S. Khetani

发表

Physiologically Inspired Culture Medium Prolongs the Lifetime and Insulin Sensitivity of Human Hepatocytes in Micropatterned Co-cultures.

M. D. Davidson, Joshua Pickrell, S. Khetani, 2020, Toxicology.

The European charter for counteracting obesity: A late but important step towards action. Observations on the WHO-Europe ministerial conference, Istanbul, November 15–17, 2006

Sangeeta N. Bhatia, S. Bhatia, Alice A. Chen, 2007, The international journal of behavioral nutrition and physical activity.

Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

M. D. Davidson, S. Khetani, Kimberly R Ballinger, 2016, Scientific Reports.

In vitro zonation and toxicity in a hepatocyte bioreactor.

S. Bhatia, S. Khetani, J. W. Allen, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Microengineered Liver Tissues for Drug Testing

M. D. Davidson, S. Khetani, Kimberly R Ballinger, 2015, Journal of laboratory automation.

Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury

S. Khetani, Christine Lin, 2016, BioMed research international.

Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies

S. Khetani, G. Underhill, Gregory H. Underhill, 2017, Cellular and molecular gastroenterology and hepatology.

Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system

Sangeeta N. Bhatia, Charles M. Rice, Christopher T. Jones, 2010, Nature Biotechnology.

Micropatterned Co‐Cultures of Human Hepatocytes and Stromal Cells for the Assessment of Drug Clearance and Drug‐Drug Interactions

S. Khetani, Christine Lin, 2017, Current protocols in toxicology.

Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety

D. Hay, S. Khetani, J. Blanco, 2017, The AAPS Journal.

A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells

S. Khetani, B. Ware, Michael J Durham, 2017, Cellular and molecular gastroenterology and hepatology.

Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development.

M. D. Davidson, S. Khetani, D. Kukla, 2017, Integrative biology : quantitative biosciences from nano to macro.

Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures.

M. D. Davidson, S. Khetani, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures

M. D. Davidson, S. Khetani, 2019, bioRxiv.

Transmitted/Founder Hepatitis C Viruses Induce Cell-Type- and Genotype-Specific Differences in Innate Signaling within the Liver

G. Shaw, Hui Li, S. Khetani, 2015, mBio.

In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression.

S. Bhatia, S. Khetani, R. Johnson, 2006, Tissue engineering.

Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.

G. Shaw, S. Lemon, V. Shah, 2015, Gastroenterology.

Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.

K. V. Van Vliet, S. Bhatia, Alice A. Chen, 2009, Biomaterials.

Microfabrication of liver and heart tissues for drug development

S. Khetani, Grace E. Brown, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

High Throughput Interrogation of Human Liver Stellate Cells Reveals Microenvironmental Regulation of Phenotype.

S. Khetani, G. Underhill, D. Kukla, 2021, Acta biomaterialia.

High Throughput Interrogation of Human Liver Stellate Cells Reveals Microenvironmental Regulation of Phenotype

S. Khetani, G. Underhill, Gregory H. Underhill, 2021, Acta biomaterialia.

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional Models

D. K. Wood, S. Khetani, Alexandra L. Crampton, 2019, bioRxiv.

Water-Stable Metal-Organic Framework/Polymer Composites Compatible with Human Hepatocytes.

Melissa M. Reynolds, S. Khetani, B. Ware, 2016, ACS applied materials & interfaces.

Pluripotent Stem Cell-Derived Human Liver Organoids Enter the Realm of High-Throughput Drug Screening.

S. Khetani, 2020, Gastroenterology.

Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies

S. Khetani, B. Ware, 2017 .

Long-term Engineered Cultures of Primary Mouse Hepatocytes for Strain and Species Comparison Studies During Drug Development.

S. Khetani, B. Ware, V. Soldatow, 2019, Gene expression.

DMD066027 127..136

S. Khetani, Christine Lin, A. Moore, 2015 .

Modulation of Human iPSC-derived Hepatocyte Phenotype Via Extracellular Matrix Microarrays.

S. Khetani, G. Underhill, Gregory H. Underhill, 2022, Acta biomaterialia.

Engineered matrix microenvironments reveal the heterogeneity of liver sinusoidal endothelial cell phenotypic responses

S. Khetani, G. Underhill, Gregory H. Underhill, 2022, APL bioengineering.

HCV Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cell and Release of Exosomes, Which Inhibits Viral Replication

G. Shaw, V. Shah, Hui Li, 2016 .

A polyelectrolyte multilayer platform for investigating growth factor delivery modes in human liver cultures.

S. Khetani, M. Kipper, Laura W. Place, 2018, Journal of biomedical materials research. Part A.

Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration-Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress

S. Khetani, A. Kornienko, G. Munirathinam, 2022, Cancers.

The application of engineered liver tissues for novel drug discovery

Christine Lin, Salman R Khetani, S. Khetani, 2015, Expert opinion on drug discovery.

Microscale culture of human liver cells for drug development

S. Bhatia, S. Khetani, 2008, Nature Biotechnology.

Bioengineered Liver Models for Investigating Disease Pathogenesis and Regenerative Medicine

S. Khetani, D. Kukla, David A. Kukla, 2021, Seminars in Liver Disease.

Emerging trends in modeling human liver disease in vitro

S. Khetani, G. Underhill, Gregory H. Underhill, 2019, APL bioengineering.

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

Heather E Fleming, Vyas Ramanan, Sangeeta N Bhatia, 2015, Nature Protocols.

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.

Salman R Khetani, S. Khetani, D. Berger, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Superhydrophobic Coatings with Edible Materials.

Wei Wang, Arun K. Kota, M. D. Davidson, 2016, ACS applied materials & interfaces.

Chapter Forty-Eight – Liver

S. Bhatia, Alice A. Chen, S. Khetani, 2007 .

CELL SOURCES FOR LIVER CELL – BASED THERAPIES

S. Bhatia, Alice A. Chen, S. Khetani, 2007 .

Assessing the compatibility of primary human hepatocyte culture within porous silk sponges

D. Kaplan, S. Khetani, W. Stoppel, 2020, RSC advances.

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

D. B. Duignan, R. Obach, S. Khetani, 2010, Drug Metabolism and Disposition.

Engineered Liver Platforms for Different Phases of Drug Development.

Salman R Khetani, S. Khetani, B. Ware, 2017, Trends in biotechnology.

LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer

B. Prabhakar, A. Maker, S. Khetani, 2022, Oncogene.

Micropatterned co-cultures of hepatocytes and nonparenchymal cells : mechanisms of differentiation, dynamics and applications

S. Khetani, 2006 .

Stem cell-derived liver cells for drug testing and disease modeling.

M. D. Davidson, S. Khetani, B. Ware, 2015, Discovery medicine.

Engineered Human Liver Cocultures for Investigating Drug-Induced Liver Injury

S. Khetani, Chase P. Monckton, 2018 .

Advances in Engineered Human Liver Platforms for Drug Metabolism Studies

S. Khetani, G. Underhill, Gregory H. Underhill, 2018, Drug Metabolism and Disposition.

Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro

M. D. Davidson, S. Khetani, D. Berger, 2015, Hepatology.

Pluripotent stem cell-derived hepatocyte-like cells.

S. Bhatia, R. Schwartz, S. Khetani, 2014, Biotechnology advances.

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

Sangeeta N. Bhatia, Charles M. Rice, Christopher T. Jones, 2010, Proceedings of the National Academy of Sciences.

For submission to Toxicological Sciences In Vitro Zonation and Toxicity in a Perfused Hepatocyte Co-Culture

S. Bhatia, S. Khetani, Jared W. Allen, 2004 .

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.

Yvonne Will, Chitra Kanchagar, Salman R Khetani, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC–derived atrial fibrillation model

Mahmud Arif Pavel, M. Maienschein-Cline, S. Khetani, 2022, JCI insight.

Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes

Christine Lin, Salman R Khetani, S. Khetani, 2016, Drug Metabolism and Disposition.

The Role of Liver Zonation in Physiology, Regeneration, and Disease.

S. Khetani, Chase P. Monckton, Regeant Panday, 2022, Seminars in liver disease.

Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity

I. Rusyn, J. Corton, K. Guyton, 2021, Hepatology.

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Hongbin Yu, Donald Tweedie, D. Tweedie, 2018, Drug Metabolism and Disposition.

Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Hongbin Yu, Donald Tweedie, D. Tweedie, 2013 .

Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterization

I. Rusyn, S. Khetani, W. Chiu, 2022, Environmental health perspectives.

Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease Modeling

S. Khetani, Yang Yuan, Kristen Y. Cotton, 2023, Cellular and molecular gastroenterology and hepatology.

Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro

S. Bhatia, S. Khetani, G. Underhill, 2009, Hepatology.

Long‐Term Stability of Primary Rat Hepatocytes in Micropatterned Cocultures

Melvin E Andersen, Chitra Kanchagar, Salman R Khetani, 2013, Journal of biochemical and molecular toxicology.

Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling

Sangeeta N Bhatia, Salman R Khetani, Carrolee Barlow, 2004, Hepatology.

A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B

Y. Peterson, S. Khetani, J. Carten, 2023, Communications biology.

Bioengineering approaches to mature induced pluripotent stem cell-derived atrial cardiomyocytes to model atrial fibrillation

S. Khetani, D. Darbar, Grace E. Brown, 2021, Experimental biology and medicine.

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

P. Watkins, O. J. Trask, W. J. Brock, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters

Chitra Kanchagar, Salman R Khetani, R. Evers, 2015, Drug Metabolism and Disposition.

Microsoft Word-23398812-file00.docx

R. Evers, O. Irrechukwu, S. Khetani, 2015 .

Micropatterned Coculture with 3T3-J2 Fibroblasts Enhances Hepatic Functions and Drug Screening Utility of HepaRG Cells.

S. Khetani, Kimberly R Ballinger, B. Ware, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling

S. Khetani, B. Ware, Michael McVay, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Engineering tissues for in vitro applications.

Sangeeta N Bhatia, Salman R Khetani, S. Bhatia, 2006, Current opinion in biotechnology.

T‐cadherin modulates hepatocyte functions in vitro

Sangeeta N Bhatia, Salman R Khetani, S. Bhatia, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Primary Human Hepatocytes Maintain Long-term Functions in Porous Silk Scaffolds Containing Extracellular Matrix Proteins

D. Kaplan, S. Khetani, W. Stoppel, 2020, bioRxiv.

Bioactivation and Toxicity of Acetaminophen in a Rat Hepatocyte Micropatterned Coculture System

M. Andersen, S. Khetani, E. LeCluyse, 2013, Journal of biochemical and molecular toxicology.

Tissue engineering: Liver

Alice A. Chen, S. Khetani, A. Demetriou, 2009 .

Elucidating Extracellular Matrix and Stiffness Control of Primary Human Hepatocyte Phenotype via Cell Microarrays

S. Khetani, G. Underhill, Gregory H. Underhill, 2021, Advanced materials interfaces.

A polyelectrolyte multilayer platform for investigating growth factor delivery modes in human liver cultures.

S. Khetani, M. Kipper, Laura W. Place, 2018, Journal of biomedical materials research. Part A.

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver.

S. Khetani, Matthew D Davidson, Michael Lehrer, 2015, Tissue engineering. Part C, Methods.

Superhydrophobic Coatings with Edible Materials.

M. D. Davidson, S. Khetani, A. Kota, 2016, ACS applied materials & interfaces.

Decellularized Liver Nanofibers Enhance and Stabilize the Long‐Term Functions of Primary Human Hepatocytes In Vitro

S. Khetani, M. Kipper, Jennifer S. Liu, 2023, Advanced healthcare materials.

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional Models.

D. K. Wood, S. Khetani, Alexandra L. Crampton, 2020, Gene expression.

Engineered Liver Platforms for Different Phases of Drug

S. Khetani, 2017 .

Genetics and Pharmacogenetics of Atrial Fibrillation

S. Khetani, A. Sridhar, Hanna Chen, 2024, JACC. Basic to translational science.

Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation

S. Khetani, Alfred L. George, C. Vanoye, 2024, Science advances.

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver

Salman R Khetani, M. D. Davidson, S. Khetani, 2015 .

Long-term HBV infection of engineered cultures of induced pluripotent stem cell-derived hepatocytes.

S. Khetani, Christine Lin, Vedant V Bodke, 2024, Hepatology communications.