J. Linders

发表

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling

E. Jacoby, N. Jordan, D. Brehmer, 2016, PloS one.

Structural investigation of B-Raf paradox breaker and inducer inhibitors.

Lennart Martens, Edgar Jacoby, Kris Gevaert, 2015, Journal of medicinal chemistry.

Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.

E. Jacoby, R. Zubarev, K. Gevaert, 2015, Journal of proteome research.

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

D. Roden, E. Schulze-Bahr, L. Pott, 2016, Nature Communications.

Abstract DDT02-04: A novel PRMT5 inhibitor with potent in vitro and in vivo activity in preclinical lung cancer models

Italo Poggesi, Vineet Pande, James P. Edwards, 2017 .

High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity

M. Connelly, J. Linders, Charles D Smith, 2010, Journal of Lipid Research.

DERVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS (75) Inventors: Libuse Jaroskova, Vosselaar (BE):

J. Linders, Elisabeth Van Der Veken, Celia Chang, 2017 .

Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.

F. Sommen, A. Sharff, V. Berdini, 2015, ACS medicinal chemistry letters.

An expeditious preparation of E-2-amino-5-hydroxyadamantane and its Z-isomer

J. Linders, A. Groot, G. Diels, 2006 .

CASE HISTORIES OF PEPTIDOMIMETICS : PROGRESSION FROM PEPTIDES TO DRUGS

Harry C. J. Ottenheijm, J. Linders, Pedro H. H. Hermkens, 1994 .

Probes for narcotic receptor-mediated phenomena. 33. Construction of a strained trans-5,6-ring system by displacement of a nitro-activated aromatic fluorine. synthesis of the penultimate oxide-bridged phenylmorphans.

J. Deschamps, C. George, J. Flippen-Anderson, 2004, The Journal of organic chemistry.

Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.

W. Bowen, J. Linders, C. Dominguez, 1993, Journal of medicinal chemistry.

Diene systems in N‐formylmorphinans; formation of a dibenz[d,f]azonine: A new example of molecular acrobatics in morphinans1 (chemistry of opium alkaloids, part XXVII)

J. Linders, L. Maat, A. Kieboom, 1989 .

Preparation of 6‐demethoxy‐N‐formyl‐N‐northebaine and its Diels‐Alder reactions with methyl vinyl ketone and nitroethene; novel 8‐nitro‐substituted 6α,14α‐ethenoisomorphinans and 6β,14β‐ethenomorphinans (chemistry of opium alkaloids, part XXVIII)

J. Linders, L. Maat, T. Lie, 2010 .

Face Selectivity of the Diels‐Alder Reaction of Thebaine‐Like Morphinandienes, A Computational Approach (Chemistry of Opium Alkaloids, Part XXXI)

J. Linders, L. Maat, 2010 .

A 1H and 13C NMR study of N‐formylmorphinans and their 6,14‐bridged derivatives; Comparison with N‐Me and NH analogues

J. Linders, L. Maat, T. Lie, 1989 .

Synthesis of rac-(1R,4aR,9aR)-2-methyl-1,3,4,9a-tetrahydro-2H-1,4a-propanobenzofuro[2,3-c]pyridin-6-ol. An unusual double rearrangement leading to the ortho- and para-f oxide-bridged phenylmorphan isomers.

J. Deschamps, J. Flippen-Anderson, J. Linders, 2004, Organic & biomolecular chemistry.

Probes for Narcotic Receptor Mediated Phenomena

C. George, J. Flippen-Anderson, J. Linders, 2003 .

Synthesis and preliminary pharmacology* of the rigid dehydroxylated etorphine analogue 4,5α-epoxy-α,α,17-trimethyl-6α,14α-etheno-isomorphinan-7α-methanol (chemistry of opium alkaloids, part XXVI**)

J. Linders, L. Maat, T. Lie, 2010 .

Probes for narcotic receptor mediated phenomena. Part 31: Synthesis of rac-(3R,6aS,11aS)-2-methyl-1,3,4,5,6,11a-hexahydro-2H-3,6a-methanobenzofuro[2,3-c]azocine-10-ol, and azocine-8-ol, the ortho-c and the para-c oxide-bridged phenylmorphan isomers

J. Flippen-Anderson, J. Linders, K. Rice, 2003 .

Synthesis of 6, 14-ethenoisomorphinans and 6, 14-ethenomorphinans based on Diels-Alder adducts of 6-demethoxythebaine and 6-demethoxy-β-dihydrothebaine; pharmacology of the isomorphinans (Chemistry of Opium Alkaloids, Part XIX)†‡

J. Linders, L. Maat, T. Lie, 2010 .

Synthesis and biological evaluation of methylene-bridged analogs of the potent cannabinoid receptor antagonist rimonabant

J. Linders, F. Deroose, W. D. Borggraeve, 2008 .

An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2

J. Linders, K. Rice, R. Rothman, 1994, Neurochemical Research.

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.

V. Berdini, D. Brehmer, J. Linders, 2015, ACS medicinal chemistry letters.

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

M. Bollen, D. Brehmer, M. Paradé, 2015, Bioscience reports.

Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor.

S. Knapp, D. Brehmer, J. Linders, 2023, European journal of medicinal chemistry.

Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?

Ard Teisman, J. Linders, J. Rohrbacher, 2009, Journal of pharmacological and toxicological methods.

Chemistry of opium alkaloids. Part 44: synthesis and opioid receptor binding profile of substituted ethenoisomorphinans and ethenomorphinans.

R. H. Woudenberg, J. Linders, L. Maat, 1999, Bioorganic & medicinal chemistry.

Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.

C. George, J. Linders, K. Rice, 1993, Journal of medicinal chemistry.

Diels-Alder reaction of 6-demethoxy-β-dihydrothebaine with methyl vinyl ketone using microwave heating; preparation and pharmacology of 3-hydroxy-α,α, 17-trimethyl-6β,14β-ethenomorphinan-7β-methanol, a novel deoxygenated diprenorphine analogue (chemistry of opium alkaloids, part XXV†‡

J. Linders, M. Overhand, L. Maat, 1988 .

Scission of the epoxy ring in 4,5α‐epoxymorphinans: A convenient synthesis of β‐dihydrothebaine, 6‐demethoxy‐β‐dihydrothebaine and desoxycodeine‐A (Chemistry of opium alkaloids, Part XXI)

J. Linders, L. Maat, T. Lie, 1986 .

Synthesis and Preliminary Biochemical Evaluation of Novel Derivatives of PCP

J. Linders, K. Rice, M. Mattson, 2010 .

An expedient synthesis of 9-keto-2-methyl-5-(dimethoxyphenyl)morphans

C. George, J. Flippen-Anderson, J. Linders, 1999 .

Synthesis of unlabelled and tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine (fourphit), tools for the study of the dopamine reuptake complex.

J. Linders, K. Rice, B. Costa, 1992 .

Synthesis and diels-alder reactions of novel morphinandienes

J. Linders, 1989 .

Diels-Alder Adducts From 4-O-Acetyl-6-Demethoxy-N-Formyl-β-Dihydro-N-Northebaine With Methyl Vinyl Ketone and Nitroethene (Chemistry of Opium Alkaloids, Part XXIX)†

J. Linders, P. Lipman, L. Maat, 2010 .

Hydrogen Bonds in Ethenoisomorphinan‐7α‐Carboxamides Studied by Molecular Modelling (Chemistry of Opium Alkaloids, Part XXXIV

J. Linders, L. Maat, J. Cappon, 2010 .