F. Hakuno

S. Seino, F. Hakuno, Shin-ichiro Takahashi, 2012, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Tyrosine kinase and phosphatidylinositol 3-kinase activation are required for cyclic adenosine 3',5'-monophosphate-dependent potentiation of deoxyribonucleic acid synthesis induced by insulin-like growth factor-I in FRTL-5 cells.

F. Hakuno, Shin-ichiro Takahashi, T. Nedachi, 2000, Endocrinology.

A novel amino acid signaling process governs glucose-6-phosphatase transcription

N. Kataoka, F. Hakuno, D. Yamanaka, 2021, iScience.

IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

M. Komada, T. Asano, N. Kataoka, 2018, Oncotarget.

Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates.

F. Hakuno, Shin-ichiro Takahashi, K. Takano, 2009, Endocrine journal.

The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells

F. Hakuno, Shin-ichiro Takahashi, H. Kamei, 2017, Front. Endocrinol..

In vivo loss of function study reveals the short stature homeobox‐containing (shox) gene plays indispensable roles in early embryonic growth and bone formation in zebrafish

F. Hakuno, Shin-ichiro Takahashi, H. Kamei, 2015, Developmental dynamics : an official publication of the American Association of Anatomists.

Mechanical guidance of self-condensation patterns of differentiating progeny

R. Kawamura, H. Nakauchi, H. Taniguchi, 2022, iScience.

Paraquat-induced Oxidative Stress Represses Phosphatidylinositol 3-Kinase Activities Leading to Impaired Glucose Uptake in 3T3-L1 Adipocytes*

T. Asano, F. Hakuno, Shin-ichiro Takahashi, 2010, The Journal of Biological Chemistry.

Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes

K. Wada, N. Kataoka, F. Hakuno, 2020, Autophagy.

Novel missense mutation in the IGF‐I receptor L2 domain results in intrauterine and postnatal growth retardation

K. Higaki, F. Hakuno, Shin-ichiro Takahashi, 2012, Clinical endocrinology.

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

M. Komada, T. Asano, T. Natsume, 2017, Biochemical and biophysical research communications.

Insulin Receptor Substrate-3 Functions as Transcriptional Activator in the Nucleus*

T. Asano, F. Hakuno, Shin-ichiro Takahashi, 2002, The Journal of Biological Chemistry.

Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth

F. Hakuno, Y. Toyoshima, I. Miyata, 2022, Cells.

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.

F. Hakuno, Shin-ichiro Takahashi, T. Nedachi, 2008, Endocrinology.

Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat

F. Hakuno, T. Matsuwaki, K. Yamanouchi, 2022, Skeletal Muscle.

Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats

F. Hakuno, Shin-ichiro Takahashi, Y. Toyoshima, 2017, Nutrition & Metabolism.

Insulin-Like Growth Factor-1 Potentiates Induced by Thyrotropin in FRTL-5 Cells : Induction of Protein Synthesis and DNA Protein Synthesis Comparison of Synthesis

Ito, F. Hakuno, T. Nedachi, 2006 .

Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells.

Y. Ito, F. Hakuno, Shin-ichiro Takahashi, 2001, Biochimica et biophysica acta.

Insulin-like growth factor-I potentiates protein synthesis induced by thyrotropin in FRTL-5 cells: comparison of induction of protein synthesis and DNA synthesis.

Y. Ito, F. Hakuno, Shin-ichiro Takahashi, 1998, Endocrine journal.

Insulin Receptor Substrate-1 Associates with Small Nucleolar RNA Which Contributes to Ribosome Biogenesis

T. Asano, N. Kataoka, F. Hakuno, 2014, Front. Endocrinol..

Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences

Kenji Suzuki, S. Ogawa, Y. Shiozawa, 2019, Front. Genet..

Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells.

N. Kataoka, M. Matsuo, F. Hakuno, 2021, Biochimie.

Effect of Paraquat-Induced Oxidative Stress on Insulin Regulation of Insulin-Like Growth Factor-Binding Protein-1 Gene Expression

F. Hakuno, Shin-ichiro Takahashi, Yoshitake Cho, 2010, Journal of clinical biochemistry and nutrition.

Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver.

F. Hakuno, Shin-ichiro Takahashi, Y. Toyoshima, 2010, Journal of molecular endocrinology.

PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation.

F. Hakuno, Shin-ichiro Takahashi, T. Hara, 2012, Anticancer research.

The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity

M. Yamamoto, F. Hakuno, Masayuki Yamamoto, 1996, Genes to cells : devoted to molecular & cellular mechanisms.

The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats.

Y. Uchijima, F. Hakuno, Shin-ichiro Takahashi, 2006, Endocrinology.

Insulin/insulin-like growth factor-like activity in the aqueous extracts of the rotifer Brachionus plicatilis

S. Watabe, F. Hakuno, Shin-Ichiro Takahashi, 2012, Fisheries Science.

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes

M. Taira, F. Hakuno, Shin-ichiro Takahashi, 2015, PloS one.

Somatic GJA4 gain-of-function mutation in orbital cavernous venous malformations

S. Ishikawa, D. Komura, T. Matsukawa, 2022, Angiogenesis.

The AP-1 Complex Regulates Intracellular Localization of Insulin Receptor Substrate 1, Which Is Required for Insulin-Like Growth Factor I-Dependent Cell Proliferation

F. Hakuno, Shin-ichiro Takahashi, Tomohiro Kabuta, 2013, Molecular and Cellular Biology.

Constitutive Expression of Insulin Receptor Substrate (IRS)-1 Inhibits Myogenic Differentiation through Nuclear Exclusion of Foxo1 in L6 Myoblasts

J. Nakae, F. Hakuno, Shin-ichiro Takahashi, 2011, PloS one.

Nexilin, a Cardiomyopathy-Associated F-Actin Binding Protein, Binds and Regulates IRS1 Signaling in Skeletal Muscle Cells

Andrew Lee, F. Hakuno, J. Pessin, 2013, PloS one.

Low-arginine and low-protein diets induce hepatic lipid accumulation through different mechanisms in growing rats

F. Hakuno, Y. Toyoshima, H. Kato, 2020, Nutrition & Metabolism.

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

Y. Saeki, Keiji Tanaka, T. Asano, 2012, Biochemical and biophysical research communications.

Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.

F. Hakuno, Shin-ichiro Takahashi, Yunzhang Liu, 2014, General and comparative endocrinology.

Motility Response to Insulin-like Growth Factor-I (IGF-I) in MCF-7 Cells is Associated with IRS-2 Activation and Integrin Expression

D. Yee, F. Hakuno, Shin-ichiro Takahashi, 2004, Breast Cancer Research and Treatment.

Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces

F. Hakuno, Shin-ichiro Takahashi, Julian Weghuber, 2015, The FEBS journal.

Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats

F. Hakuno, Yuki Goda, D. Yamanaka, 2020, Scientific Reports.

Elaidate, a trans fatty acid, suppresses insulin signaling for glucose uptake in a manner distinct from that of stearate.

G. Atsumi, F. Hakuno, Shin-ichiro Takahashi, 2020, Biochimie.

Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats

N. Kataoka, F. Hakuno, K. Yamanouchi, 2021, The Journal of biological chemistry.

Importance of Serum Amino Acid Profile for Induction of Hepatic Steatosis under Protein Malnutrition

N. Kataoka, F. Hakuno, Y. Toyoshima, 2018, Scientific Reports.

Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age

F. Hakuno, A. Ishigami, Y. Noda, 2023, GeroScience.

Rapid manipulation of mitochondrial morphology in a living cell with iCMM

Hideki Uosaki, N. Hattori, F. Hakuno, 2021, Cell reports methods.

Structures and biological activities of new carnosic acid- and carnosol-related compounds generated by heat treatment of rosemary

F. Hakuno, K. Shindo, D. Yamanaka, 2019, Phytochemistry Letters.

Importance of Serum Amino Acid Profile for Induction of Hepatic Steatosis under Protein Malnutrition

N. Kataoka, F. Hakuno, Shin-ichiro Takahashi, 2018, Scientific Reports.

Interaction between cAMP-dependent and insulin-dependent signal pathways in tyrosine phosphorylation in primary cultures of rat hepatocytes.

Y. Ito, Y. Uchijima, F. Hakuno, 1997, The Biochemical journal.

RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

K. Wada, F. Hakuno, Shin-ichiro Takahashi, 2015, Nucleic acids research.

Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy

M. Oyama, K. Wada, H. Kozuka-Hata, 2017, Journal of Cell Science.

Insulin/insulin-like growth factor-like activity in the aqueous extracts of the rotifer Brachionus plicatilis

S. Watabe, F. Hakuno, Shin-ichiro Takahashi, 2012, Fisheries Science.

Familial short stature is associated with a novel dominant‐negative heterozygous insulin‐like growth factor 1 receptor (IGF1R) mutation

F. Hakuno, Shin-ichiro Takahashi, T. Fukushima, 2014, Clinical endocrinology.

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

T. Umehara, S. Yokoyama, F. Hakuno, 2018, eLife.

Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.

Y. Saeki, F. Hakuno, Shin-ichiro Takahashi, 2016, Experimental cell research.

Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.

F. Hakuno, Shin-ichiro Takahashi, T. Nedachi, 2012, Molecular endocrinology.

Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters.

F. Hakuno, Shin-ichiro Takahashi, S. Minami, 2014, Biochemical and biophysical research communications.

Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells

R. Kawamura, H. Nakauchi, H. Taniguchi, 2023, STAR protocols.

Identification of Bombyx mori Akt and its phosphorylation by bombyxin stimulation.

F. Hakuno, Shin-ichiro Takahashi, H. Nagasawa, 2008, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

40 YEARS OF IGF1: IGF1 receptor signaling pathways

F. Hakuno, Shin-ichiro Takahashi, 2018, Journal of Molecular Endocrinology.

Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver.

F. Hakuno, Shin-ichiro Takahashi, Y. Toyoshima, 2010, Journal of Molecular Endocrinology.

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Y. Saeki, Keiji Tanaka, T. Asano, 2015, Nature Communications.

Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

K. Nagata, T. Terada, K. Shimizu, 2021, Communications Biology.

Growth hormone resistance induced by amino acid deprivation in fao cells is independent of FGF21

F. Hakuno, Shin-Ichiro Takahashi, Hiroki Nishi, 2024, Biochemical and Biophysical Research Communications.