J. Prchal

R. Hoffman, J. Prchal, S. Ciurea, 2007, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

In vitro expansion of erythroid progenitors from polycythemia vera patients leads to decrease in JAK2 V617F allele.

J. Prchal, Ko-Tung Chang, R. Nussenzveig, 2007, Experimental hematology.

Numerical gain and structural rearrangements of JAK2, identified by FISH, characterize both JAK2617V>F-positive and -negative patients with Ph-negative MPD, myelodysplasia, and B-lymphoid neoplasms.

V. Najfeld, J. Prchal, A. Cozza, 2007, Experimental hematology.

Award Number: W81XWH-05-1-0535 TITLE: DNA Methylation as an Epigenetic Factor in the Development and Progression of Polycythemia Vera

Yongli, J. Issa, J. Jelinek, 2006 .

An Unconventional Antigen Translated by a Novel Internal Ribosome Entry Site Elicits Antitumor Humoral Immune Reactions1

S. Verstovsek, R. Silver, J. Prchal, 2006, The Journal of Immunology.

Antitumor Humoral Immune Reactions Novel Internal Ribosome Entry Site Elicits An Unconventional Antigen Translated by a

S. Verstovsek, R. Silver, J. Prchal, 2006 .

JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.

E. Estey, J. Issa, J. Jelinek, 2005, Blood.

Chronic myeloproliferative disorders--introduction.

R. Skoda, J. Prchal, 2005, Seminars in hematology.

Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera.

R. Kralovics, J. Prchal, Y. Guan, 2002, Experimental hematology.

Mitochondrial Iron Metabolism and Sideroblastic Anemia

D. Richardson, J. Prchal, P. Ponka, 2009, Acta Haematologica.

The ‘GGCC’ haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera

M. Cazzola, S. Carillo, A. Vannucchi, 2009, Leukemia.

Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia.

J. Prchal, K. Sundar, Jihyun Song, 2017, Journal of applied physiology.

Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas.

R. Lonser, S. Rahimpour, J. Prchal, 2013, Blood.

Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism

J. Prchal, D. McClain, V. Gordeuk, 2012, Journal of Molecular Medicine.

Genetic association analysis of chronic mountain sickness in an Andean high-altitude population.

F. Léon-Velarde, D. Stockton, J. Prchal, 2005, Haematologica.

Angiotensin II receptor type 1 expression in erythroid progenitors: Implications for the pathogenesis of postrenal transplant erythrocytosis.

B. Julian, M. Mrug, J. Prchal, 2004, Seminars in nephrology.

Endemic polycythemia in Russia: mutation in the VHL gene.

D. Stockton, R. Kralovics, J. Prchal, 2002, Blood cells, molecules & diseases.

Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor

H. Votavova, V. Divoky, J. Prchal, 2015, Journal of molecular medicine.

RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.

K. Kapralova, V. Divoky, J. Prchal, 2014, Blood.

Congenital polycythemia with homozygous and heterozygous mutations of von Hippel-Lindau gene: five new Caucasian patients.

R. Gatti, J. Prchal, Ko-Tung Chang, 2005, Haematologica.

Erythropoietic agents and the elderly.

N. Agarwal, J. Prchal, 2008, Seminars in hematology.

Genetic mechanisms underlying regulation of hemoglobin mass.

N. Agarwal, J. Prchal, R. V. Gordeuk, 2007, Advances in experimental medicine and biology.

Congenital polycythemias/erythrocytoses.

D. Stockton, J. Prchal, V. Gordeuk, 2005, Haematologica.

Regulation of ferrochelatase gene expression by hypoxia.

J. Prchal, D. Weigent, J. Bloomer, 2004, Life sciences.

abnormalities but not tumors Chuvash polycythemia VHL mutation with thrombosis and vascular Congenital disorder of oxygen sensing: association of the homozygous

P. Choyke, J. Butman, J. Prchal, 2013 .

Erythropoiesis—genetic abnormalities

J. Prchal, X. Gregg, Xylina T. Gregg, 2009 .

Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin.

G. Semenza, J. Prchal, L. Sokol, 1995, Blood.

The homozygous VHLD126N missense mutation is associated with dramatically elevated erythropoietin levels, consequent polycythemia, and early onset severe pulmonary hypertension

K. Kapralova, J. Prchal, L. Lanikova, 2014, Pediatric blood & cancer.

HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Xin Yi Chan, S. Gerecht, J. Prchal, 2020, iScience.

Molecular basis of polycythemic disorders due to aberrant hypoxia sensing and its relevance to acute leukemia.

J. Prchal, 2012, Best practice & research. Clinical haematology.

Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHLR200W mutation (Chuvash polycythemia)

M. Gladwin, A. Remaley, G. Kato, 2012, Haematologica.

The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia

T. Ganz, J. Prchal, V. Gordeuk, 2011, Haematologica.

Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α

G. Semenza, J. Prchal, V. Gordeuk, 2010, Journal of Molecular Medicine.

Vascular complications in Chuvash polycythemia.

J. Prchal, V. Gordeuk, 2006, Seminars in thrombosis and hemostasis.

Molecular basis for polycythemia.

J. Prchal, J. Prchal, J. Prchal, 1999, Current opinion in hematology.

Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?

M. Hentze, M. Muckenthaler, M. McMullin, 2007, Blood.

activating mutations within the HIF-2 { alpha } iron-responsive element ? Is congenital secondary erythrocytosis / polycythemia caused

M. Hentze, M. Muckenthaler, M. McMullin, 2007 .

The Cornerstone of the Aberrant Pathophysiology of Obstructive Sleep Apnea: Tissue Responses to Chronic Sustained Versus Intermittent Hypoxia.

J. Prchal, K. Sundar, 2017, American journal of respiratory cell and molecular biology.

Allo-SCT for myelofibrosis: reversing the chronic phase in the JAK inhibitor era?

R. Hoffman, J. Prchal, J. Mascarenhas, 2015, Bone Marrow Transplantation.

Whole-exome sequencing of polycythemia vera revealed novel driver genes and somatic mutation shared by T cells and granulocytes

R. Gibbs, D. Muzny, D. Wheeler, 2014, Leukemia.

The origin of glucose-6-phosphate-dehydrogenase (G6PD) polymorphisms in African-Americans.

J. Prchal, E. Beutler, W. Kuhl, 1992, American journal of human genetics.

Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation.

J. Prchal, S. Swierczek, A. Agarwal, 2009, Blood cells, molecules & diseases.

Polycythemia and oxygen sensing.

J. Prchal, J. Maran, 2004, Pathologie-biologie.

Human hematopoietic progenitors express erythropoietin.

J. Prchal, T. Stopka, P. Stopkova, 1998, Blood.

Haematopoietic progenitors and signal transduction in polycythaemia vera and primary thrombocythaemia.

R. Kralovics, J. Prchal, 1998, Bailliere's clinical haematology.

Cre recombinase expression controlled by the hematopoietic regulatory domain of Gata-1 is erythroid-specific.

J. Prchal, Bumjun Kim, D. Yoon, 2008, Blood cells, molecules & diseases.

Molecular basis of spectrin and ankyrin deficiencies in severe hereditary spherocytosis: evidence implicating a primary defect of ankyrin.

J. Prchal, J. Palek, Huilan Yu, 1991, Blood.

Sickle cell disease resulting from uniparental disomy in a child who inherited sickle cell trait.

E. Lyon, J. Swensen, J. Prchal, 2010, Blood.

Aberrant expression of microRNA in polycythemia vera

J. Prchal, M. Merkerova, H. Bruchova, 2008, Haematologica.

Detection of Nine Mediterranean β-Thalassemia Mutations in Palestinians Using Three Restriction Enzyme Digest Panels: A Reliable Method for Developing Countries

J. Prchal, N. S. Reading, M. Sirdah, 2014, Hemoglobin.

High levels of circulating CD34 cells, dacrocytes, clonal hematopoiesis, and JAK2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension.

A. Frost, J. Prchal, U. Popat, 2006, Blood.

New onset of myelofibrosis in association with pulmonary arterial hypertension.

A. Frost, J. Prchal, U. Popat, 2005, Annals of internal medicine.

Marrow fibrosis does not account for circulating CD34+ cells in myelofibrosis with myeloid metaplasia.

J. Prchal, U. Popat, S. Samuelson, 2007, Haematologica.

“Benign erythrocytosis” and other familial and congenital polycythemias

J. Prchal, L. Sokol, 1996, European journal of haematology.

Experimental Modeling of Myeloproliferative Neoplasms

Olga Babosova, J. Prchal, L. Lanikova, 2019, Genes.

Plasma/serum levels of flt3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia.

J. Prchal, R. Hanna, J. Zappone, 1995, Blood.

Presence of erythroid and nonerythroid spectrin transcripts in human lens and cerebellum.

J. Prchal, H. Skalka, S. Yoon, 1989, Investigative ophthalmology & visual science.

Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin.

J. Conboy, Y. Kan, J. Prchal, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis.

N. Mahmud, R. Hoffman, G. Barosi, 2005, Blood.

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders

L. Moore, P. Koul, C. Huff, 2017, Journal of Molecular Medicine.

A patient with both methemoglobinemia and G6PD deficiency: A therapeutic conundrum

J. Prchal, R. Christensen, N. S. Reading, 2017, American journal of hematology.

A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.

Sunil V. Rao, H. Cohen, G. Chelune, 2014, Blood Cells, Molecules & Diseases.

Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization

V. Divoky, J. Prchal, M. Hartnett, 2018, Scientific Reports.

Red cell enzymes.

J. Prchal, X. Gregg, 2005, Hematology. American Society of Hematology. Education Program.

Three Novel Spectrin Variants in Jaundiced Neonates

J. Prchal, H. Yaish, R. Christensen, 2018, Clinical pediatrics.

Coexistence of gain-of-function JAK2 germ line mutations with JAK2V617F in polycythemia vera.

D. Wheeler, Linghua Wang, Olga Babosova, 2016, Blood.

Peripheral blood mononuclear cells show prominent gene expression by erythroid progenitors in diseases characterized by heightened erythropoiesis

S. Nekhai, J. Prchal, V. Gordeuk, 2020, British journal of haematology.

Effect of recombinant human erythropoietin combined with granulocyte/ macrophage colony-stimulating factor in the treatment of patients with myelodysplastic syndrome

D. Gilliland, J. Bennett, J. Prchal, 2000 .

Development of a symptom assessment in patients with myelofibrosis: qualitative study findings

A. Shields, J. Cappelleri, E. Jabbour, 2019, Health and Quality of Life Outcomes.

Safety and Efficacy of Ruxolitinib in Patients with Myelofibrosis and Low Platelet Counts (50 - 100 × 109/L): Final Analysis of an Open-Label Phase 2 Study.

M. Arcasoy, S. Verstovsek, M. Talpaz, 2021, Clinical lymphoma, myeloma & leukemia.

MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis.

V. Najfeld, R. Hoffman, G. Barosi, 2014, Blood.

Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts

H. Kantarjian, S. Verstovsek, R. Paquette, 2013, Journal of Hematology & Oncology.

Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate- or high-risk patients with myelofibrosis with myeloid metaplasia.

R. Hoffman, B. Smith, G. Barosi, 2005, Blood.

Evolving understanding of the cellular defect in polycythemia vera: implications for its clinical diagnosis and molecular pathophysiology [editorial; comment]

J. Prchal, J. Prchal, J. Prchal, 1994 .

Evolving understanding of the cellular defect in polycythemia vera: implications for its clinical diagnosis and molecular pathophysiology.

J. Prchal, J. Prchal, 1994, Blood.

the iron transport pathway in erythroid cells Severe hypochromic microcytic anemia caused by a congenital defect of

V. Divoky, J. Prchal, D. Pospíšilová, 2011 .

Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells.

V. Divoky, J. Prchal, V. Mihál, 2004, Blood.

RFLP of the X chromosome-linked glucose-6-phosphate dehydrogenase locus in blacks.

J. Prchal, A. Yoshida, T. Takizawa, 1988, American journal of human genetics.

Copper deficiency masquerading as myelodysplastic syndrome.

J. Prchal, V. Reddy, X. Gregg, 2002, Blood.

Familial Polycythemia Caused by a Novel Mutation in the Beta Globin Gene: Essential Role of P50 in Evaluation of Familial Polycythemia

N. Agarwal, J. Prchal, C. Ou, 2007, International journal of medical sciences.

New syndrome of paraganglioma and somatostatinoma associated with polycythemia.

A. Tischler, T. Fojo, M. Merino, 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Myelofibrotic Transformations of Polycythemia Vera and Essential Thrombocythemia are Morphologically, Biologically, and Prognostically Indistinguishable From Primary Myelofibrosis

S. Perkins, M. Salama, J. Prchal, 2014, Applied immunohistochemistry & molecular morphology : AIMM.

Could hypoxia increase the prevalence of thrombotic complications in polycythemia vera?

L. Fink, J. Prchal, M. Zangari, 2013, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Heterogeneity of the molecular biology of methemoglobinemia: a study of eight consecutive patients.

J. Prchal, C. Ou, Y. Guan, 2004, Haematologica.

Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses

M. Salama, J. Prchal, T. Tashi, 2018, Leukemia.

Presence of Polyclonal Hematopoiesis in Females with Ph-negative Myeloproliferative Neoplasms

J. Prchal, T. Tashi, Soo Jin Kim, 2015, Leukemia.

Calreticulin mutated prefibrotic-stage myelofibrosis and PMF represent an independent clone from coexisting CLL.

M. Salama, J. Prchal, T. Tashi, 2014, Blood.

A Novel Unconventional Antigen MPD5 Elicits Anti-Tumor Humoral Immune Responses in a Subset of Patients with Polycythemia Vera

S. Verstovsek, R. Silver, J. Prchal, 2007, International journal of immunopathology and pharmacology.

Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera.

S. Verstovsek, R. Silver, J. Prchal, 2007, Clinical immunology.

Stable transduction of recombinant adeno-associated virus into hematopoietic stem cells from normal and sickle cell patients.

J. Prchal, J. Dong, T. Townes, 1996, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Possible primary familial and congenital polycythemia locus at 7q22.1-7q22.2.

D. Stockton, J. Prchal, K. Jedličková, 2003, Blood cells, molecules & diseases.

Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia.

J. Prchal, T. Tashi, K. Sundar, 2020, Blood advances.

β‐Thalassemia Due to Intronic LINE‐1 Insertion in the β‐Globin Gene (HBB): Molecular Mechanisms Underlying Reduced Transcript Levels of the β‐GlobinL1 Allele

J. Issa, V. Divoky, J. Prchal, 2013, Human mutation.

A novel clonality assay based on transcriptional polymorphism of X chromosome gene p55.

J. Prchal, M. Belickova, Y. Liu, 1995, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

D. Bluteau, W. Vainchenker, N. Debili, 2011, Blood.

Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate- or high-risk patients with myeloﬁbrosis with myeloid metaplasia

R. Hoffman, B. Smith, G. Barosi, 2005 .

Effect of recombinant human erythropoietin combined with granulocyte/ macrophage colony-stimulating factor in the treatment of patients with myelodysplastic syndrome. GM/EPO MDS Study Group.

J. Thompson, J. Bennett, J. Prchal, 2000, Blood.

Thrombotic Thrombocytopenic Purpura Associated With Pegylated Interferon Alfa-2 a Use in a Patient With Polycythemia

J. Prchal, Soo Jin Kim, Jing-fei Dong, 2017 .

Chapter 12 – Polycythemia

J. Prchal, T. Tashi, 2016 .

Optimal therapy for polycythemia vera and essential thrombocythemia can only be determined by the completion of randomized clinical trials

R. Hoffman, R. Mesa, J. Prchal, 2014, Haematologica.

Interferon and PV stem cells.

J. Prchal, 2011, Blood.

Evaluation of Erythrocyte Changes After Normoxic Return from Hypoxia.

J. Prchal, Jihyun Song, 2018, Methods in molecular biology.

Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide

M. Cazzola, H. Deeg, R. Schlenk, 2020, Leukemia.

HIF-2 inhibitor, erythrocytosis, and pulmonary hypertension.

J. Prchal, V. Gordeuk, 2021, Blood.

The Addition of Navitoclax to Ruxolitinib Demonstrates Efficacy within Different High-Risk Populations in Patients with Relapsed/Refractory Myelofibrosis

S. Verstovsek, Jacqueline S. Garcia, C. Harrison, 2020 .

Phlebotomy-Induced Iron Deficiency Increases the Expression of Prothrombotic Genes

J. Prchal, T. Tashi, V. Gordeuk, 2020 .

Characterization of Tissue-Specific HIF-1 and HIF-2 Regulatory Elements of the Erythropoietin Gene

S. Elliott, J. Prchal, Jihyun Song, 2008 .

Systemic immunization for the induction of IgA responses.

J. Mcghee, H. Kiyono, J. Prchal, 1989, Current topics in microbiology and immunology.

Expression of NK-lineage markers on peripheral blood lymphocytes with T-helper (Leu3+/T4+) phenotype in B cell chronic lymphocytic leukemia.

A. Velardi, J. Prchal, C. Grossi, 1985, Blood.

Erratum to: Genetic adaptation to extreme hypoxia: Study of high-altitude pulmonary edema in a three-generation Han Chinese family [Blood Cells Mol. Dis. 43:3 (2009) 221-225].

L. Jorde, J. Prchal, T. Simonson, 2010, Blood cells, molecules & diseases.

Transcriptional analysis of the active X-chromosome in normal and clonal hematopoiesis.

F. Barany, J. Prchal, J. Prchal, 1993, Blood.

Angiogenesis in pulmonary hypertension with myelofibrosis

J. Palmblad, J. Prchal, U. Popat, 2008, Haematologica.

An acute myeloproliferative disorder characterized by myelofibrosis and blast cells that express phenotypic properties associated with multiple hematopoietic lineages.

R. Hoffman, A. Carroll, J. Prchal, 1985, American journal of clinical pathology.

Hereditary Pyropoikilocytosis and Elliptocytosis: Clinical, Laboratory, and Ultrastructural Features in Infants and Children

R. Parmley, J. Prchal, W. Crist, 1982, Pediatric Research.

Treatment target in polycythemia vera.

J. Prchal, V. Gordeuk, 2013, The New England journal of medicine.

Oxygen-dependent regulation of erythropoiesis.

J. Jelinek, J. Prchal, 2004, Methods in enzymology.

Abnormal T-cell functions in B-cell chronic lymphocytic leukemia do not imply T-lymphocyte involvement in the leukemic process: Report of a case with demonstrated “polyclonality” of T lymphocytes

L. Bonomo, J. Prchal, S. Antonaci, 1983, Journal of Clinical Immunology.

Novel Insights from Clinical Practice

J. Prchal, P. Li, C. C. Yost, 2009 .

Editorial Comment on: Inhibition of Suicidal Erythrocyte Death by Chronic Hypoxia by Tang et al. (From: Tang F, Feng L, Li R, Wang W, Liu H, Yang Q, Ge R-L. High Alt Med Biol 2019;20:112-119; DOI: 10.1089/ham.2017.0159).

J. Prchal, T. Tashi, Jihyun Song, 2019, High altitude medicine & biology.

Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome.

A. Tischler, E. Chew, T. Fojo, 2016, Endocrine-related cancer.

Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals.

J. Prchal, C. Temm, M. Yoder, 2007, Blood.

Delivery on demand--a new era of gene therapy?

J. Prchal, 2003, The New England journal of medicine.

A new glucose-6-phosphate dehydrogenase deficient variant in a patient with Chediak-Higashi syndrome.

A. Carroll, J. Prchal, A. Vítek, 1980, Blood.

Genetic determinants of Tibetan high-altitude adaptation

L. Jorde, J. Prchal, D. McClain, 2012, Human Genetics.

Leukocyte Transfusion-Associated Granulocyte Responses in a Patient with X-Linked Hyper-IgM Syndrome

M. Cooper, Y. Hsu, J. Prchal, 1998, Journal of Clinical Immunology.

Loss of Major DNase I Hypersensitive Sites in Duplicated β‐globin Gene Cluster Incompletely Silences HBB Gene Expression

V. Divoky, J. Prchal, L. Lanikova, 2016, Human mutation.

Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells.

J. Prchal, M. Goodell, K. Matatall, 2015, Experimental hematology.

A molecular defect of spectrin in a subset of patients with hereditary elliptocytosis. Alterations in the alpha-subunit domain involved in spectrin self-association.

J. Lawler, J. Prchal, S. Liu, 1984, The Journal of clinical investigation.

Molecular heterogeneity of hereditary pyropoikilocytosis: identification of a second variant of the spectrin alpha-subunit.

J. Lawler, J. Prchal, S. Liu, 1983, Blood.

Molecular defect of spectrin in hereditary pyropoikilocytosis. Alterations in the trypsin-resistant domain involved in spectrin self-association.

J. Lawler, J. Prchal, Shih-Chun Liu, 1982, The Journal of clinical investigation.

Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo.

J. Prchal, G. Spangrude, Xiaosong Huang, 2010, Blood cells, molecules & diseases.

Results of Phase II Clinical Trial MPD-RC 101: Allogeneic Hematopoietic Stem Cell Transplantation Conditioned with Fludarabine/Melphalan in Patients with Myelofibrosis

V. Najfeld, R. Hoffman, G. Barosi, 2012 .

Combined De-Novo Mutation and Non-Random X-Chromosome Inactivation Causing Wiskott-Aldrich Syndrome in a Female with Thrombocytopenia

S. Scherer, H. Ochs, T. Torgerson, 2013, Journal of Clinical Immunology.

cDNA sequence for human erythrocyte ankyrin.

Y. Kan, D. Speicher, J. Lawler, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Analysis with antiidiotype antibody of a patient with chronic lymphocytic leukemia and a large cell lymphoma (Richter's syndrome).

J. Kearney, M. Cooper, J. Prchal, 1987, Blood.

Molecular basis of two novel mutations found in type I methemoglobinemia.

P. Koul, S. Schrier, J. Prchal, 2011, Blood cells, molecules & diseases.

Molecular determinants of clinical expression of hereditary elliptocytosis and pyropoikilocytosis.

J. Lawler, J. Prchal, T. Coetzer, 1987, Blood.

HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis

J. Prchal, R. Christensen, P. Thiagarajan, 2015, Journal of Molecular Medicine.

Chronic Myeloproliferative Disorders:From Molecular Pathogenesis to Targeted Therapy

J. Prchal, R. Walgren, 2012 .

A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.

N. Jing, J. Prchal, R. Nussenzveig, 2006, Haematologica.

Plasmacytoid T-cell lymphoma associated with chronic myeloproliferative disorder.

W. Grizzle, J. Prchal, C. Grossi, 1985, The American journal of surgical pathology.

Accelerated healing of chronic sickle-cell leg ulcers treated with RGD peptide matrix

J. Prchal, J. Eckman, M. Steinberg, 1994 .

Accelerated healing of chronic sickle-cell leg ulcers treated with RGD peptide matrix. RGD Study Group.

J. Prchal, J. Eckman, M. Steinberg, 1994, Blood.

How Do Red Blood Cells Die?

J. Prchal, C. Parker, P. Thiagarajan, 2021, Frontiers in Physiology.

Altered spectrin dimer-dimer association and instability of erythrocyte membrane skeletons in hereditary pyropoikilocytosis.

J. Prchal, S. Liu, J. Palek, 1981, The Journal of clinical investigation.

Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases.

R. Hoffman, G. Barosi, J. Prchal, 2005, Blood.

Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Gaza Strip Palestinians

S. Perkins, J. Prchal, H. Vankayalapati, 2012 .

Two siblings with unusually mild homozygous beta-thalassemia: a didactic example of the effect of a nonallelic modifier gene of the expressivity of a monogenic disorder.

G. Stamatoyannopoulos, J. Prchal, 1981, American journal of medical genetics.

Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia.

R. Kralovics, J. Prchal, L. Sokol, 1998, The Journal of clinical investigation.

Pegylated Interferon Alfa-2a for Polycythemia Vera or Essential Thrombocythemia Resistant or Intolerant to Hydroxyurea.

E. Papaemmanuil, J. Tripodi, V. Najfeld, 2019, Blood.

Hypoxic Response Contributes to Altered Gene Expression and Precapillary Pulmonary Hypertension in Patients With Sickle Cell Disease

P. Sebastiani, Wei Zhang, R. Kittles, 2014, Circulation.

T-cell Acute Leukemia 1 (TAL1) Regulation of Erythropoietin Receptor and Association with Excessive Erythrocytosis*

Kairong Cui, K. Zhao, J. Bieker, 2012, The Journal of Biological Chemistry.

Essential role for Nix in autophagic maturation of erythroid cells

H. Sandoval, J. Prchal, Min Chen, 2008, Nature.

A computational study of structural differences of binding of NADP+ and G6P substrates to G6PD Mediterraneanc.563T, G6PD A-c.202A/c.376G, G6PD Cairoc.404C and G6PD Gazac.536A mutations.

J. Prchal, H. Vankayalapati, N. S. Reading, 2021, Blood cells, molecules & diseases.

Favism, the commonest form of severe hemolytic anemia in Palestinian children, varies in severity with three different variants of G6PD deficiency within the same community.

L. Luzzatto, J. Prchal, N. S. Reading, 2016, Blood cells, molecules & diseases.

Clinical Significance of G6PD Variants among Palestinians

L. Luzzatto, J. Prchal, N. S. Reading, 2016 .

Hemolysis and Mediterranean G6PD mutation (c.563 C>T) and c.1311 C>T polymorphism among Palestinians at Gaza Strip.

S. Perkins, J. Prchal, N. S. Reading, 2012, Blood cells, molecules & diseases.

Fatal sickle cell crisis after granulocyte colony-stimulating factor administration.

J. Prchal, V. Reddy, W. Vaughan, 2001, Blood.

J. chain disease: a novel form of plasma cell dyscrasia.

B. Julian, J. Prchal, J. Mestecky, 1990, The American journal of medicine.

concentration but not increased haemolysis in patients with sickle cell anaemia

M. Gladwin, G. Kato, O. Castro, 2010 .

Case report: alpha G-Philadelphia, beta O-Arab, and beta C globins present in a single patient.

A. Kutlar, J. Prchal, C. A. Robinson, 1993, The American journal of the medical sciences.

Mild sickle cell anemia associated with alpha globin mutant alpha Montgomery.

R. Nagel, A. Kutlar, J. Prchal, 1989, The American journal of medicine.

Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis.

J. Mendell, J. Prchal, Archana M Agarwal, 2007, Experimental hematology.

Polycythemia vera and other primary polycythemias

J. Prchal, 2005, Current opinion in hematology.

Lessons from familial myeloproliferative disorders.

R. Skoda, J. Prchal, 2005, Seminars in hematology.

Results of the Myeloproliferative Neoplasms - Research Consortium (MPN-RC) 112 Randomized Trial of Pegylated Interferon Alfa-2a (PEG) Versus Hydroxyurea (HU) Therapy for the Treatment of High Risk Polycythemia Vera (PV) and High Risk Essential Thrombocythemia (ET)

A. Mead, J. Tripodi, V. Najfeld, 2018, Blood.

Impact on MPN Symptoms and Quality of Life of Front Line Pegylated Interferon Alpha-2a Vs. Hydroxyurea in High Risk Polycythemia Vera and Essential Thrombocythemia: Results of Myeloproliferative Disorders Research Consortium (MPD-RC) 112 Global Phase III Trial

R. Schlenk, A. Mead, T. Barbui, 2016, Blood.

Usefulness of HPLC methodology for the characterization of combinations of the common β chain variants HBS s, c, and o-ARAB, and the α chain variant HB g-philadelphia

A. Kutlar, J. Prchal, T. Huisman, 1993 .

Molecular heterogeneity of glucose-6-phosphate dehydrogenase A-. Blood

J. Prchal, E. Beutler, W. Kuhl, 1989 .

TheOrigin ofGlucose-6-Phosphate-Dehydrogenase

J. Prchal, 1992 .

Genetic determinants of Tibetan high-altitude adaptation

L. Jorde, J. Prchal, D. McClain, 2011, Human Genetics.

Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.

R. Nielsen, Fernando Racimo, J. Rotter, 2017, American journal of human genetics.

Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice

J. Prchal, H. Mok, P. Balogh, 2004, Development.

Large-Scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers.

L. Jorde, J. Rodriguez-Flores, B. Welm, 2021, Blood cancer discovery.

Polycythemia vera and its molecular basis: an update.

J. Prchal, George L. Chen, 2006, Best practice & research. Clinical haematology.

Endogenous Erythropoietin Signaling Is Required for Normal Neural Progenitor Cell Proliferation*

J. Prchal, C. Noguchi, Zhi-yong Chen, 2007, Journal of Biological Chemistry.

Clonal hematopoiesis in familial polycythemia vera suggests the involvement of multiple mutational events in the early pathogenesis of the disease.

D. Stockton, R. Kralovics, J. Prchal, 2003, Blood.

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors.

P. Choyke, J. Butman, J. Prchal, 2004, Blood.

Clonality in juvenile chronic myelogenous leukemia.

D. Gilliland, J. Prchal, L. Busque, 1995, Blood.

leukemia and a large cell lymphoma (Richter's syndrome) Analysis with antiidiotype antibody of a patient with chronic lymphocytic

J. Kearney, J. Prchal, H. Kubagawa, 2011 .

Band 3 Tuscaloosa: Pro327----Arg327 substitution in the cytoplasmic domain of erythrocyte band 3 protein associated with spherocytic hemolytic anemia and partial deficiency of protein 4.2.

J. Prchal, P. Jarolim, C. M. Cohen, 1992, Blood.

Nuclear–Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis

M. Salama, E. Baloglu, M. Deininger, 2018, Clinical Cancer Research.

Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia

P. Koul, J. Prchal, P. Guchhait, 2021, EBioMedicine.

Development of a novel trans-lentiviral vector that affords predictable safety.

J. Wakefield, J. Kappes, R. Kralovics, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Imatinib effect on growth and signal transduction in polycythemia vera.

W. Vainchenker, J. Cortes, T. Manshouri, 2007, Experimental hematology.

Hematopoiesis is not clonal in healthy elderly women.

N. Agarwal, H. Kantarjian, M. Routbort, 2008, Blood.

Acquired uniparental disomy of chromosome 9p in hematologic malignancies.

D. Wheeler, Linghua Wang, J. Prchal, 2016, Experimental Hematology.

The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W)

S. Nekhai, C. Huff, J. Prchal, 2013, Haematologica.

Methylation of AR locus does not always reflect X chromosome inactivation state.

B. Cairns, N. Agarwal, J. Jelinek, 2012, Blood.

Breast Cancer in African-American Women Mitochondrial DNA G 10398 A Polymorphism and Invasive

S. Leal, T. Wheeler, M. Ittmann, 2005 .

Acquired and inherited risk factors for splanchnic venous thrombosis

J. Prchal, V. Reddy, W. Vaughan, 2001 .

Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia.

J. Prchal, H. Hasle, J. Fahner, 2003, American journal of human genetics.

Anti-inflammatory effect of methyl dehydrojasmonate (J2) is mediated by the NF-κB pathway

Jee H Jung, J. Prchal, E. Yoo, 2010, Journal of Molecular Medicine.

Allogeneic haematopoietic cell transplantation for myelofibrosis in 30 patients 60–78 years of age

R. Storb, B. Sandmaier, H. Heslop, 2011, British journal of haematology.

EPO Receptor Gain-of-Function Causes Hereditary Polycythemia, Alters CD34+ Cell Differentiation and Increases Circulating Endothelial Precursors

S. Perrotta, F. Della Ragione, A. Migliaccio, 2010, PloS one.

EPO Receptor Gain-of-Function Causes Hereditary Polycythemia, Alters CD34+ Cell Differentiation and Increases Circulating Endothelial Precursors

S. Perrotta, F. Della Ragione, A. Migliaccio, 2010, PloS one.

Genetic heterogeneity of primary familial and congenital polycythemia

R. Kralovics, J. Prchal, 2001, American journal of hematology.

Congenital and inherited polycythemia.

R. Kralovics, J. Prchal, Josef T Prchal, 2000, Current opinion in pediatrics.

Polycythemia Vera and Other Polycythemic Disorders — Biological Aspects

J. Prchal, S. Ang, 2007 .

Molecular biology of polycythemias.

J. Prchal, 2001, Internal medicine.

Lessons to better understanding of hypoxia sensing

J. Prchal, V. Divoký, 2001 .

Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders.

J. Prchal, 2001, Seminars in hematology.

The erythropoietin receptor gene is not linked with the polycythemia phenotype in a family with autosomal dominant primary polycythemia.

R. Kralovics, J. Prchal, L. Sokol, 1997, Proceedings of the Association of American Physicians.

Erythropoietin receptor mutations and human disease.

J. Prchal, J. Prchal, X. Gregg, 1997, Seminars in hematology.

A novel clonality assay based on transcriptional analysis of the active X chromosome

J. Prchal, Y. Guan, 1993, Stem cells.

End-tidal carbon monoxide as an indicator of the hemolytic rate.

J. Prchal, H. Yaish, R. Christensen, 2015, Blood cells, molecules & diseases.

The evolution of cellular deficiency in GATA2 mutation.

N. McGovern, J. Dick, M. Haniffa, 2014, Blood.

Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development*

G. Semenza, J. Prchal, P. Ponka, 2006, Journal of Biological Chemistry.

Clonal Hematopoiesis and Acquired Thalassemia in Common Variable Immunodeficiency

M. Cooper, J. Prchal, M. Belickova, 1994, Molecular medicine.

Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.

J. Lawler, B. Alter, J. Prchal, 1990, Blood.

Viscoelastic properties of red cell membrane in hereditary elliptocytosis.

K. Sung, S. Chien, J. Prchal, 1989, Blood.

Spectrin-alpha I/61: a new structural variant of alpha-spectrin in a double-heterozygous form of hereditary pyropoikilocytosis.

J. Lawler, J. Prchal, R. Moore, 1988, Blood.

Does Erythropoietin Promote Tumor Growth?

N. Agarwal, J. Prchal, D. Yoon, 2008, Clinical Cancer Research.

Complications in children and adolescents with Chuvash polycythemia.

J. Prchal, V. Gordeuk, M. Nouraie, 2015, Blood.

A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma

J. Prchal, K. Pacak, F. Lorenzo, 2012, Journal of Molecular Medicine.

The worldwide distribution of the VHL 598C>T mutation indicates a single founding event.

S. Shete, C. Amos, D. Stockton, 2004, Blood.

The HIF2A gene in familial erythrocytosis.

J. Prchal, V. Gordeuk, 2008, The New England journal of medicine.

Idiopathic erythrocytosis and other non-clonal polycythemias.

T. Barbui, J. Prchal, G. Finazzi, 2006, Best practice & research. Clinical haematology.

Search for genetic determinants of individual variability of the erythropoietin response to high altitude.

B. Levine, J. Jelinek, D. Stockton, 2003, Blood cells, molecules & diseases.

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.

J. Rabinowitz, A. Berghuis, P. Gros, 2020, Cell reports.

Divalent metal transporter 1

J. Prchal, M. Mims, 2005, Hematology.

Williams manual of hematology

Thomas J. Kipps, Marshall A. Lichtman, T. Kipps, 2011 .

Acute myelofibrosis and multiple chloromas of the mandible and skin.

J. Prchal, B. Rodu, M. Saleh, 1987, International journal of oral and maxillofacial surgery.

Molecular heterogeneity of hereditary pyropoikilocytosis: identification of a second variant of the spectrin alpha-subunit

J. Lawler, J. Prchal, Shih-Chun Liu, 1983 .

Defective spectrin dimer-dimer association with hereditary elliptocytosis.

J. Prchal, Shih-Chun Liu, S. Liu, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Altered assembly of spectrin in red cell membranes in hereditary pyropoikilocytosis.

J. Prchal, S. Liu, J. Palek, 1981, Blood.

Novel mechanism of hereditary pyropoikilocytosis phenotype due to co‐inheritance of β globin and α spectrin mutations

A. Kutlar, J. Prchal, T. Coetzer, 2021, American journal of hematology.

Partial ankyrin and spectrin deficiency in severe, atypical hereditary spherocytosis.

J. Lawler, J. Prchal, S. Liu, 1988, The New England journal of medicine.

Novel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer.

J. Prchal, L. Lanikova, F. Lorenzo, 2013, Blood.

polycythemia but not with cancer mutation in exon 2 is associated with congenital VHL Novel homozygous

J. Prchal, L. Lanikova, F. Lorenzo, 2013 .

Clonality studies in cancer based on X chromosome inactivation phenomenon.

J. Prchal, J. Phelan, 2002, Methods in molecular medicine.

Congenital methemoglobinemia due to methemoglobin reductase deficiency in two unrelated American black families.

N. Borgese, J. Prchal, M. Moore, 1990, The American journal of medicine.

Clonal hematopoiesis in hematological disorders.

J. Prchal, S. Swierczek, 2020, Experimental hematology.

miR-451 enhances erythroid differentiation in K562 cells

J. Prchal, Donghoon Yoon, Josef T Prchal, 2010, Leukemia & lymphoma.

Early Hyperbilirubinemia in Neonates with Down Syndrome.

V. Bhutani, J. Prchal, Timothy M. Bahr, 2020, The Journal of pediatrics.

A genetic mechanism for Tibetan high-altitude adaptation

G. Semenza, L. Jorde, P. Koul, 2014, Nature Genetics.

A Phase 2 Study to Evaluate the Efficacy and Safety of Selinexor in Patients with Myelofibrosis Refractory or Intolerant to JAK Inhibitors

M. Deininger, T. George, J. Prchal, 2021, Blood.

A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

M. Gladwin, Wei Zhang, Tatiana Ammosova, 2016, Human molecular genetics.

Response to interferon treatment in essential thrombocythemia with inv(3)(q21q26)

A. Carroll, J. Prchal, Radhika Gangaraju, 2019, Annals of Hematology.

Interim Analysis of the Myeloproliferative Disorders Research Consortium (MPD-RC) 112 Global Phase III Trial of Front Line Pegylated Interferon Alpha-2a Vs. Hydroxyurea in High Risk Polycythemia Vera and Essential Thrombocythemia

R. Schlenk, A. Mead, T. Barbui, 2016 .

Whole Exome Sequencing of Polycythemia Vera Reveals Novel Recurrent Somatic and Germline Variation

D. Wheeler, Linghua Wang, J. Prchal, 2012 .

Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice

J. Jelinek, J. Prchal, H. Youssoufian, 2004, Development.

Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system.

J. Prchal, H. Yaish, R. Christensen, 2013, Blood cells, molecules & diseases.

Ironing out the role of hepcidin in infection.

J. Prchal, 2017, Blood.

HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis

J. Prchal, R. Christensen, P. Thiagarajan, 2015, Journal of Molecular Medicine.

Epigenetic control of PRV-1 expression on neutrophils.

J. Issa, J. Jelinek, J. Prchal, 2007, Experimental hematology.

Blastic transformation of essential thrombocythemia: dual expression of myelomonoblastic/megakaryoblastic phenotypes.

R. Hoffman, J. Prchal, J. Barton, 1984, Blood.

Somatic mosaicism of EPAS1 mutations in the syndrome of paraganglioma and somatostatinoma associated with polycythemia

J. Prchal, K. Pacak, Chunzhang Yang, 2015, Human Genome Variation.

Patterns of spectrin transcripts in erythroid and non‐erythroid cells

J. Prchal, T. Papayannopoulou, Sahyun Yoon, 1990, Journal of cellular physiology.

Identification of an unusual deletion within homologous repeats of human reticulocyte beta-spectrin and probable peptide polymorphism.

C. Kentros, J. Prchal, S. Yoon, 1990, Gene.

Trilineage extramedullary myeloid cell tumor in myelodysplastic syndrome.

J. Bennett, J. Prchal, C. Listinsky, 1997, Archives of pathology & laboratory medicine.

A specific test for polycythemia vera

J. Prchal, J. Prchal, 2003 .

Neonatal Death Suspected To Be From Sepsis Was Found To Be Kernicterus With G6PD Deficiency

T. Pysher, J. Prchal, H. Yaish, 2013, Pediatrics.

abstract cared for a term male infant born to Burmese immigrants. At

T. Pysher, J. Prchal, H. Yaish, 2013 .

A prospective evaluation of pegylated interferon alfa-2a therapy in patients with polycythemia vera and essential thrombocythemia with a prior splanchnic vein thrombosis

J. Tripodi, V. Najfeld, M. Arcasoy, 2019, Leukemia.

Allogeneic hsct with reduced intensity conditioning regimens in high risk patients with myelofibrosis

R. Hoffman, G. Barosi, J. Prchal, 2004 .

A phase 1 study of the Janus kinase 2 (JAK2)V617F inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia.

M. Salama, S. Verstovsek, R. Mesa, 2017, Leukemia research.

Phase I dose escalation study of lestaurtinib in patients with myelofibrosis

V. Najfeld, R. Hoffman, H. Pahl, 2015, Leukemia & lymphoma.

Idiopathic myelofibrosis without dacryocytes.

J. Prchal, U. Popat, T. Coetzer, 2006, Haematologica.

Convergent mechanisms of somatic mutations in polycythemia vera.

Hakon Hakonarson, H. Hakonarson, Kai Wang, 2010, Discovery medicine.

The evolution of cellular de fi ciency in GATA 2 mutation

N. McGovern, J. Dick, M. Haniffa, 2014 .

Results from a Phase 2 Study of Navitoclax in Combination with Ruxolitinib in Patients with Primary or Secondary Myelofibrosis

Jacqueline S. Garcia, R. Mesa, C. Harrison, 2019, Blood.

Mutation of EPO 5`UTR Facilitates Interaction with HIF2 and Causes Autosomal Dominant Erythrocytosis

Olga Babosova, J. Prchal, L. Lanikova, 2020 .

Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia

Tatiana Ammosova, S. Nekhai, J. Prchal, 2017, Haematologica.

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload.

J. Prchal, D. Pospíšilová, K. Indrák, 2005, Blood.

A polymorphism of the X‐linked gene IDS increases the number of females informative for transcriptional clonality assays

R. Kralovics, J. Prchal, X. Gregg, 2000, American journal of hematology.

Two apparent glucose-6-phosphate dehydrogenase variants in normal XY males: G6PD Alabama.

J. Prchal, R. Berkow, C. W. Scott, 1988, The American journal of medicine.

Missense mutation of the last nucleotide of exon 1 (G->C) of β globin gene not only leads to undetectable mutant peptide and transcript but also interferes with the expression of wild allele

N. Agarwal, A. Kutlar, J. Prchal, 2007, Haematologica.

High altitude genetic adaptation in Tibetans: no role of increased hemoglobin-oxygen affinity.

P. Koul, J. Prchal, T. Tashi, 2014, Blood cells, molecules & diseases.

Evolutionary history of Tibetans inferred from whole-genome sequencing

L. Hood, J. Roach, L. Jorde, 2017, PLoS genetics.

A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma

J. Prchal, K. Pacak, F. Lorenzo, 2013, Journal of Molecular Medicine.

G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth.

G. Semenza, N. Jing, J. Prchal, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia

M. Gladwin, G. Kato, O. Castro, 2011, Haematologica.

Congenital and evolutionary modulations of hypoxia sensing and their erythroid phenotype

J. Prchal, T. Tashi, Jihyun Song, 2019, Current Opinion in Physiology.

“What We Know and What We Do Not Know about Evolutionary Genetic Adaptation to High Altitude Hypoxia in Andean Aymaras”

J. Prchal, V. Gordeuk, N. S. Reading, 2023, Genes.

Genetic selection by high altitude: Beware of experiments at ambient conditions

J. Prchal, 2015, Proceedings of the National Academy of Sciences.

A Novel PHD2 Mutation Associated with Tibetan Genetic Adaptation to High Altitude Hypoxia.

J. Prchal, T. Simonson, F. Lorenzo, 2010 .

Metabolic aspects of high‐altitude adaptation in Tibetans

J. Prchal, D. McClain, T. Simonson, 2015, Experimental physiology.

Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism

J. Prchal, D. McClain, V. Gordeuk, 2012, Journal of Molecular Medicine.

Plasma quantitation of JAK2 mutation is not suitable as a clinical test: an artifact of storage.

M. Salama, J. Prchal, S. Swierczek, 2009, Blood.

The CYB5R3c.350C>G and G6PD A alleles modify severity of anemia in malaria and sickle cell disease

M. Gladwin, G. Kato, R. Machado, 2020, American journal of hematology.

A novel mutation found in the 3' domain of NADH-cytochrome B5 reductase in an African-American family with type I congenital methemoglobinemia.

J. Prchal, M. M. Jenkins, Josef T Prchal, 1996, Blood.

A high-frequency polymorphism of NADH-cytochrome b5 reductase in African-Americans

J. Prchal, M. M. Jenkins, Josef T Prchal, 1997, Human Genetics.

Metabolic insight into mechanisms of high-altitude adaptation in Tibetans.

L. Jorde, D. Witherspoon, Jinchuan Xing, 2012, Molecular genetics and metabolism.

Revised criteria for the myeloproliferative disorders: too much too soon?

J. Prchal, C. Parker, S. Samuelson, 2008, Blood.

Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing.

Wei Zhang, Tatiana Ammosova, S. Nekhai, 2014, Blood cells, molecules & diseases.

Active transport of GSSG from reconstituted erythrocyte ghosts.

S. Srivastava, J. Prchal, E. Beutler, 1975, Blood.

Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization

J. Prchal, M. Hartnett, Haibo Wang, 2018, Scientific Reports.

Hemoglobin Long Island is caused by a single mutation (adenine to cytosine) resulting in a failure to cleave amino-terminal methionine.

Y. Kan, J. Prchal, D. P. Cashman, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Anticoagulation management post-transjugular intrahepatic portosystemic shunt in portal hypertension associated with myeloproliferative neoplasms.

J. Prchal, M. Y. Lim, C. Parker, 2021, Blood Coagulation and Fibrinolysis.

Containing Heterodimeric Molecules

J. Prchal, K. Siebenlist, M. Mosesson, 2017 .

Fibrinogen Birmingham: a heterozygous dysfibrinogenemia (A alpha 16 Arg----His) containing heterodimeric molecules.

J. Prchal, K. Siebenlist, M. Mosesson, 1988, Blood.

Preliminary safety and efficacy of ruxolitinib in patients (pts) with primary and secondary myelofibrosis (MF) with platelet counts (PC) of 50-100x109/L.

H. Kantarjian, S. Verstovsek, M. Talpaz, 2012 .

Diagnosing or ruling out polycythemia vera in patients with erythrocytosis.

J. Prchal, 2019, Clinical advances in hematology & oncology : H&O.

A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity

J. Prchal, C. C. Yost, Timothy M. Bahr, 2020, Neonatology.

The transcriptional and regulatory identity of erythropoietin producing cells

I. Amit, Fernando Racimo, Amir Giladi, 2023, Nature Medicine.

Does HUMARA assay for assessment of clonal hematopoiesis have shortcomings?

N. Agarwal, J. Prchal, C. Parker, 2009, Blood.

(globin/initiation codon/methionine cleavage/protein processing)

J. Prchal, 2016 .

Immunoblastic lymphoma: An immunologic study

J. Prchal, J. Mestecky, S. Crago, 1981, Cancer.

Involvement of chromosomes 9 and 11 in familial and sporadic polycythemia vera

R. Kralovics, J. Prchal, 2000 .

Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression

J. Prchal, Soo Jin Kim, P. Thiagarajan, 2022, Blood advances.

Biogenesis of erythrocyte membrane skeleton in health and disease

J. Prchal, J. Palek, M. Hanspal, 1993, Stem cells.

Systematic Evaluation of DNA-Based Quantitative-Polymerase Chain Reaction (Q-PCR) Assays to Track Treatment Response in Patients with JAK2-V617F Associated Myeloproliferative Neoplasms: A Joint European LeukemiaNet/ MPN&MPNr-EuroNet Study

T. Barbui, P. Guglielmelli, A. Pancrazzi, 2011 .

A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population

L. Jorde, P. Koul, J. Prchal, 2016, PloS one.

Variations in Both α-Spectrin (SPTA1) and β-Spectrin (SPTB) in a Neonate with Prolonged Jaundice in a Family where Nine Individuals Had Hereditary Elliptocytosis

J. Prchal, H. Yaish, R. Christensen, 2013, Neonatology.

A TaqI polymorphism in the human erythroid β spectrin gene

J. Prchal, T. Coetzer, L. Beeton, 1995, Human Genetics.

Novel α-Spectrin Mutation in Trans with α-SpectrinLEPRA Causing Severe Neonatal Jaundice from Hereditary Spherocytosis

J. Prchal, H. Yaish, R. Christensen, 2014, Neonatology.

Presence of J chain in human lymphoid cells.

J. Prchal, J. Mestecky, S. Crago, 1980, Clinical and experimental immunology.

JAK2ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera.

M. Deininger, N. Cross, J. Prchal, 2019, Blood.

Are erythropoietin receptors expressed in tumors? Facts and fiction--more careful studies are needed.

N. Agarwal, J. Prchal, V. Gordeuk, 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Mouse surviving solely on human erythropoietin receptor (EpoR): model of human EpoR-linked disease.

J. Prchal, V. Divoký, 2002, Blood.

Hb Long Island: a hemoglobin variant with a methionyl extension at the NH2 terminus and a prolyl substitution for the normal histidyl residue 2 of the beta chain.

J. Prchal, R. Jones, D. Shih, 1985, Proceedings of the National Academy of Sciences of the United States of America.

HB Bibba OR α2136(H19)LEU→PROβ2 in a Caucasian Family from Alabama

J. Prchal, E. Baysal, B. Adler, 1995 .

e- Blood Methylation of AR locus does not always reﬂect X chromosome inactivation state

N. Agarwal, J. Jelinek, J. Prchal, 2012 .

Molecular defect of truncated beta-spectrin associated with hereditary elliptocytosis. Beta-spectrin Gottingen.

J. Prchal, Huilan Yu, S. Eber, 1991, The Journal of biological chemistry.

Three Novel EPAS1/HIF2A Somatic and Germline mutations Associated with Polycythemia and Pheochromocytoma/Paraganglioma.

J. Prchal, K. Pacak, F. Lorenzo, 2012 .

Extent of hematopoietic involvement by TET2 mutations in JAK2V617F polycythemia vera

C. Bellanné-Chantelot, F. Delhommeau, J. Prchal, 2011, Haematologica.

Pediatric essential thrombocythemia (ET) from the Czech Republic.

J. Prchal, S. Samuelson, 2008, Leukemia research.

The amount of JAK2 617V>F matters

J. Prchal, 2007 .

Will Imitanib Be Useful for Patients with Polycythemia Vera

W. Vainchenker, J. Cortes, S. Verstovsek, 2005 .

In Vitro Expansion of Polycythemia Vera Progenitors Favors Expansion of Erythroid Precursors without JAK2 V617F Mutation.

J. Issa, J. Jelinek, J. Prchal, 2005 .

A Multicenter, Open Label Phase I/II Study of CEP701 (Lestaurtinib) in Adults with Myelofibrosis; a Report On Phase I: A Study of the Myeloproliferative Disorders Research Consortium (MPD-RC).

J. Tripodi, V. Najfeld, M. Carroll, 2009 .

Philadelphia chromosome-negative myeloproliferative disorders: an historical perspective.

J. Prchal, 2008, Hematology. American Society of Hematology. Education Program.

Cytochrome b5 Reductase T116S Mutation and Hemolysis in Sickle Cell Disease.

M. Gladwin, G. Kato, O. Castro, 2009 .

Evaluation of the methemoglobinemia associated with Sulofenur

J. Prchal, R. Wheeler, D. Molthrop, 2004, Investigational New Drugs.

Allogeneic Hematopoietic Cell Transplants in Patients with Myelofibrosis Age 60 and Older

B. Sandmaier, H. Heslop, J. Prchal, 2008 .

Congenital polycythemia in Chuvashia.

J. Prchal, V. Gordeuk, Y. Tokarev, 1997, Blood.

Phase I Study Of LY2784544, a JAK2 Selective Inhibitor, In Patients With Myelofibrosis (MF), Polycythemia Vera (PV), and Essential Thrombocythemia (ET)

M. Salama, S. Verstovsek, R. Mesa, 2013 .

Congenital Causes of Erythrocytosis/Polycythemias and Thrombocytosis

R. Skoda, J. Prchal, 2007 .

Acute Kernicterus in a Neonate With O/B Blood Group Incompatibility and a Mutation in SLC4A1

J. Prchal, H. Yaish, R. Christensen, 2013, Pediatrics.

Gene expression changes in sickle cell reticulocytes and their clinical associations

M. Gladwin, S. Nekhai, J. Prchal, 2023, Scientific reports.

Chronic Myeloproliferative Disorders:From Molecular Pathogenesis to Targeted Therapy

J. Prchal, R. Walgren, 2012 .

Full-length human L1 insertions retain the capacity for high frequency retrotransposition in cultured cells.

W. Berger, H. Kazazian, U. Schwahn, 1999, Human molecular genetics.

Thrombotic Thrombocytopenic Purpura Associated With Pegylated Interferon Alfa-2a Use in a Patient With Polycythemia Vera.

J. Prchal, Soo Jin Kim, Jing-fei Dong, 2017, Journal of the National Comprehensive Cancer Network : JNCCN.

Hematopoiesis is not clonal in healthy elderly women.

N. Agarwal, J. Prchal, A. Artz, 2008, Blood.

Clonal stability of blood cell lineages indicated by X-chromosomal transcriptional polymorphism

M. Cooper, J. Prchal, M. Belickova, 1996, The Journal of experimental medicine.

Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family.

L. Jorde, J. Prchal, T. Simonson, 2009, Blood cells, molecules & diseases.

The Tibetan PHD2 Polymorphism Asp4Glu Is Associated with Hypersensitivity of Erythroid Progenitors to EPO and Upregulation of HIF-1 Regulated Genes Hexokinase (HK1) and Glucose Transporter 1 (SLC2A/GLUT1),

C. Huff, J. Prchal, F. Lorenzo, 2011 .

Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer

C. Huff, A. Sapkota, Hao Hu, 2016, Oncotarget.

Defective membrane skeleton assembly in hereditary elliptocytosis.

J. Prchal, J. Palek, S. C. Liu, 1981, Progress in clinical and biological research.

Role of African American genetic polymorphisms in prostate cancer.

S. Leal, M. Ittmann, J. Prchal, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Rapid determination of clonality by detection of two closely-linked X chromosome exonic polymorphisms using allele-specific PCR.

J. Prchal, R. Go, Y. Liu, 1997, The Journal of clinical investigation.

An antibody cytotoxic to megakaryocyte progenitor cells in a patient with immune thrombocytopenic purpura.

R. Hoffman, J. Prchal, A. Lobuglio, 1985, The New England journal of medicine.

G6PD activity is essential for definite erythropoiesis

J. Prchal, 2004 .

Aberrant expression of microRNA in polycythemia vera

J. Prchal, A. Bashirullah, J. Prchal, 2008, Haematologica.

Angiotensin II stimulates proliferation of normal early erythroid progenitors.

B. Julian, M. Mrug, J. Prchal, 1997, The Journal of clinical investigation.

Combined De-Novo Mutation and Non-Random X-Chromosome Inactivation Causing Wiskott-Aldrich Syndrome in a Female with Thrombocytopenia

S. Scherer, H. Ochs, T. Torgerson, 2013, Journal of Clinical Immunology.

Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis

J. Prchal, D. Malleske, R. Christensen, 2015, Neonatology.

Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia

M. Gladwin, G. Kato, O. Castro, 2011, Haematologica.

Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression.

Tatiana Ammosova, S. Nekhai, T. Ganz, 2011, Blood.

Molecular Basis of Neocytolysis.

J. Prchal, P. Thiagarajan, Jihyun Song, 2012 .

Hemoglobin Birmingham and hemoglobin Galicia: two unstable beta chain variants characterized by small deletions and insertions.

A. Kutlar, J. Prchal, J. B. Wilson, 1990, Blood.

X-linked clonality testing: interpretation and limitations.

J. Prchal, George L. Chen, 2007, Blood.

Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia.

T. Fojo, C. Stratakis, E. Kebebew, 2012, The New England journal of medicine.

Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHLR200W mutation (Chuvash polycythemia)

M. Gladwin, A. Remaley, G. Kato, 2012, Haematologica.

The Clinical Utility Of Next-Generation Sequencing In The Diagnosis Of Hereditary Hemolytic Anemias

M. Salama, J. Prchal, H. Yaish, 2013 .

The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W)

S. Nekhai, C. Huff, J. Prchal, 2013, Haematologica.

Hematopoiesis is not clonal in healthy elderly women.

N. Agarwal, J. Prchal, A. Artz, 2008, Blood.

Phase I Study of the JAK2 V617F Inhibitor, LY2784544, in Patients with Myelofibrosis (MF), Polycythemia Vera (PV), and Essential Thrombocythemia (ET)

S. Verstovsek, R. Mesa, J. Prchal, 2011 .