P. Strålfors

发表

Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients

Gunnar Cedersund, Mika Gustafsson, Rasmus Magnusson, 2016, Bioscience reports.

Systems-wide Experimental and Modeling Analysis of Insulin Signaling through Forkhead Box Protein O1 (FOXO1) in Human Adipocytes, Normally and in Type 2 Diabetes*

G. Cedersund, P. Strålfors, E. Nyman, 2016, The Journal of Biological Chemistry.

6 Hormone-Sensitive Lipase

P. Strålfors, H. Olsson, P. Belfrage, 1987 .

Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control.

Peter Strålfors, Margareta Karlsson, Anna Danielsson, 2004, European journal of biochemistry.

Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control*

P. Strålfors, M. Karlsson, Hans Thorn, 2001, The Journal of Biological Chemistry.

Localization of the insulin receptor in caveolae of adipocyte plasma membrane

P. Strålfors, M. Karlsson, Hans Thorn, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Isolation of phosphooligosaccharide/phosphoinositol glycan from caveolae and cytosol of insulin-stimulated cells

P. Strålfors, J. Gustavsson, S. Parpal, 1995, The Journal of cell biology.

Putting the pieces together in diabetes research: towards a hierarchical model of whole-body glucose homeostasis.

G. Cedersund, P. Strålfors, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A Hierarchical Whole-body Modeling Approach Elucidates the Link between in Vitro Insulin Signaling and in Vivo Glucose Homeostasis*

Gunnar Cedersund, Elin Nyman, Jan Brugård, 2011, The Journal of Biological Chemistry.

Insulin Signaling in Type 2 Diabetes

Gunnar Cedersund, Elin Nyman, Linnéa Bergenholm, 2013, The Journal of Biological Chemistry.

Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-free Modeling Framework*

Gunnar Cedersund, Peter Strålfors, T. Glad, 2010, The Journal of Biological Chemistry.

Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.

P. Strålfors, P. Belfrage, G. Fredrikson, 1981, The Journal of biological chemistry.

Insulin signaling – mathematical modeling comes of age

G. Cedersund, P. Strålfors, E. Nyman, 2012, Trends in Endocrinology & Metabolism.

Hormone‐sensitive lipase of rat adipose tissue: Identification and some properties of the enzyme protein

P. Strålfors, P. Belfrage, H. Tornqvist, 1977, FEBS letters.

Insulin and β-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes

P. Strålfors, P. Kjølhede, C. Jönsson, 2019, The Biochemical journal.

PPAR-γ response element activity in intact primary human adipocytes: effects of fatty acids

P. Strålfors, P. Kjølhede, K. Stenkula, 2006 .

PPAR-gamma response element activity in intact primary human adipocytes: effects of fatty acids.

P. Strålfors, P. Kjølhede, K. Stenkula, 2006, Nutrition.

The protein phosphatases involved in cellular regulation. Purification and characterisation of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscle.

P. Cohen, P. Strålfors, A. Hiraga, 1985, European journal of biochemistry.

Inhibition of FOXO1 transcription factor in primary human adipocytes mimics the insulin-resistant state of type 2 diabetes.

P. Strålfors, E. Nyman, M. R. Rajan, 2018, The Biochemical journal.

Short-Term Overeating Induces Insulin Resistance in Fat Cells in Lean Human Subjects

P. Strålfors, P. Kjølhede, A. Danielsson, 2009, Molecular medicine.

Caveolins and caveolae, roles in insulin signalling and diabetes.

P. Strålfors, 2012, Advances in experimental medicine and biology.

Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes – Role of insulin and IGF-I receptors

P. Strålfors, H. Arnqvist, C. Brännmark, 2011, Molecular and Cellular Endocrinology.

Autolysis of isolated adipocytes by endogenously produced fatty acids

P. Strålfors, 1990, FEBS letters.

Insulin-Stimulated Glucose Uptake Involves the Transition of Glucose Transporters to a Caveolae-Rich Fraction within the Plasma Membrane: Implications for Type II Diabetes

P. Strålfors, J. Gustavsson, S. Parpal, 1996, Molecular medicine.

Adiponectin is secreted via caveolin 1-dependent mechanisms in white adipocytes.

P. Strålfors, C. Olofsson, C. Brännmark, 2020, The Journal of endocrinology.

Chapter 8 Insulin Signaling and Caveolae

P. Strålfors, 2005 .

Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue

P. Rorsman, P. Strålfors, C. Olofsson, 2022, bioRxiv.

Insulin induces translocation of glucose transporter GLUT4 to plasma membrane caveolae in adipocytes

P. Strålfors, M. Karlsson, Hans Thorn, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes.

P. Strålfors, M. Karlsson, Hans Thorn, 2003, Molecular biology of the cell.

The Concentration of β-Carotene in Human Adipocytes, but Not the Whole-Body Adipocyte Stores, Is Reduced in Obesity

P. Strålfors, P. Kjølhede, A. Öst, 2014, PloS one.

Glucose transport is equally sensitive to insulin stimulation, but basal and insulin-stimulated transport is higher, in human omental compared with subcutaneous adipocytes.

P. Strålfors, A. Danielsson, F. Nystrom, 2005, Metabolism: clinical and experimental.

Subcutaneous adipocytes from obese hyperinsulinemic women with polycystic ovary syndrome exhibit normal insulin sensitivity but reduced maximal insulin responsiveness.

M. Hammar, L. Lindh-Åstrand, P. Strålfors, 2005, European journal of endocrinology.

Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual

P. Strålfors, K. Stenkula, F. Nystrom, 2007, Diabetologia.

Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes.

P. Strålfors, A. Danielsson, F. Nystrom, 2006, Biochemical and biophysical research communications.

Scaffolding protein IQGAP1: an insulin-dependent link between caveolae and the cytoskeleton in primary human adipocytes?

P. Strålfors, M. Turkina, C. Jönsson, 2016, The Biochemical journal.

Human, but not rat, IRS1 targets to the plasma membrane in both human and rat adipocytes.

P. Strålfors, Hans Thorn, K. Stenkula, 2007, Biochemical and biophysical research communications.

A new role for caveolae as metabolic platforms

P. Strålfors, A. Öst, Nabila Aboulaich, 2007, Trends in Endocrinology & Metabolism.

Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions

P. Strålfors, F. Nystrom, H. Karlsson, 2006, The FEBS journal.

Triacylglycerol Is Synthesized in a Specific Subclass of Caveolae in Primary Adipocytes*

P. Strålfors, J. Gustavsson, F. Nystrom, 2005, Journal of Biological Chemistry.

N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes.

P. Strålfors, A. Vener, M. Turkina, 2004, Biochemical and biophysical research communications.

Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes

P. Strålfors, S. Alemany, J. Mato, 1987, Nature.

Insulin second messengers

P. Strålfors, 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

Isoproterenol and insulin control the cellular localization of ATP citrate-lyase through its phosphorylation in adipocytes.

P. Strålfors, 1987, The Journal of biological chemistry.

Insulin stimulation of glucose uptake can be mediated by diacylglycerol in adipocytes

P. Strålfors, 1988, Nature.

muscle of obese Zucker rats Exercise training increases ERK2 activity in skeletal

M. Vinciguerra, P. Meda, S. Kosuda, 2013 .

Expression of a mutant IRS inhibits metabolic and mitogenic signalling of insulin in human adipocytes

P. Strålfors, P. Kjølhede, M. Karlsson, 2004, Molecular and Cellular Endocrinology.

Acute effects of insulin on the activity of mitochondrial GPAT1 in primary adipocytes.

P. Strålfors, A. Vener, G. Bronnikov, 2008, Biochemical and biophysical research communications.

Regulation of adipose tissue lipolysis: effects of noradrenaline and insulin on phosphorylation of hormone‐sensitive lipase and on lipolysis in intact rat adipocytes

P. Strålfors, P. Belfrage, G. Fredrikson, 1980, FEBS letters.

Phosphorylation of IRS1 at Serine 307 in Response to Insulin in Human Adipocytes Is Not Likely to be Catalyzed by p70 Ribosomal S6 Kinase

P. Strålfors, P. Kjølhede, Siri Fagerholm, 2013, PloS one.

Siri ADIPOCYTES INSULIN RESISTANCE IN HUMAN ANALYSES REVEAL MECHANISMS OF EXPERIMENTAL AND MODELING Insulin Signaling in Type 2 Diabetes : Molecular Bases of Disease

G. Cedersund, P. Strålfors, E. Nyman, 2013 .

Hormonal Control of Reversible Translocation of Perilipin B to the Plasma Membrane in Primary Human Adipocytes*

P. Strålfors, A. Vener, Nabila Aboulaich, 2006, Journal of Biological Chemistry.

Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.

P. Strålfors, P. Belfrage, P. Björgell, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Removal of nonionic detergent from proteins fractionated by electrofocusing.

P. Strålfors, P. Belfrage, H. Tornqvist, 1978, Biochimica et biophysica acta.

Identification and some characteristics of the enzyme protein of the hormone-sensitive lipase from rat adipose tissue.

P. Strålfors, P. Belfrage, H. Tornqvist, 1978, Advances in experimental medicine and biology.

Adipose tissue protein phosphatase inhibitor-2.

P. Strålfors, 1988, European journal of biochemistry.

Phosphorylation of the basal site of hormone‐sensitive lipase by glycogen synthase kinase‐4

P. Strålfors, H. Olsson, P. Belfrage, 1986, FEBS letters.

Phosphorylation of hormone‐sensitive lipase by cyclic GMP‐dependent protein kinase

P. Strålfors, P. Belfrage, 1985, FEBS letters.

Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase.

P. Strålfors, P. Belfrage, 1983, The Journal of biological chemistry.

Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.

P. Strålfors, A. Vener, Nabila Aboulaich, 2006, Biochemical and biophysical research communications.

Regulation of adipose-tissue lipolysis by phosphorylation of hormone-sensitive lipase.

P. Strålfors, P. Belfrage, G. Fredrikson, 1981, International journal of obesity.

Regulation of adipose tissue lipolysis: phosphorylation of hormone‐sensitive lipase in intact rat adipocytes

P. Strålfors, P. Belfrage, G. Fredrikson, 1980, FEBS letters.

[74] Hormone-sensitive lipase from adipose tissue of rat

P. Strålfors, P. Belfrage, G. Fredrikson, 1981 .

Inhibition of Raf-1 kinase expression abolishes insulin stimulation of DNA synthesis in H4IIE hepatoma cells.

P. Strålfors, J. Gustavsson, S. Parpal, 1994, The Journal of biological chemistry.

Direct evidence that cholesterol ester hydrolase from adrenal cortex is the same enzyme as hormone-sensitive lipase from adipose tissue.

K. G. Cook, P. Strålfors, P. Belfrage, 1982, European journal of biochemistry.

Properties and purification of the catalytic subunit of cyclic AMP-dependent protein kinase of adipose tissue.

P. Strålfors, P. Belfrage, 1982, Biochimica et biophysica acta.

A systems biology analysis of lipolysis and fatty acid release from adipocytes in vitro and from adipose tissue in vivo

G. Cedersund, P. Strålfors, E. Nyman, 2020, bioRxiv.

Regulation of adipose tissue lipolysis through reversible phosphorylation of hormone-sensitive lipase.

P. Strålfors, H. Olsson, P. Belfrage, 1984, Advances in cyclic nucleotide and protein phosphorylation research.

ZINC OXIDE NANORODS AS AN INTRACELLULAR pH SENSOR

A. Sa’ar, M. Willander, P. Strålfors, 2007 .

Synthesis of inositol phosphoglycans containing thiol-terminated spacers for efficient coupling to maleimide functionalized solid phases or proteins

P. Strålfors, J. Lindberg, P. Konradsson, 2002 .

Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity.

P. Strålfors, P Strålfors, R C Honnor, 1989, European journal of biochemistry.

Histone Variants and Their Post-Translational Modifications in Primary Human Fat Cells

P. Strålfors, A. Vener, Åsa Jufvas, 2011, PloS one.

Attenuated mTOR Signaling and Enhanced Autophagy in Adipocytes from Obese Patients with Type 2 Diabetes

P. Strålfors, P. Kjølhede, A. Öst, 2010, Molecular medicine.

Peroxisome proliferator activated receptor gamma activity is low in mature primary human visceral adipocytes

P. Strålfors, P. Kjølhede, F. Nystrom, 2006, Diabetologia.

Rapid Insulin-Dependent Endocytosis of the Insulin Receptor by Caveolae in Primary Adipocytes

P. Strålfors, M. Karlsson, Siri Fagerholm, 2009, PloS one.

Global differences in specific histone H3 methylation are associated with overweight and type 2 diabetes

P. Strålfors, A. Vener, S. Sjödin, 2013, Clinical Epigenetics.

Hormone-sensitive lipase from adipose tissue of rat.

P. Strålfors, P. Belfrage, G. Fredrikson, 1981, Methods in enzymology.

A Single Mechanism Can Explain Network-wide Insulin Resistance in Adipocytes from Obese Patients with Type 2 Diabetes*

Gunnar Cedersund, Elin Nyman, Peter Strålfors, 2014, The Journal of Biological Chemistry.

Diabetes Adipocytes from Obese Patients with Type Network-wide Insulin Resistance in A Single Mechanism Can Explain Molecular Bases of Disease :

Gunnar, P. Strålfors, E. Nyman, 2014 .

Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetes

Peter Strålfors, Anna Danielsson, P. Strålfors, 2004, The FEBS journal.

Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle.

H. Tung, P. Cohen, B. Hemmings, 1988, Methods in enzymology.

Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

P. Strålfors, A. Vener, J. Vainonen, 2004, The Biochemical journal.

Lipids and glycosphingolipids in caveolae and surrounding plasma membrane of primary rat adipocytes.

Maria Blomqvist, Peter Strålfors, Margareta Karlsson, 2004, European journal of biochemistry.

Intracellular K$^+$ Determination With a Potentiometric Microelectrode Based on ZnO Nanowires

B. Danielsson, O. Nur, M. Willander, 2011, IEEE Transactions on Nanotechnology.

Attenuation of Insulin-stimulated Insulin Receptor Substrate-1 Serine 307 Phosphorylation in Insulin Resistance of Type 2 Diabetes*

P. Strålfors, A. Danielsson, F. Nystrom, 2005, Journal of Biological Chemistry.

Functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose.

Magnus Willander, Omer Nur, Fredrik Elinder, 2010, Biosensors & bioelectronics.

Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State

Peter A. J. Hilbers, Gunnar Cedersund, Fianne L. P. Sips, 2015, PloS one.

Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes

Natal A W van Riel, Gunnar Cedersund, Elin Nyman, 2016, Interface Focus.

A Miniature Graphene-based Biosensor for Intracellular Glucose Measurements

O. Nur, M. Willander, M. Sandberg, 2015 .

An intracellular glucose biosensor based on nanoflake ZnO

B. Danielsson, M. Willander, P. Strålfors, 2010 .

Combining test statistics and models in bootstrapped model rejection: it is a balancing act

Gunnar Cedersund, Rikard Johansson, Peter Strålfors, 2014, BMC Systems Biology.

Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical.

P. Greengard, H. Hemmings, P. Strålfors, 1989, European journal of biochemistry.

Model-Based Hypothesis Testing of Key Mechanisms in Initial Phase of Insulin Signaling

Jacob Roll, Gunnar Cedersund, Anna Danielsson, 2008, PLoS Comput. Biol..

European Obesity Summit (EOS) – Joint Congress of EASO and IFSO-EC, Gothenburg, Sweden, June 1 – 4, 2016: Abstracts

Parashu Ram Pal, S. A. Todd, Jimmy D Bell, 2016, Obesity Facts.

Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.

P. Strålfors, E. Degerman, V. Manganiello, 2009, The Biochemical journal.

Growth and Structure of ZnO Nanorods on a Sub-Micrometer Glass Pipette and Their Application as Intracellular Potentiometric Selective Ion Sensors

O. Nur, M. Willander, P. Strålfors, 2010, Materials.

A two-dimensional bootstrap approach to model discrimination

Jens Timmer, Rickard Johansson, Gunnar Cedersund, 2013 .

Retinol‐binding protein‐4 attenuates insulin‐induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes

P. Strålfors, A. Danielsson, F. Nystrom, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Zinc Oxide Nanorods and their Application to Intracellular Glucose Measurements

B. Danielsson, M. Willander, P. Strålfors, 2012 .

Direct evidence for protein phosphatase-catalyzed dephosphorylation/deactivation of hormone-sensitive lipase from adipose tissue.

P. Strålfors, H. Olsson, P. Belfrage, 1984, Biochimica et biophysica acta.

Electrophoretic elution of proteins from polyacrylamide gel slices.

P. Strålfors, P. Belfrage, 1983, Analytical biochemistry.

Mechanistic explanations for counter‐intuitive phosphorylation dynamics of the insulin receptor and insulin receptor substrate‐1 in response to insulin in murine adipocytes

Gunnar Cedersund, Elin Nyman, Peter Strålfors, 2012, The FEBS journal.

Putting the pieces together in diabetes research: towards a hierarchical model of whole-body glucose homeostasis.

G. Cedersund, P. Strålfors, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Functionalized zinc oxide nanorod with ionophore-membrane coating as an intracellular Ca2+ selective sensor

O. Nur, M. Willander, P. Strålfors, 2009 .

Multilevel-Modeling, Core Predictions, and the Concept of Final Conclusions

Gunnar Cedersund, Elin Nyman, Peter Strålfors, 2011 .

Dominant negative inhibition data should be analyzed using mathematical modeling – re‐interpreting data from insulin signaling

Gunnar Cedersund, Rikard Johansson, Peter Strålfors, 2015, The FEBS journal.