P. Little

D. Bowtell, A. Möller, P. Little, 2013, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways.

P. Little, M. E. Ivey, 2008, Thrombosis research.

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.

M. Hollenberg, Wenhua Zheng, P. Little, 2016, Cellular signalling.

Artemisinin inhibits glycosaminoglycan chain synthesizing gene expression but not proliferation of human vascular smooth muscle cells.

P. Little, D. Kamato, Ying Zhou, 2020, Biochemical and biophysical research communications.

Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways

U. Gaur, Xia Zhao, Jiankang Fang, 2018, International journal of molecular sciences.

Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans

Wenhua Zheng, P. Little, N. Osman, 2016, Journal of ophthalmology.

Bioavailability of dihydroergotamine in man.

G. Jennings, P. Little, A. Bobik, 1982, British journal of clinical pharmacology.

Benzo(a)pyrene metabolism in hepatic microsomes from feral and 3-methycholanthrene-treated southern flounder, Paralichthys lethostigma.

P. Little, M. James, J. Bend, 1984, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.

Polyhalogenated biphenyls and phenobarbital: evaluation as inducers of drug metabolizing enzymes in the sheepshead, Archosargus probatocephalus.

P. Little, M. James, Peter J. Little, 1981, Chemico-biological interactions.

Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans

A. Chait, P. Little, P. Barrett, 2004, Diabetologia.

The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells

P. Little, J. Nigro, M. E. Ivey, 2008 .

Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells.

P. Little, K. Hannan, R. Dilley, 2001, Journal of diabetes and its complications.

In vitro and in vivo metabolism of benzo(a)pyrene by selected marine crustacean species

P. Little, M. James, J. Bend, 1981 .

Temperature-dependent disposition of [14C]benzo(a)pyrene in the spiny lobster, Panulirus argus.

P. Little, M. James, J. Bend, 1985, Toxicology and applied pharmacology.

Cardiovascular actions and therapeutic potential of tanshinone IIA.

P. Little, Suowen Xu, Hong Li, 2012, Atherosclerosis.

Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents.

P. Little, M. Ballinger, J. Nigro, 2007, Journal of diabetes and its complications.

Modification of benzo(a)pyrene metabolism in hepatic microsomes from untreated and induced rats by imidazole derivatives which inhibit monooxygenase activity and enhance epoxide hydrolase activity.

P. Little, M. James, 1983, Drug metabolism and disposition: the biological fate of chemicals.

Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.

P. Little, R. Dilley, J. Nigro, 2002, Atherosclerosis.

Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL.

A. Chait, P. Little, T. Wight, 2002, Journal of lipid research.

Mechanisms regulating the vascular smooth muscle Na/H exchanger (NHE-1) in diabetes.

P. Little, K. Hannan, 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis

P. Little, N. Osman, M. Ballinger, 2007, Vascular health and risk management.

Proteoglycans Synthesized by Arterial Smooth Muscle Cells in the Presence of Transforming Growth Factor‐&bgr;1 Exhibit Increased Binding to LDLs

A. Chait, P. Little, T. Wight, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis.

P. Little, N. Osman, M. E. Ivey, 2008, Current vascular pharmacology.

Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications.

P. Little, I. Blakey, H. Ta, 2021, ACS biomaterials science & engineering.

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

P. Little, N. Osman, M. Ballinger, 2007, Cardiovascular diabetology.

Angiotensin II and noradrenaline increase PDGF-BB receptors and potentiate PDGF-BB stimulated DNA synthesis in vascular smooth muscle.

P. Little, G. Jackman, A. Bobik, 1990, Biochemical and biophysical research communications.

REGULATION OF SODIUM INFLUX AND SODIUM, POTASSIUM PUMP ACTIVITY BY A SODIUM‐HYDROGEN ANTIPORT IN RAT VASCULAR SMOOTH MUSCLE

P. Weissberg, P. Little, A. Bobik, 1987, Clinical and experimental pharmacology & physiology.

Na-H exchange is a major pathway for Na influx in rat vascular smooth muscle.

P. Little, A. Bobik, E. Cragoe, 1986, The American journal of physiology.

Imidazole derivatives as inhibitors of cytochrome P-450-dependent oxidation and activators of epoxide hydrolase in hepatic microsomes from a marine fish.

P. Little, M. James, J. Bend, 1981, Biochemical pharmacology.

Na-H antiport in cultured rat aortic smooth muscle: its role in cytoplasmic pH regulation.

P. Weissberg, P. Little, A. Bobik, 1987, The American journal of physiology.

Desensitization of the alpha1 adrenoceptor system in vascular smooth muscle

Julie H. Campbell, P. Little, A. Bobik, 1984 .

Suramin inhibits PDGF‐stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms.

A. Dart, M. Esler, P. Little, 1998, Journal of cardiovascular pharmacology.

A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice.

P. Little, Suowen Xu, Mengyun Xu, 2022, Biochemical and biophysical research communications.

YY-11, a camel milk-derived peptide, inhibits TGF-β-mediated atherogenic signaling in human vascular smooth muscle cells.

P. Little, D. Kamato, Yingnan Cao, 2021, Journal of food biochemistry.

Metabolic ischemia in vascular smooth muscle causes adrenomedullin gene expression by a calcium dependent mechanism

P. Little, D. Autelitano, 1997 .

MECHANISMS INVOLVED IN THE STIMULATION OF ALDOSTERONE PRODUCTION BY ANGIOTENSIN II, VASOPRESSIN AND ENDOTHELIN

P. Little, E. Woodcock, J. K. Tanner, 1990, Clinical and experimental pharmacology & physiology.

Identification of a novel, inhibitory action of amiodarone on vesicular monoamine transport.

A. Dart, P. Little, D. Kaye, 1999, The Journal of pharmacology and experimental therapeutics.

Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.

P. Little, M. Johnson, L. Melvin, 1988, The Journal of pharmacology and experimental therapeutics.

Thrombin-induced Ca2+ mobilization in vascular smooth muscle utilizes a slowly ribosylating pertussis toxin-sensitive G protein. Evidence for the involvement of a G protein in inositol trisphosphate-dependent Ca2+ release.

V. Tkachuk, P. Little, A. Bobik, 1992, The Journal of biological chemistry.

Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review

P. Little, Suo Xu, J. Weng, 2022, Acta Pharmacologica Sinica.

Role of Ca2+ in metabolic inhibition-induced norepinephrine release in rat brain synaptosomes.

A. Dart, M. Esler, P. Little, 1997, Circulation research.

Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP

P. Little, Lisa R Tannock, Katherine D. Drennon, 2008 .

Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease.

P. Little, N. Osman, M. Ballinger, 2007, Cardiovascular research.

Androgens stimulate human vascular smooth muscle cell proteoglycan biosynthesis and increase lipoprotein binding.

P. Little, P. Komesaroff, K. Hashimura, 2005, Endocrinology.

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1[S]

P. Little, K. Tian, Suowen Xu, 2014, Journal of Lipid Research.

Role of Cyclic AMP in Cardiac β‐Adrenoceptor Desensitization: Studies Using Prenalterol and Inhibitors of Phosphodiesterase

P. Little, A. Bobik, 1984, Journal of cardiovascular pharmacology.

Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies

P. Little, Suowen Xu, Xiaoyue Pan, 2022, International journal of biological sciences.

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

P. Little, Yujie Liu, S. Luo, 2021, Signal Transduction and Targeted Therapy.

Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells

G. Gao, Wenhua Zheng, P. Little, 2012, Neuroscience Letters.

Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2).

J. Pouysségur, P. Little, M. Donowitz, 1993, The Journal of biological chemistry.

Potential of Small Molecule Protein Tyrosine Kinase Inhibitors as Immunomodulators and Inhibitors of the Development of Diabetes

G. Morahan, P. Little, N. Cohen, 2009, TheScientificWorldJournal.

Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential.

P. Little, Suowen Xu, A. Sahebkar, 2020, European journal of pharmacology.

Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor.

G. Jennings, P. Little, R. Dilley, 2001, American journal of hypertension.

Troglitazone Stimulates Repair of the Endothelium and Inhibits Neointimal Formation in Denuded Rat Aorta

P. Little, K. Hannan, R. Dilley, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Mouse models of atherosclerosis in translational research.

P. Little, D. Kamato, B. Berk, 2022, Trends in pharmacological sciences.

The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+/H+ antiport.

P. Weissberg, P. Little, A. Bobik, 1989, Circulation research.

Na+/H+ exchanger-1 alleles: strain distribution and correlation with activity

G. Morahan, P. Little, P. McClive, 2004, Immunogenetics.

Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL.

P. Little, N. Osman, M. Ballinger, 2009, Atherosclerosis.

Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis

P. Little, Suowen Xu, A. Sahebkar, 2022, Frontiers in Cardiovascular Medicine.

The effects of alterations in membrane sodium transport on rat aortic smooth muscle proliferation

P. Little, A. Bobik, A. Grooms, 1988, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Endothelin‐1 dependent expression of GAG genes involves NOX and p38 mediated Smad linker region phosphorylation

P. Little, Azam Khedri, Reyhaneh Niayesh Mehr, 2022, Clinical and experimental pharmacology & physiology.

Endothelin‐1 (ET‐1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis

P. Little, D. Kamato, M. Ghaffari, 2016, The Journal of pharmacy and pharmacology.

Stereoselective Reduction of 1‐O‐Isopropyloxygenipin Enhances Its Neuroprotective Activity in Neuronal Cells from Apoptosis Induced by Sodium Nitroprusside

Rikang Wang, Wenhua Zheng, P. Little, 2014, ChemMedChem.

Amiloride analogues cause endothelium‐dependent relaxation in the canine coronary artery in vitro: possible role of Na+/Ca2+ exchange

P. Little, J. Angus, T. Cocks, 1988, British journal of pharmacology.

Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation.

Sayoko Ogura, P. Little, Suowen Xu, 2012, Translational research : the journal of laboratory and clinical medicine.

Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation.

Wenhua Zheng, P. Little, Haitao Wang, 2014, Cellular signalling.

Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle.

V. Tkachuk, P. Little, A. Bobik, 1992, Biochemical and biophysical research communications.

Kaempferol and atherosclerosis: From mechanism to medicine.

P. Little, Jianbo Xiao, H. El‐Seedi, 2022, Critical reviews in food science and nutrition.

Mouse models of atherosclerosis in translational research Trends in Pharmacological Sciences

P. Little, D. Kamato, B. Berk, 2022 .

Endothelin‐1 increases CHSY‐1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin‐1

P. Little, F. Seif, H. Babaahmadi-Rezaei, 2019, The Journal of pharmacy and pharmacology.

Total synthesis of the cyclic depsipeptide YM-280193, a platelet aggregation inhibitor.

P. Little, M. Brimble, P. Harris, 2015, Organic letters.

Non-Mouse Models of Atherosclerosis: Approaches to Exploring the Translational Potential of New Therapies

P. Little, D. Kamato, Suowen Xu, 2022, International journal of molecular sciences.

Dependence of Na+/H+ antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP. Evidence for the involvement of calmodulin-dependent kinases.

P. Weissberg, P. Little, A. Bobik, 1988, The Journal of biological chemistry.

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Wenhua Zheng, P. Little, N. Osman, 2014, Cellular and Molecular Life Sciences.

Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons

Xia Zhao, Linlin Liu, Wenhua Zheng, 2020, Oxidative medicine and cellular longevity.

Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway

Fengxia Yan, Wenhua Zheng, Rifang Liao, 2016, Molecular Neurobiology.

Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors

M. Hollenberg, P. Little, D. Kamato, 2017, Journal of Cell Communication and Signaling.

Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways

Lihua Zhou, Wenhua Zheng, P. Little, 2016, Psychopharmacology.

Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells

Wenhua Zheng, P. Little, N. Osman, 2016, International journal of biological sciences.

Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogues of 10-substituted cannabidiol and 11- or 12-substituted delta 8-tetrahydrocannabinol.

P. Little, D. R. Compton, R. Razdan, 1990, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of mercapto and thioacetyl analogues of cannabidiol and Δ8-tetrahydrocannabinol

P. Little, D. R. Compton, R. Razdan, 1989 .

IONIC MECHANISMS REGULATING SODIUM ENTRY INTO VASCULAR SMOOTH MUSCLE

P. Little, A. Bobik, C. Neylon, 1991, Clinical and experimental pharmacology & physiology.

Developmental differences in the acquisition of tolerance to ethanol.

W. A. Wilson, P. Little, H. Swartzwelder, 1998, Alcohol.

Hydrogels Based on Poly(aspartic acid): Synthesis and Applications

P. Little, I. Blakey, H. Ta, 2019, Front. Chem..

Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis.

A. Chait, P. Little, A. Bobik, 2011, Pharmacology & therapeutics.

Differential effects of ethanol in adolescent and adult rats.

W. A. Wilson, C. Kuhn, P. Little, 1996, Alcoholism, clinical and experimental research.

Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships.

P. Little, M. Murray, A. J. Ryan, 1982, Journal of medicinal chemistry.

Inhibitors of hepatic mixed function oxidases--II. Some benzimidazole, benzoxazole and benzothiazole derivatives.

P. Little, G. Holder, T. Watson, 1976, Biochemical pharmacology.

Actions of Calcium Channel Blockers on Vascular Proteoglycan Synthesis: Relationship to Atherosclerosis

P. Little, N. Osman, J. Nigro, 2005, Vascular health and risk management.

Effects of sex and gonadectomy on cocaine metabolism in the rat.

Q. D. Walker, C. Kuhn, P. Little, 1999, The Journal of pharmacology and experimental therapeutics.

Effects of Sex and Gonadectomy on Cocaine Metabolism in the Rat 1

Q. D. Walker, C. Kuhn, P. Little, 1999 .

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

P. Little, Suowen Xu, Xiaojun Feng, 2020, Frontiers in Pharmacology.

GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species

Wenhua Zheng, P. Little, D. Kamato, 2019, Vascular biology.

Novel iron oxide-cerium oxide core-shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases.

P. Little, Wei Zhao, Z. Xu, 2018, Journal of materials chemistry. B.

Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen

P. Little, Suowen Xu, Jian-Mei Fang, 2018, Medicinal research reviews.

Gaq proteins: molecular pharmacology and therapeutic potential

Wenhua Zheng, P. Little, N. Osman, 2017, Cellular and Molecular Life Sciences.

Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet.

P. Little, Suowen Xu, Peiqing Liu, 2011, Archives of biochemistry and biophysics.

Relationship between the biodisposition of [3H]soman and its pharmacological effects in mice.

P. Little, B. Thomas, B. Martin, 1985, Toxicology and applied pharmacology.

Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats.

C. Kuhn, P. Little, J. Gingras, 1997, The Journal of pharmacology and experimental therapeutics.

Role of noradrenergic hyperactivity in neonatal opiate abstinence.

R. Price, C. Kuhn, P. Little, 1996, Drug and alcohol dependence.

Intracellular pH in vascular smooth muscle: regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3- mechanisms.

P. Weissberg, P. Little, A. Bobik, 1995, Cardiovascular research.

SODIUM‐DEPENDENT, ETHYLISOPROPYLAMILORIDE‐SENSITIVE MECHANISMS REGULATE INTRACELLULAR pH IN HUMAN VASCULAR SMOOTH MUSCLE

P. Weissberg, P. Little, A. Bobik, 1990, Clinical and experimental pharmacology & physiology.

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.

P. Little, D. Kamato, J. Pelisek, 2019, Pharmacology & therapeutics.

SIRT6 protects against endothelial dysfunction and atherosclerosis in mice

P. Little, Marina Koroleva, Suowen Xu, 2016, Aging.

The Role of Toll-like Receptors in Atherothrombotic Cardiovascular Disease.

P. Little, D. Kamato, Ying Zhou, 2020, ACS pharmacology & translational science.

Toll-like Receptor 4 Stimulates Gene Expression via Smad2 Linker Region Phosphorylation in Vascular Smooth Muscle Cells.

P. Little, D. Kamato, J. Stow, 2020, ACS pharmacology & translational science.

Smad2 linker region phosphorylation is an autonomous cell signalling pathway: Implications for multiple disease pathologies.

P. Little, D. Kamato, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis.

P. Little, H. Ta, N. N. Yusof, 2019, Thrombosis research.

The possible role of the Akt signaling pathway in schizophrenia

Wenhua Zheng, P. Little, Haitao Wang, 2012, Brain Research.

Forkhead box O transcription factors as possible mediators in the development of major depression

Haitao Wang, Jiangping Xu, Zhong-Ping Feng, 2015, Neuropharmacology.

Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes.

P. Little, D. Kamato, Yingnan Cao, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Distribution of [3H]diisopropylfluorophosphate, [3H]soman, [3H]sarin, and their metabolites in mouse brain.

P. Little, J. Scimeca, B. Martin, 1988, Drug Metabolism And Disposition.

Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies

U. Gaur, Yizhou Jiang, Wenhua Zheng, 2019, Front. Cell. Neurosci..

The localisation of cephaloridine and nitrofurantoin in the kidney.

P. Little, G. Currie, S. J. McDonald, 1966, Nephron.

Endothelial function and dysfunction: Impact of metformin

M. Barras, P. Little, D. Kamato, 2018, Pharmacology & therapeutics.

The ontogeny of mu opiate tolerance and dependence in the rat: antinociceptive and biochemical studies.

C. Kuhn, P. Little, R. Windh, 1995, The Journal of pharmacology and experimental therapeutics.

Forkhead family transcription factor FoxO and neural differentiation

Wenhua Zheng, P. Little, Haitao Wang, 2012, neurogenetics.

Relationship between the pharmacological effects and the biodisposition of [3H]diisopropylfluorophosphate in mice after inhalation.

P. Little, J. Scimeca, B. Martin, 1985, Toxicology and applied pharmacology.

Naringenin and naringin in cardiovascular disease prevention: A preclinical review.

M. Farzaei, P. Little, Suowen Xu, 2020, European journal of pharmacology.

Poly(ADP‐ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications

P. Little, Suowen Xu, P. Bai, 2014, Medicinal research reviews.

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis

Wenhua Zheng, P. Little, N. Osman, 2018, Pharmacology & therapeutics.

Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease.

P. Little, D. Kamato, Ying Zhou, 2019, Pharmacology & therapeutics.

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2017, PloS one.

Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11

Wenhua Zheng, P. Little, N. Osman, 2015, Front. Cardiovasc. Med..

GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical Gαq protein signalling pathways.

P. Little, 2013, Life sciences.

Therapeutic implications of endothelin and thrombin G‐protein‐coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Lipid: Extracellular Matrix Interactions as Therapeutic Targets in the Atherosclerosis of Diabetes

P. Little, N. Osman, 2014 .

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects

P. Little, J. Pelisek, Marina Koroleva, 2018, Theranostics.

The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma

Haitao Wang, Jiangping Xu, Zhong-Ping Feng, 2014, BioMed research international.

3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene.

P. Little, M. James, M. O. James, 1984, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Smad linker region phosphorylation in the regulation of extracellular matrix synthesis

Wenhua Zheng, P. Little, Micah L. Burch, 2010, Cellular and Molecular Life Sciences.

REGULATION AND ROLE OF UROKINASE PLASMINOGEN ACTIVATOR IN VASCULAR REMODELLING

V. Tkachuk, P. Little, A. Bobik, 1996, Clinical and experimental pharmacology & physiology.

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

Wenhua Zheng, P. Little, N. Osman, 2013, Cellular signalling.

Transforming growth factor‐β regulation of proteoglycan synthesis in vascular smooth muscle: Contribution to lipid binding and accelerated atherosclerosis in diabetes

P. Little, N. Osman, Micah L. Burch, 2010, Journal of diabetes.

Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.

Fengxia Yan, Wenhua Zheng, Rifang Liao, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Is high-dose β-lactam therapy associated with excessive drug toxicity in critically ill patients?

P. Little, J. Roberts, J. Ungerer, 2016, Minerva anestesiologica.

Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells

P. Little, D. Kamato, Reyhaneh Niayesh Mehr, 2018, Journal of Cell Communication and Signaling.

Honey-derived flavonoids: natural products for the prevention of atherosclerosis and cardiovascular diseases

P. Little, R. Afroz, E. Tanvir, 2016 .

G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors

P. Little, D. Kamato, H. B. Rezaei, 2018, Life sciences.

The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development

M. Tsao, Fengxia Yan, Shuai Li, 2020, Medicinal research reviews.

Transforming growth factor β‐mediated site‐specific Smad linker region phosphorylation in vascular endothelial cells

Wenhua Zheng, P. Little, N. Osman, 2014, The Journal of pharmacy and pharmacology.

TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2

P. Little, N. Osman, Robel Getachew, 2010, Cellular and Molecular Life Sciences.

Akt acts as a switch for GPCR transactivation of the TGF‐β receptor type 1

P. Little, Aravindra Shajimoon, D. Kamato, 2021, The FEBS journal.

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.

P. Little, N. Osman, Robel Getachew, 2013, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Endothelin-1 Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle is Mediated by Endothelin Receptor Transactivation of the Transforming Growth Factor-β Type I Receptor

P. Little, N. Osman, Robel Getachew, 2010, Journal of cardiovascular pharmacology.

Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease.

P. Little, D. Kamato, Ran Wang, 2023, Trends in cardiovascular medicine.

Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship

C. Askew, P. Little, D. Kamato, 2021, Biomedicines.

Metformin, Macrophage Dysfunction and Atherosclerosis

P. Little, J. Weng, Suowen Xu, 2021, Frontiers in Immunology.

The effect of MDMA (“Ecstasy”) and its optical isomers on schedule-controlled responding in mice

R. Glennon, P. Little, J. Rosecrans, 1987, Pharmacology Biochemistry and Behavior.

Animal Models for the Evaluation of the Cardiometabolic Therapeutic Potential of Traditional Chinese and Natural Product Medicines

P. Little, D. Kamato, Yingnan Cao, 2017 .

Methotrexate Inhibits Proliferation but not Proteoglycan Synthesis or Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells

P. Little, N. Osman, Robel Getachew, 2015 .

Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins

P. Little, N. Osman, Micah L. Burch, 2009 .

Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on Vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding

A. Wilks, P. Little, N. Osman, 2008, Journal of cardiovascular pharmacology.

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

P. Little, N. Osman, K. O’Brien, 2008, Current opinion in lipidology.

Calcific aortic valve disease and hypertension

P. Little, N. Osman, M. Ballinger, 2008 .

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

P. Little, N. Osman, M. Ballinger, 2007, Cardiovascular diabetology.

Regulation of glycosaminoglycan structure and atherogenesis

A. Dart, P. Little, M. Ballinger, 2004, Cellular and Molecular Life Sciences CMLS.

Aortic Smooth Muscle Cells from ApoE (-/-) Mice Secrete Biglycan with Hyperelongated Glycosaminoglycan Chains

P. Little, N. Osman, Robel Getachew, 2013 .

Intracellular pH in human arterial smooth muscle. Regulation by Na+/H+ exchange and a novel 5-(N-ethyl-N-isopropyl)amiloride-sensitive Na(+)- and HCO3(-)-dependent mechanism.

P. Little, A. Bobik, E. Cragoe, 1990, Circulation research.

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

T. Sawamura, P. Little, K. Tian, 2018, Annals of the New York Academy of Sciences.

Zinc and cardiovascular disease.

P. Little, A. Moreyra, I. Korichneva, 2010, Nutrition.

The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway

Wenhua Zheng, P. Little, R. Quirion, 2017, Molecular Neurobiology.

estradiol in human vascular smooth muscle cells β High glucose abolishes the antiproliferative effect of 17

P. Little, P. Komesaroff, K. Hashimura, 2016 .

High glucose abolishes the antiproliferative effect of 17beta-estradiol in human vascular smooth muscle cells.

P. Little, P. Komesaroff, K. Hashimura, 2002, American journal of physiology. Endocrinology and metabolism.

Characterisation of Ki11502 as a potent inhibitor of PDGF beta receptor-mediated proteoglycan synthesis in vascular smooth muscle cells.

P. Little, N. Osman, Robel Getachew, 2010, European journal of pharmacology.

Inhibitory Activity of Clinical Thiazolidinedione Peroxisome Proliferator Activating Receptor-&ggr; Ligands Toward Internal Mammary Artery, Radial Artery, and Saphenous Vein Smooth Muscle Cell Proliferation

G. Jennings, P. Little, D. Bruemmer, 2003, Circulation.

Vascular derived growth factors: potential role in the development of the tumour vasculature

P. Little, A. Agrotis, A. Bobik, 1997 .

p38 MAP kinase mediated proteoglycan synthesis as a target for the prevention of atherosclerosis.

P. Little, N. Osman, Robel Getachew, 2008, Cardiovascular & hematological disorders drug targets.

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

J. Moss, Jiawei Chen, P. Little, 2012, Cellular and Molecular Life Sciences.

Emerging Lipoprotein-Related Therapeutics for Patients with Diabetes

A. Jenkins, A. Januszewski, A. Chait, 2014 .

The emerging role of metformin in gestational diabetes mellitus

P. Little, N. Cohen, T. Mcguire, 2017, Diabetes, obesity & metabolism.

Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses following endothelin-1 stimulation.

P. Little, C. Mitchell, C. Neylon, 1999, Journal of cell science.

Underexpression of the 43 kDa inositol polyphosphate 5‐phosphatase is associated with cellular transformation.

P. Little, C. Mitchell, J. Hayman, 1996, The EMBO journal.

Corrigendum to: cardiovascular actions and therapeutic potential of tanshinone IIA [Atherosclerosis 220 (2012) 3-10]

P. Little, Suowen Xu, Hong Li, 2012 .

Transforming growth factor-beta 1 regulates the expression of ryanodine-sensitive Ca2+ oscillations in cardiac myocytes.

S. Bryant, P. Little, A. Bobik, 1994, Biochemical and Biophysical Research Communications - BBRC.

Tissue disposition of [3H]sarin and its metabolites in mice.

P. Little, B. Martin, E. Bowman, 1986, Toxicology and applied pharmacology.

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle

Wenhua Zheng, P. Little, N. Osman, 2014, Cardiovascular Diabetology.

Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins

P. Little, N. Osman, Robel Getachew, 2015 .

Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy

P. Little, G. Ross, A. Sweeting, 2018, Journal of diabetes.

Another piece of cell biology in the puzzle of inflammation, glucose and diabetic vascular disease.

P. Little, R. Dilley, 2008, Journal of hypertension.

Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding

G. Jennings, P. Little, M. Ballinger, 2004, Diabetologia.

PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.

P. Little, N. Osman, Robel Getachew, 2010, Endocrinology.

Platelet-derived Growth Factor Differentially Regulates the Expression and Post-translational Modification of Versican by Arterial Smooth Muscle Cells through Distinct Protein Kinase C and Extracellular Signal-regulated Kinase Pathways*

Christina K. Chan, K. Bornfeldt, P. Little, 2009, The Journal of Biological Chemistry.

Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation

P. Little, N. Osman, Robel Getachew, 2009, Archives of physiology and biochemistry.

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor‐like domain

V. Tkachuk, P. Little, E. Goncharova, 1997, FEBS letters.

Understanding diabetes and its complications for biomedical research

P. Little, N. Osman, N. Cohen, 2013 .

Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries.

G. Morahan, M. Cooper, P. Little, 2005, Diabetes research and clinical practice.

ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells.

M. Barras, Wenhua Zheng, P. Little, 2019, Biochimica et biophysica acta. General subjects.

(S)‐[6]‐Gingerol inhibits TGF‐β‐stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Smad and p 38 MAP Kinase-mediated Signaling of Proteoglycan Synthesis in Vascular Smooth Muscle *

P. Little, N. Osman, Robel Getachew, 2008 .

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

J. D. de Haan, J. Rutledge, P. Little, 2009, Journal of cellular and molecular medicine.

Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.

C. Kuhn, P. Little, S. Blackford, 1992, Endocrinology.

Androgens: New Effects on Proteoglycan Biosynthesis and Its Consequences for Atherosclerosis

P. Little, N. Osman, J. Nigro, 2005, TheScientificWorldJournal.

Alcohol affects rat testicular interstitial fluid volume and testicular secretion of testosterone and beta-endorphin.

P. Little, T. Cicero, M. Adams, 1991, The Journal of pharmacology and experimental therapeutics.

Effects of alterations in cell phenotype and hypokalemia on sodium-potassium pump activity in rabbit vascular smooth muscle.

P. Little, A. Bobik, 1985, Clinical and experimental hypertension. Part A, Theory and practice.

VASCULAR LOCALIZATION OF THE 11β‐HYDROXYSTEROID DEHYDROGENASE TYPE II ENZYME

P. Little, Z. Krozowski, Robin E. Smith, 1996, Clinical and Experimental Pharmacology and Physiology.

Ontogenetic studies of tolerance development: effects of chronic morphine on the hypothalamic-pituitary-adrenal axis

C. Kuhn, P. Little, 1995, Psychopharmacology.

Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP.

P. Little, Lisa R Tannock, Katherine D. Drennon, 2008, Archives of Physiology and Biochemistry.

Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

P. Little, Suowen Xu, M. Geng, 2023, Signal transduction and targeted therapy.

Growth differentiation factor 15 is dispensable for acetaminophen‐induced liver injury in mice

P. Little, Suowen Xu, Zhidan Zhang, 2023, Basic & clinical pharmacology & toxicology.

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

J. Moss, Jiawei Chen, P. Little, 2013, Cellular and Molecular Life Sciences.

Assessing the role of Gαq/11 in cellular responses: an analysis of investigative tools

P. Little, N. Osman, D. Kamato, 2014 .

Role of IGF-1 signaling in the pathology of diabetic retinopathy

Wenhua Zheng, P. Little, Haitao Wang, 2015 .

IGF-1 Signaling via the PI3K/Akt Pathway Confers Neuroprotection in Human Retinal Pigment Epithelial Cells Exposed to Sodium Nitroprusside Insult

P. Lazarovici, Fengxia Yan, Wenhua Zheng, 2015, Journal of Molecular Neuroscience.

Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the developing male rat.

P. Little, T. Cicero, M. Adams, 1992, The Journal of pharmacology and experimental therapeutics.

Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells

Wenhua Zheng, P. Little, N. Osman, 2022, International journal of molecular sciences.

Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor

P. Little, D. Kamato, Reyhaneh Niayesh Mehr, 2022, Molecular and Cellular Biochemistry.

Mechanism of isoprenaline induced desensitization of rabbit aortic smooth muscle beta-adrenoceptor responses.

P. Little, J. Campbell, A. Bobik, 1984, Clinical and experimental pharmacology & physiology.

Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling

P. Little, N. Osman, D. Kamato, 2019, Cellular and Molecular Life Sciences.

Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo

Fengxia Yan, Rikang Wang, Wenhua Zheng, 2017, Molecular and Cellular Endocrinology.

Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia–reperfusion in rats

Wenhua Zheng, Rifang Liao, P. Little, 2015, Growth factors.

Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.

P. Little, A. J. Ryan, 1982, Journal of medicinal chemistry.

Dihydropyridine Ca2+ channel antagonists inhibit the salvage pathway for DNA synthesis in human vascular smooth muscle cells.

P. Little, A. Agrotis, A. Bobik, 1993, European journal of pharmacology.

Phosphorylated Troglitazone Activates PPARγ and Inhibits Vascular Smooth Muscle Cell Proliferation and Proteoglycan Synthesis

P. Little, N. Osman, D. Bruemmer, 2008, Journal of cardiovascular pharmacology.

Underexpression of the 43 KDA inositol polyphosphate 5-phosphatase is associated with cellular transformation

P. Little, C. Mitchell, J. Hayman, 1996 .

Bacterial variants in the human kidney.

P. Little, J. C. Coleman, 1967, The Journal of pathology and bacteriology.

Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR1 signalling

M. Hollenberg, Wenhua Zheng, P. Little, 2016, British journal of pharmacology.

Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor

P. Little, D. Kamato, Reyhaneh Niayesh Mehr, 2022, Molecular and Cellular Biochemistry.

The Growing Promiscuity of G Protein Coupled Receptors

P. Little, N. Osman, Micah L. Burch, 2012 .

The effects of endogenous phospholipase A2 activation on beta adrenoceptor function in cardiac cells.

P. Little, J. Campbell, A. Bobik, 1983, Journal of molecular and cellular cardiology.

Transforming growth factor‐β regulation of proteoglycan synthesis in vascular smooth muscle: Contribution to lipid binding and accelerated atherosclerosis in diabetes

P. Little, N. Osman, Micah L. Burch, 2010, Journal of diabetes.

Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet.

P. Little, Suowen Xu, Peiqing Liu, 2011, Archives of Biochemistry and Biophysics.

Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.

Fengxia Yan, Wenhua Zheng, Rifang Liao, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Wenhua Zheng, P. Little, N. Osman, 2014, Cellular and Molecular Life Sciences.

Therapeutic implications of endothelin and thrombin G‐protein‐coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Forkhead family transcription factor FoxO and neural differentiation

Wenhua Zheng, P. Little, Haitao Wang, 2012, neurogenetics.

Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs.

P. Little, R. Mechoulam, D. R. Compton, 1989, Pharmacology, biochemistry, and behavior.

Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2).

J. Pouysségur, P. Little, M. Donowitz, 1993, Biochemical and biophysical research communications.

Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling

P. Little, N. Osman, D. Kamato, 2019, Cellular and Molecular Life Sciences.