S. Hedrick

发表

Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes.

A. Dejean, Caroline Stienne, Michaël F Michieletto, 2016, Immunity.

Foxo3 controls the magnitude of T cell immune responses by modulating dendritic cell function

Daniel R. Beisner, R. DePinho, A. Dejean, 2009, Nature Immunology.

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.

Daniel R. Beisner, R. DePinho, A. Dejean, 2009, Nature immunology.

Highly conserved T-cell receptor junctional regions. Evidence for selection at the protein and the DNA level

S. Hedrick, S. Sorger, 2004, Immunogenetics.

Differentiation of CD8 memory T cells depends on Foxo1

Stephen M. Hedrick, A. Goldrath, S. Hedrick, 2013, The Journal of experimental medicine.

Differentiation of CD 8 memory T cells depends on Foxo 1

A. Goldrath, S. Hedrick, R. Michelini, 2013 .

Identification of RIP1 kinase as a specific cellular target of necrostatins.

Alexei Degterev, Chengye Yuan, Junying Yuan, 2008, Nature chemical biology.

Effects of a Constitutively Active Form of Calcineurin on T Cell Activation and Thymic Selection1

S. Hedrick, L. Kane, Kristine Hayden-Martinez, 2000, The Journal of Immunology.

Trade-Off Theory and the Evolution of Parasite Virulence

S. Hedrick, 2017 .

Understanding Immunity through the Lens of Disease Ecology.

S. Hedrick, 2017, Trends in immunology.

Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a.

T. Irimura, Yosuke Kumamoto, S. Hedrick, 2005, Blood.

Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity.

F. Hooshmand, S. Hedrick, C. Katayama, 1995, The EMBO journal.

Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis

R. Månsson, E. Stone, S. Hedrick, 2015, PloS one.

Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies.

L. Ruff, José M. Morachis, S. Hedrick, 2013, Integrative biology : quantitative biosciences from nano to macro.

Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway

S. Hedrick, F. V. Mariani, I. K. Mah, 2015, Stem cell reports.

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

P. Schwartzberg, S. Hedrick, B. Fowlkes, 2006, Immunity.

TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection.

S. Hedrick, J. Peschon, D. M. Page, 1998, Journal of immunology.

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

John T. Chang, A. Goldrath, S. Hedrick, 2020, Proceedings of the National Academy of Sciences.

A role for FADD in T cell activation and development.

A. Chinnaiyan, V. Dixit, K. O'rourke, 1998, Immunity.

Thymus lineage commitment: a single switch.

S. Hedrick, 2008, Immunity.

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

N. Killeen, S. Hedrick, B. Fowlkes, 1996, Immunity.

The influence of the MAPK pathway on T cell lineage commitment.

C. Marshall, S. Hedrick, C. Marshall, 1997, Immunity.

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

S. Hedrick, J. Kaye, N. J. Vasquez, 1992, Journal of immunology.

SubsetsOpposites: Erk Direction of CD4 T Cell

Irene L. Ch, J. Pouysségur, S. Hedrick, 2012 .

Schlafen, a new family of growth regulatory genes that affect thymocyte development.

S. Hedrick, C. Katayama, D. Schwarz, 1998, Immunity.

Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling.

S. Hedrick, L. Sharp, 1999, Journal of immunology.

Molecular Cloning and Characterization of a Novel Mouse Macrophage C-type Lectin, mMGL2, Which Has a Distinct Carbohydrate Specificity from mMGL1*

T. Irimura, S. Hedrick, M. Tsuiji, 2002, The Journal of Biological Chemistry.

Role of Myeloid Hypoxia-Inducible Factor-1alpha in the Tumor Microenvironment A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Biology

S. Hedrick, A. Doedens, 2008 .

A mouse strain defective for αβ versus γδ T cell lineage commitment

J. Marth, J. Esko, F. Ramsdell, 2002 .

Autoimmune Disease Cells and Is Required for Organ-Specific Drak2 Regulates the Survival of Activated T

S. Hedrick, M. McGargill, B. Wen, 2008 .

Autoimmune Disease Cells and Is Required for Organ-Specific Drak2 Regulates the Survival of Activated T

S. Hedrick, M. McGargill, B. Wen, 2008 .

Antigen analogs as therapeutic agents.

H. Grey, A. Sette, S. Hedrick, 1995, Advances in experimental medicine and biology.

Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation.

S. Hedrick, A. A. Brian, G. Siu, 1989, Journal of immunology.

DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection.

C. Murre, B. Kee, S. Hedrick, 2005, International immunology.

Generation of Mice Deficient for Macrophage Galactose- and N-Acetylgalactosamine-Specific Lectin: Limited Role in Lymphoid and Erythroid Homeostasis and Evidence for Multiple Lectins

A. Varki, J. Marth, T. Irimura, 2002, Molecular and Cellular Biology.

The Requirements for Fas-Associated Death Domain Signaling in Mature T Cell Activation and Survival1

Daniel R. Beisner, S. Hedrick, C. Walsh, 2003, The Journal of Immunology.

T cell development: bottoms-up.

S. Hedrick, 2002, Immunity.

A rheostat tuning thymic selection

S. Hedrick, G. P. Morris, G. Morris, 2017, Nature Immunology.

of Developing T Cells Selection Kinase Is Not Required for Negative Cutting Edge: Extracellular Signal-Related

Irene L. Ch, G. Pagès, S. Hedrick, 2012 .

Cutting Edge: Extracellular Signal-Related Kinase Is Not Required for Negative Selection of Developing T Cells1

J. Pouysségur, G. Pagès, S. Hedrick, 2009, The Journal of Immunology.

Central tolerance matters.

A. Goldrath, S. Hedrick, 2005, Immunity.

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

C. Heyser, L. Petrucelli, C. Shaw, 2016, Neuron.

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection

J. Qi, A. Goldrath, K. Ozato, 2021, The Journal of experimental medicine.

Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1.

S. Hedrick, Xin Huang, R. Thimme, 2018, Cell reports.

Programwith a Unique Differentiation Cutting Edge: Latecomer CD8 T Cells Are

S. Hedrick, Warren N D'Souza, 2017 .

ProgramImprinted with a Unique Differentiation Cutting Edge: Latecomer CD8 T Cells Are

S. Hedrick, Warren N D'Souza, 2006 .

The enigmatic specificity of γδ T cells

S. Hedrick, B. Weintraub, 1995 .

Phenotypic and Functional Analysis of Positive Selection in the T Cell Lineage

J. Bluestone, J. Allison, L. Matis, 2003 .

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage

J. Bluestone, J. Allison, L. Matis, 1993, The Journal of experimental medicine.

NF-kappaB as a determinant of distinct cell death pathways.

A. Hoffmann, S. Hedrick, Irene L. Ch’en, 2008, Methods in enzymology.

NF-k B as a Determinant of Distinct Cell Death Pathways

A. Hoffmann, S. Hedrick, Irene L. Ch’en, 2008 .

Phenotypic and Functional Analysis of Positive Selection in the T Cell Lineage By Faith B. Wells,* Yoichi Tatsumi, t Jeffrey A. Bluestone, t

J. Allison, L. Matis, S. Hedrick, 1993 .

Molecular analysis of the influences of positive selection, tolerance induction, and antigen presentation on the T cell receptor repertoire

P. Fink, L. Matis, S. Hedrick, 1990, The Journal of experimental medicine.

Activation and Survival Domain Signaling in Mature T Cell The Requirements for Fas-Associated Death

Daniel R. Beisner, S. Hedrick, C. Walsh, 2003 .

Mechanism of Serf-Tolerance of 3~/~ T Cells in

J. Bluestone, L. Matis, S. Hedrick, 1992 .

Mechanism of Serf-Tolerance of 3~/~ T Cells in

J. Bluestone, L. Matis, S. Hedrick, 1992 .

Expression of the CD4 gene requires a Myb transcription factor

J. Lipsick, S. Hedrick, G. Siu, 1992, Molecular and cellular biology.

In vivo and in vitro clonal deletion of double-positive thymocytes

S. Hedrick, J. Kaye, N. J. Vasquez, 1992, The Journal of experimental medicine.

Control of self-reactivity in the intestine

J. Bluestone, L. Matis, S. Hedrick, 1991, Immunologic research.

Antigen compartmentation and T helper cell tolerance induction

Y. Xia, L. Feng, S. Hedrick, 1996, The Journal of experimental medicine.

13 – The Antigen Receptor on T Cells

S. Hedrick, 1987 .

An essential role for gp39, the ligand for CD40, in thymic selection

R. Flavell, A. Aruffo, S. Hedrick, 1995, The Journal of experimental medicine.

Isolation of a cDNA clone corresponding to an X-linked gene family (XLR) closely linked to the murine immunodeficiency disorder xid

Mark M. Davis, P. D’Eustachio, F. Ruddle, 1985, Nature.

On the other hand , CD 28 has a major role in providing a

A. Chinnaiyan, V. Dixit, K. O'rourke, 1998 .

Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.

R. Germain, P. Fink, M. Dorf, 1985, Proceedings of the National Academy of Sciences of the United States of America.

SelectionCalcineurin on T Cell Activation and Thymic Effects of a Constitutively Active Form of

S. Hedrick, L. Kane, Kristine Hayden-Martinez, 2000 .

Proliferation and Survival The Erk2 MAPK Regulates CD8 T Cell

S. Hedrick, Chiung-Fang Chang, Warren N D'Souza, 2008 .

CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion

S. Hedrick, E. Bier, Zhi-Qian Li, 2021, Nature Communications.

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.

M. Carleton, S. Hedrick, D. Wiest, 2014, Immunity.

Dawn of the hunt for nonclassical MHC function

S. Hedrick, 1992, Cell.

Analysis of specificity for antigen, Mls, and allogeneic MHC by transfer of T-cell receptor α- and β-chain genes

S. Hedrick, J. Kaye, 1988, Nature.

Specificity for molecules of the major histocompatibility complex mediated by a hybrid immunoglobulin-T cell receptor.

S. Hedrick, H. Kawasaki, M. L. Becker, 1991, The New biologist.

Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells

S. Hedrick, I. Catlett, 2005, Nature Immunology.

Suppressor of cytokine signaling 1 is required for the differentiation of CD 4 + T cells

S. Hedrick, I. Catlett, 2005 .

Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells.

T. Mak, H. Nishina, J. Penninger, 1995, Journal of immunology.

Two signals are required for negative selection of CD4+CD8+ thymocytes.

J. Allison, S. Hedrick, L. Kane, 1993, Journal of immunology.

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

C. Murre, S. Hedrick, J. Alberola-Ila, 2001, Nature Immunology.

Peer Reviewed Title: Cholera Toxin Induces cAMP-dependent Th17 Differentiation by Dendritic Cells

Leann Nguyen, S. Hedrick, Phung Nguyen, 2009 .

Two distinct mechanisms account for the immune response (Ir) gene control of the T cell response to pigeon cytochrome c.

L. Matis, S. Hedrick, S. Sorger, 1988, Journal of immunology.

The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones

P. Fink, L. Matis, S. Hedrick, 1987, Cell.

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

H. Grey, A. Sette, E. Appella, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Tonsil-Specific Inflammation is Present in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis (PFAPA) syndrome

S. Hedrick, Irene M. Luu, E. Zuñiga, 2018 .

UNIVERSITY OF CALIFORNIA, SAN DIEGO REGULATION OF TYPE I IFN PRODUCTION IN PLASMACYTOID DENDRITIC CELLS BY SRC-FAMILY KINASES AND CD28 A thesis submitted in partial satisfaction of the requirements

S. Hedrick, E. Zuñiga, C. Hesser, 2012 .

Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines

Craig W. Reynolds, H. Young, S. Hedrick, 1985, The Journal of experimental medicine.

The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype.

E. Margoliash, L. Matis, C. Hannum, 1982, Journal of immunology.

Positive Selection in the Thymus: An Enigma Wrapped in a Mystery

S. Hedrick, 2012, The Journal of Immunology.

Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47

C. Murre, S. Hedrick, G. Bain, 1999, The Journal of experimental medicine.

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO 1 to Promote Tfh Cell Differentiation Highlights

E. Yang, A. Goldrath, E. Stone, 2015 .

The Influence of MHC Gene Products on the Generation of an Antigen‐Specific T‐Cell Repertoirea

P. Fink, L. Matis, S. Hedrick, 1988, Annals of the New York Academy of Sciences.

The structure of the T cell receptor for antigen is correlated with T cell specificity.

P. Fink, L. Matis, S. Hedrick, 1988, The Year in immunology.

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

D. Longo, R. Schwartz, L. Matis, 1982, Cell.

The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire.

S. Hedrick, H. Bhayani, 1991, Journal of immunology.

Role of TCR specificity in CD4 versus CD8 lineage commitment.

S. Hedrick, G. Kersh, 1995, Journal of immunology.

Role of αβ and γδ T Cells in the Host Response toSalmonella Infection as Demonstrated in T-Cell-Receptor-Deficient Mice of Defined Ity Genotypes

L. Eckmann, J. Fierer, S. Hedrick, 1998, Infection and Immunity.

Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes

L. Eckmann, J. Fierer, S. Hedrick, 1997, Infection and immunity.

Molecular Analysis of Major Histocompatibility Complex (MHC) Molecule Recognition by the T Cell Receptor Alpha-Beta (α-β) Heterodimer

P. Fink, L. Matis, S. Hedrick, 1987 .

Expression Patterns of the Beta Chain of the T Cell Receptor for Antigen

Mark M. Davis, S. Hedrick, 1985 .

The Influence of MHC Gene Products on the Generation of an Antigen‐Specific T‐Cell Repertoire a

P. Fink, L. Matis, S. Hedrick, 1988 .

A n Essential R o l e for gp 39 , the Ligand for C D 4 0 , in Thymic Selection

A. Aruffo, S. Hedrick, J. Ledbetter, 2003 .

The TCR of Mice and Men

S. Hedrick, 2006, The Journal of Immunology.

The Tumor Microenvironment of B-cell Chronic Lymphocytic Leukemia A Thesis submitted in partial satisfaction of the requirement for the degree Master of Science in Biology by Hsu-Hsiang Chang Committee in charge: Thomas J. Kipps, Chair

C. Ware, S. Hedrick, D. Messmer, 2008 .

Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement.

F. Hooshmand, S. Hedrick, G. Kersh, 1995, Journal of immunology.

Evidence for programmed cell death of self‐reactive γδ T cell receptor‐positive thymocytes

J. Bluestone, L. Matis, S. Hedrick, 1993 .

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

Mark M. Davis, David I. Cohen, Stephen M. Hedrick, 1984, Nature.

Organization and Expression of the Murine T-Cell Receptor β-Chain Gene Complex

Mark M. Davis, Y. Chien, S. Hedrick, 1985 .

Inherited incomplete deficiency of the fourth component of complement (C4) determined by a gene not linked to human histocompatibility leukocyte antigens.

S. Hedrick, C. Alper, W. Muir, 1984, The Journal of clinical investigation.

SubsetsPolar Opposites: Erk Direction of CD4 T Cell

J. Pouysségur, G. Pagès, S. Hedrick, 2012 .

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

Mark M. Davis, S. Hedrick, J. Kavaler, 1984, Nature.

Foxo transcription factors control regulatory T cell development and function.

Daniel R. Beisner, E. Stone, S. Hedrick, 2010, Immunity.

Mechanisms of Development of αβ T Cell Antigen Receptor-Bearing Cells in γδ T Cell Antigen Receptor Transgenic Mice

S. Hedrick, A. Dent, 1991 .

Structure and specificity of the T cell antigen receptor.

S. Hedrick, J. Kaye, I. Engel, 1991, Seminars in immunology.

T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones.

P. Fink, S. Hedrick, S. Sorger, 1990, Journal of immunology.

Recepteur de lymphocyte specifique pour des polypeptides d'antigenes et polynucleotides apparentes

Mark M. Davis, S. Hedrick, 1985 .

Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue

J. Bluestone, L. Matis, S. Hedrick, 1992, Journal of Experimental Medicine.

I region-restricted antigen presentation by B cell–B lymphoma hybridomas

W. Paul, R. Schwartz, L. Glimcher, 1982, Nature.

into the Brain and Lethal Encephalitis Drak2 Contributes to West Nile Virus Entry

E. Fikrig, S. Hedrick, M. McGargill, 2013 .

Drak2 Contributes to West Nile Virus Entry into the Brain and Lethal Encephalitis1

E. Fikrig, R. Flavell, S. Hedrick, 2008, The Journal of Immunology.

Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C.

E. Margoliash, D. Longo, R. Schwartz, 1983, Journal of immunology.

Noncanonical Mode of ERK Action Controls Alternative ab and gd T Cell Lineage Fates

M. Carleton, S. Hedrick, D. Wiest, 2014 .

Genetic control of the immune response to collagen. III. Coordinate restriction of cellular cooperation and antigen responsiveness by thymus-directed maturation.

J. Watson, S. Hedrick, 1980, Journal of immunology.

Non-canonical mode of ERK action controls alternative αβ and γδ T lineage fates

M. Carleton, S. Hedrick, D. Wiest, 2014 .

MHC blocking peptides and T-cell receptor antagonists: novel paths to selective immunosuppression?

H. Grey, A. Sette, S. Hedrick, 1995, Chemical immunology.

Characterization of T cell growth factors for the clonal analysis of recognition properties of T cells.

J. Watson, S. Hedrick, 1980, Molecular immunology.

A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter

S. Hedrick, K. Marcu, D. D. Duncan, 1995, Molecular and cellular biology.

The enigmatic specificity of gamma delta T cells.

S. Hedrick, B. Weintraub, 1995, Immunologic research.

Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides.

M. Jackson, S. Hedrick, B. Weintraub, 1994, Journal of immunology.

A Role for CaMKII in T Cell Memory

Jack D Bui, S. Hedrick, L. Kane, 2000, Cell.

Active Ca2+/Calmodulin-Dependent Protein Kinase IIγB Impairs Positive Selection of T Cells by Modulating TCR Signaling1

Maureen A. McGargill, Stephen M. Hedrick, S. Hedrick, 2005, The Journal of Immunology.

CD33/Siglec-3 Binding Specificity, Expression Pattern, and Consequences of Gene Deletion in Mice

A. Varki, S. Hedrick, E. B. D. Brinkman-van der Linden, 2003, Molecular and Cellular Biology.

Intracellular signals that mediate thymic negative selection.

S. Hedrick, L. Kane, N. J. Vasquez, 1994, Immunity.

The acquired immune system: a vantage from beneath.

S. Hedrick, Stephen M Hedrick, 2004, Immunity.

Repertoire Development and Ligand Specificity of Murine TCRγδ Cells

J. Bluestone, B. Rellahan, B. Houlden, 1991, Immunological reviews.

The cunning little vixen: Foxo and the cycle of life and death

S. Hedrick, 2009, Nature Immunology.

Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice

M. N. Margolies, S. Hedrick, J. Kaye, 1989, Cell.

The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus

D. Kingsbury, J. Watson, S. Hedrick, 1977, The Journal of experimental medicine.

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

M. Croft, S. Hedrick, A. Weinberg, 1991, Immunological reviews.

Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase

Ajit Varki, Nissi M. Varki, Sandra Diaz, 1991, Cell.

A semisynthetic epitope for kinase substrates

Alma L Burlingame, Dan Wang, Kevan M Shokat, 2007, Nature Methods.

Mechanisms of necroptosis in T cells

M. Komatsu, S. Hedrick, Irene L. Ch’en, 2011, The Journal of experimental medicine.

Intertwined pathways of programmed cell death in immunity

S. Hedrick, Irene L. Ch’en, Bryce N. Alves, 2010, Immunological reviews.

Unresponsiveness Kinase II in T Cells : From Activation to Calcium / Calmodulin-Dependent Protein A Pivotal Role for the Multifunctional Gascoigne

S. Hedrick, T. Zal, N. Gascoigne, 2005 .

Caspase-8 regulates TNF-alpha induced epithelial necroptosis and terminal ileitis

Helmut Neumann, Stefan Tenzer, Markus F. Neurath, 2011, Nature.

A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation

S. Hedrick, Nimi Marcel, Chen-Yen Lai, 2022, The Journal of Immunology.

FOXO transcription factors throughout T cell biology

A. Goldrath, E. Stone, S. Hedrick, 2012, Nature Reviews Immunology.

Highly specialized role of Forkhead box O transcription factors in the immune system.

A. Dejean, S. Hedrick, Y. Kerdiles, 2011, Antioxidants & redox signaling.

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

Daniel R. Beisner, R. DePinho, A. Dejean, 2009, Nature Immunology.

FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity

S. Hedrick, A. Doedens, Arnaud Delpoux, 2017, Proceedings of the National Academy of Sciences.

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

E. Yang, A. Goldrath, E. Stone, 2015, Immunity.

T‐cell fate

S. Hedrick, L. Sharp, Leslie N. Sharp, 1998, Immunological reviews.

Specificity of the T cell receptor for antigen.

S. Hedrick, 1988, Advances in immunology.

MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility

Stephen M. Hedrick, Masayuki Shimada, Peter F. Johnson, 2009, Science.

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.

G. Linette, L. Glimcher, S. Hedrick, 1994, Immunity.

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

C. Glass, E. Stone, S. Hedrick, 2016, eLife.

Murine T cell receptor beta chain is encoded on chromosome 6

P. D’Eustachio, F. Ruddle, M. Davis, 1984, The Journal of experimental medicine.

Elf-1 binds to a critical element in a second CD4 enhancer

S. Hedrick, J. Leiden, G. Siu, 1994, Molecular and cellular biology.

A transcriptional silencer controls the developmental expression of the CD4 gene.

S. Hedrick, D. D. Duncan, G. Siu, 1994, The EMBO journal.

B cell tolerance to a minor, but not to a major, antigenic surface of the self antigen, cytochrome c.

S. Hedrick, R. Jemmerson, S. Oehen, 1998, Journal of immunology.

Cutting Edge: Innate Immunity Conferred by B Cells Is Regulated by Caspase-81

Daniel R. Beisner, Ravi V. Kolla, A. Hoffmann, 2005, The Journal of Immunology.

A Pivotal Role for the Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II in T Cells: From Activation to Unresponsiveness1

S. Hedrick, Irene L. Ch’en, T. Zal, 2005, The Journal of Immunology.

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

J. Greenbaum, S. Hedrick, Goo-Young Seo, 2021, bioRxiv.

Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

Kristen Jepsen, Gail Mandel, Vivek Kumar, 2000, Cell.

FOXO1 constrains activation and regulates senescence in CD8 T cells.

C. Glass, L. Loh, K. Kedzierska, 2021, Cell reports.

A key control point in the T cell response to chronic infection and neoplasia: FOXO1.

S. Hedrick, Nimi Marcel, 2020, Current opinion in immunology.

The biology of the T-cell antigen receptor and its role in the skin immune system.

S. Hedrick, E. Springer, G. Siu, 1990, The Journal of investigative dermatology.

Chimeric T cell receptor-immunoglobulin molecules: function and applications.

S. Hedrick, Stephen M Hedrick, 1993, International reviews of immunology.

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells

C. Benedict, A. Goldrath, Shilpi Verma, 2018, The Journal of experimental medicine.

Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c

P. Fink, L. Matis, S. Hedrick, 1987, The Journal of experimental medicine.

Self-reactive γδ T cells are eliminated in the thymus

J. Bluestone, L. Matis, F. Hooshmand, 1990, Nature.

Genetic control of the immune response to collagen. II. Antibody responses produced in fetal liver restored radiation chimeras and thymus reconstituted F1 hybrid nude mice

J. Watson, S. Hedrick, 1979, The Journal of experimental medicine.

The CD95 Receptor: Apoptosis Revisited

M. Peter, J. Desbarats, M. Newell, 2007, Cell.

The role of erk1 and erk2 in multiple stages of T cell development.

J. Pouysségur, S. Hedrick, C. Katayama, 2005, Immunity.

Multivalent Porous Silicon Nanoparticles Enhance the Immune Activation Potency of Agonistic CD40 Antibody

L. Ruff, S. Hedrick, M. Sailor, 2012, Advanced materials.

Targeted Deletion of Protein Kinase C λ Reveals a Distribution of Functions between the Two Atypical Protein Kinase C Isoforms1

J. Feramisco, S. Hedrick, M. Lin, 2004, The Journal of Immunology.

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

S. Jameson, S. Hedrick, J. Kaye, 1989, Nature.

A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection.

S. Hedrick, L. Kane, Lawrence P. Kane, 1996, Journal of immunology.

Thymocyte Negative Selection Differences Between Several Models of TNF Receptor-Deficient Mice Reveal Striking

Stephen M. Hedrick, Dawne M. Page, Edda M. Roberts, 2013 .

A Murine T Cell Receptor Gene Complex: Isolation, Structure and Rearrangement

Y. Chien, M. Davis, S. Hedrick, 1984, Immunological reviews.

A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity.

S. Hedrick, M. McGargill, B. Wen, 2004, Immunity.

Antigen-mediated T cell expansion regulated by parallel pathways of death

Daniel R. Beisner, A. Hoffmann, A. Degterev, 2008, Proceedings of the National Academy of Sciences.

Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptide recognition

S. Hedrick, I. Engel, 1988, Cell.

The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival1

S. Hedrick, Chiung-Fang Chang, Warren N D'Souza, 2008, The Journal of Immunology.

Selection of amino acid sequences in the beta chain of the T cell antigen receptor.

P. Fink, L. Matis, S. Hedrick, 1988, Science.

Genetic markers of the antigen-specific T cell receptor locus

M. Cohn, P. Marrack, J. Kappler, 1985, The Journal of experimental medicine.

B Cells Is Regulated by Caspase-8 Cutting Edge: Innate Immunity Conferred by

Stephen M. Hedrick, Daniel R. Beisner, Irene L. Ch, 2013 .

Correspondence between functionally significant sequences in immunoglobulin and the T cell receptor for antigen.

P. Fink, S. Hedrick, I. Engel, 1987, Advances in experimental medicine and biology.

Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation

J. Hutcheson, G. Haines, C. Mohan, 2014, The Journal of Immunology.

Relative Over-Reactivity of Human versus Chimpanzee Lymphocytes: Implications for the Human Diseases Associated with Immune Activation

A. Varki, S. Hedrick, Nancy Hurtado-Ziola, 2010, The Journal of Immunology.

Associated with Immune Activation Implications for the Human Diseases versus Chimpanzee Lymphocytes: Relative Over-Reactivity of Human

A. Varki, S. Hedrick, Nancy Hurtado-Ziola, 2010 .

Activation the Human Diseases Associated with Immune Chimpanzee Lymphocytes: Implications for Relative Over-Reactivity of Human versus

A. Varki, S. Hedrick, L. Stein, 2010 .

Commitment to the CD 4 Lineage Mediated by Extracellular Signal-Related Kinase Mitogen-Activated Protein Kinase and Lck Signaling 1

S. Hedrick, L. Sharp, 1999 .

Signaling Mitogen-Activated Protein Kinase and Lck by Extracellular Signal-Related Kinase Commitment to the CD 4 Lineage Mediated

S. Hedrick, L. Sharp, 1999 .

In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors.

J. Bluestone, B. Houlden, S. Hedrick, 1992, Journal of immunology.

Transcription Factor Binding Site Analysis Identifies FOXO Transcription Factors as Regulators of the Cutaneous Wound Healing Process

V. Nizet, E. Stone, Srinivas Veerla, 2014, PloS one.

The Imperative to Vaccinate

S. Hedrick, 2018, The Journal of Pediatrics.

Cutting Edge: Latecomer CD8 T Cells Are Imprinted with a Unique Differentiation Program1

Stephen M. Hedrick, S. Hedrick, Warren N. D’Souza, 2006, The Journal of Immunology.

The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection

S. Hedrick, Xin Huang, Chen-Yen Lai, 2018, The Journal of Immunology.

Polar Opposites: Erk Direction of CD4 T Cell Subsets

J. Pouysségur, G. Pagès, S. Hedrick, 2012, The Journal of Immunology.

Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline

S. Hedrick, E. Bier, Hannah A. Grunwald, 2021, PLoS biology.

The T cell response to allelic determinants on Igh-1-encoded IgG2a antibodies: dual recognition examined by using antigenic antibodies with binding affinity for Ia molecules.

R. Schwartz, S. Hedrick, 1983, Journal of immunology.

To T or not to T: is it selection?

J. Bluestone, S. Hedrick, Lou Matis, 1991, Current Biology.

Development of TCR γ δ Cells

J. Bluestone, L. Matis, S. Hedrick, 1993 .

A model for γδ T-cell development: Rearranged γ- and δ-chain genes incorporated into the germline of mice

S. Hedrick, A. Dent, 1990 .

Cellular and biochemical requirements for thymocyte negative selection.

S. Hedrick, L. Kane, T. Onami, 1996, Seminars in immunology.

Meiotic Cas9 expression mediates genotype conversion in the male and female mouse germline

S. Hedrick, E. Bier, Hannah A. Grunwald, 2021, bioRxiv.

Gain of Toxicity from ALS / F TD-Linked Repeat Expansions in C 9 ORF 72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs Highlights

C. Heyser, L. Petrucelli, C. Shaw, 2016 .

Correlations between T-cell specificity and the structure of the antigen receptor

P. Fink, L. Matis, S. Hedrick, 1986, Nature.

GENETIC CONTROL OF THE IMMUNE RESPONSE TO COLLAGEN: I. QUANTITATIVE DETERMINATION OF RESPONSE LEVELS BY MULTIPLE I‐REGION GENES

S. Hedrick, J. Watson, 1980, Journal of immunogenetics.

Self-reactive gamma delta T cells are eliminated in the thymus.

J. Bluestone, L. Matis, F. Hooshmand, 1990, Nature.

The role of erk1 and erk2 in multiple stages of T cell development.

J. Pouysségur, S. Hedrick, C. Katayama, 2005, Immunity.

SubsetsPolar Opposites: Erk Direction of CD4 T Cell

J. Pouysségur, G. Pagès, S. Hedrick, 2012 .

This information is current as Subsets Polar Opposites : Erk Direction of CD 4 T Cell

J. Pouysségur, S. Hedrick, Irene L. Ch’en, 2012 .

Requirement for positive selection of gamma delta receptor-bearing T cells

J. Bluestone, L. Matis, S. Hedrick, 1991, Science.

The role of erk1 and erk2 in multiple stages of T cell development.

J. Pouysségur, S. Hedrick, C. Katayama, 2005, Immunity.

A mouse strain defective for alphabeta versus gammadelta T cell lineage commitment.

J. Marth, J. Esko, F. Ramsdell, 2002, International immunology.

Relative Over-Reactivity of Human versus Chimpanzee Lymphocytes: Implications for the Human Diseases Associated with Immune Activation

A. Varki, S. Hedrick, Nancy Hurtado-Ziola, 2010, The Journal of Immunology.

Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes.

A. Dejean, Caroline Stienne, Mehdi Benamar, 2016, Immunity.

Understanding Immunity through the Lens of Disease Ecology.

S. Hedrick, 2017, Trends in immunology.

Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1.

S. Hedrick, Xin Huang, R. Thimme, 2018, Cell reports.

Intertwined pathways of programmed cell death in immunity

S. Hedrick, Irene L. Ch’en, Bryce N. Alves, 2010, Immunological reviews.

The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection

S. Hedrick, Xin Huang, Chen-Yen Lai, 2018, The Journal of Immunology.

Transcriptomes and metabolism define mouse and human MAIT cell populations

S. Hedrick, Goo-Young Seo, Li-Fan Lu, 2023, Science Immunology.