I. Brodsky

发表

BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

Uri Hershberg, B. Freedman, Xiaohong Liu, 2020, Cell reports.

TLR signaling augments macrophage bactericidal activity through mitochondrial ROS

H. Erdjument-Bromage, P. Tempst, S. Ghosh, 2011, Nature.

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

E. Radaelli, T. Roger, I. Brodsky, 2020, Science Advances.

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

M. Bertrand, P. Vandenabeele, A. Heck, 2019, Nature Communications.

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

D. Green, J. Bertin, C. Dillon, 2017, The Journal of experimental medicine.

Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis

D. Green, J. Bertin, C. Dillon, 2016, The Journal of Immunology.

Cell death programs in Yersinia immunity and pathogenesis

I. Brodsky, Naomi H Philip, 2012, Front. Cell. Inf. Microbio..

A role for the ITAM signaling module in specifying cytokine-receptor functions

Jelena S. Bezbradica, R. Medzhitov, R. Rosenstein, 2014, Nature Immunology.

To catch a thief: regulated RIPK1 post-translational modifications as a fail-safe system to detect and overcome pathogen subversion of immune signaling.

I. Brodsky, L. Peterson, 2020, Current opinion in microbiology.

Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems

I. Brodsky, Jennifer Martinez, E. Feeley, 2017, Proceedings of the National Academy of Sciences.

T cell-intrinsic role of IL-6 signaling in primary and memory responses

Yan Gao, Hongyu Zhao, Xiting Yan, 2014, eLife.

Interferon-γ in Salmonella pathogenesis: New tricks for an old dog.

I. Brodsky, S. Balachandran, Justin P. Ingram, 2017, Cytokine.

HVEM LIGHTs the Way for ILC3s.

I. Brodsky, D. Sorobetea, 2018, Cell host & microbe.

Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

Sunny Shin, I. Brodsky, Timothy J. Nice, 2022, Infection and immunity.

Salmonella Typhimurium induces NAIP/NLRC4- and NLRP3/ASC-independent, caspase-1/4-dependent inflammasome activation in human intestinal epithelial cells

Sunny Shin, I. Brodsky, I. Rauch, 2021, bioRxiv.

The Evolving Erythrocyte: Red Blood Cells as Modulators of Innate Immunity

I. Brodsky, N. Mangalmurti, Nilam S. Mangalmurti, 2018, The Journal of Immunology.

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

Yue Zhang, R. Medzhitov, Ying Zheng, 2011, PLoS pathogens.

Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity

Sunny Shin, M. Marks, I. Brodsky, 2017, PLoS pathogens.

The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6

C. Hunter, I. Brodsky, J. Henao-Mejia, 2020, Proceedings of the National Academy of Sciences.

Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

I. Brodsky, Meghan A Wynosky-Dolfi, Ç. Tükel, 2014, Infection and Immunity.

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.

D. Kastner, P. Hearing, I. Brodsky, 2016, Cell host & microbe.

Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular autoprocessing

Sunny Shin, I. Brodsky, D. Grubaugh, 2022, bioRxiv.

Two Modes of Ligand Recognition by TLRs

R. Medzhitov, I. Brodsky, 2007, Cell.

CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

A. M. Carvalho, I. Brodsky, D. Beiting, 2017, PLoS pathogens.

Modulation of innate immune responses by Yersinia type III secretion system translocators and effectors

I. Brodsky, G. Viboud, J. Bliska, 2013, Cellular microbiology.

RNA helicase DHX33 puts a new twist on NLRP3 inflammasome activation.

I. Brodsky, 2013, Immunity.

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

D. Green, Sunny Shin, A. Oberst, 2014, Proceedings of the National Academy of Sciences.

TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts Legionella pneumophila infection

Sunny Shin, I. Brodsky, Tzvi Pollock, 2022, bioRxiv.

Activation and Evasion of Inflammasomes by Yersinia.

I. Brodsky, Naomi H Philip, Erin E. Zwack, 2016, Current topics in microbiology and immunology.

A Mouse Model of Persistent Salmonella Infection

S. Falkow, D. Bouley, I. Brodsky, 2004 .

Analysis of Inflammasome Activation in Response to Yersinia Infection by Fluorescence Microscopy Detection of Active Caspase-1 Puncta.

I. Brodsky, Erin E. Zwack, 2019, Methods in molecular biology.

Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation.

Sunny Shin, I. Brodsky, Natasha Lopes Fischer, 2021, Cell reports.

Salmonella "RecAmends" self-healing.

I. Brodsky, Marisa S Egan, Beatrice I. Herrmann, 2021, Cell host & microbe.

Caspase-8 protein cuts a brake on immune defences

I. Brodsky, 2020, Nature.

Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation

J. Buxbaum, Sunny Shin, I. Brodsky, 2022, Infection and immunity.

A bacterial sensory system that activates resistance to innate immune defenses: potential targets for antimicrobial therapeutics.

I. Brodsky, J. Gunn, 2005, Molecular interventions.

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signalling

E. Radaelli, I. Brodsky, J. Henao-Mejia, 2021, bioRxiv.

Role of the Yersinia pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes

J. Mecsas, I. Brodsky, J. Bliska, 2021, EcoSal Plus.

Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11

Sunny Shin, I. Brodsky, R. Ernst, 2021, bioRxiv.

Immune sensing of the Gram-negative bacterial membrane glycolipid lipopolysaccharide

Sunny Shin, I. Brodsky, R. Ernst, 2021 .

The inflammasome: Learning from bacterial evasion strategies.

Sunny Shin, I. Brodsky, 2015, Seminars in immunology.

Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variants

J. Buxbaum, Sunny Shin, I. Brodsky, 2021, bioRxiv.

The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade.

Nancy R. Zhang, Zhaojun Zhang, A. Minn, 2022, Immunity.

virK, somA and rcsC are important for systemic Salmonella enterica serovar Typhimurium infection and cationic peptide resistance

Stanley Falkow, S. Falkow, I. Brodsky, 2003, Molecular microbiology.

Effector-triggered immunity and pathogen sensing in metazoans

Sunny Shin, I. Brodsky, Nawar Naseer, 2019, Nature Microbiology.

NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens.

I. Brodsky, D. Monack, 2009, Seminars in immunology.

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

J. Rinn, L. Goff, A. Raj, 2017, Immunity.

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

Hongyu Zhao, R. Medzhitov, I. Brodsky, 2014, Immunity.

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii

Uri Hershberg, B. Freedman, C. Hunter, 2019, Proceedings of the National Academy of Sciences.

Arresting microbiome development limits immune system maturation and resistance to infection

I. Brodsky, P. Planet, M. Silverman, 2022, bioRxiv.

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

F. Bushman, C. Ziegler, Kyoung-Jae Won, 2013, Nature.

JAK-ing into M1/M2 Polarization SteErs Salmonella-Containing Macrophages Away from Immune Attack to Promote Bacterial Persistence.

I. Brodsky, 2020, Cell host & microbe.

Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication

Sunny Shin, I. Brodsky, Valeria M Reyes Ruiz, 2021, bioRxiv.

Differential Induction of TLR3-Dependent Innate Immune Signaling by Closely Related Parasite Species

E. Wherry, D. Roos, C. Hunter, 2014, PloS one.

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

Janet M. Young, D. Stetson, I. Brodsky, 2012, The Journal of experimental medicine.

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

Sunny Shin, R. Flavell, I. Brodsky, 2013, PLoS pathogens.

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

G. Ruthel, I. Brodsky, J. Bliska, 2015, mBio.

PD-L1 – PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection

C. Hunter, A. Sharpe, I. Brodsky, 2022, Nature Immunology.

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

Ronald N. Germain, Michael Y. Gerner, Yasmine Belkaid, 2015, Cell.

Targeting of immune signalling networks by bacterial pathogens

R. Medzhitov, I. Brodsky, 2009, Nature Cell Biology.

mig-14 Is a Salmonella Gene That Plays a Role in Bacterial Resistance to Antimicrobial Peptides

Samuel I. Miller, S. Falkow, I. Brodsky, 2002, Journal of bacteriology.

Inflammatory monocytes promote granuloma control of Yersinia infection

M. Mack, I. Brodsky, D. Sorobetea, 2023, Nature Microbiology.

Caspase-11: the noncanonical guardian of cytosolic sanctity.

Sunny Shin, I. Brodsky, 2013, Cell host & microbe.

NAIP‐NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL‐18 Release via Activation of Caspase‐1 and ‐8

I. Brodsky, K. Gronert, R. Vance, 2017, Immunity.

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome

Russell G. Jones, B. Freedman, R. Flavell, 2014, The Journal of experimental medicine.

Pyroptosis: Macrophage Suicide Exposes Hidden Invaders

R. Medzhitov, I. Brodsky, 2011, Current Biology.

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

A. Oberst, I. Brodsky, A. Rongvaux, 2016, PLoS pathogens.

Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components

Masahiro Yamamoto, I. Brodsky, J. Bliska, 2017, Infection and Immunity.

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM

A. Koller, R. Flavell, I. Brodsky, 2014, mBio.

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

M. Bertrand, P. Vandenabeele, A. Heck, 2019, Nature Communications.

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

I. Brodsky, J. Henao-Mejia, D. Beiting, 2021, bioRxiv.

The Card19 locus of murine chromosome 13 regulates terminal cell lysis downstream of caspase activation and Gasdermin-D cleavage Card19 locus regulates caspase-dependent cell lysis

I. Brodsky, J. Henao-Mejia, D. Beiting, 2021 .

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system.

F. Sutterwala, R. Flavell, Saheli Sadanand, 2010, Cell host & microbe.

A Nonpyroptotic IFN-γ–Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo

B. Finlay, Wei Guo, Masahiro Yamamoto, 2018, The Journal of Immunology.

Caspase‐8 Collaborates with Caspase‐11 to Drive Tissue Damage and Execution of Endotoxic Shock

Michelle C. Schaeffer, Carol A. Capriotti, J. Bertin, 2018, Immunity.

A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.

J. Mecsas, I. Brodsky, Erin R Green, 2015, Cell Host and Microbe.

Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence

R. Medzhitov, I. Brodsky, 2008, PLoS pathogens.

Inflammatory monocytes promote pyogranuloma formation to counteract Yersinia blockade of host defense

E. Radaelli, I. Brodsky, D. Sorobetea, 2022, bioRxiv.

White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection

Allyson L. Byrd, Y. Belkaid, Vinícius Andrade-Oliveira, 2017, Immunity.

Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bile.

S. Falkow, R. Belas, I. Brodsky, 2004, FEMS immunology and medical microbiology.

Mig‐14 is an inner membrane‐associated protein that promotes Salmonella typhimurium resistance to CRAMP, survival within activated macrophages and persistent infection

S. Falkow, I. Brodsky, D. Monack, 2004, Molecular microbiology.

Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium.

S. Falkow, I. Brodsky, J. Gunn, 2004, Microbiology.

A TNF-IL-1 circuit controls Yersinia within intestinal granulomas

Sunny Shin, I. Brodsky, James P. Grayczyk, 2023, bioRxiv.

Yersinia Type III-Secreted Effectors Subvert Caspase-4-dependent Inflammasome Activation in 1 Human Cells 2

Sunny Shin, I. Brodsky, Jenna Zhang, 2023 .

Effector-triggered immunity and pathogen sensing in metazoans

Sunny Shin, I. Brodsky, Nawar Naseer, 2019, Nature Microbiology.

Yersinia interactions with regulated cell death pathways.

I. Brodsky, Kaiwen W. Chen, 2022, Current opinion in microbiology.

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

Sunny Shin, Yi-Wei Chang, I. Brodsky, 2023, bioRxiv.

Blockade of IKK signaling induces RIPK1-independent apoptosis in human cells

Sunny Shin, I. Brodsky, Beatrice Herrmann, 2023, bioRxiv.

Yersinia Type III-Secreted Effectors Evade the Caspase-4 Inflammasome in Human Cells

Sunny Shin, I. Brodsky, Jenna Zhang, 2023, bioRxiv.

Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis

X. Wang, Ning Li, Christopher Joachim Lengner, 2023, bioRxiv.

Yersinia deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human cells

Sunny Shin, I. Brodsky, Jenna Zhang, 2023, mBio.

Collab or Cancel? Bacterial Influencers of Inflammasome Signaling.

I. Brodsky, James P. Grayczyk, Beatrice I Herrmann, 2023, Annual review of microbiology.

The inflammasome: Learning from bacterial evasion strategies.

Sunny Shin, I. Brodsky, 2015, Seminars in immunology.

Yersinia Type III-Secreted Effectors Subvert Caspase-4-dependent Inflammasome Activation in 1 Human Cells 2

Sunny Shin, I. Brodsky, Jenna Zhang, 2023 .

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

Hongyu Zhao, R. Medzhitov, I. Brodsky, 2014, Immunity.

Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling

I. Brodsky, B. S. Saller, Olaf Groß, 2023, bioRxiv.

Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS

Sunny Shin, I. Brodsky, D. Grubaugh, 2024, eLife.

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling

E. Radaelli, I. Brodsky, F. Tacchini-Cottier, 2021, Proceedings of the National Academy of Sciences.

A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas

Sunny Shin, I. Brodsky, D. Sorobetea, 2024, The Journal of experimental medicine.