David A Hildeman

K. Roskin, David A Hildeman, D. Allman, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

J. Woodgett, Harinder Singh, David A Hildeman, 2018, Nature Communications.

A prospective, iterative, adaptive trial of carfilzomib‐based desensitization

David A Hildeman, R. Alloway, E. Woodle, 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Interleukin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through γδ T-Cell IL-17 Production in a Murine Model of Sepsis

Caldwell, R. Hotchkiss, David A Hildeman, 2010, Infection and Immunity.

Helios-controller of Treg stability and function.

C. Chougnet, David A Hildeman, 2016, Translational cancer research.

Homeostasis and function of regulatory T cells in aging.

C. Chougnet, David A Hildeman, C. S. Lages, 2012, Current opinion in immunology.

T Cell + Not Control Contraction of CD 4 Cutting Edge : Limiting Amounts of IL-7 Do

F. Finkelman, David A Hildeman, P. Tripathi, 2007 .

Cutting Edge: Limiting Amounts of IL-7 Do Not Control Contraction of CD4+ T Cell Responses1

F. Finkelman, David A Hildeman, P. Tripathi, 2007, The Journal of Immunology.

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

David A. Williams, David A Hildeman, H. Chae, 2006, Nature Immunology.

NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma

F. Finkelman, David A Hildeman, Zhenqi Zhu, 2017, PloS one.

Assessment of CD4(+) and CD8 (+) T cell responses using MHC class I and II tetramers.

David A Hildeman, S. Kurtulus, 2013, Methods in molecular biology.

T-CELL ACTIVATION DIFFERENTIALLY MEDIATES THE HOST RESPONSE TO SEPSIS

J. Dattilo, David A Hildeman, C. Caldwell, 2010, Shock.

SepsisProduction in a Murine Model of T-Cell δ γ Neutrophil Recruitment through Interleukin-7 (IL-7) Treatment Accelerates

R. Hotchkiss, David A Hildeman, Cristina Mazuski, 2014 .

ProliferationStimulates CD8+ T Cell Endogenously Produced IL-4

F. Finkelman, David A Hildeman, C. Perkins, 2013 .

Endogenously Produced IL-4 Nonredundantly Stimulates CD8+ T Cell Proliferation1

F. Finkelman, M. Khodoun, David A Hildeman, 2009, The Journal of Immunology.

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

S. Way, Harinder Singh, Emily R. Miraldi, 2020, Science Advances.

Etoposide Selectively Ablates Activated T Cells To Control the Immunoregulatory Disorder Hemophagocytic Lymphohistiocytosis

David A Hildeman, J. Katz, M. Jordan, 2014, The Journal of Immunology.

Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice

B. Beutler, P. Krebs, H. Grimes, 2010, The Journal of Immunology.

MiceIntestinal Inflammation in Gimap5-Deficient Flora-Dependent Wasting Disease and Precedes the Onset of Microbial Loss of T Cell and B Cell Quiescence

B. Beutler, P. Krebs, H. Grimes, 2010 .

IL‐4 and IL‐15 promotion of virtual memory CD8+ T cells is determined by genetic background

F. Finkelman, David A Hildeman, P. Tripathi, 2016, European journal of immunology.

VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.

L. Boon, David A Hildeman, A. Sholl, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Homeostasis of alpha beta TCR+ T cells.

P. Marrack, J. Kappler, David A Hildeman, 2000, Nature immunology.

Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological disease

David A Hildeman, T. Havighurst, D. Muller, 1997, Journal of virology.

Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.

T. Doetschman, David A Hildeman, A. Sholl, 2011, Clinical immunology.

×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils*

David A Hildeman, S. K. Frankel, P. Henson, 2004, Journal of Biological Chemistry.

Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock

H. Wong, David A Hildeman, A. Opoka, 2017, Critical care medicine.

Optimization of de novo belatacept‐based immunosuppression administered to renal transplant recipients

A. Kirk, E. Woodle, David A Hildeman, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Stronger Correlation of bcl‐3 than bcl‐2, bcl‐xL, Costimulation, or Antioxidants with Adjuvant‐Induced T Cell Survival

P. Marrack, J. Kappler, David A Hildeman, 2002, Annals of the New York Academy of Sciences.

Sensitization of T cells to apoptosis—A role for ROS?

David A Hildeman, P. Tripathi, 2004, Apoptosis.

Gamma Interferon Signaling in Macrophage Lineage Cells Regulates Central Nervous System Inﬂammation and Chemokine Production (cid:1)

David A Hildeman, P. Tripathi, A. Sholl, 2009 .

Control of Bcl-2 expression by reactive oxygen species

B. Aronow, P. Marrack, J. Kappler, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection

Michael I. Jordan, David A Hildeman, K. Hoebe, 2020, Frontiers in Immunology.

CD40 Ligand Dysregulation in HIV Infection: HIV Glycoprotein 120 Inhibits Signaling Cascades Upstream of CD40 Ligand Transcription1

C. Fichtenbaum, J. Lifson, C. Chougnet, 2004, The Journal of Immunology.

TranscriptionCascades Upstream of CD40 Ligand HIV Glycoprotein 120 Inhibits Signaling CD40 Ligand Dysregulation in HIV Infection:

C. Fichtenbaum, J. Lifson, C. Chougnet, 2004 .

This information is current as Lymphohistiocytosis Disorder Hemophagocytic Cells To Control the Immunoregulatory Etoposide Selectively Ablates Activated T

David A Hildeman, J. Katz, M. Jordan, 2013 .

Eosinophils Respond to Acidic Environments with cAMP Production, Decreased Apoptosis, and a Decrease in the Expression of Pro-apoptotic Bcl-2 Family Members

David A Hildeman, M. Montrose, M. Rothenberg, 2009 .

Olfactomedin 4 marks a subset of neutrophils in mice

H. Wong, David A Hildeman, A. Opoka, 2018, Innate immunity.

Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development

David A Hildeman, S. Kurtulus, P. Tripathi, 2013, Front. Immun..

The immune cell landscape in kidneys of lupus nephritis patients

Nir Hacohen, Matthias Kretzler, Chad Nusbaum, 2018, bioRxiv.

Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis

H. Grimes, David A Hildeman, P. Tripathi, 2010, Proceedings of the National Academy of Sciences.

Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid Precursors

B. Aronow, T. Möröy, H. Grimes, 2013, PLoS genetics.

Dying to protect: cell death and the control of T‐cell homeostasis

David A Hildeman, J. Katz, M. Jordan, 2017, Immunological reviews.

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

Susan M. Schlenner, A. Strasser, P. Bouillet, 2013, Nature Immunology.

Undermining Protective Immunity Eliminating Encephalitogenic T Cells without

David A Hildeman, J. Katz, M. Jordan, 2017 .

Eliminating Encephalitogenic T Cells without Undermining Protective Immunity

David A Hildeman, J. Katz, M. Jordan, 2014, The Journal of Immunology.

Regulation of Cell Death in the Lymphoid System by Bcl-2 Family Proteins

David A Hildeman, J. Hardwick, I. Ivanovska, 2003, Acta Haematologica.

Accelerating Drug Discovery and Repurposing by Combining Transcriptional Signature Connectivity with Docking

Michal Kouril, Rafal Adamczak, Jarek Meller, 2020, bioRxiv.

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

J. Licht, H. Perlman, N. Chandel, 2013, Immunity.

C5a negatively regulates toll-like receptor 4-induced immune responses.

Y. Belkaid, J. Köhl, David A Hildeman, 2005, Immunity.

Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.

David A Hildeman, E. Gulbins, C. Caldwell, 2017, Cellular immunology.

A protocol for single-cell transcriptomics from cryopreserved renal tissue and urine for the Accelerating Medicine Partnership (AMP) RA/SLE network

N. Hacohen, T. Eisenhaure, M. Kretzler, 2018, bioRxiv.

Advanced Genomics-Based Approaches for Defining Allograft Rejection With Single Cell Resolution

K. Roskin, B. Baker, E. Woodle, 2021, Frontiers in Immunology.

Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases

Michael M. Henry, M. Hermiston, P. Andreassen, 2017, Proceedings of the National Academy of Sciences.

Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation1

Y. Belkaid, C. Chougnet, David A Hildeman, 2008, The Journal of Immunology.

T CELLS ARE POTENT EARLY MEDIATORS OF THE HOST RESPONSE TO SEPSIS

David A Hildeman, C. Caldwell, J. Tschöp, 2010, Shock.

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses

J. Opferman, David A Hildeman, P. Tripathi, 2013, Cell Death and Differentiation.

Contracting the ‘mus cells’– does down‐sizing suit us for diving into the memory pool?

J. Opferman, David A Hildeman, S. Kurtulus, 2010, Immunological reviews.

T‐cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients

David A Hildeman, E. Woodle, D. Leino, 2023, Pediatric transplantation.

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

John O. Trent, H. Leighton Grimes, S. Bertolone, 2008, Immunity.

Distinct Roles of Cdc42 in Thymopoiesis and Effector and Memory T Cell Differentiation

H. Grimes, David A Hildeman, J. Mattner, 2011, PloS one.

IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome.

David A Hildeman, A. Sholl, J. Bleesing, 2015, The Journal of allergy and clinical immunology.

It's hard to get downstream without a raft: a commentary on "reactive oxygen species promote raft formation in T lymphocytes".

C. Chougnet, David A Hildeman, 2007, Free radical biology & medicine.

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder.

P. Marrack, J. Kappler, David A Hildeman, 2004, Blood.

The immune cell landscape in kidneys of patients with lupus nephritis

Paul J. Hoover, Shuqiang Li, N. Hacohen, 2019, Nature Immunology.

Plasma cell biology: Foundations for targeted therapeutic development in transplantation

David A Hildeman, R. Alloway, E. Woodle, 2021, Immunological reviews.

Distinct Roles of Cdc 42 in Thymopoiesis and Effector and Memory T Cell Differentiation

H. Grimes, David A Hildeman, J. Mattner, 2011 .

Gamma Interferon Signaling in Macrophage Lineage Cells Regulates Central Nervous System Inflammation and Chemokine Production

David A Hildeman, P. Tripathi, A. Sholl, 2009, Journal of Virology.

Activation-Induced Inhibition of Interleukin 6–Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling

P. Marrack, J. Kappler, David A Hildeman, 2000, The Journal of experimental medicine.

High-Dimensional Renal Profiling: Towards a Better Understanding of Renal Transplant Immune Suppression

David A Hildeman, R. Alloway, E. Woodle, 2019, Current Transplantation Reports.

An adenoviral vector for probing promoter activity in primary immune cells.

Xiaojing Ma, C. Chougnet, David A Hildeman, 2006, JIM - Journal of Immunological Methods.

Tissue-specific control of latent CMV reactivation by regulatory T cells

Maha Almanan, C. Chougnet, David A Hildeman, 2017, PLoS pathogens.

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate

David A Hildeman, S. Kurtulus, A. Sholl, 2019, Cell Death & Differentiation.

T Cells Compete for Access to Antigen-Bearing Antigen-Presenting Cells

Philippa Marrack, Ross M. Kedl, Brian Schaefer, 2000, The Journal of experimental medicine.

Genomic-scale analysis of gene expression in resting and activated T cells.

P. Marrack, J. Kappler, David A Hildeman, 2000, Current opinion in immunology.

An atlas of gene regulatory networks for T memory cells in youth and old age

A. Barski, Emily R. Miraldi, J. Wayman, 2023, bioRxiv.

IFN-γ and self-absorbed CD4+ T cells: a regulatory double negative

David A Hildeman, E. Janssen, 2008, Nature Immunology.

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

P. Marrack, J. Kappler, David A Hildeman, 2001, Nature Immunology.

mTOR Inhibitor Therapy Diminishes Circulating CD8+ CD28− Effector Memory T Cells and Improves Allograft Inflammation in Belatacept-refractory Renal Allograft Rejection

E. Woodle, David A Hildeman, R. Alloway, 2020, Transplantation.

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

P. Bouillet, D. Plas, C. Chougnet, 2013, Front. Immunol..

Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality

K. Roskin, B. Baker, David A Hildeman, 2023, bioRxiv.

IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age

Maha Almanan, C. Chougnet, David A Hildeman, 2015, The Journal of Immunology.

Bax does not have to adopt its final form to drive T cell death

P. Marrack, J. Kappler, David A Hildeman, 2006, The Journal of experimental medicine.

PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer

David A Hildeman, E. Janssen, Hannah S Newton, 2020, Journal for ImmunoTherapy of Cancer.

Homeostasis of αβ TCR+ T cells

P. Marrack, J. Kappler, David A Hildeman, 2000, Nature Immunology.

T‐cell survival

P. Marrack, J. Kappler, David A Hildeman, 1998, Immunological reviews.

IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation.

N. Salomonis, A. Jobe, C. Chougnet, 2018, JCI insight.

Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury

David A Hildeman, C. Caldwell, D. Healy, 2016, Shock.

Determining the Potentiative State of a Chromatin Domain Precipitation Dna Yield a Absorbance B Table 1. Dna Yield and Purity from First and Second Ethanol Precipitations

David A Hildeman, D. Muller, 1999 .

Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells

David A Hildeman, J. Katz, M. Jordan, 2018, Diabetes.

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.

P. Marrack, J. Kappler, David A Hildeman, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Vaccination protects beta 2 microglobulin deficient mice from immune mediated mortality but not from persisting viral infection.

David A Hildeman, J. Whitton, M. Salvato, 1996, Vaccine.

An atlas of gene regulatory networks for memory CD4+ T cells in youth and old age

A. Barski, Emily R. Miraldi, J. Wayman, 2023, bioRxiv.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

J. Woodgett, Harinder Singh, David A Hildeman, 2017, Nature Communications.

Response to Comment on “IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis” and Comment on “IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis”

R. Hotchkiss, David A Hildeman, C. Caldwell, 2010, The Journal of Immunology.

A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap

H. Grimes, David A Hildeman, Andre Olsson, 2018, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity

P. Grandi, David A Hildeman, J. Glorioso, 2015, Molecular therapy oncolytics.

IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression.

S. Way, Harinder Singh, Emily R. Miraldi, 2020, Science Advances.

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins

David A Hildeman, S. Kurtulus, P. Tripathi, 2014, Cell Death and Differentiation.

Subset-specific and temporal control of effector and memory CD4+ T cell survival

David A Hildeman, J. Katz, M. Herold, 2023, bioRxiv.

Role of Bim in Regulating CD8+ T-Cell Responses during Chronic Viral Infection

David A Hildeman, J. Grayson, Beth C. Holbrook, 2006, Journal of Virology.

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

David A. Williams, David A Hildeman, H. Chae, 2010, PloS one.

Slp‐76 is a critical determinant of NK‐cell mediated recognition of missing‐self targets

Hao Fang, David Hildeman, David A Hildeman, 2015, European journal of immunology.

Type I interferons regulate susceptibility to inflammation-induced preterm birth.

S. Way, C. Chougnet, David A Hildeman, 2017, JCI insight.

Immunopathologic weight loss in intracranial LCMV infection initiated by the anorexigenic effects of IL-1beta.

David A Hildeman, D. Muller, 2000, Viral immunology.

Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity.

Emily R. Miraldi, J. Wayman, C. Chougnet, 2023, Seminars in immunology.

Dying to protect: cell death and the control of T‐cell homeostasis

David A Hildeman, J. Katz, M. Jordan, 2017, Immunological reviews.

This information is current as T Cell Responses + STAT 5 Is Critical To Maintain Effector CD 8 Finkelman

F. Finkelman, H. Grimes, David A Hildeman, 2010 .

Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells

C. Chougnet, David A Hildeman, T. Tilburgs, 2023, JCI insight.

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

E. Jaffee, David A Hildeman, J. Powell, 2016, Proceedings of the National Academy of Sciences.

Activation-Induced Inhibition of Interleukin 6–Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling

P. Marrack, J. Kappler, David A Hildeman, 2000, The Journal of experimental medicine.

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6

David A Hildeman, C. Serhan, C. Karp, 2009, The Journal of experimental medicine.

Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality

J. T. Caldwell, K. Roskin, B. Baker, 2023, The Journal of clinical investigation.

Prior viral infection primes cross-reactive CD8+ T cells that respond to mouse heart allografts

David A Hildeman, J. Maltzman, P. Chukwuma, 2023, Frontiers in immunology.

Type I interferons regulate susceptibility to inflammation-induced preterm birth.

S. Way, C. Chougnet, David A Hildeman, 2017, JCI insight.

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

Shuqiang Li, N. Hacohen, C. Nusbaum, 2019, Nature Immunology.

The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1

David A Hildeman, I. Berberich, 2017, Cell Death and Differentiation.

Androgens suppress antigen-specific T cell responses and IFN-γ production during intracranial LCMV infection

David A Hildeman, A. Lin, Sara Wojciechowski, 2010, Journal of Neuroimmunology.

Immune responses to coiled coil supramolecular biomaterials.

Jangwook P. Jung, J. Collier, David A Hildeman, 2010, Biomaterials.

IL‐4 and IL‐15 promotion of virtual memory CD8+ T cells is determined by genetic background

F. Finkelman, David A Hildeman, P. Tripathi, 2016, European journal of immunology.