M. Rahmani

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oxidative stress and histone deacetylase inhibitors involves Akt down-regulation and Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME)

Xianglin Shi, P. Dent, S. Grant, 2013 .

Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress.

Xianglin Shi, P. Dent, S. Grant, 2006, Blood.

2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process

P. Dent, S. Grant, N. Gao, 2005, Oncogene.

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

D. Conrad, P. Dent, S. Grant, 2003, Cancer research.

UCN-01 (7-Hydroxystauorsporine) Blocks PMA-Induced Maturation and Reciprocally Promotes Apoptosis in Human Myelomonocytic Leukemia Cells (U937)

S. Grant, M. Rahmani, 2002, Cell cycle.

The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

D. Paik, S. Payne, S. Spiegel, 2004, Cancer Research.

Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.

Paul Dent, Chunrong Yu, P. Dent, 2002, Cancer research.

The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.

P. Dent, S. Grant, M. Rahmani, 2004, Experimental cell research.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

The Kinase Inhibitor Sorafenib Induces Cell Death through a Process Involving Induction of Endoplasmic Reticulum Stress

P. Dent, S. Grant, M. Rahmani, 2007, Molecular and Cellular Biology.

Apoptosis Induced by the Kinase Inhibitor BAY 43-9006 in Human Leukemia Cells Involves Down-regulation of Mcl-1 through Inhibition of Translation*

P. Dent, S. Grant, M. Rahmani, 2005, Journal of Biological Chemistry.

Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.

Jorge A. Almenara, D. Conrad, P. Dent, 2003, Cancer research.

Melanoma Differentiation Associated Gene-7/Interleukin-24 Potently Induces Apoptosis in Human Myeloid Leukemia Cells through a Process Regulated by Endoplasmic Reticulum Stress

P. Fisher, P. Dent, S. Grant, 2010, Molecular Pharmacology.

Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process

S. Grant, M. Rahmani, Yun Dai, 2003, Oncogene.

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

P. Fisher, D. Häussinger, P. Dent, 2010, Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics 17-Allylamino-17-Demethoxygeldanamycin and MEK 1 / 2 Inhibitors Kill GI Tumor Cells via Ca 2 +-Dependent Suppression of GRP 78 / BiP and Induction of Ceramide and Reactive Oxygen Species

P. Fisher, D. Häussinger, P. Dent, 2010 .

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

S. Grant, M. Rahmani, A. Ferreira-Gonzalez, 2013, Cancer Research.

Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways

D. Conrad, P. Dent, S. Grant, 2003, Cancer biology & therapy.

Kinase 1 Activation Downregulation, and C-jun N-terminal Mediated by Oxidative Damage, Xiap Leukemia Cells through a Process B Activation Potentiates Apoptosis in Κ Nf- Inhibitor-induced Rela/p65 Acetylation and Blockade of Histone Deacetylase

P. Dent, S. Grant, M. Rahmani, 2005 .

Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.

P. Dent, S. Grant, M. Rahmani, 2003, Cancer research.

Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways

P. Dent, S. Grant, M. Rahmani, 2005, Molecular Cancer Therapeutics.

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.

E. Sausville, P. Dent, S. Grant, 2003, Blood.

The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism

P. Dent, S. Grant, N. Gao, 2006, Molecular Pharmacology.

The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.

S. Grant, A. Berger, L. Povirk, 2016, Blood.

Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload.

J. Woodgett, D. Tilley, M. Rahmani, 2019, Journal of molecular and cellular cardiology.

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

John D. Roberts, P. Fisher, P. Dent, 2008, Clinical Cancer Research.

Induced G 2 M Arrest and Attenuates Mitochondrial Injury and Apoptosis in p53-Null Human Leukemia Cells

P. Dent, S. Grant, M. Rahmani, 2004 .

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity

P. Fisher, John Calvin Reed, P. Dent, 2011, Proceedings of the National Academy of Sciences.

resistant to STI 571 cells sensitive and + deacetylase inhibitors to induce apoptosis in Bcr / Abl

D. Conrad, P. Dent, S. Grant, 2003 .

CellsSynergistically Induces Apoptosis in Human Leukemia Suberoylanilide Hydroxamic Acid or Sodium Butyrate 17-Allylamino-17-demethoxygeldanamycin with Coadministration of the Heat Shock Protein 90 Antagonist Updated

P. Dent, S. Grant, M. Rahmani, 2003 .

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

Barbara S. Paugh, S. Milstien, S. Spiegel, 2008, Blood.

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

P. Fisher, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Contribution of Disruption of the Nuclear Factor-κB Pathway to Induction of Apoptosis in Human Leukemia Cells by Histone Deacetylase Inhibitors and Flavopiridol

P. Dent, S. Grant, N. Gao, 2004, Molecular Pharmacology.

Targeting Mcl-1 for the therapy of cancer

P. Fisher, John Calvin Reed, P. Dent, 2011, Expert opinion on investigational drugs.

Functional cooperation between JunD and NF-κB in rat hepatocytes

J. Weitzman, M. Rahmani, L. Bakiri, 2001, Oncogene.

Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.

D. Conrad, P. Dent, S. Grant, 2004, Blood.

Interruption of the NF-B pathway by Bay 11-7082 promotes UCN-01 – mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

D. Conrad, P. Dent, S. Grant, 2003 .

therapeutic targets in human leukemia A selective sphingosine kinase 1 inhibitor integrates multiple molecular

Barbara S. Paugh, S. Milstien, S. Spiegel, 2013 .

oxygen species (ROS)-dependent mechanism inhibitors to induce apoptosis in human leukemia cells through a reactive The tyrphostin adaphostin interacts synergistically with proteasome

P. Dent, S. Grant, M. Rahmani, 2013 .

The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism.

P. Dent, S. Grant, M. Rahmani, 2006, Blood.

Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling*

P. Fisher, P. Dent, S. Grant, 2008, Journal of Biological Chemistry.

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells.

S. Grant, J. Leverson, M. Rahmani, 2018, Cancer research.

Hepatocyte growth factor activates the AP-1 complex: a comparison between normal and transformed rat hepatocytes.

M. Rahmani, D. Bernuau, B. Lardeux, 1999, Journal of hepatology.

HER2 overexpression is a putative diagnostic and prognostic biomarker for late-stage colorectal cancer in North African patients

R. Hamoudi, K. Bajbouj, M. Rahmani, 2021, The Libyan journal of medicine.

An Intact NF-kappaB Pathway is Required for Histone Deacetylase Inhibitor Induced G1 Arrest and Maturation in U937 Human Myeloid Leukemia Cells

S. Grant, M. Rahmani, Yun Dai, 2003, Cell cycle.

Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.

Jorge A. Almenara, P. Dent, S. Grant, 2002, Molecular pharmacology.

Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells.

M. Rahmani, S. Ahmed, S. Prigent, 2019, The international journal of biochemistry & cell biology.

Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather than AKT inhibition

P. Dent, S. Grant, M. Rahmani, 2003, Oncogene.

The Histone Deacetylase Inhibitor Sodium Butyrate Interacts Synergistically with Phorbol Myristate Acetate (PMA) to Induce Mitochondrial Damage and Apoptosis in Human Myeloid Leukemia Cells through a Tumor Necrosis Factor-α-Mediated Process

S. Grant, M. Rahmani, Yun Dai, 2002 .

Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients

Arab M. Hammoudeh, H. Busch, R. Hamoudi, 2021, Frontiers in Immunology.

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.

S. Payne, S. Spiegel, P. Dent, 2005, Cancer research.

Potentiation of Smad Transactivation by Jun Proteins during a Combined Treatment with Epidermal Growth Factor and Transforming Growth Factor-β in Rat Hepatocytes

M. Rahmani, D. Bernuau, B. Lardeux, 2001, The Journal of Biological Chemistry.

Presence of distinct AP‐1 dimers in normal and transformed rat hepatocytes under basal conditions and after epidermal growth factor stimulation

M. Rahmani, D. Bernuau, B. Lardeux, 1997, Hepatology.

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

P. Fisher, S. Spiegel, K. Ryan, 2008, Cancer biology & therapy.

The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

Paul Dent, Chunrong Yu, D. Conrad, 2003, Blood.

The Multikinase Inhibitor Sorafenib Induces Apoptosis in Highly Imatinib Mesylate-Resistant Bcr/Abl+ Human Leukemia Cells in Association with Signal Transducer and Activator of Transcription 5 Inhibition and Myeloid Cell Leukemia-1 Down-Regulation

Paul Dent, P. Dent, S. Grant, 2007, Molecular Pharmacology.

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.

S. Grant, M. Rahmani, C. Dumur, 2015, Blood.

Functional cooperation between JunD and NF-kappaB in rat hepatocytes.

J. Weitzman, M. Rahmani, L. Bakiri, 2001, Oncogene.

Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives

M. Rahmani, Shirin Hafezi, 2021, Cancers.

Abl/Src inhibitor BMS-354/825 MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual

P. Dent, S. Grant, H. Harada, 2013 .

MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825.

P. Dent, S. Grant, H. Harada, 2007, Blood.

Synergistic Interactions between DMAG and Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors in Bcr/abl+ Leukemia Cells Sensitive and Resistant to Imatinib Mesylate

B. Druker, P. Dent, S. Grant, 2006, Clinical Cancer Research.

Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.

D. Conrad, P. Dent, S. Grant, 2003, Cancer research.

PI3K/mTOR Inhibition Markedly Potentiates HDAC Inhibitor Activity in NHL Cells through BIM- and MCL-1–Dependent Mechanisms In Vitro and In Vivo

J. Friedberg, S. Grant, M. Rahmani, 2014, Clinical Cancer Research.

Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

Jing Wang, M. Konopleva, M. Andreeff, 2019, Haematologica.

Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine.

P. Fisher, John Calvin Reed, P. Dent, 2010, Cancer research.

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

P. Dent, S. Grant, M. Rahmani, 2005, Blood.

INTERRUPTION OF BOTH AKT AND MEK / ERK PATHWAYS AND ACTIVATION OF SEK 1 / JNK

P. Dent, S. Grant, M. Rahmani, 2004 .

Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.

S. Grant, M. Rahmani, P. Bose, 2014, Physiological genomics.

The Cyclin-Dependent Kinase Inhibitor p21CIP1/WAF1 Blocks Paclitaxel-Induced G2M Arrest and Attenuates Mitochondrial Injury and Apoptosis in p53-Null Human Leukemia Cells

P. Dent, S. Grant, M. Rahmani, 2004 .

Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology

Arab M. Hammoudeh, R. Hamoudi, Q. Hamid, 2021, World journal of gastroenterology.

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.

P. Dent, S. Grant, M. Rahmani, 2004, Blood.

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

Paul Dent, Hisashi Harada, Andrea Ferreira-Gonzalez, 2009, Blood.

Systems Immunology Analysis Reveals an Immunomodulatory Effect of Snail-p53 Binding on Neutrophil- and T Cell-Mediated Immunity in KRAS Mutant Non-Small Cell Lung Cancer

R. Hamoudi, Q. Hamid, M. Rahmani, 2020, Frontiers in Immunology.

A Bcr/Abl-independent, Lyn-dependent Form of Imatinib Mesylate (STI-571) Resistance Is Associated with Altered Expression of Bcl-2*

Yun Dai, Paul Dent, Seth J Corey, 2004, Journal of Biological Chemistry.

BCL-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress

J. Friedberg, R. Fisher, P. Dent, 2009, Cancer biology & therapy.

Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process

Jorge A. Almenara, E. Sausville, P. Dent, 2004, Oncogene.

Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms

S. Grant, M. Rahmani, B. Holkova, 2017, Oncotarget.

The development of MDA-7/IL-24 as a cancer therapeutic.

P. Fisher, P. Dent, A. Yacoub, 2010, Pharmacology & therapeutics.

MDA-7/IL-24 as a cancer therapeutic: from bench to bedside

P. Fisher, P. Dent, A. Yacoub, 2010, Anti-cancer drugs.

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

P. Houghton, P. Dent, A. Yacoub, 2009, Molecular Pharmacology.

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing

A. Thorburn, D. Häussinger, P. Dent, 2009, Molecular Pharmacology.

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.

S. Grant, M. Rahmani, A. Ferreira-Gonzalez, 2012, Blood.

The BH 3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI 3 K / Akt and MEK / ERK 1 / 2 pathways

P. Dent, S. Grant, H. Harada, 2009 .

Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation

S. Grant, M. Rahmani, C. Dumur, 2015, Haematologica.

Inhibition Of PI3K/mTOR By BEZ235 Dramatically Potentiates Panobinostat-Induced Lethality In Diffuse Large B-Cell Lymphoma Through Multiple Mechanisms

S. Grant, M. Rahmani, M. Aust, 2013 .

The cyclin-dependent kinase inhibitor p21(CIP1/WAF1) blocks paclitaxel-induced G2M arrest and attenuates mitochondrial injury and apoptosis in p53-null human leukemia cells.

P. Dent, S. Grant, M. Rahmani, 2004, Cell cycle.

PROTACs: Walking through hematological malignancies

Habiba S. Alsafar, M. Rahmani, S. Ibrahim, 2023, Frontiers in Pharmacology.

The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process.

S. Grant, M. Rahmani, Yun Dai, 2002, Experimental cell research.

The Farnesyltransferase Inhibitor L744832 Potentiates UCN-01–Induced Apoptosis in Human Multiple Myeloma Cells

P. Dent, S. Grant, M. Rahmani, 2005, Clinical Cancer Research.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

cells sensitive and resistant to STI-571 in association with down-regulation of Bcr- Abl, abrogation of STAT5 activity, and Bax conformational change.

R. Jove, Meijuan Huang, P. Dent, 2004 .

The BH3-only protein Bim plays a critical role in cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK pathways in human leukemia cells

P. Dent, S. Grant, M. Rahmani, 2008 .

The 14-Kilodalton Human Growth Hormone Fragment a Potent Inhibitor of Angiogenesis and Tumor Metastasis

M. Rahmani, I. Struman, K. Bajou, 2023, International journal of molecular sciences.

GLS Inhibitor CB-839 Modulates Cellular Metabolism in AML and Potently Suppresses AML Cell Growth when Combined with 5-Azacitidine

D. Rakheja, M. Konopleva, A. Verma, 2016 .

The kinase inhibitor sorafenib induces cell death through a process involving induction of ER stress

P. Dent, S. Grant, M. Rahmani, 2007 .

THE MULTIKINASE INHIBITOR SORAFENIB INDUCES APOPTOSIS IN HIGHLY IMATINIB MESYLATE-RESISTANT BCR/ABL + HUMAN LEUKEMIA CELLS IN ASSOCIATION WITH STAT5 INHIBITION AND MCL-1 DOWN-REGULATION

P. Dent, S. Grant, M. Rahmani, 2007 .

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

S. Grant, M. Rahmani, A. Ferreira-Gonzalez, 2013, Cancer research.

BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing

A. Thorburn, D. Häussinger, P. Dent, 2009, Molecular Pharmacology.

Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

P. Houghton, P. Dent, A. Yacoub, 2009, Molecular Pharmacology.

Blockade of Histone Deacetylase Inhibitor-Induced RelA/p65 Acetylation and NF-κB Activation Potentiates Apoptosis in Leukemia Cells through a Process Mediated by Oxidative Damage, XIAP Downregulation, and c-Jun N-Terminal Kinase 1 Activation

P. Dent, S. Grant, M. Rahmani, 2005, Molecular and Cellular Biology.

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.

E. Sausville, P. Dent, S. Grant, 2003, Blood.

The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.

S. Grant, A. Berger, L. Povirk, 2016, Blood.

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

Barbara S. Paugh, Jorge A. Almenara, S. Milstien, 2008, Blood.

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity

P. Fisher, John Calvin Reed, P. Dent, 2011, Proceedings of the National Academy of Sciences.

Apoptosis in Bcr/abl-expressing Human Leukemia Cells Kinase Inhibitors Interact Synergistically with Sti571 to Induce Signal-regulated Kinase Kinase/mitogen-activated Protein Pharmacologic Mitogen-activated Protein/extracellular Updated Version Cited Articles Citing Articles E-mail Alerts Pharmacolo

M. Rahmani, Chunrong Yu, G. Krystal, 2022 .