J. Primrose

M. Mcphail, J. Primrose, M. Abu Hilal, 2008, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies

O. Garden, G. Poston, J. Primrose, 2006, British Journal of Cancer.

Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma

J. Primrose, C. Ottensmeier, G. Thomas, 2015, British Journal of Cancer.

Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.

M. Jones, J. Primrose, P. Selby, 1997, British Journal of Cancer.

T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases

S. Khakoo, J. Primrose, R. Harrison, 2014, BMC Cancer.

Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR‐200 levels in extracellular vesicles

O. De Wever, J. Primrose, A. Mirnezami, 2022, Journal of extracellular vesicles.

High-affinity binding sites for gastrin-releasing peptide on human colorectal cancer tissue but not uninvolved mucosa.

J. Primrose, S. Preston, G. Miller, 1995, British Journal of Cancer.

Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer.

D. Tompkins, J. Primrose, J. Crabtree, 1993, Gut.

Peri‐operative modulation of cellular immunity in patients with colorectal cancer

J. Primrose, L. Trejdosiewicz, J. Primrose, 1993, Clinical and Experimental Immunology.

Somatostatin and Human Gastrointestinal Cancer

J. Primrose, S. Preston, G. Miller, 1993 .

Surgical Management of Benign and Indeterminate Hepatic Lesions in the Era of Laparoscopic Liver Surgery

J. Primrose, D. A. Godfrey, M. Abu Hilal, 2011, Digestive Surgery.

Are the current difficulty scores for laparoscopic liver surgery telling the whole story? An international survey and recommendations for the future.

J. Primrose, D. Cherqui, M. Abu Hilal, 2017, HPB : the official journal of the International Hepato Pancreato Biliary Association.

Single-Centre Comparative Study of Laparoscopic Versus Open Right Hepatectomy

J. Primrose, M. Abu Hilal, N. Pearce, 2011, Journal of Gastrointestinal Surgery.

Outcome and Learning Curve in 159 Consecutive Patients Undergoing Total Laparoscopic Hemihepatectomy.

J. Primrose, M. Besselink, S. van Dieren, 2016, JAMA surgery.

Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.

J. Raftery, J. Neoptolemos, D. Stocken, 2019, The Lancet. Oncology.

Intrahepatic cholangiocarcinoma as the new field of implementation of laparoscopic liver resection programs. A comparative propensity score-based analysis of open and laparoscopic liver resections

J. Primrose, L. Aldrighetti, M. Abu Hilal, 2020, Surgical Endoscopy.

Assessment of the financial implications for laparoscopic liver surgery: a single-centre UK cost analysis for minor and major hepatectomy

J. Primrose, Shareef Syed, M. Abu Hilal, 2013, Surgical Endoscopy.

Propensity score‐based analysis of outcomes of laparoscopic versus open liver resection for colorectal metastases

J. Primrose, L. Stanton, T. Armstrong, 2016, The British journal of surgery.

Gastric juice ascorbic acid: effects of disease and implications for gastric carcinogenesis.

J. Primrose, C. Schorah, G. Sobala, 1991, The American journal of clinical nutrition.

Body Composition, Physiological Function and Psychological Changes in Patients with Predicted Severe Acute Pancreatitis

J. Primrose, R. Gupta, R. Rajani, 2001, Pancreatology.

Somatostatin binding in human gastrointestinal tissues : effect ofcations and somatostatin analogues TABLE I Characterisation of somatostatin binding in rat cerebral cortex and human gastrointestinal tissues Rat Gastric Gastric Colonic Colonic cortex mucosa cancer mucosa cancer

J. Primrose, S. Preston, G. Miller, 2006 .

Somatostatin binding in human gastrointestinal tissues: effect of cations and somatostatin analogues.

J. Primrose, S. Preston, G. Miller, 1993, Gut.

Carcinoembryonic antigen monitoring to detect recurrence of colorectal cancer: how should we interpret the test results?

D. Mant, J. Primrose, B. Nicholson, 2014, Clinical chemistry.

Serum CEA trends for Diagnosing Colorectal Cancer Recurrence in the FACS Randomised Clinical Trial

R. Perera, D. Mant, J. Primrose, 2017 .

Current standards and future perspectives in adjuvant treatment for biliary tract cancers.

M. Nagino, J. Bridgewater, J. Primrose, 2019, Cancer treatment reviews.

Is antral gastrin important in the resistance of duodenal ulcers to H2 receptor antagonists or in recurrent ulceration after highly selective vagotomy?

J. Primrose, D. Johnston, J. Holmfield, 1990, Gut.

Total laparoscopic hemihepatectomy: Outcome and learning curve in 159 consecutive patients

J. Primrose, M. Besselink, T. Armstrong, 2016 .

Perioperative immunotherapy with recombinant interleukin 2 in patients undergoing surgery for colorectal cancer.

J. Primrose, P. Sedman, U. Ward, 1992, Cancer research.

Reduction in Factor VII, Fibrinogen and Plasminogen Activator Inhibitor-1 Activity after Surgical Treatment of Morbid Obesity

J. Primrose, D. Johnston, C. Prentice, 1992, Thrombosis and Haemostasis.

Molecular profiling of the invasive tumor microenvironment in a 3-dimensional model of colorectal cancer cells and ex vivo fibroblasts.

G. Packham, M. Bullock, J. Primrose, 2014, Journal of visualized experiments : JoVE.

The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer.

J. Bridgewater, H. Verheul, J. Primrose, 2018, European journal of cancer.

No Association between Cytochrome P450 and Glutathione S-Transferase Gene Polymorphisms and Risk of Colorectal Adenoma: Results from the UK Flexible Sigmoidoscopy Screening Trial

M. Watson, M. Gunter, S. Bingham, 2005, Cancer Epidemiology Biomarkers & Prevention.

Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa.

J. Primrose, J. Crabtree, N. Ramsay, 1994, Journal of clinical pathology.

Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.

J. Barber, D. Eccles, R. Fodde, 1996, American journal of human genetics.

Effects of impaired renal function on the pharmacokinetics of raltitrexed (Tomudex ZD1694).

P. Beale, P. Hoskin, I. Judson, 1998, British Journal of Cancer.

High affinity binding sites for gastrin releasing peptide on human gastric cancer and Ménétrier's mucosa.

J. Primrose, S. Preston, L. Woodhouse, 1993, Cancer research.

The impact of enhanced recovery on open and laparoscopic liver resections

J. Primrose, F. Giovinazzo, T. Armstrong, 2020, Updates in Surgery.

EORTC liver metastases intergroup randomized phase III study 40983: Long-term survival results.

P. Schlag, B. Nordlinger, M. Mauer, 2012 .

Mir-31-3p as a predictive biomarker of cetuximab effects in a post hoc analysis of new EPOC phase III trial.

S. Imbeaud, P. Laurent-Puig, J. Bridgewater, 2014 .

Adjuvant Chemotherapy in Resected Biliary Tract Cancer

J. Primrose, 2020, Annals of Surgical Oncology.

Evaluation and management of incidental gallbladder cancer.

S. Maithel, G. Abou-Alfa, J. Primrose, 2019, Chinese clinical oncology.

Cetuximab Is Contraindicated in the Perioperative Treatment of Colorectal Liver Metastases.

T. Hickish, O. Garden, D. Cunningham, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

BILCAP: A randomized clinical trial evaluating adjuvant chemotherapy with capecitabine compared to expectant treatment alone following curative surgery for biliary tract cancer.

J. Bridgewater, J. Primrose, C. Stubbs, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Patterns of progression, treatment of progressive disease, and postprogression survival in the new EPOC study.

O. Garden, D. Cunningham, J. Bridgewater, 2014 .

Indications, trends, and perioperative outcomes of minimally invasive and open liver surgery in non-obese and obese patients: An international multicentre propensity score matched retrospective cohort study of 9963 patients.

F. Giuliante, B. Edwin, M. Vivarelli, 2022, International journal of surgery.

Optimisation of DNA and RNA extraction from archival formalin-fixed tissue.

J. Primrose, A. Gough, N. Coombs, 1999, Nucleic acids research.

Tumor response to pre-operative chemotherapy (CT) with FOLFOX-4 for resectable colorectal cancer liver metastases (LM). Interim results of EORTC Intergroup randomized phase III study 40983.

E. Van Cutsem, B. Nordlinger, H. Sorbye, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study.

M. Watson, M. Gunter, S. Bingham, 2006, Carcinogenesis.

Helicobacter pylori in gastric cancer . Systemic and mucosal humoral responses to and

D. Tompkins, J. Primrose, J. Crabtree, 2006 .

A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy

R. Weichselbaum, M. Talamonti, M. D'Angelica, 2022, npj Precision Oncology.

Haemostatic responses and vasopressin release during colonoscopy in man.

J. Primrose, P. Grant, C. Prentice, 1991, Clinical science.

Surgeons' assessment versus risk models for predicting complications of hepato-pancreato-biliary surgery (HPB-RISC): a multicenter prospective cohort study.

H. Verkooijen, J. Primrose, M. Besselink, 2018, HPB : the official journal of the International Hepato Pancreato Biliary Association.

A randomized clinical trial of chemotherapy compared to chemotherapy in combination with cetuximab in k-RAS wild-type patients with operable metastases from colorectal cancer: The new EPOC study.

T. Hickish, J. Gardner-Thorpe, D. Cunningham, 2013 .

Analysis of somatostatin receptor subtype mRNA expression in human breast cancer.

T. Crook, J. Primrose, S. Laws, 1997, British Journal of Cancer.

Surveillance for recurrence of colorectal cancer--reply.

D. Mant, J. Primrose, 2014, JAMA.

Comment on “Considerations for the treatment of pancreatic cancer during the COVID-19 pandemic: the UK consensus position”

J. Primrose, A. Dennison, A. Cook, 2020, British Journal of Cancer.

Hyperkalemia in patients on enteral feeding.

J. Primrose, A. Shenkin, A. Sim, 1981, JPEN. Journal of parenteral and enteral nutrition.

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

R. Spizzo, M. Fabbri, G. Calin, 2015, Gut.

Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression

K. Veselkov, N. Shomron, O. De Wever, 2017, Aging.

Somatostatin binding in normal and malignant human gastrointestinal mucosa.

J. Primrose, G. Miller, S. Farmery, 1992, British Journal of Cancer.

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

M. Ducreux, L. Rimassa, J. Bridgewater, 2022, Annals of oncology : official journal of the European Society for Medical Oncology.

Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial

David Goldstein, John Bridgewater, Alexander Stein, 2015 .

Long-Term Outcomes and Exploratory Analyses of the Randomized Phase III BILCAP Study

D. Stocken, J. Bridgewater, J. Primrose, 2022, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The eflects of 300 mg ranitidine at night, twice daily and four times daily on intragastric acidity in normal subjects

J. Primrose, J. Holmfield, J. Primrose, 1993, Alimentary pharmacology & therapeutics.

Cellular resistance to mitomycin C is associated with overexpression of MDR‐1 in a urothelial cancer cell line (MGH‐U1)

J. Primrose, M. Hayes, B.R. Birch, 2001, BJU international.

Adenoid cystic carcinoma of the lacrimal gland metastasising to the liver: report of a case

J. Primrose, M. Hilal, B. Zeidan, 2006, World journal of surgical oncology.

The effect of 5-fluorouracil and alpha interferon and 5-fluorouracil and leucovorin on cellular anti-tumour immune responses in patients with advanced colorectal cancer.

J. Primrose, U. Ward, C. Ramsden, 1994, British Journal of Cancer.

Exploring the role of laparoscopic surgery in two-stage hepatectomy for bilobar colorectal liver metastases.

J. Primrose, R. Whistance, M. Abu Hilal, 2012, Journal of laparoendoscopic & advanced surgical techniques. Part A.

Perioperative chemotherapy with or without cetuximab in patients (pts) with resectable colorectal liver metastasis (CRLM): Mature analysis of overall survival (OS) in the New EPOC randomised controlled trial

T. Hickish, D. Cunningham, J. Bridgewater, 2017 .

Minimally invasive ver-sus open liver resection for hepatocellular carcinoma in the elderly: international multicentre propensity score-matched study.

F. Giuliante, B. Edwin, M. Vivarelli, 2022, The British journal of surgery.

Assessment of the secretin provocation test in the diagnosis of gastrinoma

J. Primrose, J. Ratcliffe, S. Joffe, 1980, The British journal of surgery.

The effects of 15 days of dosing with placebo, sufotidine 600 mg nocte or sufotidine 600 mg twice daily upon 24-hour intragastric acidity and 24-hour plasma gastrin.

J. Primrose, D. Johnston, J. Holmfield, 1990, Alimentary Pharmacology and Therapeutics.

Extended scope of nursing practice: a multicentre randomised controlled trial of appropriately trained nurses and pre-registration house officers in pre-operative assessment in elective general surgery.

C. Czoski-Murray, C. McCabe, J. Primrose, 2001, Health technology assessment.

Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma cross-talk.

G. Calin, G. Packham, M. Bullock, 2018, Cancer letters.

Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial

Thomas Gruenberger, Laurence Collette, Peter M Schlag, 2008, The Lancet.

Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer

E. King, S. Jogai, J. Primrose, 2013, British Journal of Cancer.

Minisatellite instability is found in colorectal tumours with mismatch repair deficiency

D. Eccles, J. Primrose, A. Gough, 2001, British Journal of Cancer.

miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance.

G. Packham, C. Paraskeva, M. Bullock, 2013, Cancer research.

A top-down view of the tumor microenvironment: structure, cells and signaling

M. Bullock, J. Primrose, A. Mirnezami, 2015, Front. Cell Dev. Biol..

Perioperative chemotherapy with FOLFOX 4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer ( EORTC Intergroup trial 40983 ) : a randomised controlled trial

R. Parks, L. Collette, P. Schlag, 2008 .

MicroRNAs: key players in carcinogenesis and novel therapeutic targets.

G. Packham, J. Primrose, A. Mirnezami, 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

R. Spizzo, M. Fabbri, G. Calin, 2015, Gut.

Obstructive jaundice causes reduced expression of polymorphonuclear leucocyte adhesion molecules and a depressed response to bacterial wall products in vitro.

S. Plusa, J. Primrose, N. Webster, 1996, Gut.

The ZEB2‐dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer

G. Berx, B. Price, R. Sreekumar, 2021, Molecular oncology.

P 53 independent activation of the hdm 2P 2 promoter through multiple transcription factor response elements results in elevated hdm 2 expression in estrogen receptor-α positive breast cancer cells

J. Blaydes, J. Primrose, M. Phelps, 2010 .

Hdm2 Recruits a Hypoxia-Sensitive Corepressor to Negatively Regulate p53-Dependent Transcription

J. Blaydes, S. Campbell, J. Primrose, 2003, Current Biology.

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

J. Blaydes, J. Primrose, M. Phelps, 2003, Cancer research.

Hdm 2 recruits a hypoxia-sensitive co-repressor to negatively regulate p 53-dependent transcription

J. Blaydes, S. Campbell, J. Primrose, 2003 .

Translational aspects in targeting the stromal tumour microenvironment: From bench to bedside

M. Bullock, J. Primrose, G. Thomas, 2016, New horizons in translational medicine.

Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer

M. Bullock, J. Primrose, A. Mirnezami, 2018, Cancer letters.

Comprehensive Imaging Characterization of Colorectal Liver Metastases

D. Breen, F. Gleeson, J. Primrose, 2021, Frontiers in Oncology.

Assessment of Nuclear ZEB2 as a Biomarker for Colorectal Cancer Outcome and TNM Risk Stratification

R. Sreekumar, J. Primrose, G. Thomas, 2018, JAMA network open.

Assessment of Nuclear ZEB 2 as a Biomarker for Colorectal Cancer Outcome and TNMRisk Stratification

R. Sreekumar, J. Primrose, G. Thomas, 2018 .

A randomised controlled trial to assess the cost-effectiveness of intensive versus no scheduled follow-up in patients who have undergone resection for colorectal cancer with curative intent.

D. Mant, A. Gray, J. Primrose, 2017, Health technology assessment.

A Randomised Clinical Trial to Assess the Effect of Total Enteral and Total Parenteral Nutritional Support on Metabolic, Inflammatory and Oxidative Markers in Patients with Predicted Severe Acute Pancreatitis (APACHE II >6) (R. Gupta et al., Southampton)

P. Calder, J. Primrose, R. Gupta, 2003, Pancreatology.

A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II > or =6).

P. Calder, J. Primrose, R. Gupta, 2003, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Chromosomal instability mediates immune exclusion and response to cytotoxic chemotherapy in colorectal liver metastases

R. Weichselbaum, M. Talamonti, M. D'Angelica, 2021, bioRxiv.

Symptoms and signs in patients with colorectal cancer

J. Primrose, J. Fozard, S. John, 2011, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

A minimum core outcome dataset for the reporting of preclinical chemotherapeutic drug studies: Lessons learned from multiple discordant methodologies in the setting of colorectal cancer.

S. Wedge, J. Primrose, A. Mirnezami, 2017, Critical reviews in oncology/hematology.

Modification of N staging systems for penile cancer: a more precise prediction of prognosis

S. Roman-Roman, L. Desjardins, Fan Zhou, 2015, British Journal of Cancer.

Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma

J. Blaydes, J. Primrose, G. Thomas, 2015, The Journal of pathology.

Bombesin-like peptides and cancer.

J. Primrose, S. Preston, G. Miller, 1996, Critical reviews in oncology/hematology.

Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies.

J. Nemunaitis, A. Rosemurgy, J. Primrose, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

The Miami International Evidence-Based Guidelines on Minimally Invasive Pancreas Resection.

U. Boggi, Song-Cheol Kim, G. Wakabayashi, 2019, Annals of surgery.

Diagnosis and management of pancreatic cancer in adults: A summary of guidelines from the UK National Institute for Health and Care Excellence.

J. Neoptolemos, J. Primrose, L. McGeeney, 2018, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

OncoSurge: a strategy for improving resectability with curative intent in metastatic colorectal cancer.

S. Curley, J. Kahan, B. Nordlinger, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.

J. Iredale, M. Arthur, J. Primrose, 2001, Gastroenterology.

Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.

R. Parks, W. Scheithauer, P. Schlag, 2013, The Lancet. Oncology.

Perioperative FOLFOX 4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer ( EORTC 40983 ) : long-term results of a randomised , controlled , phase 3 trial

R. Parks, W. Scheithauer, P. Schlag, 2013 .

The adaptive immune response to colorectal cancer: from the laboratory to clinical practice.

J. Primrose, C. Ottensmeier, G. Thomas, 2012, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial.

T. Hickish, R. Butler, O. Garden, 2014, The Lancet. Oncology.

Predictive Factors for the Benefit of Perioperative FOLFOX for Resectable Liver Metastasis in Colorectal Cancer Patients (EORTC Intergroup Trial 40983)

R. Parks, L. Collette, W. Scheithauer, 2012, Annals of surgery.

Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma

A. Bateman, J. Primrose, G. Thomas, 2016, Cancer Immunology, Immunotherapy.

Adjuvant capecitabine for biliary tract cancer: The BILCAP randomized study.

D. Stocken, O. Garden, D. Cunningham, 2017 .

Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1

S. Tavaré, P. Edwards, H. Barr, 2015, Scientific Reports.

Body Composition, Muscle Function and Psychological Changes in Patients Undergoing Operation for Hepatic or Pancreatic Disease

J. Primrose, R. Thurairaja, R. Gupta, 2001, Pancreatology.

Consensus and controversies regarding follow‐up after treatment with curative intent of nonmetastatic colorectal cancer: a synopsis of guidelines used in countries represented in the European Society of Coloproctology

R. Labianca, S. Laurberg, J. Primrose, 2019, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

Will Rogers revisited: prospective observational study of survival of 3592 patients with colorectal cancer according to number of nodes examined by pathologists

J. Primrose, R. Talbot, M. Mullee, 2006, British Journal of Cancer.

The clinical effectiveness and cost-effectiveness of ablative therapies in the management of liver metastases: systematic review and economic evaluation.

D. Breen, G. Poston, J. Primrose, 2014, Health technology assessment.

Interleukin 2 and interferon alpha-2a do not improve anti-tumour activity of 5-fluorouracil in advanced colorectal cancer.

J. Verweij, R. Mertelsmann, J. Primrose, 1996, British Journal of Cancer.

Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study

U. Boggi, B. Gayet, A. Pietrabissa, 2017, Annals of surgery.

A comparison of primary oesophageal squamous epithelial cells with HET‐1A in organotypic culture

J. Blaydes, J. Primrose, G. Thomas, 2010, Biology of the cell.

MTHFR (C677T and A1298C) Polymorphisms and Risk of Sporadic Distal Colorectal Adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom)

M. Watson, M. Gunter, S. Bingham, 2006, Cancer Causes & Control.

No Association between Cytochrome P450 and Glutathione S-Transferase Gene Polymorphisms and Risk of Colorectal Adenoma: Results from the UK Flexible Sigmoidoscopy Screening Trial

M. Watson, M. Gunter, S. Bingham, 2005, Cancer Epidemiology Biomarkers & Prevention.

Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa

J. Primrose, S. Preston, A. Gough, 1999, British Journal of Cancer.

Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs

G. Calin, C. Ivan, G. Packham, 2015, Oncotarget.

Association between miR-31-3p expression and cetuximab efficacy in patients with KRAS wild-type metastatic colorectal cancer: a post-hoc analysis of the New EPOC trial

P. Laurent-Puig, J. Bridgewater, J. Primrose, 2017, Oncotarget.

The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via αv Integrin Ligation

J. Iredale, G. Packham, A. Bateman, 2008, Clinical Cancer Research.

The use of tumour markers CEA, CA-195 and CA-242 in evaluating the response to chemotherapy in patients with advanced colorectal cancer.

J. Primrose, P. Selby, T. Perren, 1993, British Journal of Cancer.

A prospective randomised comparison of minor surgery in primary and secondary care. The MiSTIC trial.

R. Kneebone, C. McCabe, J. Primrose, 2008, Health technology assessment.

Treatment of colorectal metastases: surgery, cryotherapy, or radiofrequency ablation

J. Primrose, 2002, Gut.

Gemcitabine‐based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score‐matched cohort study

U. Boggi, N. Jamieson, C. Bassi, 2020, The British journal of surgery.

Guidelines for resection of colorectal cancer liver metastases

R. Parks, J. Ledermann, O. Garden, 2006, Gut.

IL‐12 and IL‐15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells

S. Khakoo, J. Primrose, L. Walter, 2017, Immunity, inflammation and disease.

Effectiveness of appropriately trained nurses in preoperative assessment: randomised controlled equivalence/non-inferiority trial

C. Czoski-Murray, C. McCabe, J. Primrose, 2002, BMJ : British Medical Journal.

Predicting colorectal cancer risk in patients with rectal bleeding.

D. Mant, J. Primrose, D. Weller, 2006, The British journal of general practice : the journal of the Royal College of General Practitioners.

Octreotide in the treatment of the dumping syndrome.

J. Primrose, 1990, Digestion.

Recognition of skin malignancy by general practitioners: observational study using data from a population-based randomised controlled trial

R. Kneebone, J. Primrose, P. Little, 2009, British Journal of Cancer.

British Association for the Study of the Liver

A. Perelson, C. Dejong, Y. Ma, 1991 .

Pain provocation test in peptic duodenitis.

J. Primrose, S. Joffe, 1983, Gastrointestinal endoscopy.

Proceedings of the American Society for Enhanced Recovery/Evidence Based Peri-Operative Medicine 2016 Annual Congress of Enhanced Recovery and Perioperative Medicine

Christopher L. Wu, W. Sandberg, J. Efron, 2016, Perioperative Medicine.

Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery

M. Grocott, S. Rensen, J. Primrose, 2019, Journal of cachexia, sarcopenia and muscle.

Discussion on Low-Tension Glaucoma

J. Primrose, E. Perkins, J. Winstanley, 1959, Proceedings of the Royal Society of Medicine.

Highly selective vagotomy and duodenal ulcers that fail to respond to H2 receptor antagonists

A. Axon, J. Primrose, D. Johnston, 1988, British medical journal.

Blind total gastrectomy for massive bleeding from the stomach

P. Quirke, J. Primrose, D. Johnston, 1986, The British journal of surgery.

Soft tissue tumours. 3rd ed. F. M. Enzinger and S. W. Weiss (eds). 284 × 220 mm. Pp. 1120. Illustrated. 1995. St Louis, Missouri: Mosby‐Year‐Book. £160

J. Primrose, 1995 .

Validation of the Lower Gastrointestinal Electronic Referral Protocol

J. Primrose, S. K. P. John, S. George, 2008, The British journal of surgery.

Adjuvant Therapy for Resected Biliary Tract Cancer: ASCO Clinical Practice Guideline.

S. Maithel, A. El-Khoueiry, T. Bekaii-Saab, 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Short- and long-term outcomes after laparoscopic and open hepatic resection: systematic review and meta-analysis.

J. Primrose, A. Mirnezami, R. Mirnezami, 2011, HPB : the official journal of the International Hepato Pancreato Biliary Association.

D. Goldstein, J. Bridgewater, A. Lohse, 2015, BMC Cancer.

Development and validation of a model to predict outcomes of colon cancer surveillance

M. Kattan, G. Cooper, C. Kong, 2019, Cancer Causes & Control.

Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial

T. Hickish, N. Heaton, O. Garden, 2020, The Lancet. Oncology.

Laparoscopic versus open major hepatectomy: a systematic review and meta‐analysis of individual patient data

B. Gayet, J. Primrose, B. Topal, 2018, Surgery.

The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation

G. Wakabayashi, B. Gayet, B. Edwin, 2017, Annals of surgery.

The diagnostic accuracy of a single CEA blood test in detecting colorectal cancer recurrence: Results from the FACS trial

Brian D Nicholson, Bethany Shinkins, Rafael Perera, 2017, PloS one.

TACE 2: A randomized placebo-controlled, double-blinded, phase III trial evaluating sorafenib in combination with transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC)

D. Stocken, T. Meyer, P. Johnson, 2018 .

A randomised placebo-controlled , double-blinded , phase 3 trial evaluating sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma

D. Stocken, T. Meyer, D. Cunningham, 2017 .

Oncofetal fibronectin and oral squamous cell carcinoma.

A. Bateman, J. Primrose, U. Mandel, 2001, The British journal of oral & maxillofacial surgery.

Prayers From The Ark

R. Godden, J. Primrose, Carmen Bernos de Gasztold, 1962 .

Gastrin-producing ovarian mucinous cystadenomas: a cause of the Zollinger-Ellison syndrome.

J. Primrose, D. Johnston, M. Wells, 1988, Surgery.

Vasopressin and haemostatic responses to inguinal hernia repair under local anaesthesia

J. Primrose, P. Grant, C. Prentice, 1991, Blood Coagulation and Fibrinolysis.

Adjuvant therapy of biliary tract cancers

J. Bridgewater, A. Stein, J. Primrose, 2023, Therapeutic advances in medical oncology.

384O Laparoscopic versus open hemihepatectomy: The ORANGE II PLUS multicenter randomized controlled trial

B. Edwin, R. Troisi, J. Primrose, 2021, Annals of Oncology.

Laparoscopic Right Hemihepatectomy after Future Liver Remnant Modulation: A Single Surgeon’s Experience

J. Primrose, M. Abu Hilal, M. Garatti, 2023, Cancers.

Clinician engagement is critical to public engagement with clinical trials

J. Primrose, C. McGrath, S. Faust, 2015, BMJ : British Medical Journal.

Laparoscopic right hepatectomy: a challenging, but feasible, safe and efficient procedure.

J. Primrose, M. Abu Hilal, N. Pearce, 2011, American journal of surgery.

What carcinoembryonic antigen level should trigger further investigation during colorectal cancer follow-up? A systematic review and secondary analysis of a randomised controlled trial.

R. Perera, D. Mant, J. Primrose, 2017, Health technology assessment.

A prospective randomised controlled study of the use of ranitidine in patients with gastric cancer

J. Primrose, S. Preston, G. Miller, 1998 .

Serum carcinoembryonic antigen trends for diagnosing colorectal cancer recurrence in the FACS randomized clinical trial

R. Perera, D. Mant, J. Primrose, 2018, The British journal of surgery.

Simultaneous resection of colorectal cancer and synchronous liver metastases: what determines the risk of unfavorable outcomes? An international multicenter retrospective cohort study

F. Giuliante, B. Edwin, M. Masetti, 2023, International journal of surgery.

T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases

S. Khakoo, J. Primrose, R. Harrison, 2014, BMC Cancer.

Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

B. Nielsen, G. Packham, M. Bullock, 2013, Cell Death and Disease.

Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study

T. Hickish, O. Garden, D. Cunningham, 2016, British Journal of Cancer.

Lung metastasectomy in colorectal cancer: Is this surgery effective in prolonging life?

T. Treasure, J. Primrose, F. Fiorentino, 2010, Respirology.

Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

B. Nielsen, G. Packham, M. Bullock, 2013, Cell Death and Disease.

Phase III randomized study of two fluorouracil combinations with either interferon alfa-2a or leucovorin for advanced colorectal cancer. Corfu-A Study Group.

G. Batist, T. Shore, F. Porzsolt, 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival: Data From the FACS Randomized Controlled Trial

D. Mant, J. Primrose, B. Shinkins, 2016, Annals of surgery.

This is a repository copy of Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival: Data From the FACS

J. Primrose, B. Shinkins, A. Fuller, 2018 .

Marimastat in recurrent colorectal cancer: exploratory evaluation of biological activity by measurement of carcinoembryonic antigen

J. Neoptolemos, J. Neoptolemos, P. Johnson, 1999, British Journal of Cancer.

Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial

U. Boggi, A. Vanoli, R. D. de Kleine, 2023, The Lancet regional health. Europe.

Theuseoftumourmarkers CEA,CA-195andCA-242inevaluating the responsetochemotherapy inpatients withadvanced colorectal cancer

J. Primrose, P. Selby, T. Perren, 1993 .

Integrated Clinical-Molecular Classification of Colorectal Liver Metastases: A Biomarker Analysis of the Phase 3 New EPOC Randomized Clinical Trial.

R. Weichselbaum, M. Talamonti, M. Posner, 2023, JAMA oncology.

How to manage excess treatment costs

J. Primrose, R. Peveler, A. Frater, 2013 .

Author Correction: Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1

S. Tavaré, A. Hindmarsh, V. Sujendran, 2019, Scientific Reports.

Systemic neoadjuvant chemotherapy in modern pancreatic cancer treatment: a systematic review and meta-analysis.

P. Pucher, J. Primrose, T. Armstrong, 2019, Annals of the Royal College of Surgeons of England.

Surgical Resection Versus Radiofrequency Ablation in the Treatment of Small Unifocal Hepatocellular Carcinoma

M. Abu-Hilal, M. Mcphail, J. Primrose, 2008, Journal of Gastrointestinal Surgery.

Minimally invasive versus open distal pancreatectomy for ductal adenocarcinoma (DIPLOMA): a pan-European propensity score matched study

U. Boggi, B. Gayet, A. Pietrabissa, 2019, HPB.

EGFR ligand expression levels and detriment from cetuximab in patients with operable liver metastases from colorectal cancer

J. Bridgewater, J. Primrose, S. Pugh, 2016 .

Scheduled use of CEA and CT follow-up to detect recurrence of colorectal cancer: 6-12 year results from the FACS randomised controlled trial

R. Perera, D. Mant, J. Primrose, 2016 .

The follow-up after colorectal cancer surgery trial: randomised trial of follow-up after colorectal cancer surgery and outcome following recurrence

R. Perera, D. Mant, J. Primrose, 2014 .

Follow-up after colorectal cancer surgery: Preliminary observational findings from the UK FACS trial.

D. Mant, J. Primrose, P. Rose, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Deregulated stromal microRNA-21 and promotion of metastatic progression in colorectal cancer

B. Nielsen, G. Packham, M. Bullock, 2014, The Lancet.

The Prevalence of Gastrinomas in Recurrent Peptic Ulceration

J. Primrose, J. Ratcliffe, S. Joffe, 1983, Scottish Medical Journal.

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival: Data From the FACS Randomized Controlled Trial

D. Mant, J. Primrose, B. Shinkins, 2016, Annals of surgery.

Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer

E. Giovannetti, T. Rockall, J. Primrose, 2023, Expert review of molecular diagnostics.

ASPIRATION CYTOLOGY AND OUTPATIENT EXCISION OF BREAST LUMPS

J. Primrose, S. Joffe, H. Hughes, 1979, The Lancet.

D. Goldstein, J. Bridgewater, A. Lohse, 2015, BMC Cancer.

Characterization of a bombesin/gastrin‐releasing peptide receptor on a human gastric‐cancer cell line

J. Primrose, S. Preston, G. Miller, 1994, International journal of cancer.

Hepatic metastases resection after cetuximab: are we missing something? - Authors' reply.

J. Bridgewater, J. Primrose, S. Pugh, 2020, The Lancet. Oncology.

Treatment of colorectal metastases: surgery, cryotherapy, or radiofrequency ablation

J. Primrose, 2002, Gut.

Are the current difficulty scores for laparoscopic liver surgery telling the whole story? An international survey and recommendations for the future.

J. Primrose, D. Cherqui, M. Abu Hilal, 2017, HPB : the official journal of the International Hepato Pancreato Biliary Association.

Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population

S. Khakoo, J. Primrose, T. Armstrong, 2015, The Lancet.

Intratumoural immune signature to identify patients with primary colorectal cancer who do not require follow-up after resection: an observational study.

D. Mant, J. Primrose, G. Thomas, 2021, Health technology assessment.

Laparoscopic vs Open Liver Resection

L. Nathanson, O. Garden, G. Poston, 2017 .