J. A. Parker

发表

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

Jean-Philippe Vert, Wange Lu, Christian Neri, 2014, PLoS biology.

Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans

J. A. Parker, A. Ashe, Arnaud Tauffenberger, 2014, PLoS genetics.

Rescue of ATXN3 neuronal toxicity in Caenorhabditis elegans by chemical modification of endoplasmic reticulum stress

J. A. Parker, Arnaud Tauffenberger, Yasmin Fardghassemi, 2017, Disease Models & Mechanisms.

Rescue of ATXN3 neuronal toxicity in Caenorhabditis elegans by chemical modification of endoplasmic reticulum stress

J. A. Parker, Arnaud Tauffenberger, Yasmin Fardghassemi, 2017, Disease Models & Mechanisms.

Explorer G 3 BP 1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA

Christos G. Gkogkas, N. Leclerc, N. Sonenberg, 2017 .

G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA

Christos G. Gkogkas, N. Leclerc, N. Sonenberg, 2015, The Journal of cell biology.

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

P. Drapeau, J. A. Parker, E. Kabashi, 2013, Neurobiology of Disease.

Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity

J. A. Parker, Arnaud Tauffenberger, C. Julien, 2013, Neurobiology of Aging.

A single copy transgenic mutant FUS strain reproduces age-dependent ALS phenotypes in C. elegans

J. A. Parker, C. Maios, A. Labarre, 2021, microPublication biology.

The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis

R. Robitaille, P. Drapeau, J. A. Parker, 2019, Neurotherapeutics.

FET proteins regulate lifespan and neuronal integrity

G. Rouleau, J. A. Parker, P. Dion, 2016, Scientific Reports.

Deletion of C9ORF72 Results in Motor Neuron Degeneration and Stress Sensitivity in C. elegans

G. Rouleau, J. A. Parker, P. Dion, 2013, PloS one.

Fishing for causes and cures of motor neuron disorders

P. Drapeau, J. A. Parker, E. Kabashi, 2014, Disease Models & Mechanisms.

Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects

Babykumari P. Chitramuthu, J. A. Parker, A. Bateman, 2021, Proceedings of the National Academy of Sciences.

Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms.

G. Rouleau, P. Drapeau, J. A. Parker, 2016, Human molecular genetics.

TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia

L. Zinman, P. Legault, M. Tétreault, 2021, Brain : a journal of neurology.

TDP-43 stabilizes transcripts encoding stress granule protein G3BP1: potential relevance to ALS/FTD

L. Zinman, P. Legault, M. Tétreault, 2020, bioRxiv.

Glucose delays age-dependent proteotoxicity

J. A. Parker, A. Aulas, C. V. Velde, 2012, Aging cell.

TMEM106B, an unexpected point of contact between FTD, ageing and a hypomyelination disorder.

J. A. Parker, A. Bateman, J. J. Doyle, 2020, Brain : a journal of neurology.

Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression

J. A. Parker, É. Samarut, N. Pilon, 2021, EMBO reports.

C. elegans Neurons Jettison Protein Aggregates and Mitochondria Under Neurotoxic Stress

D. Hall, M. Driscoll, Girish Harinath, 2017, Nature.

Simple animal models for amyotrophic lateral sclerosis drug discovery

P. Drapeau, J. A. Parker, X. Wen, 2016, Expert opinion on drug discovery.

Deciphering genetic interactions between ALS genes using C. elegans

J. A. Parker, Martine Therrien, 2014, Worm.

Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans

M. Markaki, J. A. Parker, Martine Therrien, 2014, Front. Genet..

Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans

G. Rouleau, P. Drapeau, J. A. Parker, 2012, PloS one.

Worms on the spectrum - C. elegans models in autism research

J. A. Parker, Kathrin Schmeisser, Alex J. Parker, 2018, Experimental Neurology.

A rapid chemical-genetic screen utilizing impaired movement phenotypes in C. elegans: Input into genetics of neurodevelopmental disorders

J. A. Parker, Yasmin Fardghassemi, Kathrin Schmeisser, 2017, Experimental Neurology.

Integration of β-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity

C. Tourette, F. Farina, R. Vázquez-Manrique, 2012, The Journal of Neuroscience.

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

Christian Néri, Emmanuel Lambert, C. Tourette, 2005, Nature Genetics.

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

E. Hirsch, M. Guillermier, S. Humbert, 2006, The Journal of clinical investigation.

Pleiotropic Effects of mTOR and Autophagy During Development and Aging

J. A. Parker, Kathrin Schmeisser, 2019, Front. Cell Dev. Biol..

Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C. elegans

B. Brais, G. Rouleau, J. A. Parker, 2010, Neurobiology of Disease.

Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy

J. A. Parker, C. Maios, S. A. Patten, 2020, Disease Models & Mechanisms.

Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.

O. Suchowersky, G. Rouleau, P. Drapeau, 2016, American journal of human genetics.

Genetic and pharmacological PARP inhibition reduces axonal degeneration in C. elegans models of ALS.

J. A. Parker, C. Maios, A. Labarre, 2022, Human molecular genetics.

TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans

L. Petrucelli, J. A. Parker, Y. Carlomagno, 2012, PLoS genetics.

Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans

M. Prentki, J. A. Parker, S. Madiraju, 2022, Nature Communications.

Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.

B. Brais, G. Rouleau, C. Tourette, 2008, Human molecular genetics.

Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans

J. A. Parker, C. Néri, S. Holbert, 2007, Journal of Molecular Neuroscience.

Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS).

J. A. Parker, Martine Therrien, G. Beaudry, 2016, Journal of agricultural and food chemistry.

Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy

J. A. Parker, Kathrin Schmeisser, J. Alex Parker, 2018, PLoS genetics.

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.

Babykumari P. Chitramuthu, J. A. Parker, A. Bateman, 2013, Human molecular genetics.

Huntingtin-Interacting Protein 1 Influences Worm and Mouse Presynaptic Function and Protects Caenorhabditis elegans Neurons against Mutant Polyglutamine Toxicity

J. Roder, M. Hayden, J. A. Parker, 2007, The Journal of Neuroscience.

Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.

S. Hébert, F. Cicchetti, Stephanie L Bissonnette, 2015, Human molecular genetics.

Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis

Jason R. Neuswanger, Elena M. Vayndorf, M. Driscoll, 2016, npj Aging and Mechanisms of Disease.

Fragile lifespan expansion by dietary mitohormesis in C. elegans

J. A. Parker, Arnaud Tauffenberger, Alexandra Vaccaro, 2016, Aging.

Small Molecule Rescue of ATXN3 Toxicity in C. elegans via TFEB/HLH-30

J. A. Parker, C. Maios, Yasmin Fardghassemi, 2021, Neurotherapeutics.

Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio

P. Drapeau, J. A. Parker, E. Kabashi, 2012, PloS one.

TDP-43 Toxicity Proceeds via Calcium Dysregulation and Necrosis in Aging Caenorhabditis elegans Motor Neurons

J. A. Parker, Arnaud Tauffenberger, Dina Aggad, 2014, The Journal of Neuroscience.

The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease

E. Baulieu, F. Farina, J. A. Parker, 2017, Scientific Reports.

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

Daniela C. Zarnescu, D. Dickman, D. Zarnescu, 2023, Cell.

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons

J. A. Parker, Lucresse Fossouo, J. Vérièpe, 2015, Nature Communications.

Overexpression of FKH-2/FOXG1 is neuroprotective in a C. elegans model of Machado-Joseph disease

J. A. Parker, Yasmin Fardghassemi, 2020, Experimental Neurology.

Rescue of ATXN 3 neuronal toxicity in C . elegans by chemical modification of ER stress

J. A. Parker, Arnaud Tauffenberger, Yasmin Fardghassemi, 2017 .

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

Jean-Philippe Vert, L. Mesrob, C. Tourette, 2012, BMC Genomics.

Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo Using Caenorhabditis elegans.

J. A. Parker, J. J. Doyle, 2018, Methods in molecular biology.

Mimicking of tau hyperphosphorylation in GABAergic motoneurons of C. elegans induces severe peripheral and neuronal alterations

N. Leclerc, J. A. Parker, J. Pilliod, 2023, bioRxiv.

Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.

O. Suchowersky, G. Rouleau, P. Drapeau, 2016, American journal of human genetics.

Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons

Elena M. Vayndorf, M. Driscoll, J. A. Parker, 2014, Front. Genet..