W. Engel

P. Neuhaus, W. Engel, K. Nayernia, 2005, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Pluripotency of spermatogonial stem cells from adult mouse testis

Stefan Wagner, Wolfgang Engel, Ralf Dressel, 2006, Nature.

Ausgewählte Publikationen / Selected Publications

G. Hasenfuss, W. Engel, Frieder Wolf, 2012 .

Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.

W. Engel, S. Yalcin, P. Grzmil, 2010, The International journal of developmental biology.

Isolation and cultivation of stem cells from adult mouse testes

G. Hasenfuss, W. Engel, K. Nayernia, 2009, Nature Protocols.

Potency of germ cells and its relevance for regenerative medicine

W. Engel, K. Nayernia, K. Guan, 2008, Journal of anatomy.

From stem cells to germ cells and from germ cells to stem cells

T. Haaf, W. Engel, K. Nayernia, 2007 .

Compositions et procedes de production de cellules pluripotentes a partir de testicules adultes

G. Hasenfuss, W. Engel, K. Nayernia, 2006 .

Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3).

M. Mattei, I. Adham, W. Engel, 1994, Genomics.

Somatic pairings of the Y heterochromatin in human XYY and XYqi cells.

M. Schmid, W. Engel, A. Poppen, 1981, Cytogenetics and cell genetics.

Maternal storage in the mammalian oocyte.

W. Engel, W. Franke, 1976, Current topics in pathology. Ergebnisse der Pathologie.

Molybdenum cofactor-deficient mice resemble the phenotype of human patients.

J. Reiss, J. Sass, I. Adham, 2002, Human molecular genetics.

Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes

W. Engel, K. Nayernia, Jae Ho Lee, 2006, Molecular reproduction and development.

The Leydig insulin-like peptide

I. Adham, W. Engel, E. Burkhardt-Göttges, 1996 .

Influence of mutation type and location on phenotype in 123 patients with Rett syndrome.

P. Huppke, F. Hanefeld, W. Engel, 2002, Neuropediatrics.

Cyclic AMP phosphodiesterase in Leydig cell preparations of the rat testis.

J. Schmidtke, W. Engel, J. Epplen, 1981, Differentiation; research in biological diversity.

Molecular and cellular approaches for establishment of an in vitro spermatogenesis system.

W. Engel, K. Nayernia, 2004, Methods in molecular biology.

Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG)

W. Engel, P. Burfeind, A. Mannan, 2000, Cytogenetic and Genome Research.

Isolation and characterization of differentially expressed genes in invasive and non-invasive immortalized murine male germ cells in vitro.

W. Engel, K. Nayernia, P. Burfeind, 2001, International journal of oncology.

A human Y-chromosomal DNA sequence expressed in testicular tissue.

J. Schmidtke, W. Engel, J. Epplen, 1987, Nucleic acids research.

WITHDRAWN; Impaired spermatogenesis in mice overexpressing stem cell protein Piwil2 (Mili)

D. D. de Rooij, W. Engel, K. Nayernia, 2010, Molecular reproduction and development.

A direct demonstration of somatically paired heterochromatin of human chromosomes.

M. Schmid, T. Haaf, W. Engel, 1983, Cytogenetics and cell genetics.

Molecular cloning of a SALL1-related pseudogene and mapping to chromosome Xp11.2

H. Jäckle, W. Engel, J. Kohlhase, 1999, Cytogenetic and Genome Research.

Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism.

I. Adham, W. Engel, J. Grootegoed, 2000, Endocrinology.

Induction of testis alcohol dehydrogenase in prepubertal rats

W. Krone, W. Engel, U. Wolf, 1972, Clinical genetics.

Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene

W. Engel, H. Glander, M. Diaconu, 2006, Andrologia.

Gene action in fish of tetraploid origin. V. Cellular RNA and protein content and enzyme activities in cyprinid, clupeoid, and salmonoid species

J. Schmidtke, W. Engel, B. Schulte, 1976, Biochemical Genetics.

Proacrosin/acrosin activity during spermiohistogenesis of the bull.

W. Engel, L. Phi-Van, A. Mansouri, 1983, Differentiation; research in biological diversity.

Three novel SALL1 mutations extend the mutational spectrum in Townes-Brocks syndrome

W. Engel, M. Patel, A. Bottani, 1999, Journal of medical genetics.

The bovine protamine 2 gene: evidence for alternative splicing.

W. Engel, H. Kremling, N. Reinhart, 1992, Biochimica et biophysica acta.

Hspa4l-Deficient Mice Display Increased Incidence of Male Infertility and Hydronephrosis Development

I. Adham, W. Engel, A. Meinhardt, 2006, Molecular and Cellular Biology.

Phospholipid hydroperoxide glutathione peroxidase: expression pattern during testicular development in mouse and evolutionary conservation in spermatozoa

G. Wennemuth, W. Engel, M. Diaconu, 2004, Molecular reproduction and development.

Interphase chromosome arrangement in Sertoli cells of adult mice.

M. Schmid, W. Engel, M. Guttenbach, 1996, Biology of reproduction.

MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin.

P. Huppke, F. Hanefeld, W. Engel, 2001, American journal of human genetics.

Calgizarrin like gene (Cal) deficient mice undergo normal spermatogenesis

W. Engel, C. Mueller, G. Nica, 2003, Molecular reproduction and development.

TSPY Expression Is Variably Altered in Transgenic Mice with Testicular Feminization1

J. Schmidtke, I. Adham, W. Engel, 2008, Biology of reproduction.

The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.

W. Engel, P. Burfeind, A. Meinhardt, 2002, Human molecular genetics.

Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo

T. Renné, I. Adham, W. Engel, 2004, Thrombosis and Haemostasis.

Biochemical and Genetic Investigation of Round‐headed Spermatozoa in Infertile Men including two Brothers and their Father

W. Engel, W. Müller-Esterl, E. Töpfer‐Petersen, 2009, Andrologia.

Binding of human chorionic gonadotrophin to rat ovary during development.

J. Schmidtke, W. Engel, J. Siebers, 1977, The Journal of endocrinology.

Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility.

I. Adham, W. Engel, K. Nayernia, 2002, Molecular human reproduction.

In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice.

T. Haaf, W. Engel, V. Okpanyi, 2006, Developmental cell.

Putative human male germ cells from bone marrow stem cells.

J. Schmidtke, W. Engel, K. Nayernia, 2007, Society of Reproduction and Fertility supplement.

Disturbances of nuclear condensation in human spermatozoa: search for mutations in the genes for protamine 1, protamine 2 and transition protein 1.

W. Engel, V. Schnülle, V. Vorob'ev, 1994, Human reproduction.

Artificial Sperm Artificial Sperm

W. Engel, J. Nolte, 2019 .

Artificial Sperm

W. Engel, J. Nolte, 2018 .

The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis.

Enrico Garattini, Wolfgang Engel, Olaf Riess, 2005, Molecular genetics and metabolism.

Overexpression of Lis1 in Different Stages of Spermatogenesis Does Not Result in an Aberrant Phenotype

H. Arnold, W. Engel, K. Nayernia, 2011, Cytogenetic and Genome Research.

In vitro inhibition of cyclic AMP phosphodiesterase by cortisol

T. Wienker, J. Schmidtke, W. Engel, 1976, Nature.

Patterns of cyclic AMP phosphodiesterases during rat testis development

J. Schmidtke, W. Engel, J. Epplen, 1980, Human Genetics.

Glucocorticoids and hCG sensitivity of rat testicular Leydig cell

W. Engel, J. Frowein, 1974, Nature.

Impact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteome.

H. Dihazi, W. Engel, O. Jahn, 2013, World journal of stem cells.

Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells

R. Jaenisch, P. Novota, G. Hasenfuss, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Evidence for an unusual ZW/ZW'/ZZ sex-chromosome system in Scardinius erythrophthalmus (Pisces, Cyprinidae), as detected by cytogenetic and H-Y antigen analyses.

M. Schartl, M. Schmid, W. Engel, 1995, Cytogenetics and cell genetics.

Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11.

A. Edelmann, H. Gröne, W. Engel, 1996, Human molecular genetics.

H-Y antigen as a tool for the determination of the heterogametic sex in Amphibia.

M. Schmid, W. Engel, 1981, Cytogenetics and cell genetics.

The structures of the bovine and porcine proacrosin genes and their conservation among mammals.

I. Adham, W. Engel, M. Hummel, 1996, Biological chemistry Hoppe-Seyler.

Onset of synthesis of mitochondrial enzymes during mouse development

W. Engel, 1973, Humangenetik.

ISOZYMES AS GENETIC MARKERS IN EARLY MAMMALIAN DEVELOPMENT

W. Engel, W. Franke, U. Petzoldt, 1975 .

Expression of the paternally derived phosphoglucose isomerase genes during hybrid trout development.

J. Schmidtke, W. Engel, P. Kuhl, 1977, Comparative biochemistry and physiology. B, Comparative biochemistry.

THE ROLE OF ACROSIN IN REPRODUCTION

W. Engel, K. Nayernia, E. Adham, 2000 .

Constitutivity of the HCG-receptor protein in the testis of rat and man

W. Engel, J. Frowein, 1974, Nature.

Effect of neuraminidase on luteinizing hormone/chorionic gonadotrophin binding to the ovarian and testicular membranes from different mammalian species.

W. Engel, U. Uçer, M. Müller, 1983, Biochimica et Biophysica Acta.

LH/HCG receptors of the ovary during early postnatal development

W. Engel, J. Siebers, U. Müller, 1979 .

HCG-receptor present in the gonadotrophin insensitive Leydig cell of the immature rat.

W. Engel, H. Weise, J. Frowein, 1973, Nature: New biology.

Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice.

I. Adham, W. Engel, A. Agoulnik, 2006, The Journal of urology.

The roles of DAZL in RNA biology and development

W. Engel, Xingbo Xu, D. V. K. Pantakani, 2014, Wiley interdisciplinary reviews. RNA.

Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.

W. Engel, Q. Lin, B. Schmidt, 2013, Biochimica et biophysica acta.

Silver staining of nucleolus organizer regions during human spermatogenesis

M. Schmid, W. Engel, H. Müller, 2004, Human Genetics.

Analysis of structural and numerical chromosome abnormalities in sperm of normal men and carriers of constitutional chromosome aberrations. A review

M. Schmid, W. Engel, M. Guttenbach, 1997, Human Genetics.

Segregation of sex chromosomes into sperm nuclei in a man with 47,XXY Klinefelter’s karyotype: a FISH analysis

M. Schmid, W. Engel, H. Michelmann, 1997, Human Genetics.

Targeted expression of SV40 large tumour antigen (TAg) induces a transient enhancement of spermatocyte proliferation and apoptosis.

W. Engel, K. Nayernia, P. Burfeind, 2001, Molecular human reproduction.

Organization in vitro of ovarian cells into testicular structures

W. Engel, U. Wolf, M. Zenzes, 1978, Human Genetics.

Studies on the function of H-Y antigen: dissociation and reorganization experiments on rat gonadal tissue.

W. Engel, U. Wolf, M. Zenzes, 1978, Cytogenetics and cell genetics.

Analyses of meiotic chromosomes in testicular biopsies of infertile patients.

W. Engel, W. Krause, R. Lange, 1997, Human reproduction.

Analysis of meiotic chromosomes in ejaculates of infertile patients with an increased number of immature germ cells in semen samples

W. Engel, R. Lange, G. Wilke, 2009, Andrologia.

Mouse Leydig insulin‐like (Ley I‐L) gene: Structure and expression during testis and ovary development

I. Adham, W. Engel, S. Zimmermann, 1997, Molecular reproduction and development.

Stage-Specific Germ-Cell Marker Genes Are Expressed in All Mouse Pluripotent Cell Types and Emerge Early during Induced Pluripotency

W. Engel, R. Dressel, U. Zechner, 2011, PloS one.

Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway.

H. Radzun, W. Engel, L. Füzesi, 2006, Human molecular genetics.

Derivation of male germ cells from bone marrow stem cells

W. Engel, K. Nayernia, R. Dressel, 2006, Laboratory Investigation.

Acrosin and the acrosome in human spermatogenesis

W. Engel, W. Müller-Esterl, E. Töpfer‐Petersen, 2004, Human Genetics.

Running title : In Vitro Derived Human Sperm Title : Derivation of Human Sperm from Embryonic Stem Cells

A. Murdoch, M. Herbert, M. Stojkovic, 2009 .

Translational control in spermatogenesis.

W. Engel, K. Nayernia, W Engel, 1995, Developmental biology.

The capacity of testicular cells of the postnatal rat to reorganize into histotypic structures.

W. Engel, M. Zenzes, 1981, Differentiation; research in biological diversity.

Are there genetic risks associated with microassisted reproduction?

M. Schmid, W. Engel, D. Murphy, 1996, Human reproduction.

Hidden breaks in ribosomal RNA of phylogenetically tetraploid fish and their possible role in the diploidization process

W. Engel, M. Leipoldt, 1983, Biochemical Genetics.

Bibliography of Ulrich Wolf

C. Tyler-Smith, P. Yen, K. Hirschhorn, 2001, Cytogenetic and Genome Research.

Human lymphocytes, fibroblasts and amniotic fluid cells are not endowed with human chorionic gonadotropin receptors.

W. Engel, W. Vogel, J. Siebers, 1978, American journal of obstetrics and gynecology.

Hormonal Control of Gubernaculum Development during Testis Descent: Gubernaculum Outgrowth in Vitro Requires Both Insulin-Like Factor and Androgen* *This work was supported by a grant from the Deutsche Forschungsgemeinschaft (through SFB 271, to I.M.A.).

I. Adham, W. Engel, J. Grootegoed, 2000, Endocrinology.

Hspa4l-Deﬁcient Mice Display Increased Incidence of Male Infertility and Hydronephrosis Development (cid:1)

I. Adham, W. Engel, A. Meinhardt, 2006 .

Genetic studies on a minute centric fragment transmitted through three generations.

H. Hoehn, W. Engel, H. Reinwein, 1970, Cytogenetics.

Incidence of diploid and disomic sperm nuclei in 45 infertile men.

M. Schmid, W. Engel, H. Michelmann, 1997, Human reproduction.

Pregnancy after intracytoplasmic sperm injection with sperm from a man with a 47,XXY Klinefelter's karyotype.

M. Schmid, W. Engel, H. Michelmann, 1997, Fertility and sterility.

High Incidence of Minor Chromosomal Variants in Teratozoospermic Males

W. Engel, W. Krause, B. Eiben, 2009, Andrologia.

On the capacity of mouse spermatozoa for spontaneous acrosome reaction in the male and female genital tract

W. Engel, M. Klemm, 2009, Andrologia.

Molecular cloning of preproacrosin and analysis of its expression pattern in spermatogenesis.

I. Adham, W. Engel, S. Hoyer-Fender, 1989, European journal of biochemistry.

Germ cell‐specific expression of a proacrosin‐cat fusion gene in transgenic mouse testis

W. Engel, K. Nayernia, S. Keime, 1992, Molecular reproduction and development.

Relevance of genetic counselling in couples prior to intracytoplasmic sperm injection.

W. Engel, B. Zoll, H. Pauer, 1997, Human reproduction.

Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization.

W. Engel, R. Jones, J C Pascall, 2001, Journal of cell science.

Meiotic Nondisjunction of Chromosomes 1, 17, 18, X, and Y in Men More Than 80 Years of Age

M. Schmid, W. Engel, F. Köhn, 2000, Biology of reproduction.

Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice.

I. Adham, W. Engel, P. Grzmil, 2013, Reproduction.

H-Y antigen in transsexuality, and how to explain testis differentiation in H-Y antigen-negative males and ovary differentiation in H-Y antigen-positive females

W. Engel, F. Pfäfflin, C. Wiedeking, 2004, Human Genetics.

Development of hCG sensitivity in the testis of the immature rat.

W. Engel, J. Frowein, 1974, Cell.

Evolution and Development of the Outer Acrosomal Membrane (OAM) and Evidence that Acrosin‐lnhibitors are Proteins of the OAM

W. Engel, E. Töpfer‐Petersen, W. Schill, 2009 .

Pattern of activity of nucleolus organizers during spermatogenesis in mammals as analyzed by silver-staining

M. Schmid, W. Krone, W. Engel, 1979, Chromosoma.

Cytogenetic and biochemical differences between Apodemus sylvaticus and Apodemus flavicollis, possibly responsible for the failure to interbreed.

H. Ropers, W. Engel, I. Voiculescu, 1973, Comparative biochemistry and physiology. B, Comparative biochemistry.

Expression and chromosomal mapping of the gene encoding the human histone H1.1

W. Engel, D. Doenecke, P. Burfeind, 1994, Human Genetics.

Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene

I. Adham, W. Engel, A. Çelik, 1996, Molecular reproduction and development.

Nucleotide sequence of a bovine protamine cDNA.

W. Engel, N. Hecht, W. Hecht, 1987, Biological chemistry Hoppe-Seyler.

Gene action in fish of tetraploid origin. II. Cellular and biochemical parameters in clupeoid and salmonoid fish

J. Schmidtke, W. Engel, N. B. Atkin, 1975, Biochemical Genetics.

H-Y antigen in Turner's syndrome patients with different sex chromosome constitutions

W. Engel, I. Hansmann, B. Klemme, 2004, Human Genetics.

Serological evidence for H-Y antigen in XO-female mice

W. Engel, B. Klemme, A. Ebrecht, 2004, Human Genetics.

Generation and Characterization of a Transgenic Mouse with a Functional Human TSPY1

M. Schmid, J. Schmidtke, W. Engel, 2003, Biology of reproduction.

The role of the testicular factor INSL3 in establishing the gonadal position

I. Adham, W. Engel, J. Emmen, 2000, Molecular and Cellular Endocrinology.

HCG-binding capacity of the rat ovary during pregnancy.

W. Engel, J. Siebers, W. Wuttke, 1977, Acta endocrinologica.

Mutation analysis in a German family identified a new cataract-causing allele in the CRYBB2 gene

N. Klopp, T. Illig, W. Engel, 2007, Molecular vision.

The effects of distamycin A on gorilla-, chimpanzee- and orangutan lymphocyte cultures.

M. Schmid, W. Engel, A. Poppen, 1981, Cytogenetics and cell genetics.

MicroRNA signature in various cell types of mouse spermatogenesis: Evidence for stage‐specifically expressed miRNA‐221, ‐203 and ‐34b‐5p mediated spermatogenesis regulation

W. Engel, U. Zechner, D. V. K. Pantakani, 2012, Biology of the cell.

Pathways of proliferation and antiapoptosis driven in breast cancer stem cells by stem cell protein piwil2.

J. Hengstler, C. Robson, M. Shoukier, 2010, Cancer research.

300 million years of conserved synteny between chicken Z and human chromosome 9

M. Schartl, M. Schmid, D. Burt, 1999, Nature Genetics.

How to distinguish genetically between an alleged father and his monozygotic twin: a thought experiment.

D. Cooper, M. Krawczak, J. Schmidtke, 2012, Forensic science international. Genetics.

Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6).

I. Adham, W. Engel, K. Nayernia, 2003, Molecular human reproduction.

SALL3, a new member of the human spalt-like gene family, maps to 18q23.

W. Schulz-Schaeffer, W. Engel, J. Kohlhase, 1999, Genomics.

Contrasting DNA sequence organisation patterns in sauropsidian genomes

J. Schmidtke, W. Engel, J. Epplen, 1979, Chromosoma.

Stage and developmental specific gene expression during mammalian spermatogenesis.

I. Adham, W. Engel, K. Reim, 1996, The International journal of developmental biology.

A reply: the human proacrosin gene

I. Adham, W. Engel, H. Kremling, 1992 .

Characterization of a gene encoding a basic protein of the spermatid nucleus, TNP2, and its close linkage to the protamine genes in the bull.

I. Adham, W. Engel, H. Kremling, 1991, Biological chemistry Hoppe-Seyler.

Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice

S. Thoms, W. Engel, A. Meinhardt, 2011, Molecular biology of the cell.

Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting

Tohru Kimura, Toshinobu Nakamura, W. Engel, 2015, Nature Communications.

Global and gene-specific histone modification profiles of mouse multipotent adult germline stem cells.

W. Engel, R. Dressel, U. Zechner, 2011, Molecular human reproduction.

Comparative methylation profiles and telomerase biology of mouse multipotent adult germline stem cells and embryonic stem cells.

T. Haaf, W. Engel, U. Zechner, 2009, Molecular human reproduction.

Adult Germ Line Stem Cells as a Source of Functional Neurons and Glia

B. Fleischmann, P. Sasse, W. Engel, 2008, Stem cells.

Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells.

W. Engel, U. Zechner, Xingbo Xu, 2013, Stem cell research.

Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells.

W. Engel, U. Zechner, J. Nolte, 2014, Stem cells and development.

Multipotent adult germline stem cells and embryonic stem cells: comparative proteomic approach.

H. Dihazi, W. Engel, O. Jahn, 2009, Journal of proteome research.

Male Mice Lacking Three Germ Cell Expressed Genes Are Fertile1

I. Adham, W. Engel, B. Drabent, 2003, Biology of reproduction.

Teratozoospermia in mice lacking the transition protein 2 (Tnp2).

I. Adham, W. Engel, K. Nayernia, 2001, Molecular human reproduction.

Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules

G. Hasenfuss, W. Engel, K. Nayernia, 2009, Biology Direct.

DNA sequence organisation in avian genomes

J. Schmidtke, W. Engel, J. Epplen, 1978, Chromosoma.

Molecular analysis of SALL1 mutations in Townes-Brocks syndrome.

W. Reardon, K. Devriendt, O. Gabrielli, 1999, American journal of human genetics.

Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome

W. Engel, J. Kohlhase, U. Froster, 1998, Nature Genetics.

Isoenzyme polymorphism of the sorbitol dehydrogenase and the NADP‐dependent isocitrate dehydrogenases in the fish family Cyprinidae

W. Engel, U. Wolf, J. Faust, 2009 .

Duplication of the gene loci coding for the supernatant aspartate aminotransferase by polyploidization in the fish familyCyprinidae

J. Schmidtke, W. Engel, 1972, Experientia.

Genetic polymorphism of lactate dehydrogenase isoenzymes in the carp (Cyprinus carpio) apparently due to a “null allele”

J. Schmidtke, W. Engel, U. Wolf, 1973, Biochemical Genetics.

Isozymes of a tunicate and a cephalochordate as a test of polyploidisation in chordate evolution

J. Schmidtke, W. Engel, B. Kunz, 1977, Nature.

Male mice deficient for germ-cell cyritestin are infertile.

I. Adham, W. Engel, K. Nayernia, 1999, Biology of reproduction.

Members of the miR-290 cluster modulate in vitro differentiation of mouse embryonic stem cells.

A. Pantazi, W. Engel, Athanasios Zovoilis, 2009, Differentiation; research in biological diversity.

Fas-associated factor (FAF1) is required for the early cleavage-stages of mouse embryo.

I. Adham, W. Engel, A. Meinhardt, 2008, Molecular human reproduction.

Premature translation of transition protein 2 mRNA causes sperm abnormalities and male infertility

I. Adham, W. Engel, K. Nayernia, 2007, Molecular reproduction and development.

Regulation of cell size in fish of tetraploid origin

J. Schmidtke, W. Engel, M. Zenzes, 1975, Nature.

Sox15 Is Required for Skeletal Muscle Regeneration

M. Ochs, I. Adham, W. Engel, 2004, Molecular and Cellular Biology.

Heat-shock protein HSPA4 is required for progression of spermatogenesis.

I. Adham, W. Engel, A. Meinhardt, 2011, Reproduction.

Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2.

K. Grzeschik, M. Mattei, I. Adham, 1990, Genomics.

Gene mapping data – recommendations for more efficient dissemination

T. Mohandas, R. Eddy, T. Shows, 1983 .

Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency.

B. Habermann, R. Kirschner, I. Adham, 2001, Human molecular genetics.

Maternal Serum Placental Growth Hormone and Insulinlike Growth Factor Binding Proteins 1 and 3 in Pregnancies Affected by Fetal Aneuploidy and Other Abnormalities: Implications for Prenatal Diagnosis of Trisomy 21

W. Engel, G. Hennen, A. Igout, 1998, Fetal Diagnosis and Therapy.

On the expression of protamine genes in the testis of man and other mammals

W. Engel, L. Domenjoud, H. Kremling, 2009, Andrologia.

Brief Gene Mapping Reports A / B / C / D / E / F / G

C. Auffray, A. Zinn, K. Kratochwil, 2002, Cytogenetic and Genome Research.

Assignment of the Leydig insulin-like hormone to porcine Chromosome 2q12-q13 by somatic cell hybrid analysis and fluorescence in situ hybridization

H. Hameister, I. Adham, W. Engel, 1994, Mammalian Genome.

Refinement of the expression pattern of a mouse homologue of the porcine 135-kDa alpha-d-mannosidase (MAN2B2).

W. Engel, K. Nayernia, P. Burfeind, 2000, Biochemical and Biophysical Research Communications - BBRC.

Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia.

I. Adham, W. Engel, Sajid Rashid, 2010, Reproduction.

Rett syndrome: analysis of MECP2 and clinical characterization of 31 patients.

P. Huppke, F. Hanefeld, W. Engel, 2000, Human molecular genetics.

On the biochemical systematics of three apodemus species

J. Schmidtke, W. Engel, F. Csaikl, 1980 .

Stem cell based therapeutical approach of male infertility by teratocarcinoma derived germ cells.

M. Korabiowska, W. Engel, K. Nayernia, 2004, Human molecular genetics.

Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice

I. Adham, W. Engel, B. Zoll, 2008, Cytogenetic and Genome Research.

Sox 15 Is Required for Skeletal Muscle Regeneration

M. Ochs, I. Adham, W. Engel, 2004 .

Asthenozoospermia in Mice with Targeted Deletion of the Sperm Mitochondrion-Associated Cysteine-Rich Protein (Smcp) Gene

Wolfgang Engel, I. Adham, W. Engel, 2002, Molecular and Cellular Biology.

Gene action in fish of tetraploid origin. I. Cellular and biochemical parameters in cyprinid fish

J. Schmidtke, W. Engel, 1975, Biochemical Genetics.

Gene action in fish of tetraploid origin. IV. Ribosomal DNA amount in clupeoid and salmonoid fish

J. Schmidtke, W. Engel, M. Zenzes, 1976, Biochemical Genetics.

On the Interaction of Bull and Boar Acrosins with the Zona Pellucida of Different Mammalian Species in Vitro

W. Engel, G. Aumüller, W. Wemheuer, 2009, Andrologia.

DIPLOID-TETRAPLOID RELATIONSHIPS IN TELEOSTEAN FISHES

J. Schmidtke, W. Engel, U. Wolf, 1975 .

Assignment of the porcine transition protein TNP1 to Chromosome 15q24–q25 by fluorescence in situ hybridization (FISH)

H. Hameister, I. Adham, W. Engel, 1994, Mammalian Genome.

Identification and characterization of a novel murine multigene family containing a PHD-finger-like motif.

C. Vogel, W. Engel, P. Burfeind, 2002, Biochemical and biophysical research communications.

Reevaluation of the Incidence of Thromboembolic Complications in Congenital Factor XII Deficiency

B. Lämmle, W. Engel, S. Zeerleder, 1999, Thrombosis and Haemostasis.

Mutations in the human factor XII gene.

B. Lämmle, W. Engel, S. Zeerleder, 1997, Blood.

POSTER PRESENTATIONS

R. Kirschner, W. Engel, J., 2009 .

Five novel mutations in the L1CAM gene in families with X linked hydrocephalus.

U Orth, W. Engel, E. Schwinger, 1996, Journal of medical genetics.

The novel acceptor splice site mutation 11396(G-->A) in the factor XII gene causes a truncated transcript in cross-reacting material negative patients.

B. Lämmle, W. Engel, S. Hofferbert, 1995, Human molecular genetics.

Spermatogonial stem cells.

W. Engel, K. Nayernia, Manyu Li, 2004, Methods in molecular biology.

Detection of human spermatid-specific transcripts in peripheral blood lymphocytes of males and females

J. Reiss, W. Engel, R. Słomski, 1991, Human Genetics.

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

K. Yarasheski, S. Bhasin, W. Engel, 2001, Proceedings of the National Academy of Sciences of the United States of America.

[Autoradiographic studies on X-autosomal translocation in man: 45,X.15-,tan(15qZq+)+].

W. Engel, W. Vogel, H. Reinwein, 1971, Cytogenetics.

Phosphoglucose isomerase isozymes in the characid fish Cheirodon axelrodi: evidence for a spontaneous gene duplication.

J. Schmidtke, W. Engel, P. Kuhl, 1976, Comparative biochemistry and physiology. B, Comparative biochemistry.

Genetic variation of phosphoglucose isomerase isoenzymes in fish of the orders Ostariophysi and Isospondyli.

J. Schmidtke, W. Engel, G. Dunkhase, 1975, Comparative biochemistry and physiology. B, Comparative biochemistry.

Characterization of four genes encoding basic proteins of the porcine spermatid nucleus and close linkage of three of them.

W. Engel, S. Keime, W. Holtz, 1992, Biological chemistry Hoppe-Seyler.

Inheritance of the S-Form of NADP-Dependent Isocitrate Dehydrogenase Polymorphism in Rainbow Trout

H. Ropers, W. Engel, U. Wolf, 1973 .

Molecular cloning and characterization of the bovine and porcine outer dense fibers cDNA and organization of the bovine gene.

T. Haack, I. Adham, W. Engel, 1995, Biological chemistry Hoppe-Seyler.

A conserved 8 bp motif (GCYATCAY) in the 3'UTR of transition protein 2 as a putative target for a transcript stabilizing protein factor.

W. Engel, G. Schlüter, M. Schlicker, 1993, Biochemical and biophysical research communications.

The putative peroxisomal gene Pxt1 is exclusively expressed in the testis

W. Engel, P. Burfeind, P. Grzmil, 2007, Cytogenetic and Genome Research.

Cytogenetic characterization of the TM4 mouse Sertoli cell line. I. Conventional banding techniques, FISH and SKY.

C. Steinlein, M. Schmid, W. Engel, 2001, Cytogenetics and cell genetics.

Pluripotent embryonic stem cells and multipotent adult germline stem cells reveal similar transcriptomes including pluripotency-related genes.

L. Opitz, W. Engel, S. Meyer, 2010, Molecular human reproduction.

Multipotent adult germline stem cells and embryonic stem cells functional proteomics revealed an important role of eukaryotic initiation factor 5A (Eif5a) in stem cell differentiation.

H. Dihazi, W. Engel, O. Jahn, 2011, Journal of proteome research.

Amount of repeated and non-repeated DNA in the genomes of closely related fish species with varying genome sizes.

J. Schmidtke, W. Engel, M. Leipoldt, 1979, Comparative biochemistry and physiology. B, Comparative biochemistry.

The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development.

W. Engel, R. Trappe, T. Rzymski, 2002, Biochemical and biophysical research communications.

Triple knockouts reveal gene interactions affecting fertility of male mice

I. Adham, W. Engel, B. Drabent, 2005, Molecular reproduction and development.

Transitory hemizygosity of paternally derived alleles in hybrid trout embryos

J. Schmidtke, W. Engel, P. Kuhl, 1976, Nature.

Presumed trisomy for the short arm of chromosome No. 9 not due to inherited translocation

H. Hoehn, W. Engel, H. Reinwein, 2004, Humangenetik.

Mouse pelota gene (Pelo): cDNA cloning, genomic structure, and chromosomal localization

I. Adham, W. Engel, R. Shamsadin, 2002, Cytogenetic and Genome Research.

Animal Cytogenetics and Comparative Mapping

I. Adham, W. Engel, R. Shamsadin, 2001 .

Gene action in fish of tetraploid origin. III. Ribosomal DNA amount in cyprinid fish

J. Schmidtke, W. Engel, W. Engel, 1976, Biochemical Genetics.

A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-sertoli cell interaction.

M. Schmid, W. Engel, A. Wehrend, 1999, Biology of reproduction.

Non-repetitive DNA sequence divergence in phylogenetically diploid and tetraploid teleostean species of the family cyprinidae and the order isospondyli

J. Schmidtke, W. Engel, E. Schmitt, 1979, Chromosoma.

Werner Schmid, 1930–2002

C. Auffray, A. Zinn, K. Kratochwil, 2002, Cytogenetic and Genome Research.

Assignment of the porcine acrosin gene, ACR, to Chromosome 5p15 by fluorescence in situ hybridization (FISH)

H. Hameister, I. Adham, W. Engel, 2004, Mammalian Genome.

Screening for minute deletions in patients with suspected cri-du-chat syndrome and apparently normal karyotype

H. Hoehn, W. Engel, 1969, Humangenetik.

The use of distamycin A in human lymphocyte cultures

M. Schmid, D. Hungerford, W. Engel, 2004, Human Genetics.

Genome analysis of Amphioxus and speculation as to the origin of contrasting vertebrate genome organization patterns.

J. Schmidtke, W. Engel, J. Epplen, 1979, Comparative biochemistry and physiology. B, Comparative biochemistry.

Prm3, the fourth gene in the mouse protamine gene cluster, encodes a conserved acidic protein that affects sperm motility.

I. Adham, W. Engel, G. Schlüter, 2008, Biology of reproduction.

ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia.

W. Paulus, W. Engel, A. Mannan, 2006, American journal of human genetics.

Generation of functional neurons and glia from multipotent adult mouse germ-line stem cells.

G. Hasenfuss, W. Engel, K. Nayernia, 2009, Stem cell research.

Generation of Functional Cardiomyocytes From Adult Mouse Spermatogonial Stem Cells

G. Hasenfuss, L. Maier, W. Engel, 2007, Circulation research.

Cloning, organisation, chromosomal localization and expression analysis of the mouse Prkag1 gene

I. Adham, W. Engel, R. Shamsadin, 2001, Cytogenetic and Genome Research.

Proacrosin and the differentiation of the spermatozoa.

M. Schmid, W. Engel, W. Müller-Esterl, 1983, Biology of reproduction.

Rare oculo-rhino-auditive variants of the branchial arch syndrome. Report of three cases with two necropsy records.

H. Rehder, W. Engel, S. di Lollo, 1985, Ophthalmic paediatrics and genetics.

Mutation analysis of the spastin gene (SPG4) in patients in Germany with autosomal dominant hereditary spastic paraplegia

L. Schöls, W. Engel, J. Epplen, 2002, Human mutation.

Characterization of five novel large deletions causing hereditary haemorrhagic telangiectasia

M. Shoukier, W. Engel, A. Weise, 2008, Clinical genetics.

The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans.

I. Adham, W. Engel, Maria E Altmann, 2003, Biochemical and biophysical research communications.

The multiple ADP/ATP translocase genes are differentially expressed during human muscle development.

W. Engel, G. Attardi, O. Hurko, 1992, The Journal of biological chemistry.

Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals

W. Engel, K. Nayernia, P. Burfeind, 2000, Cytogenetic and Genome Research.

Patterns of cyclic AMP phosphodiesterases in the rat pineal gland: sex differences in diurnal rhythmicity.

J. Schmidtke, W. Engel, J. Epplen, 1982, Neuroendocrinology.

[The mechanism of diploidization in vertebrate evolution: coexistence of tetrasomic and disomic gene loci for the isocitrate dehydrogenases in trout (salmo irideus)].

W. Engel, U. Wolf, J. Faust, 1970, Humangenetik.

The reduction of genic activity in the tetraploid amphibianOdontophrynus americanus is not due to loss of ribosomal DNA

J. Schmidtke, W. Engel, W. Beçak, 2005, Experientia.

On the problem of regional gene duplication in diploid fish of the orders Ostariophysi and Isospondyli

J. Schmidtke, W. Engel, 1974, Humangenetik.

Genetic variation of α-glycerophosphate — dehydrogenase isoenzymes in clupeoid and salmonoid fish

J. Schmidtke, W. Engel, U. Wolf, 1971, Experientia.

On the Teratogenesis of Round‐Headed Spermatozoa: Investigations with Antibodies Against Acrosin, an Intraacrosomally Located Acrosin‐Inhibitor, and the Outer Acrosomal Membrane

W. Engel, W. Müller-Esterl, E. Töpfer‐Petersen, 2009, Andrologia.

Expansion of the (CAG)n repeat causing Huntington's disease in 352 patients of German origin.

O. Riess, W. Engel, J. Epplen, 1993, Human molecular genetics.

ERRATUM: GENE NUMBERS AND GENIC VARIABILITY IN CIONA INTESTINALIS AND BRANCHIOSTOMA LANCEOLATUM

J. Schmidtke, W. Engel, B. Kunz, 1978 .

Acrosin in the spermiohistogenesis of mammals.

W. Engel, W. Müller-Esterl, L. Phi-Van, 1983, Differentiation; research in biological diversity.

[The genetics of 6-PGD (EC 1.1.1.44) in various mammals. II. Studies on four ungulata species. Isoenzyme polymorphisms in horse and swine].

W. Engel, K. Bender, J. Hof, 1970, Humangenetik.

Mutation analysis in hereditary haemorrhagic telangiectasia in Germany reveals 11 novel ENG and 12 novel ACVRL1/ALK1 mutations

W. Engel, K. Nayernia, Werner Ja, 2006, Clinical genetics.

DNA sequence organisation in relation to genome size in birds

J. Schmidtke, W. Engel, J. Epplen, 1981, Experientia.

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

C. Steinlein, M. Schmid, R. Kirschner, 1997, Gene.

A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype.

W. Engel, P. Burfeind, G. Haidl, 1993, Human Molecular Genetics.

Disruption of PLC-β1-Mediated Signal Transduction in Mutant Mice Causes Age-Dependent Hippocampal Mossy Fiber Sprouting and Neurodegeneration

W. Engel, K. Nayernia, P. Burfeind, 2002, Molecular and Cellular Neuroscience.

Linkage relationships and allelic associations of the cystic fibrosis locus and four marker loci

N. J. Malik, M. Krawczak, M. Schwartz, 1987, Human Genetics.

Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein.

W. Engel, P. Burfeind, R. Trappe, 2003, Biochemical and biophysical research communications.

H-Y antigen in male patients with X polysomies

C. Fonatsch, W. Engel, B. Klemme, 2004, Human Genetics.

The lack of protamine 2 (P2) in boar and bull spermatozoa is due to mutations within the P2 gene.

W. Engel, L. Domenjoud, G. Nussbaum, 1990, Nucleic Acids Research.

Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia.

W. Engel, K. Nayernia, L. Wehner, 2006, International journal of molecular medicine.

Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis.

L. Maier, I. Adham, W. Engel, 2012, Journal of molecular and cellular cardiology.

The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus.

W. Engel, P. Burfeind, R. Trappe, 2002, Biochemical and biophysical research communications.

A 74-bp promoter of the Tnp2 gene confers testis- and spermatid-specific expression in transgenic mice.

W. Engel, K. Nayernia, G. Schlüter, 2001, Biochemical and biophysical research communications.

The nucleotide sequence of human transition protein 1 cDNA.

W. Engel, H. Luerssen, S. Hoyer-Fender, 1988, Nucleic acids research.

Nucleotide sequence and exon-intron structure of the bovine transition protein 1 gene.

W. Engel, Y. Kim, H. Kremling, 1992, DNA sequence : the journal of DNA sequencing and mapping.

Validity of Prior Absorption of Serum Samples with Reiter's Spirochetes in Serological Diagnosis of Borrelia burgdorferi Infections

S. Batsford, A. Vogt, W. Engel, 2000, European Journal of Clinical Microbiology and Infectious Diseases.

Intra‐acrosomally located acrosin‐inhibitors: Evolution and developmental patterns in mammals

W. Engel, W. Müller-Esterl, H. Tschesche, 1984 .

The nucleotide sequence of rat transition protein 2 (TP2) cDNA.

W. Engel, H. Luerssen, S. Hoyer-Fender, 1989, Nucleic acids research.

The gene encoding the human preproacrosin (ACR) maps to the q13-qter region on chromosome 22

I. Adham, W. Engel, A. G. V. Geurts van Kessel, 1989, Human Genetics.

Reprogramming Male Germ Cells to Pluripotent Stem Cells

G. Hasenfuss, W. Engel, O. Brüstle, 2009 .

L. Opitz, W. Engel, R. Dressel, 2012, PloS one.

Rat sperm acrosin: cDNA sequence, derived primary structure and phylogenetic origin.

W. Engel, U. Klemm, A. Flake, 1991, Biochimica et biophysica acta.

Cytogenetic characterization of the TM4 mouse Sertoli cell line. I. Conventional banding techniques, FISH and SKY

C. Steinlein, M. Schmid, W. Engel, 2001, Cytogenetic and Genome Research.

Rat transition nuclear protein 2 regulatory region directs haploid expression of reporter gene in male germ cells of transgenic mice *

W. Engel, K. Nayernia, G. Schlüter, 2001, Molecular reproduction and development.

Generation and Characterization of Yeast Two-Hybrid cDNA Libraries Derived From Two Distinct Mouse Pluripotent Cell Types

W. Engel, J. Pyczek, D. V. K. Pantakani, 2012, Molecular Biotechnology.

Embryonic stem cell-related miRNAs are involved in differentiation of pluripotent cells originating from the germ line.

A. Pantazi, L. Opitz, C. Stewart, 2010, Molecular human reproduction.

Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles.

G. Hasenfuss, W. Engel, K. Nayernia, 2008, Molecular human reproduction.

Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo

T. Renné, I. Adham, W. Engel, 2004, Thrombosis and Haemostasis.

I. Adham, W. Engel, J. Emmen, 2000, Endocrinology.

Studies on the genetic polymorphism of lactate dehydrogenase B (phenotype B−) in rodent erythrocytes

W. Engel, U. Wolf, R. Kreutz, 1972, Biochemical Genetics.

Early developmental changes of the lactate dehydrogenase isoenzyme pattern in mouse, rat, guinea-pig, Syrian hamster and rabbit

W. Engel, U. Petzoldt, 2004, Humangenetik.

Clonal occurrence of a chromosome Dq-in myelosclerosis with myeloid metaplasia

W. Engel, U. Wolf, H. Merker, 2004, Humangenetik.

Nucleotide sequence of a cDNA encoding rat protamine and the haploid expression of the gene during rat spermatogenesis.

S. Hake, W. Engel, P. Burfeind, 1989, Biological chemistry Hoppe-Seyler.