P. Ohashi

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the Regulation of Lymphocyte Homeostasis Signaling to Distinct Survival Pathways and B Couples Protein Kinase B/Akt κ NF-

Russell G. Jones, J. Woodgett, M. Pellegrini, 2013 .

Protein Kinase B , c-Rel , θ Differentially by Protein Kinase C T Cell Survival Is Regulated + and CD 8 + CD 4

Russell G. Jones, J. Woodgett, S. Gerondakis, 2007 .

CD4+ and CD8+ T Cell Survival Is Regulated Differentially by Protein Kinase Cθ, c-Rel, and Protein Kinase B1

Russell G. Jones, J. Woodgett, S. Gerondakis, 2007, The Journal of Immunology.

NF-κB Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis In Vivo

Russell G. Jones, J. Woodgett, M. Pellegrini, 2005, The Journal of Immunology.

T-cell signalling and autoimmunity: molecular mechanisms of disease

Pamela S. Ohashi, P. Ohashi, 2002, Nature Reviews Immunology.

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

Michael J. Parsons, Russell G. Jones, J. Woodgett, 2000, The Journal of experimental medicine.

CARD6 Is Interferon Inducible but Not Involved in Nucleotide-Binding Oligomerization Domain Protein Signaling Leading to NF-κB Activation

T. Mak, A. Wakeham, G. Duncan, 2007, Molecular and Cellular Biology.

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

Trevor J Pugh, T. Pugh, D. Munn, 2019, Science Immunology.

Identification of a cross‐reactive self ligand in virus‐mediated autoimmunity

M. Tsao, M. Bachmann, P. Ohashi, 1999, European journal of immunology.

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

D. Hanahan, R. Zinkernagel, D. Speiser, 1997, The Journal of experimental medicine.

Duration of TCR stimulation determines costimulatory requirement of T cells.

T. Mak, T. Kündig, M. Bachmann, 1996, Immunity.

Shp1 regulates T cell homeostasis by limiting IL-4 signals

B. Neel, P. Ohashi, Dylan J. Johnson, 2013, The Journal of experimental medicine.

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

T. Mak, T. Kündig, A. Wakeham, 1997, Science.

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development

J. Dick, K. Eppert, F. Notta, 2010, Nature Immunology.

Cancer classification using the Immunoscore: a worldwide task force

F. Marincola, P. Gibbs, M. Mihm, 2012, Journal of Translational Medicine.

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

F. Marincola, P. Gibbs, P. Delrio, 2013, The Journal of pathology.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

F. Marincola, D. Sargent, P. Delrio, 2018, The Lancet.

Differential T cell costimulatory requirements in CD28-deficient mice.

K P Lee, T. Mak, C. Thompson, 1993, Science.

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

Michael J. Parsons, Russell G. Jones, J. Woodgett, 2002, The Journal of experimental medicine.

Selection of the T cell repertoire.

M. Bachmann, P. Ohashi, S. Mariathasan, 1999, Annual review of immunology.

Signals involved in thymocyte positive and negative selection.

P. Ohashi, S. Mariathasan, R. Jones, 1999, Seminars in immunology.

CapTCR-seq: hybrid capture for T-cell receptor repertoire profiling.

Trevor J Pugh, J. Delabie, T. Pugh, 2018, Blood advances.

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression

S. Inoue, T. Mak, H. He, 2017, Nature Communications.

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression

S. Inoue, T. Mak, H. He, 2017, Nature Communications.

Dysregulation of immune homeostasis in autoimmune diseases

V. Kuchroo, P. Ohashi, C. Vinuesa, 2012, Nature Medicine.

The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites.

A. Iwasaki, P. Ohashi, H. Robinson, 1997, Journal of immunology.

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Tak W. Mak, Akira Morimoto, Evan F. Lind, 2009, The Journal of experimental medicine.

Immunological Tolerance—T Cells

P. Ohashi, Sara R. Hamilton, S. Hamilton, 2014 .

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

T. Mak, A. Wakeham, Simon P Preston, 2012, Nature Immunology.

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

L. Salmena, T. Mak, B. Lemmers, 2005, The Journal of experimental medicine.

A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

R. Khokha, F. Notta, J. Bartlett, 2020, Clinical Cancer Research.

ICOS is essential for effective T-helper-cell responses

T. Pawson, M. Jordana, T. Mak, 2001, Nature.

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

R. DePinho, T. Mak, B. Assouline, 2011, Cell.

Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells

P. Ohashi, A. Elford, SeongJun Han, 2020, Oncoimmunology.

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

T. Mak, B. Assouline, L. Nguyen, 2009, Nature Medicine.

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation

V. Barr, L. Samelson, P. Ohashi, 2018, Cell reports.

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling

J. Penninger, I. Kozieradzki, R. Sarao, 1998, The Journal of experimental medicine.

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.

G. Crabtree, T. Mak, H. Nishina, 1998, Immunity.

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

H. Pircher, R. Zinkernagel, P. Ohashi, 1990, Nature.

Positive and negative thymocyte selection induced by different concentrations of a single peptide.

P. Ohashi, R. Yeung, E. Sebzda, 1994, Science.

T cell-specific loss of Pten leads to defects in central and peripheral tolerance.

T. Sasaki, T. Mak, T. Kaisho, 2001, Immunity.

The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens.

K. Tedford, J. Penninger, M. Bachmann, 1999, Journal of immunology.

The Quantity of TCR Signal Determines Positive Selection and Lineage Commitment of T Cells1

P. Ohashi, Takashi Saito, N. Watanabe, 2000, The Journal of Immunology.

Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials

Russell J. Dickson, L. Siu, T. McGaha, 2019, Front. Oncol..

ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

H. Atkins, P. Ohashi, A. Mercer, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice

T. Mak, W. Fung-Leung, K. Ngo, 1994, The Journal of experimental medicine.

Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer

P. Gendron, S. Lemieux, C. Perreault, 2020, Cancer Immunology Research.

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

M. Jordana, T. Mak, T. Horan, 2003, Nature Immunology.

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function.

I. Jurisica, M. Kotlyar, E. Engleman, 2021, Cell reports.

Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer

N. Donato, A. Elia, P. Ohashi, 2021, Proceedings of the National Academy of Sciences.

Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity

A. Elia, P. Ohashi, A. Elford, 2020, PloS one.

Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma

Brian D Burt, Trevor J Pugh, T. Pugh, 2020, eLife.

ILC regulation of T cell responses in inflammatory diseases and cancer.

P. Ohashi, K. Warner, Kathrin Warner, 2019, Seminars in immunology.

Innate Lymphoid Cells: Role in Immune Regulation and Cancer

P. Ohashi, N. Jacquelot, D. Chung, 2022, Cancers.

Expansion of Lymphocytes from Prostatic Adenocarcinoma and Adjacent Nonmalignant Tissue

A. Finelli, L. Nguyen, K. Hersey, 2022, Prostate cancer.

Correction for Judd et al., Behavioral dynamics and influence in networked coloring and consensus

J. Field, A. Hirao, A. Wakeham, 2011, Proceedings of the National Academy of Sciences.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Amanda R. Campbell, F. Lund-Johansen, Yair Benita, 2016 .

Targeting T cell activation in immuno-oncology.

P. Ohashi, S. Saibil, Samuel Saibil, 2019, Current oncology.

Evaluating the Cellular Targets of Anti-4-1BB Agonist Antibody during Immunotherapy of a Pre-Established Tumor in Mice

B. Kwon, T. Watts, P. Ohashi, 2010, PloS one.

Expansion and Characterization of Human Melanoma Tumor-Infiltrating Lymphocytes (TILs)

L. Nguyen, D. Hogg, P. Shaw, 2010, PloS one.

Zeroing in on Tumor-Reactive TILs

P. Ohashi, 2016, Cancer Immunology Research.

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation

T. Le Bihan, T. Mak, J. Woodgett, 2017, The Journal of Immunology.

Immune Checkpoints and Innate Lymphoid Cells—New Avenues for Cancer Immunotherapy

P. Ohashi, N. Jacquelot, S. Q. Crome, 2021, Cancers.

NK Cells Regulate CD8+ T Cell Mediated Autoimmunity

T. Mak, T. Holderried, A. Pandyra, 2020, Frontiers in Cellular and Infection Microbiology.

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

T. Mak, J. Penninger, T. Kündig, 1993, Cell.

Aggravation of viral hepatitis by platelet-derived serotonin

M. Kurrer, R. Zinkernagel, B. Ludewig, 2008, Nature Medicine.

Correlates with Thymocyte Selection Degree of TCR Internalization and Ca2+ Flux

M. Bachmann, P. Ohashi, D. Bouchard, 2013 .

Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection.

M. Bachmann, P. Ohashi, D. Bouchard, 1998, Journal of immunology.

IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function

Trevor J Pugh, B. Haibe-Kains, T. Pugh, 2020, Cancer Immunology Research.

Degree of ERK activation influences both positive and negative thymocyte selection

P. Ohashi, S. Mariathasan, A. Zakarian, 2000, European journal of immunology.

Reduced Thymic Maturation but Normal Effector Function of CD8 + T Cells in CD8fl Gene-targeted Mice By Wai-Ping Fung-Leung,* Thomas M. K~indig,~ Karen Ngo,*

T. Mak, P. Ohashi, C. Lau, 1994 .

TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.

T. Mak, M. Pellegrini, P. Ohashi, 2007, The Journal of clinical investigation.

Targeting of Pancreatic Glia in Type 1 Diabetes

D. Becker, P. Ohashi, A. Elford, 2008, Diabetes.

Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.

H. Pircher, R. Zinkernagel, P. Ohashi, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection.

H. Pircher, R. Zinkernagel, P. Ohashi, 1993, International Immunology.

Tolerance, Autoimmunity and Immunopathology

H. Pircher, R. Zinkernagel, T. Rülicke, 1993 .

Vaccination or tolerance to prevent diabetes

R. Zinkernagel, P. Ohashi, H. Hengartner, 1992, European journal of immunology.

TREM-2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases

D. Tarng, T. Mak, H. Chen, 2022, Journal of Molecular Medicine.

The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

T. Mak, H. You, M. Reth, 2012, The Journal of experimental medicine.

Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T‐cell death

T. Mak, L. Nguyen, M. Woo, 2010, European journal of immunology.

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation1

Michael J. Parsons, Russell G. Jones, J. Woodgett, 2001, The Journal of Immunology.

TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.

T. Mak, P. Ohashi, A. Zakarian, 1999, Journal of immunology.

TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

T. Mak, D. Speiser, L. Nguyen, 1999, Immunity.

Validation of the Immunoscore (IM) as a prognostic marker in stage I/II/III colon cancer: Results of a worldwide consortium-based analysis of 1,336 patients.

D. Sargent, P. Ascierto, B. Fox, 2016 .

The Immune Regulatory Function of Lymphoproliferative Double Negative T Cells In Vitro and In Vivo

Li Zhang, P. Ohashi, Zhu-Xu Zhang, 2002, The Journal of experimental medicine.

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

C. Blobel, T. Mak, R. Khokha, 2012, Science.

Diabetes an Effector Pathway in Autoimmune Cell Toxicity as b TNF Receptor 1-Dependent

T. Mak, P. Ohashi, A. Zakarian, 1999 .

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

T. Mak, D. Speiser, M. Bachmann, 1996, European journal of immunology.

Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8+ T Cell Proliferation

N. Sonenberg, P. Ohashi, A. Elford, 2022, The Journal of Immunology.

Cellular and Molecular Requirements for the Selection of In Vitro–Generated CD8 T Cells Reveal a Role for Notch

J. Cannons, P. Schwartzberg, P. Ohashi, 2013, The Journal of Immunology.

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

T. Mak, J. Fine, S. Kaech, 2011, Proceedings of the National Academy of Sciences.

DC1s shield Tpex cells to bolster PD-1 blockade.

P. Ohashi, D. Brooks, 2022, Immunity.

Mutation and Microsatellite Burden Predict Response to PD-1 Inhibition in Children with Germline DNA Replication Repair Deficiency

K. Cole, T. Pugh, C. Hawkins, 2021 .

Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

K. Köhrer, T. Mak, A. Pandyra, 2014, Immunity.

Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration.

T. Mak, T. Kündig, M. Bachmann, 1998, International immunology.

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

R. Zinkernagel, P. Ohashi, H. Hengartner, 1996, The Journal of experimental medicine.

A cortisone sensitive CD3low subset of CD4+CD8- thymocytes represents an intermediate stage in intrathymic repertoire selection.

H. Pircher, H. Macdonald, P. Ohashi, 1992, International immunology.

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell–Mediated Autoimmunity

K. McCoy, T. Junt, P. Ohashi, 2019, The Journal of Immunology.

c‐Rel but not NF‐κB1 is important for T regulatory cell development

T. Mak, M. Pellegrini, P. Ohashi, 2010, European journal of immunology.

Ablation of ‘tolerance’ and induction of diabetes by virus infection in viral antigen transgenic mice

P. Ohashi, 1991 .

T cells causing immunological disease

H. Pircher, R. Zinkernagel, P. Ohashi, 2004, Springer Seminars in Immunopathology.

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

W. Fung-Leung, P. Ohashi, E. Sebzda, 1997, Immunity.

T cell selection and autoimmunity: flexibility and tuning.

P. Ohashi, Pamela S. Ohashi, 1996, Current opinion in immunology.

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny

H. Pircher, R. Zinkernagel, D. Speiser, 1992, The Journal of experimental medicine.

Thymic ontogeny and selection of αβ and γδ T cells

T. Mak, M. Schilham, P. Ohashi, 1989 .

Supressing the supressors

W. Yeh, P. Ohashi, 2006, Nature Medicine.

Immunological function of a defined T-cell population tolerized to low-affinity self antigens

P. Ohashi, K. Kawai, 1995, Nature.

Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses

U. Eriksson, T. Pawson, M. Jordana, 2003, Nature Immunology.

Development o f Insulitis without Diabetes in Transgenic Mice Lacking Perforin-dependent Cytotoxicity By David K~igi,*

P. Ohashi, H. Hengartner, B. Odermatt, 2003 .

Acute graft-versus-host disease without costimulation via CD28.

T. Mak, D. Speiser, M. Bachmann, 1997, Transplantation.

Skin allograft rejection in CD28-deficient mice.

T. Mak, A. Shahinian, P. Ohashi, 1996, Transplantation.

Exposure to IL-15 and IL-21 Enables Autoreactive CD8 T Cells To Respond to Weak Antigens and Cause Disease in a Mouse Model of Autoimmune Diabetes

P. Ohashi, Xi-lin Chen, S. Ramanathan, 2011, The Journal of Immunology.

Model of Autoimmune Diabetes Weak Antigens and Cause Disease in a Mouse Autoreactive CD8 T Cells To Respond to Exposure to IL-15 and IL-21 Enables

P. Ohashi, Xi-lin Chen, S. Ramanathan, 2011 .

Peptide with Relatively High Affinity for Class I Tetramers Reveal a Positive Selecting TCR Binding Kinetics Measured with MHC

P. Ohashi, S. Mariathasan, T. Ohteki, 2003 .

Accessory Protein-Like Is Essential for IL-18-Mediated Signaling1

Z. Cao, W. Yeh, P. Ohashi, 2005, The Journal of Immunology.

Correlates with Thymocyte Selection Flux 2+ Degree of TCR Internalization and Ca

M. Bachmann, P. Ohashi, D. Bouchard, 1998 .

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

D. Harlan, H. Pircher, G. Freeman, 1994, Proceedings of the National Academy of Sciences of the United States of America.

AntigensProliferative Capacity toward Foreign Autoimmunity and Preserves Their of Cytokine Signaling 1 Controls Differentiation of CD8 T Cells by Suppressor Regulation of Cytokine-Driven Functional

G. Ferbeyre, P. Ohashi, R. Rottapel, 2010 .

Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice

M. Jordana, T. Mak, A. Wakeham, 2006, Molecular and Cellular Biology.

Vivo Immunity by the E 3 Ligase Cbl-b Differential Control of CD 28-Regulated In Ohashi and

Russell G. Jones, J. Penninger, P. Ohashi, 2005 .

The Inducible Costimulator Plays the Major Costimulatory Role in Humoral Immune Responses in the Absence of CD28 1

T. Mak, A. Wakeham, H. Okada, 2004, The Journal of Immunology.

This information is current as Responses in the Absence of CD 28 Costimulatory Role in Humoral Immune The Inducible Costimulator Plays the Major

T. Mak, A. Wakeham, H. Okada, 2004 .

Role of ICOS versus CD28 in antiviral immunity

T. Mak, E. Bertram, A. Shahinian, 2002, European journal of immunology.

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

D. Speiser, L. Nguyen, P. Ohashi, 2002, The Journal of experimental medicine.

Activation of cytotoxic T cells by solid tumours?

D. Speiser, P. Ohashi, Pamela S. Ohashi, 1998, Cellular and Molecular Life Sciences CMLS.

Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function

T. Mak, R. Flavell, J. Penninger, 1994, The Journal of experimental medicine.

The Transcription Factor Interferon Regulatory Factor 1 (IRF-1) Is Important during the Maturation of Natural Killer 1.1+ T Cell Receptor–α/β+ (NK1+ T) Cells, Natural Killer Cells, and Intestinal Intraepithelial T Cells

T. Mak, T. Matsuyama, G. Duncan, 1998, The Journal of experimental medicine.

The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28‐mediated co‐stimulation

K. Tedford, T. Sasaki, J. Penninger, 1999, European journal of immunology.

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon‐I‐dependent manner in mice

R. Zinkernagel, B. Ludewig, S. Scheu, 2010, Hepatology.

Antigens expressed by myelinating glia cells induce peripheral cross‐tolerance of endogenous CD8+ T cells

M. van den Broek, K. McCoy, U. Suter, 2009, European journal of immunology.

The Src-Like Adaptor Protein Regulates GM-CSFR Signaling and Monocytic Dendritic Cell Maturation

A. Weiss, P. Ohashi, C. McGlade, 2011, The Journal of Immunology.

Dendritic Cell Maturation GM-CSFR Signaling and Monocytic The Src-Like Adaptor Protein Regulates

A. Weiss, P. Ohashi, D. Dissanayake, 2011 .

Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma

T. Mak, P. Ohashi, A. Reske-Kunz, 1988, The Journal of experimental medicine.

Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy.

Russell G. Jones, L. Nguyen, P. Ohashi, 2019, Cancer research.

Activation of Peroxisome Proliferator-Activated Receptors a and d Synergizes with In ﬂ ammatory Signals to Enhance Adoptive Cell Therapy

Russell G. Jones, L. Nguyen, P. Ohashi, 2019 .

Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.

T. Mak, P. Waterhouse, D. Speiser, 1998, Journal of immunology.

Choline acetyltransferase–expressing T cells are required to control chronic viral infection

T. Mak, K. Tracey, A. Wakeham, 2019, Science.

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

H. Pircher, T. Mak, C. Levelt, 1995 .

Evidence for a selective and multi‐step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules

H. Pircher, P. Ohashi, H. Hengartner, 1994, European journal of immunology.

Absence of co‐stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo

T. Mak, D. Speiser, M. Bachmann, 1999, European journal of immunology.

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells

T. Mak, B. Snow, G. Duncan, 2014, Proceedings of the National Academy of Sciences.

Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways.

T. Mak, P. Ohashi, S. Koyasu, 1999, Journal of immunology.

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF 4 F

L. Daws, J. Field, A. Wakeham, 2011 .

Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

P. Ohashi, A. Elford, Zihai Li, 2003, Nature Medicine.

Transgenic Expression of Hsc70 in Pancreatic Islets Enhances Autoimmune Diabetes in Response to β Cell Damage1

P. Ohashi, A. Elford, Masih-ul Alam, 2009, The Journal of Immunology.

This information is current as Cell Damage β Response to Islets Enhances Autoimmune Diabetes in Transgenic Expression of Hsc 70 in Pancreatic

P. Ohashi, A. Elford, Masih-ul Alam, 2009 .

Calcineurin Aα plays an exclusive role in TCR signaling in mature but not in immature T cells

P. Ohashi, V. Chan, C. Wong, 2002, European journal of immunology.

Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

J. Gommerman, P. Ohashi, A. Elford, 2011, Nature Medicine.

This information is current as Activation Chemoattractant-Mediated Neutrophil The 3 BP 2 Adapter Protein Is Required for and

P. Kubes, P. Ohashi, R. Rottapel, 2012 .

Alterations in the level of CD45 surface expression affect the outcome of thymic selection.

H. Pircher, T. Mak, J. Penninger, 1997, Journal of immunology.

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

T. Mak, A. Pandyra, D. Häussinger, 2014, Cell Death and Differentiation.

T cell tolerance and autoimmunity.

P. Ohashi, V. Chan, K. Garza, 2000, Reviews in immunogenetics.

Innate lymphoid cells in early tumor development

P. Ohashi, N. Jacquelot, D. Chung, 2022, Frontiers in Immunology.

Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus.

M. Bachmann, M. Debenedette, T. Watts, 1999, Journal of immunology.

Development of autoreactive diabetogenic T cells in the thymus of NOD mice.

R. Flavell, H. Kwon, P. Ohashi, 2005, Journal of autoimmunity.

Peptide‐activated double‐negative T cells can prevent autoimmune type‐1 diabetes development

Li Zhang, S. Asa, P. Ohashi, 2007, European journal of immunology.

TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide‐induced deletion under limited conditions

T. Mak, D. Speiser, L. Nguyen, 2000, European journal of immunology.

c‐Rel phenocopies PKCθ but not Bcl‐10 in regulating CD8+ T‐cell activation versus tolerance

T. Mak, J. Ruland, S. Gerondakis, 2010, European journal of immunology.

Cell Response to Influenza Virus Allograft Rejection and in the Cytotoxic T CD 28 Reveals a Role for 4-1 BBL in Skin Mice and of Mice Lacking Both 4-1 BBL and Analysis of 4-1 BB Ligand ( 4-1 BBL )-Deficient

M. Bachmann, M. Debenedette, P. Ohashi, 1999 .

of T Cells Positive Selection and Lineage Commitment The Quantity of TCR Signal Determines

P. Ohashi, Takashi Saito, N. Watanabe, 2000 .

The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

T. Mak, W. Fung-Leung, K. Ngo, 1993 .

T Cell Antagonism is Functionally Uncoupled from the 21- and 23-kDa Tyrosine-Phosphorylated TCR ζ Subunits1

P. Ohashi, Lisa A. Pitcher, L. Pitcher, 2003, The Journal of Immunology.

Tyrosine-Phosphorylated TCR from the 21-and 23-kDa T Cell Antagonism is Functionally Uncoupled

P. Ohashi, Lisa A. Pitcher, L. Pitcher, 2003 .

The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes.

T. Mak, W. Fung-Leung, K. Ngo, 1993, European journal of immunology.

Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study

F. Marincola, P. Delrio, J. Lee, 2022, Cancers.

Molecular analysis of the antigen receptor of virus‐specific cytotoxic T cells and identification of a new Vα family

H. Pircher, R. Zinkernagel, T. Mak, 1987 .

Genes Encoding the α-, β-, and γ-Chains of the Human T Cell Antigen Receptor

T. Mak, P. Ohashi, Y. Yoshikai, 1986 .

Vav Is a Crucial Regulator of B Cell The Guanine-Nucleotide Exchange Factor

K. Tedford, J. Penninger, M. Bachmann, 1999 .

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor‐transgenic CTLA‐4‐deficient mice

T. Mak, P. Waterhouse, J. Penninger, 1997, European journal of immunology.

T cell responses are governed by avidity and co‐stimulatory thresholds

T. Mak, D. Speiser, T. Kündig, 1996, European journal of immunology.

IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses1

J. Penninger, W. Yeh, P. Ohashi, 2003, The Journal of Immunology.

Intricate connections between innate and adaptive autoimmunity.

P. Ohashi, A. Marshak‐Rothstein, 2007, Current opinion in immunology.

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

T. Mak, J. Penninger, T. Wada, 2002, Nature.

Homeostasis and Promotes Inflammation Cells Perturbs Both T and B Cell Expression of Active Protein Kinase B in T

Michael J. Parsons, Russell G. Jones, J. Woodgett, 2001 .

Schmits, R. et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90, 2217-2233

T. Mak, A. Wakeham, J. C. Ramos, 1997 .

ILC transdifferentiation: roles in cancer progression

P. Ohashi, M. Ghaedi, 2020, Cell Research.

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

H. Pircher, R. Zinkernagel, B. Malissen, 1991, Cell.

Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule

F. Marincola, J. Galon, S. Demaria, 2016, Journal of Immunotherapy for Cancer.

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

T. Mak, K. McCoy, D. Patel, 2015, The Journal of Immunology.

Effector T and B Cell Responses Leading to Results in Unbalanced Regulatory and Deficiency of MALT1 Paracaspase Activity

T. Mak, K. McCoy, D. Patel, 2015 .

Ontogeny and selection of the T cell repertoire in transgenic mice.

H. Pircher, T. Mak, P. Ohashi, 1989, Seminars in immunology.

GSK3: an in-Toll-erant protein kinase?

J. Woodgett, P. Ohashi, 2005, Nature Immunology.

Mutations in the RAS/MAPK pathway drive replication repair deficient hypermutated tumors and confer sensitivity to MEK inhibition.

Trevor J Pugh, T. Pugh, C. Hawkins, 2021, Cancer discovery.

B7-H4 is a positive regulator of antitumor immunity

P. Ohashi, R. Rahbar, 2015, Oncoimmunology.

Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels.

R. Zinkernagel, P. Ohashi, H. Hengartner, 1994, Cellular immunology.

Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase- deficient mice

T. Mak, P. Ohashi, K. Kawai, 1995, The Journal of experimental medicine.

Cytotoxic CD4+ T Cells in Bladder Cancer-A New License to Kill.

P. Ohashi, C. Paige, A. Sacher, 2020, Cancer cell.

Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.

D. Karlis, G. Coukos, U. Dafni, 2019 .

Tumor defense by murine cytotoxic T cells specific for peptide bound to nonclassical MHC class I.

D. Speiser, M. Bachmann, P. Ohashi, 1998, Cancer research.

Alloreactive cytotoxic T cells recognize minor transplantation antigens presented by major histocompatibility complex class Ib molecules.

D. Speiser, M. Bachmann, P. Ohashi, 1998, Transplantation.

Four types of Ca2+ signals in naive CD8+ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists

D. Speiser, M. Bachmann, P. Ohashi, 1997, European journal of immunology.

T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.

T. Mak, J. Marth, J. Penninger, 1997, Journal of immunology.

The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity.

R. Quevedo, B. Snow, T. McGaha, 2022, Immunity.

Immunoregulatory functions of innate lymphoid cells

P. Ohashi, S. Q. Crome, 2018, Journal of Immunotherapy for Cancer.

Transgenesis and targeted mutagenesis in immunology.

P. Ohashi, H. Bluethmann, 1994 .

Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling.

L. Salmena, A. Hakem, R. Hakem, 2007, The Journal of biological chemistry.

Autoimmunity a bias from tolerance to immunity.

N. Sarvetnick, P. Ohashi, 1997, Current opinion in immunology.

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Josef M. Penninger, Brad Bolon, David L. Lacey, 1999, Nature.

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Josef M. Penninger, Brad Bolon, David L. Lacey, 1999, Nature.

Differential Roles of Interleukin 15 mRNA Isoforms Generated by Alternative Splicing in Immune Responses in Vivo

P. Ohashi, T. Matsuguchi, T. Yajima, 2000, The Journal of experimental medicine.

LPS/TLR4 signal transduction pathway.

W. Yeh, P. Ohashi, Yong-Chen Lu, 2008, Cytokine.

A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology

J. Gommerman, P. Ohashi, L. Ward, 2015, The Journal of Immunology.

Immunopathology T Cells To Infiltrate a Self-Tissue and + CD 8 A Lymphotoxin / Type I IFN Axis Programs

J. Gommerman, P. Ohashi, L. Ward, 2015 .

The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation

P. Kubes, P. Ohashi, R. Rottapel, 2012, The Journal of Immunology.

ActivationMediated Neutrophil The 3BP2 Adapter Protein Is Required for

P. Kubes, P. Ohashi, R. Rottapel, 2012 .

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

H. Griesser, T. Mak, A. Hakem, 1996, Cell.

Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro

Thomas M. Schmitt, P. Ohashi, J. Zúñiga-Pflücker, 2004, Nature Immunology.

Defining the critical hurdles in cancer immunotherapy

Zhigang Tian, Sylvia Janetzki, Cedrik M Britten, 2011, Journal of Translational Medicine.

14-3-3 sigma regulates B-cell homeostasis through stabilization of FOXO1 [Erratum: Proceedings of the National Academy of Sciences of the United States of America. 2011 Jan;108(4):1555-1560.]

B. Vogelstein, H. Hermeking, T. Mak, 2011 .

14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1

B. Vogelstein, H. Hermeking, T. Mak, 2011, Proceedings of the National Academy of Sciences.

T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

H. Pircher, R. Zinkernagel, T. Mak, 1991, Immunological reviews.

Efficacy of Adoptive Therapy with Tumor-infiltrating Lymphocytes and Recombinant Interleukin-2 in Advanced Cutaneous Melanoma: A Systematic Review and Meta-analysis.

D. Karlis, G. Coukos, U. Dafni, 2019, Annals of oncology : official journal of the European Society for Medical Oncology.

Generation and molecular recognition of melanoma-associated antigen-specific human gamma delta T cells.

E. Adams, L. Nguyen, P. Ohashi, 2019 .

Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

E. Adams, L. Nguyen, P. Ohashi, 2018, Science Immunology.

Notch Shapes the Innate Immunophenotype in Breast Cancer.

H. Berman, P. Ohashi, Q. Shen, 2017, Cancer discovery.

Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives

F. Souza-Fonseca-Guimaraes, G. Belz, P. Ohashi, 2021, International journal of molecular sciences.

Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

Trevor J Pugh, Benjamin Haibe-Kains, T. Pugh, 2021, Nature Communications.

Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab

Trevor J Pugh, S. Shchegrova, T. Pugh, 2020, Nature Cancer.

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

H. Nishina, J. Penninger, I. Kozieradzki, 2000, Nature.

LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor

T. Mak, T. Kündig, M. Bachmann, 1996, The Journal of experimental medicine.

Hematopoietic cell-derived interferon controls viral replication and virus-induced disease.

K. Honda, B. Ludewig, M. Pellegrini, 2009, Blood.

Molecular Pathways: Evaluating the Potential for B7-H4 as an Immunoregulatory Target

P. Ohashi, Heather L. MacGregor, 2017, Clinical Cancer Research.

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

G. Reifenberger, T. Mak, A. Melnick, 2012, Nature.

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio

S. Inoue, D. Cescon, T. Mak, 2015, Cell Death and Differentiation.

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.

Anna Y. Lee, Eunice E. Cho, G. Giaever, 2013, The Journal of clinical investigation.

Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis

T. Mak, Xiaodong Wang, Y. Jang, 2005, Cell.

Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician

F. Mottaghy, S. Lheureux, P. Ohashi, 2017, European Journal of Nuclear Medicine and Molecular Imaging.

Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors

A. Oza, T. Pugh, B. Clarke, 2018, Genome Medicine.

Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive

D. Becker, P. Ohashi, A. Elford, 2003, Nature Medicine.

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

T. Mak, T. Kündig, A. Wakeham, 1993, Cell.

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.

T. Mak, J. Ruland, A. Brüstle, 2012, The Journal of clinical investigation.

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

T. Mak, L. Nguyen, A. Wakeham, 2001, Cell.

Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer

B. Neel, L. Nguyen, A. Fyles, 2019, Oncotarget.

Expression of costimulatory and inhibitory receptors in FoxP3+ regulatory T cells within the tumor microenvironment: Implications for combination immunotherapy approaches.

P. Ohashi, A. Toker, 2019, Advances in cancer research.

Clinical blockade of PD1 and LAG3 — potential mechanisms of action

L. Nguyen, P. Ohashi, 2014, Nature Reviews Immunology.

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes

L. Orci, D. Belin, P. Ohashi, 1992, The Journal of experimental medicine.

CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.

T. Mak, T. Kündig, A. Wakeham, 1997, Blood.

Knockout mice: a paradigm shift in modern immunology

Tak W. Mak, Josef M. Penninger, Pamela S. Ohashi, 2001, Nature Reviews Immunology.

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

M. Cybulsky, J. Penninger, I. Kozieradzki, 2001, Science.

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.

F. Alt, S. Snapper, J. Penninger, 2002, Immunity.

An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors

Trevor J Pugh, A. Oza, T. Pugh, 2020, Journal for ImmunoTherapy of Cancer.

Factors contributing to autoimmune disease.

L. Nguyen, P. Ohashi, K. Garza, 2001, Advances in experimental medicine and biology.

The Roles of CD8+ T Cell Subsets in Antitumor Immunity.

P. Ohashi, M. St Paul, 2020, Trends in cell biology.

Turning the Tide Against Regulatory T Cells

P. Ohashi, SeongJun Han, Z. Liu, 2019, Front. Oncol..

Coenzyme A fuels T cell anti-tumor immunity.

Trevor J Pugh, T. Pugh, J. Wargo, 2021, Cell metabolism.

T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten- specific cytotoxic T cell clones

H. Pircher, T. Mak, P. Ohashi, 1987, The Journal of experimental medicine.

A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells

Soo Young Lee, D. Speiser, Y. Kong, 1997, The Journal of experimental medicine.

Vav Regulates Peptide-specific Apoptosis in Thymocytes

J. Penninger, I. Kozieradzki, Y. Kong, 1998, The Journal of experimental medicine.

Micro-RNA 155 Is Required for Optimal CD8+ T Cell Responses to Acute Viral and Intracellular Bacterial Challenges

P. Ohashi, A. Elford, E. Lind, 2013, The Journal of Immunology.

Differential Role for c-Rel and C/EBPβ/δ in TLR-Mediated Induction of Proinflammatory Cytokines1

S. Akira, W. Yeh, S. Gerondakis, 2009, The Journal of Immunology.

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

T. Mak, J. Woodgett, H. Nishina, 1997, The Journal of experimental medicine.

Peptide-Pulsed Dendritic Cells Have Superior Ability to Induce Immune-Mediated Tissue Destruction Compared to Peptide with Adjuvant

P. Ohashi, A. Elford, K. Murakami, 2014, PloS one.

Immunological perspective of self versus tumor antigens: insights from the RIP‐gp model

P. Ohashi, A. Elford, D. Dissanayake, 2011, Immunological reviews.

Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth.

L. Nguyen, P. Ohashi, Anita Schildknecht, 2010, Immunology letters.

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.

D. Goeddel, T. Mak, D. Speiser, 1997, Immunity.

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1

T. Mak, A. Wakeham, D. Brenner, 2010, Proceedings of the National Academy of Sciences.

CHAPTER 8 – Tolerance and Autoimmunity: T Cells

P. Ohashi, M. Gronski, 2006 .

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

T. Mak, G. Duncan, A. Brüstle, 2011, Oncogene.

Caspase-3-Dependent β-Cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus

R. Hakem, M. Woo, P. Ohashi, 2005, Molecular and Cellular Biology.

TCR Binding Kinetics Measured with MHC Class I Tetramers Reveal a Positive Selecting Peptide with Relatively High Affinity for TCR 1

Pamela S. Ohashi, Sanjeev Mariathasan, P. Ohashi, 2003, The Journal of Immunology.

Weak agonist self‐peptides promote selection and tuning of virus‐specific T cells

D. Hunt, F. White, M. Luscher, 2003, European journal of immunology.

Peptide‐induced T cell receptor down‐regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

R. Zinkernagel, A. Oxenius, D. Speiser, 1997, European journal of immunology.

Mature T cell reactivity altered by peptide agonist that induces positive selection

J. Mayer, T. Kündig, P. Ohashi, 1996, The Journal of experimental medicine.

Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development.

T. Mak, P. Ohashi, T. Ohteki, 1997, Journal of immunology.

Involvement of Toso in activation of monocytes, macrophages, and granulocytes

G. Nolan, T. Mak, A. Pandyra, 2013, Proceedings of the National Academy of Sciences.

Prevention of autoimmune disease by retroviral-mediated gene therapy.

H. Pircher, T. Kündig, P. Ohashi, 1995, Journal of immunology.

Making and breaking tolerance.

P. Ohashi, A. DeFranco, Pamela S Ohashi, 2002, Current opinion in immunology.

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

J. Penninger, R. Sarao, T. Wada, 2004, Immunity.

Regulation of thymocyte β-selection, development and positive selection by glycogen synthase kinase-3

Michael J. Parsons, B. Doble, J. Woodgett, 2019, bioRxiv.

Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells

C. Scuoppo, D. Gibbons, J. Kurie, 2012, PloS one.

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.

W L Stanford, Russell G. Jones, T. Sasaki, 2000, Science.

miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1

P. Ohashi, W. Kerr, E. Lind, 2015, The Journal of Immunology.

Negatively Regulating SHIP 1 Sufficient To Break Tolerance In Vivo by miR-155 Upregulation in Dendritic Cells Is

P. Ohashi, E. Lind, D. Dissanayake, 2015 .

Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer

F. Marincola, P. Delrio, J. Lee, 2023, Cancers.

Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.

F. Marincola, P. Delrio, G. Botti, 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Tumoral Lymphocytic Infiltration and Expression of the Chemokine CXCL10 in Breast Cancers from the Ontario Familial Breast Cancer Registry

I. Andrulis, A. Mulligan, F. O'Malley, 2012, Clinical Cancer Research.

DNA damage- and stress-induced apoptosis occurs independently of PIDD

S. Benchimol, W. Yeh, P. Ohashi, 2009, Apoptosis.

Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

M. Battegay, T. Kündig, M. Bachmann, 1995, Science.

TNF-α is critical for antitumor but not antiviral T cell immunity in mice

T. Mak, M. Pellegrini, P. Ohashi, 2007 .

High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation

B. Clarke, Azin Sayad, M. Bernardini, 2019, Journal of Immunotherapy for Cancer.

Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

T. Mak, S. Scheu, D. Häussinger, 2013, The Journal of allergy and clinical immunology.

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells.

F. Alt, Russell G. Jones, T. Sasaki, 2000, Immunity.

Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b1

Russell G. Jones, J. Penninger, P. Ohashi, 2005, The Journal of Immunology.

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3

Michael J. Parsons, Russell G. Jones, J. Woodgett, 2000, The Journal of experimental medicine.

Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2

L. Nguyen, D. Hogg, T. Waddell, 2019, Cancer Immunology, Immunotherapy.

Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen‐induced septic shock

T. Mak, G. Kroemer, J. Penninger, 1996, European journal of immunology.

Oxidized ATP inhibits T‐cell‐mediated autoimmunity

W. Brück, D. Häussinger, A. Meryk, 2010, European journal of immunology.

Mobilizing and evaluating anticancer T cells: pitfalls and solutions

D. Speiser, L. Nguyen, P. Ohashi, 2013, Expert review of vaccines.

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.

H. Griesser, T. Kündig, A. Wakeham, 1995, Science.

A point mutation in CD28 distinguishes proliferative signals from survival signals

K. Okkenhaug, T. Mak, W. Khoo, 2001, Nature Immunology.

Reactive oxygen species delay control of lymphocytic choriomeningitis virus

T. Mak, I. Harris, A. Pandyra, 2013, Cell Death and Differentiation.

TNF receptor p55 controls early acute graft-versus-host disease.

T. Mak, D. Speiser, M. Bachmann, 1997, Journal of immunology.

Requirement of the IL-2 Receptor β Chain for the Development of Vγ3 Dendritic Epidermal T Cells

T. Mak, P. Ohashi, Haruhiko Suzuki, 1998 .

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

T. Pugh, B. Clarke, M. Bernardini, 2018, Clinical Cancer Research.

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

T. Taniguchi, T. Mak, T. Kündig, 1993, Cell.

Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function.

M. Bachmann, P. Ohashi, T. Malek, 1999, International Immunology.

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.

Trevor J Pugh, T. Pugh, A. McGuigan, 2022, Immunity.

Enhanced T cell responses contribute to the genetic predisposition of CD8‐mediated spontaneous autoimmunity

P. Ohashi, K. Garza, A. Zakarian, 2002, European journal of immunology.

TCR affinity and negative regulation limit autoimmunity

D. Moskophidis, L. Nguyen, J. Boulter, 2004, Nature Medicine.

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

H. Pircher, R. Zinkernagel, P. Ohashi, 1993, Journal of immunology.

Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling*

L. Salmena, A. Hakem, R. Hakem, 2007, Journal of Biological Chemistry.

IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV

T. Mak, D. Speiser, A. Pandyra, 2014, Cell Death and Differentiation.

RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses

T. Mak, R. Flavell, M. Wilhelm, 2008, European journal of immunology.

A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation

Takashi Saito, Pamela S. Ohashi, Nien-Jung Chen, 2006, Science.

Contribution of LCMV transgenic models to understanding T lymphocyte development, activation, tolerance, and autoimmunity.

L. Nguyen, M. Bachmann, P. Ohashi, 2002, Current topics in microbiology and immunology.

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

Tak W. Mak, Pamela S. Ohashi, Alisha R. Elford, 2008, Proceedings of the National Academy of Sciences.

Deficiency of the B Cell-Activating Factor Receptor Results in Limited CD169+ Macrophage Function during Viral Infection

T. Mak, C. Ware, A. Pandyra, 2015, Journal of Virology.

Class II major histocompatibility complex‐restricted T cell function in CD4‐deficient mice

R. Zinkernagel, T. Mak, T. Kündig, 1994, European journal of immunology.

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.

Denis Bouchard, L. Salmena, A. Hakem, 2003, Genes & development.

T CELL RECEPTOR VARIABLE GENE USAGE IN A SPECIFIC CYTOTOXIC T CELL RESPONSE Primary Structure of the Antigen-MHC Receptor of Four Hapten-specific Cyotoxic T Cell Clones

H. Pircher, T. Mak, P. Ohashi, 2003 .

T-Cell Development and Tolerance in Virus-Specific Transgenic Models

P. Ohashi, 1996 .

Thymocyte Selection and Peripheral Tolerance Using the Lymphocytic Choriomeningitis Virus as a Model Antigen

H. Pircher, R. Zinkernagel, M. Battegay, 1994 .

Overproduction of IFNγ by Cbl-b–Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity

Azin Sayad, P. Ohashi, A. Elford, 2022, Cancer immunology research.

T Cell Tolerance versus Tumor Immunity or Autoimmunity

D. Speiser, P. Ohashi, 1998 .

Chronic viral infection promotes sustained Th 1-derived immunoregulatory IL-10 via BLIMP-1

S. Kaech, C. Weaver, I. Parish, 2022 .

The role of T-cell receptor dimerization in T-cell activation.

M. Bachmann, P. Ohashi, M F Bachmann, 1999, Immunology today.

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

D. Speiser, M. Bachmann, P. Ohashi, 1998, European journal of immunology.

Functional management of an antiviral cytotoxic T-cell response

D. Speiser, M. Bachmann, P. Ohashi, 1997, Journal of virology.

Natural killer cells regulate diverse T cell responses.

P. Ohashi, P. Lang, K. Lang, 2013, Trends in immunology.

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation.

T. Mak, D. Speiser, M. Bachmann, 1997, Immunity.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production

T. Mak, A. Pandyra, D. Mcilwain, 2016, Cellular Physiology and Biochemistry.

Negative selection and autoimmunity.

P. Ohashi, Pamela S Ohashi, 2003, Current opinion in immunology.

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection1

Pamela S. Ohashi, Denis Bouchard, Sanjeev Mariathasan, 2001, The Journal of Immunology.

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

T. Mak, A. Weiss, P. Ohashi, 1985, Nature.

A randomized phase II study of cabozantinib and nivolumab versus nivolumab in recurrent endometrial cancer.

D. Matei, S. Lheureux, R. Wildman, 2020 .

Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer

Trevor J Pugh, D. Matei, T. Pugh, 2022, Journal for ImmunoTherapy of Cancer.

An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

Trevor J Pugh, Benjamin Haibe-Kains, T. Pugh, 2019, Journal of Immunotherapy for Cancer.

A distinct innate lymphoid cell population regulates tumor-associated T cells

Trevor J Pugh, T. Pugh, B. Clarke, 2017, Nature Medicine.

Different Toll-Like Receptor Stimuli Have a Profound Impact on Cytokines Required to Break Tolerance and Induce Autoimmunity

P. Ohashi, A. Elford, Salim Dhanji, 2011, PloS one.

B7-H4 Expression by Nonhematopoietic Cells in the Tumor Microenvironment Promotes Antitumor Immunity

T. Mak, H. Berman, W. Suh, 2014, Cancer Immunology Research.

Costimulation, a surprising connection for immunotherapy

P. Ohashi, Derek L. Clouthier, Pamela S Ohashi, 2017, Science.

In vitro‐generated MART‐1‐specific CD8 T cells display a broader T‐cell receptor repertoire than ex vivo naïve and tumor‐infiltrating lymphocytes

L. Nguyen, P. Ohashi, N. Hirano, 2019, Immunology and cell biology.

T cell responses are governed by avidity and costimulatory thresholds

T. Mak, D. Speiser, M. Bachmann, 1996 .

Role of Antigen-Presenting Cells in Mediating Tolerance and Autoimmunity

L. Nguyen, Steven M. Chan, P. Ohashi, 2000, The Journal of experimental medicine.

Fighting cancers from within: augmenting tumor immunity with cytokine therapy.

T. Mak, M. Pellegrini, P. Ohashi, 2010, Trends in pharmacological sciences.

On T Cell Memory: Arguments for Antigen Dependence

H. Pircher, R. Zinkernagel, M. Bachmann, 1996, Immunological reviews.

Formation of TCR dimers/trimers as a crucial step for T cell activation

Annette Oxenius, A. Oxenius, M. Bachmann, 1998, European journal of immunology.

Regulation of Cytokine-Driven Functional Differentiation of CD8 T Cells by Suppressor of Cytokine Signaling 1 Controls Autoimmunity and Preserves Their Proliferative Capacity toward Foreign Antigens

G. Ferbeyre, P. Ohashi, R. Rottapel, 2010, The Journal of Immunology.

Capacity toward Foreign Antigens and Preserves Their Proliferative Signaling 1 Controls Autoimmunity Cells by Suppressor of Cytokine Functional Differentiation of CD8 T Regulation of Cytokine-Driven

P. Ohashi, R. Rottapel, S. Mariathasan, 2010 .

PKCθ Signals Activation versus Tolerance In Vivo

Russell G. Jones, D. Littman, P. Ohashi, 2004, The Journal of experimental medicine.

In Vivo Generation of Cytotoxic T Cells from Epitopes Displayed on Peptide-Based Delivery Vehicles1

J. Gariépy, L. Nguyen, P. Ohashi, 2002, The Journal of Immunology.

Vehicles DeliveryEpitopes Displayed on Peptide-Based In Vivo Generation of Cytotoxic T Cells from

J. Gariépy, L. Nguyen, P. Ohashi, 2002 .

Selection During Positive Versus Negative Thymocyte Signal-Regulated Kinase Signals Are Altered Duration and Strength of Extracellular

P. Ohashi, D. Bouchard, S. Mariathasan, 2001 .

Hsp70 Family Members, Danger Signals and Autoimmunity

P. Ohashi, D. Millar, 2007 .

T cell receptor (TcR) β chain transgenic mice: Studies on allelic exclusion and on the TcR+ γ/δ population

H. Pircher, T. Mak, P. Ohashi, 1990 .

Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer

B. Clarke, H. Berman, Azin Sayad, 2019, Oncoimmunology.

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.

D. Jaffray, P. Ohashi, M. Milosevic, 2018, ACS nano.

Mir‐155, a central modulator of T‐cell responses

P. Ohashi, E. Lind, 2014, European journal of immunology.

SNOW: Sitravatinib and nivolumab in oral cavity cancer (OCC) window of opportunity study.

T. Pugh, A. Hope, L. Siu, 2020 .

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

M. Ikura, P. Ohashi, K. Araki, 2016, Nature Cell Biology.

Intracellular Bacterial Challenges T Cell Responses to Acute Viral and + CD8155 Is Required for Optimal

P. Ohashi, A. Elford, E. Lind, 2013 .

Intracellular Bacterial Challenges T Cell Responses to Acute Viral and + CD8Micro-RNA 155 Is Required for Optimal

P. Ohashi, A. Elford, E. Lind, 2012 .

Cutting Edge: LFA-1 Is Required for Liver NK1.1+TCRαβ+ Cell Development: Evidence That Liver NK1.1+TCRαβ+ Cells Originate from Multiple Pathways

T. Mak, P. Ohashi, S. Koyasu, 1999, The Journal of Immunology.

Liver NK 1 . 1 Cell Development : Evidence + βα TCR + NK 1 . 1 Cutting Edge : LFA-1 Is Required for Liver Mak and

P. Ohashi, S. Koyasu, T. Ohteki, 1999 .

Expression of a Tumor Necrosis Factor cr Transgene in Murine Pancreatic / 3 Cells Results in Severe and Permanent InsuHtis without Evolution towards Diabetes

J., D., P. Ohashi, 2003 .

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection

E. Kremmer, M. Ostrowski, C. Kovacs, 2012, The Journal of experimental medicine.

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes

H. Pircher, T. Mak, P. Ohashi, 1986, The Journal of experimental medicine.

IRAK‐4 kinase activity is required for IRAK‐4‐dependent innate and adaptive immune responses

P. Ohashi, A. Elford, Salim Dhanji, 2008, European journal of immunology.

Correction for “ 14-3-3 σ regulates B-cell homeostasis through stabilization of FOXO 1

A. Hirao, A. Wakeham, G. Duncan, 2011 .

T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.

H. Pircher, T. Mak, H. Macdonald, 1990, European journal of immunology.

Regulation of T cell activation, anxiety, and male aggression by RGS2.

I. Whishaw, C. Barnes, J. Roder, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes

P. Ohashi, A. Elford, H. Hall, 2017, PloS one.

Transgenic Mice as an in vivo Model for Self‐Reactivity

T. Mak, P. Ohashi, V. Wallace, 1990, Immunological reviews.

Analysis of Immature (CD4–CD8–) Thymic Subsets in T-Cell Receptor αß Transgenic Mice

H. Pircher, H. Macdonald, P. Ohashi, 1992, Developmental Immunology.

The sound of silence: modulating anergy in T lymphocytes.

P. Ohashi, S. Saibil, E. Deenick, 2007, Current opinion in immunology.

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

T. Mak, W. Stanford, J. Penninger, 2022 .

Exposing Thy Self

Pamela S. Ohashi, P. Ohashi, 2002, Science.

On the role of antigen in maintaining cytotoxic T-cell memory.

H. Pircher, R. Zinkernagel, T. Kündig, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Reorganization of unique and repetitive sequences during nuclear development in Tetrahymena thermophila.

R. Pearlman, P. Ohashi, C. Brunk, 1982, Canadian Journal of Biochemistry.

Rational design and identification of immuno-oncology drug combinations.

Benjamin Haibe-Kains, H. Selby, L. Siu, 2018, European journal of cancer.

Mir#x02010;155, a central modulator of T#x02010;cell responses

P. Ohashi, E. Lind, 2013 .

ILC transdifferentiation: roles in cancer progression

P. Ohashi, M. Ghaedi, 2020, Cell Research.

Structures and evolution of the T-cell antigen receptor genes.

T. Mak, P. Ohashi, A. Iwamoto, 1986, Cold Spring Harbor Symposia on Quantitative Biology.

Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis.

D. Speiser, M. Bachmann, P. Ohashi, 1997, Journal of immunology.

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

T. Mak, G. Duncan, A. Brüstle, 2011, Oncogene.

Immunoscore clinical utility to identify good prognostic colon cancer stage II patients with high-risk clinico-pathological features for whom adjuvant treatment may be avoided.

F. Marincola, P. Ascierto, I. Nagtegaal, 2019, Journal of Clinical Oncology.

IL-18-Mediated Signaling Accessory Protein-Like Is Essential for

Pamela S. Ohashi, Wen-Chen Yeh, Heidi Cheung, 2013 .

Specific deletion of the J‐Cδ locus in murine α/β T cell clones and studies using transgenic mice

H. Pircher, T. Mak, P. Ohashi, 1990 .

Thymic ontogeny and selection of alpha beta and gamma delta T cells.

T. Mak, M. Schilham, P. Ohashi, 1989, Immunology today.

The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28‐mediated co‐stimulation

K. Tedford, J. Penninger, I. Kozieradzki, 1999, European journal of immunology.

Regulation of T cell activation , anxiety , and male aggression by RGS 2

I. Whishaw, C. Barnes, J. Roder, 2000 .

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

D. Speiser, M. Bachmann, P. Ohashi, 1998, European journal of immunology.

Significant differences in outcome between Immunoscore categories in stage I colon cancer patients.

F. Marincola, P. Ascierto, I. Nagtegaal, 2019, Annals of Oncology.

Bespoke circulating tumor DNA (ctDNA) analysis as a predictive biomarker in solid tumor patients (pts) treated with single agent pembrolizumab (P)

S. Shchegrova, T. Pugh, H. Sethi, 2019, Annals of Oncology.

Modulating autoimmunity: pick your PI3 kinase

J. Woodgett, P. Ohashi, 2005, Nature Medicine.

Expression of CD4 can confer major histocompatibility complex class II‐associated superantigen reactivity upon a T cell receptor derived from a CD8‐dependent cytotoxic T lymphocyte clone

T. Mak, P. Ohashi, V. Wallace, 1990, European journal of immunology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Amanda R. Campbell, F. Lund-Johansen, Yair Benita, 2016 .

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

T. Mak, B. Assouline, L. Nguyen, 2009, Nature Medicine.

Corrigendum: Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

T. Mak, B. Assouline, L. Nguyen, 2009 .