H. Ichijo

S. Shioda, H. Ichijo, S. Sasaki, 1989, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

The cytoplasmic domain of Alzheimer’s amyloid- protein precursor causes sustained ASK1/JNK mediated neurotoxic signal via dimerization

I. Nishimoto, H. Ichijo, H. Nishitoh, 2003 .

Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases

H. Ichijo, S. Bhakdi, M. Husmann, 2005, Cell Death and Differentiation.

Transforming growth factor-beta: latent forms, binding proteins and receptors.

K. Miyazono, C. Heldin, H. Ichijo, 1993, Growth factors.

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases.

H. Ichijo, I. Naguro, T. Nakmura, 2019, Biochimica et biophysica acta. General subjects.

Localization of transforming growth factor-beta type I and type II receptors in mouse development.

K. Miyazono, Y. Hayashi, H. Ichijo, 1995, Experimental cell research.

CHIP‐dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

H. Shibuya, Keiji Tanaka, H. Ichijo, 2010, The EMBO journal.

Stress-responsive protein kinases in redox-regulated apoptosis signaling.

H. Ichijo, A. Matsuzawa, 2005, Antioxidants & redox signaling.

Receptors for transforming growth factor-beta.

K. Miyazono, C. Heldin, H. Ichijo, 1994, Advances in immunology.

Liver Protection from Apoptosis Requires Both Blockage of Initiator Caspase Activities and Inhibition of ASK1/JNK Pathway via Glutathione S-Transferase Regulation*

D. Lagadic-Gossmann, D. Gilot, A. Atfi, 2002, The Journal of Biological Chemistry.

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

R A Knight, G Melino, G M Cohen, 2009, Cell Death and Differentiation.

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

H. Ichijo, K. Takeda, H. Nishitoh, 2013, Molecular cell.

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

D. Riddle, K. Miyazono, C. Heldin, 1994, The Journal of biological chemistry.

Pathophysiological roles of ASK1-MAP kinase signaling pathways.

H. Ichijo, K. Takeda, T. Noguchi, 2007, Journal of biochemistry and molecular biology.

Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1*

K. Kang, Ssang-Goo Cho, H. Ichijo, 2001, The Journal of Biological Chemistry.

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling.

H. Ichijo, A. Matsuzawa, Hidenori Ichijo, 2008, Biochimica et biophysica acta.

Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes.

P. Agostinis, H. Ichijo, A. Van Laethem, 2006, Free radical biology & medicine.

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.

M. Karin, M. Omata, H. Ichijo, 2008, Gastroenterology.

Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5*

K. Miyazono, H. Ichijo, A. Yamaguchi, 1996, The Journal of Biological Chemistry.

ASK1 regulates influenza virus infection-induced apoptotic cell death.

Kazufumi Shimizu, Yasuhiro Gon, T. Horie, 2003, Biochemical and biophysical research communications.

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

T Takahashi, T. Noda, K. Miyazono, 2001, EMBO reports.

From receptors to stress-activated MAP kinases

H. Ichijo, Hidenori Ichijo, 1999, Oncogene.

ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

A. Ryo, A. Kudoh, H. Ichijo, 2015, Nature Communications.

The roles of ASK family proteins in stress responses and diseases

H. Ichijo, Christopher Runchel, K. Hattori, 2009, Cell Communication and Signaling.

The ASK1-MAP kinase cascades in mammalian stress response.

H. Ichijo, K. Takeda, A. Matsuzawa, 2004, Journal of biochemistry.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

Tohru Natsume, Yusuke Sekine, Hideyuki Kinoshita, 2009, Proceedings of the National Academy of Sciences.

The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis

Toshitaka Nakamura, H. Ichijo, K. Hattori, 2021, EMBO reports.

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M

Kazuhito Yamamoto, S. Korsmeyer, H. Ichijo, 1999, Molecular and Cellular Biology.

Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation

H. Kajiho, T. Katada, H. Nishina, 2006, The EMBO journal.

Pleiotropic properties of ASK1.

H. Ichijo, K. Hattori, Chihiro Sakauchi, 2017, Biochimica et biophysica acta. General subjects.

ASK1-signaling promotes c-Myc protein stability during apoptosis.

K. Noguchi, C. Kitanaka, H. Ichijo, 2001, Biochemical and biophysical research communications.

The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses

H. Ichijo, K. Takeda, Shiori Sekine, 2012, Journal of signal transduction.

Cell volume regulation in cancer cell migration driven by osmotic water flow

Kengo Watanabe, H. Ichijo, Kazuhiro Morishita, 2019, Cancer science.

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

K. Miyazono, P. Dijke, H. Ichijo, 1994, The Journal of biological chemistry.

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.

Kiyoshi Inoue, H. Ichijo, K. Takeda, 2002, Genes & development.

Physiological Roles of ASK 1-Mediated Signal Transduction in Oxidative Stress-and Endoplasmic Reticulum Stress-Induced Apoptosis : Advanced Findings from ASK 1 Knockout Mice

H. Ichijo, K. Takeda, H. Nishitoh, 2003 .

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

H. Ichijo, K. Takeda, H. Nishitoh, 2002, Antioxidants & redox signaling.

Apoptosis signaling kinases: from stress response to health outcomes.

H. Ichijo, K. Takeda, H. Nishitoh, 2011, Antioxidants & redox signaling.

A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.

Tsuyoshi Umeda, Kengo Watanabe, H. Ichijo, 2018, Cell reports.

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Hiromi Nakamura, S. Kōzuma, Y. Taketani, 2009, The EMBO journal.

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

Ryuji Kaji, Keiko Imamura, Shinya Yamanaka, 2017, Science Translational Medicine.

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

H. Kaneto, T. Matsuoka, Y. Nakatani, 2004, Nature Medicine.

Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities

S. Chi, Mi-Sung Kim, Ssang-Goo Cho, 2003, The Journal of cell biology.

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways*

T. Fojo, P. Giannakakou, H. Ichijo, 1998, The Journal of Biological Chemistry.

Mislocalization, aggregation formation and defect in proteolysis in ALS

H. Ichijo, Kengo Homma, A. Tsubota, 2016 .

Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation

K. Miyazono, D. Delia, M. Asada, 1999, The EMBO journal.

The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases.

H. Ichijo, K. Takeda, Y. Sekine, 2006, Current molecular medicine.

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1).

Shile Huang, P. Houghton, J. Easton, 2003, Molecular cell.

Stress signaling in cancer

H. Ichijo, K. Takeda, T. Noguchi, 2007, Cancer science.

Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor

K. Miyazono, C. Heldin, P. Dijke, 1993, Cell.

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation

T. Soga, H. Ichijo, M. Arita, 2022, The Journal of biological chemistry.

Latent form of transforming growth factor-beta 1 acts as a potent growth inhibitor on a human erythroleukemia cell line.

K. Miyazono, K. Miyagawa, H. Ichijo, 1990, Biochemical and biophysical research communications.

ASK1 signalling regulates brown and beige adipocyte function

H. Ichijo, K. Takeda, T. Funatsu, 2016, Nature Communications.

Title ASK 1 restores the antiviral activity of APOBEC 3 G bydisrupting HIV-1 Vif-mediated counteraction

A. Ryo, A. Kudoh, H. Ichijo, 2017 .

Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.

T. Miyashita, H. Fu, H. Ichijo, 2004, Experimental cell research.

The Cell Cycle-Regulatory CDC25A Phosphatase Inhibits Apoptosis Signal-Regulating Kinase 1

H. Kiyokawa, H. Ichijo, X. Zou, 2001, Molecular and Cellular Biology.

Microtubule Dysfunction Induced by Paclitaxel Initiates Apoptosis through Both c-Jun N-terminal Kinase (JNK)-dependent and -Independent Pathways in Ovarian Cancer Cells*

D. Henley, H. Ichijo, J. Wimalasena, 1999, The Journal of Biological Chemistry.

Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptor in Vivo*

K. Miyazono, H. Moses, M. Kawabata, 1996, The Journal of Biological Chemistry.

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

H. Ichijo, H. Nishitoh, H. Matsuura, 2001, The EMBO journal.

The ASK1-MAP kinase pathways in immune and stress responses.

H. Ichijo, K. Takeda, A. Matsuzawa, 2006, Microbes and infection.

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Kunihiro Matsumoto, H. Ichijo, S. Koyasu, 2005, Nature Immunology.

Serine/threonine kinase receptors.

K. Miyazono, C. Heldin, P. Dijke, 1994, Progress in growth factor research.

Characterization of type I receptors for transforming growth factor-beta and activin.

K. Miyazono, C. Heldin, M. Laiho, 1994, Science.

Biological effects and binding properties of transforming growth factor-β on human oral squamous cell carcinoma cells

K. Miyazono, H. Ichijo, F. Momose, 1990 .

Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.

M. Otsuka, M. Omata, H. Ichijo, 2010, Gastroenterology.

Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy

M. Hori, M. Taniike, K. Otsu, 2008, Circulation.

Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons

L. Rubin, K. Miyazono, T. Kanamoto, 2000, Molecular and Cellular Biology.

Signaling pathways in invertebrate immune and stress response

H. Ichijo, K. Takeda, Y. Sekine, 2009 .

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A*

H. Ichijo, T. Mitchell, A. Matsuzawa, 2009, The Journal of Biological Chemistry.

Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system

H. Ichijo, K. Takeda, 2002, Genes to cells : devoted to molecular & cellular mechanisms.

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

K. Miyazono, C. Heldin, H. Ichijo, 1993, Oncogene.

Cryo-EM structures of the human volume-regulated anion channel LRRC8

O. Nureki, M. Hattori, Kengo Watanabe, 2018, Nature Structural & Molecular Biology.

Cloning and Characterization of p70S6KβDefines a Novel Family of p70 S6 Kinases

K. Miyazono, P. Dijke, H. Ichijo, 1998 .

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

T. Taniguchi, M. Kiso, Y. Kawaoka, 2015, Science Signaling.

Apoptosis Signal-regulating Kinase 1 (ASK1) Is an Intracellular Inducer of Keratinocyte Differentiation*

K. Sayama, Y. Hanakawa, Y. Shirakata, 2001, The Journal of Biological Chemistry.

ASK1 Inhibits Interleukin-1-induced NF-κB Activity through Disruption of TRAF6-TAK1 Interaction*

K. Matsumoto, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2000, The Journal of Biological Chemistry.

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.

Xin Zhao, H. Ichijo, Xin Zhao, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a Novel Bone Morphogenetic Protein-responsive Gene That May Function as a Noncoding RNA*

K. Miyazono, H. Ichijo, K. Takeda, 1998, The Journal of Biological Chemistry.

Involvement of ASK1 in Ca2+‐induced p38 MAP kinase activation

J. Ninomiya-Tsuji, Kunihiro Matsumoto, H. Ichijo, 2004, EMBO reports.

Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin.

H. Ichijo, J. Mizuguchi, E. Takada, 2009, Experimental cell research.

Induction of a Ribotoxic Stress Response That Stimulates Stress-Activated Protein Kinases by 13-Deoxytedanolide, an Antitumor Marine Macrolide

S. Horinouchi, H. Ichijo, Minoru Yoshida, 2006, Bioscience, biotechnology, and biochemistry.

Physiological roles of stress-activated protein kinases in skin

H. Aburatani, K. Moriyama, H. Ichijo, 2005 .

Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.

Hong Zhang, H. Ichijo, K. Saeki, 2002, The Biochemical journal.

Mini-Review Transforming Growth Factor-P: Latent Forms, Binding Proteins and Receptors

K. Miyazono, C. Heldin, H. Ichijo, 1993 .

Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-β (*)

K. Miyazono, H. Ichijo, M. Takagi, 1996, The Journal of Biological Chemistry.

The DEAH-Box RNA Helicase DHX15 Activates NF-κB and MAPK Signaling Downstream of MAVS During Antiviral Responses

H. Ichijo, K. Takeda, T. Nagano, 2014, Science Signaling.

Chk2 kinase is required for methylglyoxal‐induced G2/M cell‐cycle checkpoint arrest: implication of cell‐cycle checkpoint regulation in diabetic oxidative stress signaling

N. Onishi, Y. Minami, H. Ichijo, 2007, Genes to cells : devoted to molecular & cellular mechanisms.

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

Hong Liu, H. Ichijo, J. Kyriakis, 2000, Molecular and Cellular Biology.

Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element.

T. Aso, H. Ichijo, C. Zhang, 2000, Blood.

Roles of MAPKKK ASK1 in stress-induced cell death.

H. Ichijo, K. Takeda, H. Nishitoh, 2003, Cell structure and function.

Roles of MAPKKK ASK1 in stress-induced cell death.

H. Ichijo, K. Takeda, H. Nishitoh, 2003, Cell structure and function.

Apoptosis Signal-regulating Kinase 1 (ASK1) Induces Neuronal Differentiation and Survival of PC12 Cells*

H. Ichijo, K. Takeda, H. Nishitoh, 2000, The Journal of Biological Chemistry.

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

H. Ichijo, K. Takeda, A. Matsuzawa, 2009, Molecular cell.

Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death*

J. Inoue, J. Gohda, H. Nakano, 2005, Journal of Biological Chemistry.

Activation of apoptosis signal‐regulating kinase 1 by the stress‐induced activating phosphorylation of pre‐formed oligomer

H. Ichijo, M. Saitoh, K. Tobiume, 2002, Journal of cellular physiology.

Apoptosis Signal-regulating Kinase (ASK) 2 Functions as a Mitogen-activated Protein Kinase Kinase Kinase in a Heteromeric Complex with ASK1*

H. Ichijo, K. Takeda, A. Matsuzawa, 2007, Journal of Biological Chemistry.

ASK1 promotes uterine inflammation leading to pathological preterm birth

H. Ichijo, Y. Osuga, T. Fujii, 2020, Scientific Reports.

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

T. Natsume, H. Ichijo, S. Iemura, 2012, Molecular cell.

Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity

H. Ichijo, T. Noguchi, S. Yamauchi, 2008 .

ASK Family Proteins in Stress Response and Disease

H. Ichijo, K. Takeda, T. Fujisawa, 2007, Molecular biotechnology.

β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes

T. Natsume, H. Ichijo, K. Hattori, 2020, bioRxiv.

ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

Kengo Watanabe, T. Natsume, H. Ichijo, 2021, Scientific Reports.

ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma

K. Tanaka, H. Ichijo, T. Harada, 2010, Cell Death and Differentiation.

Als-linked Mutant Sod1 Induces Er Stress-and Ask1-dependent Motor Neuron Death by Targeting Derlin-1 -induced Cell Death Remains Controversial. Here We Show That Sod1 Mut Specifically Interacted with Derlin-1, a Component of Endoplasmic Reticulum (er)-associated Degradation (erad) Machinery and Trig

Takanori Yokota, H. Ichijo, K. Takeda, 2022 .

Decreased level of transforming growth factor-beta in blood lymphocytes of patients with aplastic anemia.

K. Miyazono, K. Miyagawa, K. Oshimi, 1992, Growth factors.

The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

H. Ichijo, S. Murata, Jun Hamazaki, 2016, eLife.

Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies

G. Sobue, H. Ichijo, K. Takeda, 1999, Genes to cells : devoted to molecular & cellular mechanisms.

Mitogen-activated protein kinases as key players in osmotic stress signaling.

Kengo Watanabe, H. Ichijo, Xiangyu Zhou, 2016, Biochimica et biophysica acta.

Regulation of Cellular Signalling by Thioredoxin

H. Ichijo, I. Naguro, T. Machida, 2015 .

Apoptosis signal-regulating kinase 1 as a therapeutic target

H. Ichijo, I. Naguro, Yosuke Kawarazaki, 2014, Expert opinion on therapeutic targets.

Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

Z. Ronai, H. Ichijo, P. Aza-Blanc, 2014, Science Signaling.

Stress-Induced Cell Death Regulating ASK1 and Oxidant Is a Molecular Switch ζ Serine 58 of 14-3-3

Anthony J. Muslin, H. Ichijo, T. Force, 2014 .

Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice.

C. Waters, H. Ichijo, S. Sinclair, 2012, American journal of respiratory cell and molecular biology.

Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation

D. German, J. Im, H. Ichijo, 2012, PloS one.

Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice

N. Matsuki, H. Ichijo, K. Takeda, 2010, Neuroscience Research.

Oxidizable Residues Mediating Protein Stability and Cytoprotective Interaction of DJ-1 with Apoptosis Signal-regulating Kinase 1*

Thilo Stehle, T. Stehle, H. Ichijo, 2009, Journal of Biological Chemistry.

Serine 58 of 14-3-3ζ Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

Anthony J. Muslin, H. Ichijo, T. Force, 2009, Molecular and Cellular Biology.

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage*

H. Ichijo, K. Takeda, A. Matsuzawa, 2008, Journal of Biological Chemistry.

Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.

H. Ichijo, S. Tamura, Takayasu Kobayashi, 2007, The Biochemical journal.

Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1.

T. Nakao, H. Iwao, H. Ichijo, 2007, Oncology reports.

Inhibition of Mammalian Target of Rapamycin Activates Apoptosis Signal-regulating Kinase 1 Signaling by Suppressing Protein Phosphatase 5 Activity*

Shile Huang, P. Houghton, J. Easton, 2004, Journal of Biological Chemistry.

Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons.

H. Ichijo, K. Shimoke, T. Ikeuchi, 2003, Journal of biochemistry.

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

K. Miyazono, T. Imamura, M. Kawabata, 1999, Molecular biology of the cell.

Sympathetic Neurons Kinase Pathway and Apoptosis in in Regulation of the c-Jun N-Terminal Role of Apoptosis Signal-Regulating Kinase

K. Miyazono, T. Kanamoto, H. Ichijo, 1999 .

Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor- Binding Protein with the Extracellular Matrix (*)

K. Miyazono, C. Heldin, H. Ichijo, 1995, The Journal of Biological Chemistry.

Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1.

H. Ichijo, A. Matsuzawa, H Ichijo, 2001, Journal of biochemistry.

Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP.

H. Ichijo, K. Takeda, T. Amagasa, 1994, Biochemical and biophysical research communications.

Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes.

K. Miyazono, C. Heldin, K. Miyagawa, 1991, The Journal of biological chemistry.

Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains.

K. Miyazono, U. Hellman, C. Wernstedt, 1993, The Journal of biological chemistry.

ASK1 suppresses NK cell‐mediated intravascular tumor cell clearance in lung metastasis

H. Ichijo, K. Takeda, T. Watabe, 2021, Cancer science.

The Expression of Fn14 via Mechanical Stress-activated JNK Contributes to Apoptosis Induction in Osteoblasts*

H. Ichijo, K. Takeda, H. Nishitoh, 2014, The Journal of Biological Chemistry.

Regulation of Angiogenesis by TGF-β Superfamily

K. Miyazono, H. Ichijo, H. Nishitoh, 1997 .

ASK family kinases mediate cellular stress and redox signaling to circadian clock

Y. Fukada, H. Ichijo, H. Yoshitane, 2018, Proceedings of the National Academy of Sciences.

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

Yuki Hayashi, H. Ichijo, H. Nishitoh, 2016, Human molecular genetics.

ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice

H. Ichijo, O. Yasuda, Yu Hasegawa, 2015, Scientific Reports.

Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis.

Y. Sasaguri, H. Izumi, K. Kohno, 2014, The American journal of pathology.

Apoptosis signal-regulating kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells.

Y. Sasaguri, K. Kohno, H. Ichijo, 2013, The American journal of pathology.

Critical Role of Apoptosis Signal-Regulating Kinase 1 in Aldosterone/Salt-Induced Cardiac Inflammation and Fibrosis

H. Ichijo, K. Kataoka, H. Ogawa, 2009, Hypertension.

Activation of Apoptosis Signal-Regulating Kinase 1 in Injured Artery and Its Critical Role in Neointimal Hyperplasia

Shokei Kim, H. Iwao, H. Ichijo, 2003, Circulation.

Execution of ASK 1-induced Apoptosis by the Mitochondria-dependent Caspase Activation *

H. Ichijo, K. Sakamaki, S. Yonehara, 2000 .

FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells

H. Ichijo, Yasuyuki Fujita, I. Naguro, 2020, Current Biology.

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

O. Nureki, Kengo Watanabe, T. Nishizawa, 2020, Communications Biology.

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

O. Nureki, Kengo Watanabe, T. Nishizawa, 2020, Communications Biology.

Cryo-EM structure of the volume-regulated anion channel LRRC8

O. Nureki, M. Hattori, Kengo Watanabe, 2018, bioRxiv.

Role of Rho in rabbit parietal cell

T. Urushidani, H. Ichijo, T. Nagao, 2003, Journal of cellular physiology.

Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.

K. Miyazono, H. Ichijo, F. Momose, 1990, Experimental cell research.

ASK1 signaling regulates phase-specific glial interactions during neuroinflammation

H. Ichijo, T. Harada, C. Harada, 2022, Proceedings of the National Academy of Sciences.

Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.

H. Ichijo, Y. Osuga, T. Fujii, 2021, Placenta.

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

[Molecular mechanisms of ER stress-induced apoptosis].

H. Ichijo, H. Nishitoh, 2004, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Essential Role of E2-25K/Hip-2 in Mediating Amyloid-β Neurotoxicity

S. Kim, D. Jo, H. Ichijo, 2003 .

Prevention of Apoptosis by Mitochondrial Phosphatase PGAM5 in the Mushroom Body Is Crucial for Heat Shock Resistance in Drosophila melanogaster

H. Ichijo, M. Miura, K. Takeda, 2012, PloS one.

Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5*

H. Ichijo, K. Takeda, M. Koike, 2012, The Journal of Biological Chemistry.

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease

R. Kalb, M. Famulok, H. Ichijo, 2015, The Journal of Neuroscience.

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

K. Mikoshiba, A. Futatsugi, T. Katagiri, 2021, iScience.

Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response.

Kengo Watanabe, H. Ichijo, I. Naguro, 2023, Cell reports.

A Novel Lens for Cell Volume Regulation: Liquid-Liquid Phase Separation.

Kengo Watanabe, H. Ichijo, Shunya Ishihara, 2021, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila

R. Takahashi, H. Ichijo, K. Takeda, 2010, PLoS genetics.

Requirement of Apoptosis-Inducing Kinase 1 for the Induction of Bronchial Asthma following Stimulation with Ovalbumin

S. Nakae, H. Ichijo, K. Sudo, 2013, International Archives of Allergy and Immunology.

Title A small-molecule inhibitor of SOD 1-Derlin-1 interactionameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2019 .

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2018, Nature Communications.

Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160.

K. Miyazono, U. Hellman, C. Heldin, 1997, The Biochemical journal.

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2018, Nature Communications.

Regulation of Anoxic Death in Caenorhabditis elegans by Mammalian Apoptosis Signal-Regulating Kinase (ASK) Family Proteins

Kunihiro Matsumoto, H. Ichijo, K. Takeda, 2011, Genetics.

Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase

H. Ichijo, T. Fujisawa, Kengo Homma, 2020, The Journal of Biological Chemistry.

Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.

H. Ichijo, S. Yamaguchi, T. Nagao, 2003, Molecular pharmacology.

ASK1 promotes uterine inflammation leading to pathological preterm birth

H. Ichijo, Y. Osuga, T. Fujii, 2020, Scientific Reports.

Apoptosis signal-regulating kinase 1 in regulated necrosis

H. Ichijo, K. Hattori, 2018, Cell cycle.

Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer's Disease and Brain Aging.

H. Ichijo, Yu Hasegawa, S. Kim‐Mitsuyama, 2017, Journal of Alzheimer's disease : JAD.

Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress

Kengo Watanabe, H. Ichijo, S. Murata, 2023, bioRxiv.

Transforming growth factor-beta: latent forms, binding proteins and receptors.

K. Miyazono, C. Heldin, H. Ichijo, 1993, Growth factors.

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

D. Baltimore, Xiaolu Yang, H. Ichijo, 1998, Science.

ASK1 is essential for JNK/SAPK activation by TRAF2.

K. Miyazono, M. Rothe, H. Nakano, 1998, Molecular cell.

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

O. Ogawa, H. Ichijo, Y. Kakehi, 2001, Cancer research.

Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.

I. Komuro, H. Ichijo, K. Takeda, 2001, Journal of cell science.

Erratum: ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice

H. Ichijo, O. Yasuda, Yu Hasegawa, 2015, Scientific Reports.

KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation

H. Ichijo, Y. Sekine, I. Naguro, 2016, PloS one.

[ASK family proteins in stress and disease--"how cells sense stress"].

H. Ichijo, 2007, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

ASK1 promotes inflammation in senescence and aging

H. Ichijo, S. Yamauchi, T. Odawara, 2023, bioRxiv.

Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.

D. Jo, H. Ichijo, J. Koh, 2003, Molecular cell.

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

H. Ichijo, K. Takeda, H. Nishitoh, 2008, Genes & development.

Apoptosis signal-regulating kinase 1 as a therapeutic target

H. Ichijo, I. Naguro, Yosuke Kawarazaki, 2014, Expert opinion on therapeutic targets.

Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy

M. Hori, M. Taniike, K. Otsu, 2008, Circulation.

Regulation of Anoxic Death in Caenorhabditis elegans by Mammalian Apoptosis Signal-Regulating Kinase (ASK) Family Proteins

Kunihiro Matsumoto, H. Ichijo, K. Takeda, 2011, Genetics.

Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.

H. Ichijo, Junichi Ikenouchi, Miho Sekai, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Apoptosis signal‐regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor‐suppressing function of stress‐activated mitogen‐activated protein kinase

M. Omata, K. Koike, H. Ichijo, 2011, Hepatology.

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

T. Inada, T. Natsume, H. Ichijo, 2017, Cell reports.

Apoptosis signal‐regulating kinase‐1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer

K. Koike, H. Ichijo, Y. Hayakawa, 2012, Cancer science.

Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.

M. Otsuka, M. Omata, H. Ichijo, 2010, Gastroenterology.

Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation.

H. Ichijo, K. Neeves, K. Golla, 2017, Blood.

Involvement of Apoptosis Signal-Regulating Kinase-1 on Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression

Shokei Kim, H. Iwao, H. Ichijo, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Calcium signaling via voltage-dependent L-type Ca2+ channels

H. Ichijo, S. Adachi-Akahane, I. Naguro, 2004 .

A guideline on the molecular ecosystem regulating ferroptosis.

H. Bayır, D. Klionsky, F. Greten, 2024, Nature cell biology.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

J. Monahan, H. Ichijo, E. Welsh, 2010, International immunopharmacology.