A. Lapucci

发表

Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer.

G. Nesi, S. Sestito, V. Mey, 2013, ACS medicinal chemistry letters.

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme.

C. Martini, G. Nesi, S. Sestito, 2015, European journal of medicinal chemistry.

Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications.

A. Lapucci, M. Breschi, S. Rapposelli, 2015, Bioorganic & medicinal chemistry.

Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells.

A. Lapucci, M. Breschi, S. Fogli, 2010, European journal of medicinal chemistry.

Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein

L. Menichetti, G. Nesi, A. Lapucci, 2016, Molecular Imaging and Biology.

Synthesis and Biological Evaluation of 2′‐Oxo‐2,3‐dihydro‐3′H‐ spiro[chromene‐4,5′‐[1,3]oxazolidin]‐3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors

F. Da Settimo, C. La Motta, A. Lapucci, 2011, Archiv der Pharmazie.

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.

R. Perrone, N. Colabufo, G. Nesi, 2014, European journal of medicinal chemistry.

Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties.

A. Lapucci, S. Rapposelli, S. Nencetti, 2001, European journal of medicinal chemistry.

An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives.

A. Lapucci, M. Breschi, A. Martinelli, 1985, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.

A. Lapucci, S. Rapposelli, R. Pi, 2015, Bioorganic & medicinal chemistry letters.

CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES

A. Lapucci, M. Breschi, A. Martinelli, 1994 .

Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.

A. Lapucci, S. Rapposelli, M. Pinza, 2004, Farmaco.

Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines].

A. Lapucci, G. Giannaccini, A. Martinelli, 2002, European journal of medicinal chemistry.

Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.

C. Martini, A. Lapucci, M. Breschi, 1993, Journal of medicinal chemistry.

Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.

C. Martini, A. Lapucci, M. Breschi, 1992, Journal of medicinal chemistry.

Synthesis and evaluation of the pharmacological activity of rigid analogues of sympathomimetic catecholamines derived from bicyclo[2.2.1]heptane.

A. Lapucci, M. Breschi, S. Nencetti, 1989, Journal of medicinal chemistry.

Conformational effects on the activity of drugs. 11. Stereostructural models for the direct activation of the alpha- and beta-adrenergic receptor.

A. Lapucci, M. Breschi, E. Epifani, 1986, Journal of medicinal chemistry.

Conformational effects on the activity of drugs. 10. Synthesis, conformation, and pharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanols and their morpholine analogues.

A. Lapucci, M. Breschi, E. Epifani, 1983, Journal of medicinal chemistry.

Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole.

A. Lapucci, S. Rapposelli, A. Martinelli, 2002, Journal of medicinal chemistry.

Structure--activity relationship in cinnamamides. 3. Synthesis and anticonvulsant activity evaluation of some derivatives of (E)- and (Z)-m-(trifluoromethyl)cinnamamide.

A. Lapucci, A. Balsamo, P. Crotti, 1981, Journal of Medicinal Chemistry.

STRUCTURE-ACTIVITY RELATIONSHIP IN CINNAMAMIDES. 3. SYNTHESIS AND ANTICONVULSANT ACTIVITY EVALUATION OF SOME DERIVATIVES OF (E)- AND (Z)-M-(TRIFLUOROMETHYL)CINNAMAMIDE

A. Lapucci, A. Balsamo, P. Crotti, 1981 .

Role of the (acyloxy)methyl moiety in eliciting the adrenergic beta-blocking activity of 3-(acyloxy)propanolamines.

A. Lapucci, M. Breschi, A. Martinelli, 1987, Journal of medicinal chemistry.

Synthesis and β-Adrenergic Properties of (Z)-N-[3-(Alkylamino)-2-hydroxypropylidene](aryl-methyloxy)amines: Effects of the Configuration Around the Methyloxyiminomethyl (MOIM) Double Bond on the Biopharmacological Properties of MOIM-type β-Blocking Agents

A. Lapucci, M. Breschi, G. Chiellini, 1998 .

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma.

E. Novellino, C. Martini, G. Nesi, 2016, European journal of medicinal chemistry.

3‐[(aryl)(4‐fluorobenzyloxy)methyl]piperidine derivatives: high‐affinity ligands for the serotonin transporter

G. Demontis, A. Lapucci, S. Nencetti, 2007, The Journal of pharmacy and pharmacology.

Synthesis and in‐vitro antitumour activity of new naphthyridine derivatives on human pancreatic cancer cells

A. Lapucci, M. Breschi, S. Fogli, 2009 .

Synthesis and inhibitory activity towards human leukocyte elastase of new 7α-methoxy and 7α-chloro (2-acyloxymethyl) cephem derivatives

A. Lapucci, S. Rapposelli, E. Orlandini, 2001 .

Synthesis and pharmacological activity of 1-phenyl-2-oxa-5-azabicyclo[4.4.0]decane derivatives

A. Lapucci, A. Balsamo, F. Macchia, 1984 .

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Joel S. Freundlich, J. Sacchettini, A. Lapucci, 2009, PloS one.

Molecular design, synthesis, and antiinflammatory activity of a series of beta-aminoxypropionic acids.

A. Lapucci, A. Martinelli, S. Nencetti, 1990, Journal of medicinal chemistry.

Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties.

F. Mancini, A. Lapucci, S. Rapposelli, 2002, European journal of medicinal chemistry.

Allosteric Inhibition of ET-1 Binding to ETA Receptors by

A. Lapucci, S. Nencetti, M. Mazzoni, 2011 .