic Cardiomyopathy

S. Vatner, D. Vatner, J. Pessin, 2012 .

Cardiac Overexpression of Adenylyl Cyclase Type 5 Induces Left Ventricular Hypertrophy Potentially by Activating Calcineurin‐NFAT Signaling

S. Vatner, D. Vatner, J. Sadoshima, 2011 .

Abstract 1257: Autophagy Plays Both Protective and Detrimental Roles in Post Myocardial Infarction Hearts

S. Vatner, D. Vatner, J. Sadoshima, 2007 .

Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart.

S. Vatner, D. Vatner, L. Meggs, 2003, American journal of physiology. Heart and circulatory physiology.

Microbiota Mediate Enhanced Exercise Capacity Induced by Exercise Training

S. Vatner, Jie Zhang, Marko Oydanich, 2023, Medicine & Science in Sports & Exercise.

Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload.

S. Vatner, Y. Ishikawa, T. Wagner, 2010, American journal of physiology. Heart and circulatory physiology.

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

J. Auwerx, S. Vatner, D. Vatner, 2012, Aging cell.

Caloric restriction reduces growth of mammary tumors and metastases.

S. Vatner, P. Abarzúa, D. Vatner, 2011, Carcinogenesis.

Autophagy in ischemic preconditioning and hibernating myocardium

S. Vatner, D. Vatner, J. Sadoshima, 2009, Autophagy.

Adenylyl cyclase type 5 protein expression during cardiac development and stress.

S. Vatner, K. Iwatsubo, Y. Ishikawa, 2009, American journal of physiology. Heart and circulatory physiology.

Overexpression of Cardiomyocyte Α 1a -adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis through Heterocellular Signaling Materials and Methods Results Attenuated Cardiac Remodeling in Transgenic Rats after Chronic Mi Increased Angiogenesis in Transgenic Rats with Upregu

S. Vatner, D. Vatner, Xin Zhao, 2022 .

Metabolic Mechanisms Persistent Stunning Induces Myocardial Hibernation and Protection : Flow / Function and

S. Vatner, D. Vatner, A. Peppas, 2003 .

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

J. Auwerx, D. Sinclair, S. Vatner, 2013, Circulation.

The role of brown adipose tissue in mediating healthful longevity

S. Vatner, Jie Zhang, D. Vatner, 2024, The Journal of Cardiovascular Aging.