J. Windle

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TBK1 Mediates Critical Effects of Measles Virus Nucleocapsid Protein (MVNP) on Pagetic Osteoclast Formation

D. Galson, Quanhong Sun, G. Roodman, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

P. Fortina, Zuoren Yu, T. Hyslop, 2009, Proceedings of the National Academy of Sciences.

Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice.

D. Whyte, J. Windle, E. Alarid, 1996, Development.

Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo

Richard J. Lee, J. Engelman, M. Lisanti, 1998, The Journal of Biological Chemistry.

Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of the gonadotrope lineage.

B. Hille, M. Bosma, J. Windle, 1991, Molecular endocrinology.

Split Tolerance in a Novel Transgenic Model of Autoimmune Myasthenia Gravis1

K. A. Wall, J. Windle, B. Gelb, 2002, The Journal of Immunology.

MDA-9/Syntenin (SDCBP) Is a Critical Regulator of Chemoresistance, Survival and Stemness in Prostate Cancer Stem Cells

P. Fisher, J. Windle, D. Sarkar, 2019, Cancers.

Bone Marrow Monocyte / Macrophage Derived Activin A Mediates the Osteoclastogenic Effect of IL-3 in Multiple Myeloma

F. Aversa, G. Roodman, J. Windle, 2013, Leukemia.

High mobility group box 1 protein regulates osteoclastogenesis through direct actions on osteocytes and osteoclasts in vitro

M. Subler, J. Windle, L. Plotkin, 2019, Journal of cellular biochemistry.

Death at an early age. Apoptosis in inherited retinal degenerations.

J. Windle, D. Papermaster, 1995, Investigative ophthalmology & visual science.

Osteoblastic cell lines derived from a transgenic mouse containing the osteocalcin promoter driving SV40 T-antigen

L. Bonewald, J. Wozney, J. Windle, 1995 .

Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice.

J. Wozney, J. Windle, N. Ghosh-Choudhury, 1996, Endocrinology.

The Xenopus ribosomal DNA 60- and 81-base-pair repeats are position-dependent enhancers that function at the establishment of the preinitiation complex: analysis in vivo and in an enhancer-responsive in vitro system

J. Windle, E. Mougey, B. Sollner-Webb, 1989, Molecular and cellular biology.

Engineering T Cells to Express Tumoricidal MDA-7/IL24 Enhances Cancer Immunotherapy

P. Fisher, Xia Li, H. Bear, 2021, Cancer Research.

Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte‐Elevated Gene‐1/Metadherin

P. Fisher, I. Banerjee, M. Subler, 2021, Hepatology communications.

Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.

N. Mukhopadhyay, P. Fisher, M. Subler, 2018, Cancer research.

Genetic deletion of AEG-1 prevents hepatocarcinogenesis.

P. Fisher, M. Subler, J. Windle, 2014, Cancer research.

Knockout of MDA-9/Syntenin (SDCBP) expression in the microenvironment dampens tumor-supporting inflammation and inhibits melanoma metastasis

P. Fisher, M. Subler, J. Windle, 2016, Oncotarget.

Transgenic models of retinoblastoma: what they tell us about its cause and treatment.

P. Lambert, D. Albert, J. Windle, 1994, Transactions of the American Ophthalmological Society.

Astrocyte elevated gene‐1 promotes hepatocarcinogenesis: Novel insights from a mouse model

N. Mukhopadhyay, P. Fisher, K. Shah, 2012, Hepatology.

Retinoblastoma in transgenic mice: models of hereditary retinoblastoma.

M. Mills, D. Albert, J. Windle, 1999, Survey of ophthalmology.

Posttranscriptional Inhibition of Protein Tyrosine Phosphatase Nonreceptor Type 23 by Staphylococcal Nuclease and Tudor Domain Containing 1: Implications for Hepatocellular Carcinoma

N. Mukhopadhyay, P. Fisher, Yidong Chen, 2019, Hepatology communications.

Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo.

J. Chirgwin, D. Dempster, Hua Zhou, 2020, JCI insight.

Phenotypic characterization of transgenic mice harboring Nf1+/− or Nf1−/− osteoclasts in otherwise Nf1+/+ background

S. Peltonen, J. Peltonen, K. Väänänen, 2012, Journal of cellular biochemistry.

ADAM8 Enhances Osteoclast Precursor Fusion and Osteoclast Formation In Vitro and In Vivo

M. Subler, D. Galson, G. Roodman, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.

Jacques P. Brown, J. Morissette, D. Dempster, 2011, Cell metabolism.

A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment.

D. Dempster, Hua Zhou, M. Subler, 2008, Human molecular genetics.

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.

D. Dempster, Hua Zhou, M. Subler, 2007, The Journal of clinical investigation.

α9β1: A Novel Osteoclast Integrin That Regulates Osteoclast Formation and Function

D. Sheppard, G. Roodman, N. Kurihara, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and Adrenals

M. Subler, J. Windle, J. Strauss, 2020, International journal of molecular sciences.

3.6 kb of the 5′ Flanking DNA Activates the Mouse Tyrosine Hydroxylase Gene Promoter Without Catecholaminergic‐Specific Expression

Z. D. Sharp, J. Windle, C. Walter, 1996, Journal of neurochemistry.

Antitumor Efficacy of a Farnesyltransferase Inhibitor in Transgenic Mice

J. Windle, N. Kohl, J. Gibbs, 2001 .

Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis*

P. Fisher, G. Sundaresan, M. Subler, 2015, Journal of Biological Chemistry.

Gonadotropin-releasing hormone neuronal cell lines.

W. Wetsel, J. Windle, P. Mellon, 1992, Frontiers in neuroendocrinology.

Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.

M. Subler, J. Windle, X. Fang, 2008, Molecular biology of the cell.

Blocking the ZZ Domain of Sequestosome1/p62 Suppresses Myeloma Growth and Osteoclast Formation In Vitro and Induces Dramatic Bone Formation in Myeloma-Bearing Bones In Vivo

Wei Zhao, X. Xie, K. Mohammad, 2015, Leukemia.

A novel role of astrocyte elevated gene‐1 (AEG‐1) in regulating nonalcoholic steatohepatitis (NASH)

N. Mukhopadhyay, P. Fisher, Yidong Chen, 2017, Hepatology.

Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma.

P. Fisher, M. Subler, J. Windle, 2017, Cancer research.

Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific protein

K. Barnhart, J. Windle, F. Horn, 1992, Molecular and cellular biology.

Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53

S. Hilsenbeck, D. Troyer, M. Subler, 1997, Molecular and cellular biology.

Combretastatin A-4 prodrug in the treatment of a murine model of retinoblastoma.

W. Feuer, J. Windle, M. Jockovich, 2005, Investigative ophthalmology & visual science.

Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice.

J. Wozney, J. Windle, G. Mundy, 1996, Endocrinology.

Paget disease of bone.

J. Windle, G. David Roodman, G. Roodman, 2005, The Journal of clinical investigation.

Paget disease of bone.

J. Windle, G. Roodman, 2005, Radiographics : a review publication of the Radiological Society of North America, Inc.

Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice.

S. Reddy, D. Galson, N. Kurihara, 1998, The Journal of clinical investigation.

Osteoclast‐specific inactivation of the integrin‐linked kinase (ILK) inhibits bone resorption

S. Dedhar, G. Roodman, J. Windle, 2010, Journal of cellular biochemistry.

Genetically Engineered Mouse Models of Retinoblastoma

J. Windle, 2003 .

Half helical turn spacing changes convert a frog into a mouse rDNA promoter: a distant upstream domain determines the helix face of the initiation site.

J. Windle, B. Sollner-Webb, L. Pape, 1990, Genes & development.

Two homogeneous immunoassays for pyridoxamine.

J. Windle, D. Brandon, J. Corse, 1985, Journal of immunological methods.

Trilateral tumors in four different lines of transgenic mice expressing SV40 T-antigen.

M. Al-Ubaidi, D. Albert, J. Windle, 1996, Investigative ophthalmology & visual science.

Immortalized hypothalamic gonadotropin-releasing hormone neurons.

W. Wetsel, D. Whyte, M. Valença, 2007, Ciba Foundation symposium.

Trilateral retinoblastoma in transgenic mice.

J. O'Brien, D. Albert, J. Windle, 1989, Transactions of the American Ophthalmological Society.

Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts.

S. Reddy, J. Windle, R. Devlin, 1995, Endocrinology.

Upstream domains of the Xenopus laevis rDNA promoter are revealed in microinjected oocytes

J. Windle, B. Sollner-Webb, B. Sollner‐Webb, 1986, Molecular and cellular biology.

Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease

K. Mohammad, N. Kurihara, J. Windle, 2020, Journal of cellular biochemistry.

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease.

Jacques P. Brown, K. Mohammad, G. Roodman, 2016, The Journal of clinical investigation.

Intraflagellar transporter protein 140 (IFT140), a component of IFT‐A complex, is essential for male fertility and spermiogenesis in mice

G. Pazour, J. Windle, Zhibing Zhang, 2018, Cytoskeleton.

Two distant and precisely positioned domains promote transcription of Xenopus laevis rRNA genes: analysis with linker-scanning mutants

J. Windle, B. Sollner-Webb, 1986, Molecular and cellular biology.

In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.

Amy J. Hawkins, K. Valerie, M. Subler, 2009, DNA repair.

Local carboplatin therapy in transgenic murine retinoblastoma.

J. O'Brien, D. Hamasaki, J. Windle, 1996, Investigative ophthalmology & visual science.

Apoptosis in the Murine rd 1 Retinal Degeneration is Predominantly p 53-Independent

S. Hilsenbeck, J. Windle, D. Papermaster, 1998 .

APOPTOSIS OF PHOTORECEPTORS AND LENS FIBER CELLS WITH CATARACT AND MULTIPLE TUMOR FORMATION IN THE EYES OF TRANSGENIC MICE LACKING THE P53 GENE AND EXPRESSING THE HPV 16 E7 GENE UNDER THE CONTROL OF THE IRBP PROMOTER

J. Windle, K. Howes, D. Papermaster, 1995 .

Advances in Brief Differential Regulation of Cell Cycle Characteristics and Apoptosis in MMTV-myc and MMTV-ras Mouse Mammary Tumors '

S. Hilsenbeck, D. Troyer, Steven, 2006 .

Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumors.

S. Hilsenbeck, D. Troyer, J. Windle, 1997, Cancer research.

Gonadotropin-releasing hormone receptor expression in Xenopus oocytes.

S. Sealfon, E. Landau, J. Roberts, 1990, Molecular endocrinology.

PDGF-BB secreted by preosteoclasts induces CD31hiEmcnhi vessel subtype in coupling osteogenesis

L. Duong, L. Xian, Wei-zhong Chang, 2014, Nature Medicine.

Role of ATF7‐TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease

Jacques P. Brown, D. Dempster, Hua Zhou, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

D. Albert, J. Windle, K. Howes, 1994, Genes & development.

p53-independent response to cisplatin and oxaliplatin in MMTV-ras mouse salivary tumors.

D. Troyer, T. Petit, J. Windle, 2003, Molecular cancer therapeutics.

AEG-1 regulates retinoid X receptor and inhibits retinoid signaling.

N. Mukhopadhyay, P. Fisher, K. Shah, 2014, Cancer research.

A transgenic mouse model for trilateral retinoblastoma.

J. O'Brien, D. Albert, J. Windle, 1990, Archives of ophthalmology.

Immortalization of neuroendocrine cells by targeted oncogenesis.

J. Windle, P. Mellon, R. Weiner, 1991, Recent progress in hormone research.

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

J. Windle, James L. Roberts, P. Mellon, 1990, Neuron.

Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis.

J. Roberts, J. Windle, P. Mellon, 1990, Neuron.

Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice.

J. Windle, P. Mellon, R. Weiner, 1990, Molecular endocrinology.

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

Gang Li, J. Windle, G. Li, 2011, Cell Death and Differentiation.

Comparison of Effects of p53 Null and Gain-of-Function Mutations on Salivary Tumors in MMTV-Hras Transgenic Mice

M. Subler, J. Windle, V. Ramakrishnan, 2015, PloS one.

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.

E K Rowinsky, D. V. Von Hoff, J. Windle, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Blunted Amphetamine-induced Reinforcing Behaviors and Transporter Downregulation in Knock-in Mice Carrying Alanine Mutations at Threonine-258 and Serine-259 of Norepinephrine Transporter

M. Subler, J. Windle, S. Ramamoorthy, 2022, Journal of Molecular Neuroscience.

Osteoclasts are important for bone angiogenesis.

S. Shapiro, G. Roodman, J. Windle, 2010, Blood.

Employing a transgenic animal model to obtain cementoblasts in vitro.

J. Windle, M. Somerman, J. Berry, 2000, Journal of periodontology.

Expression of a retinoblastoma transgene results in dwarf mice.

Y. Chen, D. Riley, W. Lee, 1993, Genes & development.

Establishment of an Osteocyte‐like Cell Line, MLO‐Y4

L. Bonewald, J. Windle, G. Mundy, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Genetically engineered mice as experimental tools to dissect the critical events in breast cancer.

P. Fisher, J. Windle, D. Sarkar, 2014, Advances in cancer research.

Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation.

G. Roodman, N. Kurihara, J. Windle, 2008, Blood.

Retinoblastoma in transgenic mice

Daniel M. Albert, C. Disteche, J. O'Brien, 1990, Nature.

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model

Lisa M. Christadore, S. Schaus, P. Fisher, 2015, Oncotarget.

Astrocyte elevated gene‐1 and c‐Myc cooperate to promote hepatocarcinogenesis in mice

N. Mukhopadhyay, P. Fisher, Yidong Chen, 2015, Hepatology.

Characterization of the mouse tartrate‐resistant acid phosphatase (trap) gene promoter

S. Reddy, J. Windle, R. Leach, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Ultrastructure of Bone Cells in Paget's Disease of Bone

J. Windle, H. Gruber, G. Roodman, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

D. Troyer, M. Subler, J. Windle, 1998, Molecular and Cellular Biology.

Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency

D. Judge, T. Park, D. Tian, 2019, PLoS genetics.

Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors

D. Troyer, M. Subler, J. Windle, 2000, Oncogene.

Photoreceptor cell tumors in transgenic mice.

D. Albert, J. Windle, K. Howes, 1994, Investigative ophthalmology & visual science.

The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

S. Grossman, S. Deb, S. Deb, 2021, Nature Communications.

Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice

G. Otterson, M. Subler, Wei-Guo Zhu, 2002, Oncogene.

Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties.

D. Troyer, Richard J Lee, J. Windle, 2002, Cancer research.

Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent.

S. Hilsenbeck, J. Windle, D. Papermaster, 1998, Molecular vision.

Cloning and characterization of the 5′‐flanking region of the mouse tartrate‐resistant acid phosphatase gene

J. Chirgwin, S. Reddy, J. Windle, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cyclin kinase inhibitor p21 potentiates bile acid–induced apoptosis in hepatocytes that is dependent on p53

P. Fisher, P. Dent, S. Grant, 2002, Hepatology.

Autoimmune Myasthenia Gravis Split Tolerance in a Novel Transgenic Model Infante and

J. Windle, B. Gelb, E. Kraig, 2002 .

Humanizing mouse folate metabolism: conversion of the dual‐promoter mouse folylpolyglutamate synthetase gene to the human single‐promoter structure

J. Windle, Shirley M. Taylor, R. Moran, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Metazoan rDNA enhancer acts by making more genes transcriptionally active

B Sollner-Webb, M. O'Reilly, J. Windle, 1996, The Journal of cell biology.

Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts.

S. Reddy, N. Kurihara, J. Windle, 2001, Endocrinology.

Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein

P. Fisher, W. Cavenee, M. Subler, 2021, International journal of molecular sciences.

MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer

P. Fisher, M. C. Archer, M. Subler, 2015, Oncotarget.

Neural tissue within anterior pituitary tumors generated by oncogene expression in transgenic mice.

J. Windle, P. Mellon, J. Schechter, 1992, Neuroendocrinology.

Radiation therapy and ferromagnetic hyperthermia in the treatment of murine transgenic retinoblastoma.

A. Markoe, J. O'Brien, D. Albert, 1996, Archives of ophthalmology.

Local carboplatin and radiation therapy in the treatment of murine transgenic retinoblastoma.

A. Markoe, J. O'Brien, W. Feuer, 1996, Archives of ophthalmology.

Experimental Models of Paget's Disease

Hua Zhou, M. Subler, S. Reddy, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Expression of Measles Virus Nucleocapsid Protein in Osteoclasts Induces Paget's Disease‐Like Bone Lesions in Mice

D. Dempster, Hua Zhou, M. Subler, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

IGFBP7 Deletion Promotes Hepatocellular Carcinoma.

P. Fisher, Xia Li, Yidong Chen, 2017, Cancer research.

Increased IL‐6 Expression in Osteoclasts Is Necessary But Not Sufficient for the Development of Paget's Disease of Bone

Hua Zhou, M. Subler, D. Galson, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Initial characterization of behavior and ketamine response in a mouse knockout of the post-synaptic effector gene Anks1b

J. McClay, E. Oord, M. Subler, 2017, Neuroscience Letters.

Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor

H. Harada, J. Windle, Amanda C. Richardson, 2013, PloS one.

StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis[S]

E. Gratton, M. Subler, J. Windle, 2019, Journal of Lipid Research.

MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells

P. Fisher, W. Cavenee, F. Furnari, 2018, Proceedings of the National Academy of Sciences.

Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin

P. Fisher, W. Cavenee, F. Furnari, 2018, Autophagy.

Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling.

D. Galson, Quanhong Sun, G. Roodman, 2013, Bone.