D. Marks

D. Marks, A. Grossberg, Theodore P. Braun, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Anorexia and Cachexia in Renal Failure—Is Leptin the Culprit? Role of Leptin and Melanocortin Signaling in Uremia-Associated Cachexia. J Clin Invest 115: 1659–1665, 2005

D. Marks, W. Cheung, R. Mak, 2005 .

C Neuropeptides and the treatment of cachexia Krasnow and Marks 267 Cytokines and central inflammation

D. Marks, S. Krasnow, 2010 .

Neuropeptides in the pathophysiology and treatment of cachexia

D. Marks, S. Krasnow, 2010, Current opinion in supportive and palliative care.

Leptin and inflammation-associated cachexia in chronic kidney disease.

R. Cone, D. Marks, W. Cheung, 2006, Kidney international.

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

D. Marks, M. Culler, M. Cowley, 2013, Diabetes.

Regulation of Lean Mass, Bone Mass, and Exercise Tolerance by the Central Melanocortin System

M. Bouxsein, D. Marks, Theodore P. Braun, 2012, PloS one.

Neural Mechanisms of Cancer Cachexia

D. Marks, Tetiana Korzun, Brennan Olson, 2021, Cancers.

Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β

D. Marks, A. Grossberg, Theodore P. Braun, 2012, Journal of Neuroinflammation.

Role of leptin and melanocortin signaling in uremia-associated cachexia.

R. Cone, B. Little, D. Marks, 2005, The Journal of clinical investigation.

Hexosamine Biosynthesis Is a Possible Mechanism Underlying Hypoxia’s Effects on Lipid Metabolism in Human Adipocytes

D. Marks, C. Lumeng, Kevin A. Meyer, 2013, PloS one.

Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis*

D. Marks, A. Butler, L. Solt, 2011, The Journal of Biological Chemistry.

indispensable amino acid deficiency Hypothalamic signaling in anorexia induced by

D. Marks, A. Grossberg, Theodore P. Braun, 2012 .

Hypothalamic signaling in anorexia induced by indispensable amino acid deficiency.

D. Marks, A. Grossberg, Theodore P. Braun, 2012, American journal of physiology. Endocrinology and metabolism.

Melanocortin-4 receptor in sheep: a potential site for therapeutic intervention in disease models.

C. G. Wagner, D. Marks, C. Mcmahon, 2005, Domestic animal endocrinology.

Regulation of gonadotropin-releasing hormone (GnRH) and galanin gene expression in GnRH neurons during lactation in the rat.

R. Steiner, D. Marks, M. Smith, 1993, Endocrinology.

A role for orexin in cytotoxic chemotherapy-induced fatigue

D. Marks, L. Wood, K. Weymann, 2014, Brain, Behavior, and Immunity.

Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook

D. Marks, Brennan Olson, 2019, Cancers.

Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia.

D. Marks, A. Inui, M. Culler, 2007, Endocrinology.

Hypothalamic Dysfunction and Multiple Sclerosis: Implications for Fatigue and Weight Dysregulation

D. Marks, V. Yadav, Kevin G. Burfeind, 2016, Current Neurology and Neuroscience Reports.

Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance

S. McWeeney, D. Marks, S. Jeng, 2019, Brain, Behavior, and Immunity.

Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia

D. Marks, Xinxia Zhu, Peter R. Levasseur, 2021, Journal of cachexia, sarcopenia and muscle.

Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells

D. Marks, Peter R. Levasseur, S. Krasnow, 2017, Journal of Neuroinflammation.

TLR7 is expressed by support cells, but not sensory neurons, in ganglia

D. Marks, A. Fryer, D. Jacoby, 2021, Journal of Neuroinflammation.

Microglia in the hypothalamus respond to tumor‐derived factors and are protective against cachexia during pancreatic cancer

D. Marks, Xinxia Zhu, Peter R. Levasseur, 2020, Glia.

Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice.

C. Chen, D. Marks, W. Cheung, 2007, Journal of the American Society of Nephrology : JASN.

Body mass index predicts insulin resistance in survivors of pediatric acute lymphoblastic leukemia

D. Marks, S. Malempati, S. Lowas, 2009, Pediatric blood & cancer.

Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia

D. Marks, S. Malempati, S. Lowas, 2009, Pediatric blood & cancer.

Nanoparticle-Based Follistatin Messenger RNA Therapy for Reprogramming Metastatic Ovarian Cancer and Ameliorating Cancer-Associated Cachexia.

Jeonghwan Kim, D. Marks, Tetiana Korzun, 2022, Small.

A Role for Agouti-Related Protein in Appetite Regulation in a Species with Continuous Nutrient Delivery

C. G. Wagner, D. Marks, C. Mcmahon, 2005, Neuroendocrinology.

Leukemia inhibitory factor as a mediator of lipopolysaccharide effects on appetite and selected hormones and metabolites.

D. Marks, B. Whitlock, J. Sartin, 2016, Journal of animal science.

Effect of leukemia inhibitory factor on feed intake and body temperature in sheep

D. Marks, B. Whitlock, J. Sartin, 2010 .

A distinct brain pathway links viral RNA exposure to sickness behavior

D. Marks, Xinxia Zhu, Peter R. Levasseur, 2016, Scientific Reports.

Validation of automated body composition analysis using diagnostic computed tomography imaging in patients with pancreatic cancer.

D. Marks, C. Deig, B. Sheppard, 2022, American journal of surgery.

Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease-associated cachexia.

D. Marks, M. Callahan, K. Gruber, 2020, The Journal of clinical investigation.

Title: Regulation of AgRP mRNA transcription and peptide secretion by acute and chronic inflammation

D. Marks, M. Cowley, P. Enriori, 2008 .

Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via Toll-like receptor engagement.

D. Marks, O. Taratula, P. Kurre, 2017, The Journal of Biological Chemistry.

Regulation of Gonadotropin-Releasing Hormone (GnRH) and Galanin Gene Expression in GnRH Neurons during Lactation in the Rat*

R. Steiner, D. Marks, D. Clifton, 1993 .

Administration of IL-1β to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract

D. Marks, M. DeBoer, Jarrad M. Scarlett, 2009, Peptides.

An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity.

Troy C. Krzysiak, A. Gronenborn, P. Benos, 2018, Molecular cell.

The Melanocortin Pathway and Food Intake

R. Cone, D. Marks, 2003 .

TLR7 is expressed by support cells, but not sensory neurons, in ganglia

D. Marks, A. Fryer, D. Jacoby, 2021, Journal of Neuroinflammation.

Inhibition of Steroid‐Induced Galanin mRNA Expression in GnRH Neurons by Specific NMDA‐Receptor Blockade

R. Steiner, D. Marks, D. Clifton, 1996, Journal of neuroendocrinology.

Ala67Thr polymorphism in the Agouti‐related peptide gene is associated with inherited leanness in humans

R. Cone, Y. Chagnon, L. Pérusse, 2004, American journal of medical genetics. Part A.

Melanocortin-3 receptors expressed on agouti-related peptide neurons inhibit feeding behavior in female mice.

D. Marks, A. Butler, C. Girardet, 2018, Obesity.

The regulation of muscle mass by endogenous glucocorticoids

D. Marks, Theodore P. Braun, Daniel L. Marks, 2015, Front. Physiol..

Perinatal Exposure to a High-Fat Diet Is Associated with Reduced Hepatic Sympathetic Innervation in One-Year Old Male Japanese Macaques

D. Marks, J. Friedman, K. Grove, 2012, PloS one.

Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids

D. Marks, C. Dorrell, A. Reddy, 2022, Scientific Reports.

RHEB1 expression in embryonic and postnatal mouse

D. Marks, J. Clement, M. Danilchik, 2016, Histochemistry and Cell Biology.

Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment

D. Marks, Theodore P. Braun, Xinxia Zhu, 2021, Brain, Behavior, and Immunity.

Diverging metabolic programmes and behaviours during states of starvation, protein malnutrition, and cachexia

D. Marks, A. Grossberg, Brennan Olson, 2020, Journal of cachexia, sarcopenia and muscle.

The use of melanocortin antagonists in cachexia of chronic disease

D. Marks, J. Scarlett, 2005, Expert opinion on investigational drugs.

The central role of hypothalamic inflammation in the acute illness response and cachexia.

D. Marks, Katherine A. Michaelis, Kevin G. Burfeind, 2016, Seminars in cell & developmental biology.

Hypothalamic mechanisms in cachexia

D. Marks, A. Grossberg, J. Scarlett, 2010, Physiology & Behavior.

The Role of Central Melanocortins in Cachexia

D. Marks, 2007 .

Convergent neuronal projections from paraventricular nucleus, parabrachial nucleus, and brainstem onto gastrocnemius muscle, white and brown adipose tissue in male rats

V. Baracos, W. Colmers, D. Marks, 2019, The Journal of comparative neurology.

Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing

D. Marks, Peter R. Levasseur, S. Krasnow, 2022, Molecular metabolism.

Maternal high-fat diet and obesity compromise fetal hematopoiesis

S. McWeeney, D. Marks, S. Jeng, 2014, Molecular metabolism.

Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.

D. Marks, A. Grossberg, Theodore P. Braun, 2010, Endocrinology.

Anticatabolic properties of melanocortin-4 receptor antagonists

D. Marks, L. Madison, 2006, Current opinion in clinical nutrition and metabolic care.

Inflammation-Induced Lethargy Is Mediated by Suppression of Orexin Neuron Activity

D. Marks, M. Myers, G. Leinninger, 2011, The Journal of Neuroscience.

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

D. Marks, B. Chang, T. Horton, 2019, EMBO reports.

Pancreatic inflammation and increased islet macrophages in insulin-resistant juvenile primates.

D. Marks, K. Grove, M. Smith, 2013, The Journal of endocrinology.

Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

A. Sdrulla, D. Marks, V. Brooks, 2020, eLife.

Hypothalamic inflammation and food intake regulation during chronic illness

R. Witkamp, D. Marks, J. Dwarkasing, 2016, Peptides.

Increased maternal fat consumption during pregnancy alters body composition in neonatal mice.

D. Marks, S. Krasnow, M. L. Nguyen, 2011, American journal of physiology. Endocrinology and metabolism.

MyD88 signalling is critical in the development of pancreatic cancer cachexia

D. Marks, T. Morgan, Theodore P. Braun, 2019, Journal of cachexia, sarcopenia and muscle.

Central melanocortins and the regulation of weight during acute and chronic disease.

R. Cone, D. Marks, 2001, Recent progress in hormone research.

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

L. Coussens, K. Olive, D. Marks, 2019, Nature Communications.

Association Between Sarcopenia and Mortality in Patients Undergoing Surgical Excision of Head and Neck Cancer.

D. Marks, M. Wax, Ryan J Li, 2019, JAMA otolaryngology-- head & neck surgery.

Role of Soluble Epoxide Hydrolase in Exacerbation of Stroke by Streptozotocin-Induced Type 1 Diabetes Mellitus

D. Marks, N. Alkayed, K. Zuloaga, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Regulation of central melanocortin signaling by interleukin-1 beta.

D. Marks, M. Cowley, E. Jobst, 2007, Endocrinology.

The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia

M. Papp, D. Marks, M. Hufschmid, 2011, Journal of cachexia, sarcopenia and muscle.

Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease.

D. Marks, M. Culler, R. Datta, 2010, Kidney international.

Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

S. McWeeney, J. Raber, D. Marks, 2020, eLife.

“A distinct neutrophil population invades the central nervous system during pancreatic cancer”

S. McWeeney, J. Raber, D. Marks, 2019, bioRxiv.

Hormonal Regulators of Appetite

D. Marks, Juliana Austin, 2008, International journal of pediatric endocrinology.

P-selectin genotype is associated with the development of cancer cachexia

A. Vigano, S. Kaasa, V. Baracos, 2012, EMBO molecular medicine.

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

R. Cone, D. Marks, A. Butler, 2001, Nature Neuroscience.

Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice.

D. Marks, R. Klein, E. Larson, 2015, Endocrinology.

Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease.

D. Rowitch, E. Bongarzone, D. Marks, 2013, Human molecular genetics.

Mechanism of Protection by Soluble Epoxide Hydrolase Inhibition in Type 2 Diabetic Stroke

D. Marks, N. Alkayed, K. Zuloaga, 2014, PloS one.

Effects of S-pindolol in mouse pancreatic and lung cancer cachexia models.

D. Marks, F. López‐Soriano, S. Busquets, 2023, Journal of cachexia, sarcopenia and muscle.

Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat.

R. Steiner, D. Marks, M. Smith, 1993, Endocrinology.

Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat.

R. Steiner, D. Marks, D. Marks, 1994, Endocrinology.

Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells

D. Marks, Peter R. Levasseur, S. Krasnow, 2017, Journal of Neuroinflammation.

Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice

D. Marks, S. Krasnow, J. G. Knoll, 2017, Journal of Neuroinflammation.

Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates

D. Marks, J. Friedman, M. Gillingham, 2011, PloS one.

Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus

V. Baracos, W. Colmers, D. Marks, 2015, PloS one.

Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning

D. Marks, A. Butler, Courtney A. Miller, 2017, Scientific Reports.

Association of Sarcopenia With Oncologic Outcomes of Primary Surgery or Definitive Radiotherapy Among Patients With Localized Oropharyngeal Squamous Cell Carcinoma.

D. Marks, Ryan J Li, D. Clayburgh, 2020, JAMA otolaryngology-- head & neck surgery.

Effects on Mouse Food Consumption After Exposure to Bedding from Sick Mice or Healthy Mice.

D. Marks, K. E. Saunders, Rebecca Lovasz, 2020, Journal of the American Association for Laboratory Animal Science : JAALAS.

A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling

D. Marks, A. Butler, S. Farr, 2017, Front. Neurosci..

Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling

D. Marks, L. Stork, Xinxia Zhu, 2016, PloS one.

Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss

D. Marks, A. Butler, H. Macarthur, 2016, Molecular metabolism.

Constructing and programming a cost-effective murine running wheel with digital revolution counter

D. Marks, J. Edwards, Brennan Olson, 2021, Lab Animal.

Lipopolysaccharide‐induced hypothalamic inflammation in cancer cachexia‐anorexia is amplified by tumour‐derived prostaglandin E2

R. Witkamp, D. Marks, K. van Norren, 2022, Journal of cachexia, sarcopenia and muscle.

Development and Perspectives: Multifunctional Nucleic Acid Nanomedicines for Treatment of Gynecological Cancers.

D. Marks, Tetiana Korzun, O. Taratula, 2023, Small.

Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via Toll-like receptor engagement.

D. Marks, O. Taratula, P. Kurre, 2017, The Journal of Biological Chemistry.

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

M. Low, R. Cone, D. Marks, 2001, International Journal of Obesity.

Simultaneous visualization of two cellular mRNA species in individual neurons by use of a new double in Situ hybridization method

R. Steiner, D. Marks, D. Clifton, 1992, Molecular and Cellular Neuroscience.

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

C. Roberts, D. Marks, M. Slifka, 2009, International Journal of Obesity.

From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics

D. Marks, Tetiana Korzun, G. Sahay, 2023, Pharmaceuticals.

Role of the central melanocortin system in cachexia.

R. Cone, Nicholas Ling, D. Marks, 2001, Cancer research.

Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook

D. Marks, Brennan Olson, 2019, Cancers.

Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis*

D. Marks, A. Butler, L. Solt, 2011, The Journal of Biological Chemistry.

TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia

D. Marks, Xinxia Zhu, Peter R. Levasseur, 2017, Brain, Behavior, and Immunity.

Prostacyclin signaling regulates circulating ghrelin during acute inflammation.

D. Marks, Xinxia Zhu, Peter R. Levasseur, 2008, The Journal of endocrinology.

RHEB1 expression in embryonic and postnatal mouse

D. Marks, J. Clement, M. Danilchik, 2015, Histochemistry and Cell Biology.

Preliminary data from the phase I study of TCMCB07, a study to assess the safety, tolerability and pharmacokinetics of the melanocortin antagonist TCMCB07 in healthy subjects.

D. Marks, E. Roeland, Xinxia Zhu, 2023, Journal of Clinical Oncology.

Effect of melanocortin-4 receptor antagonist TCMCB07 on chemotherapy-induced anorexia and weight loss in rats.

D. Marks, E. Roeland, Xinxia Zhu, 2023, Journal of Clinical Oncology.

Regulation of Lean Mass, Bone Mass, and Exercise Tolerance by the Central Melanocortin System

M. Bouxsein, D. Marks, Theodore P. Braun, 2012, PloS one.