C. Welch

发表

Increased Atherosclerosis and Endothelial Dysfunction in Mice Bearing Constitutively Deacetylated Alleles of Foxo1 Gene*

Hua V. Lin, D. Accili, K. Tsuchiya, 2012, The Journal of Biological Chemistry.

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis

K. Moore, M. Reilly, A. Tall, 2018, Circulation.

FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.

R. DePinho, D. Accili, K. Tsuchiya, 2012, Cell metabolism.

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

Brian C. Pridgen, A. Tall, J. Breslow, 2009, Circulation research.

Bayesian Inference Associates Rare KDR Variants With Specific Phenotypes in Pulmonary Arterial Hypertension

W. Chung, Yufeng Shen, M. Humbert, 2019, bioRxiv.

Genetics of common forms of heart disease: a long and winding road.

A. Lusis, C. Welch, 2013, Circulation research.

Genetics and Genomics of Pediatric Pulmonary Arterial Hypertension

W. Chung, C. Welch, 2020, Genes.

Activation of Liver X Receptor Decreases Atherosclerosis in Ldlr−/− Mice in the Absence of ATP-Binding Cassette Transporters A1 and G1 in Myeloid Cells

A. Tall, A. Murphy, C. Welch, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Decreased Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice Transplanted With Abcg1−/− Bone Marrow

A. Tall, C. Welch, N. Wang, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH

W. Chung, Yufeng Shen, Yicheng Guo, 2020, bioRxiv.

Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality

W. Chung, M. Haimel, M. Bleda, 2021, Journal of Medical Genetics.

Bayesian Inference Associates Rare KDR Variants With Specific Phenotypes in Pulmonary Arterial Hypertension

W. Chung, Yufeng Shen, M. Humbert, 2019, bioRxiv.

Reduced VLDL clearance in Apoe−/−Npc1−/− mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels

A. Tall, C. Welch, M. Ishibashi, 2010, Journal of Lipid Research.

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2V617F Mice

A. Tall, R. Levine, O. Soehnlein, 2018, Circulation research.

TLR3 deficiency protects against collagen degradation and medial destruction in murine atherosclerotic plaques.

J. D’Armiento, A. Tall, C. Welch, 2013, Atherosclerosis.

Reduced transfer coefficient of carbon monoxide in pulmonary arterial hypertension implicates rare protein-truncating variants in KDR

Yufeng Shen, K. Megy, S. Gräf, 2019 .

Altered Gene Expression Pattern in the Fatty Liver Dystrophy Mouse Reveals Impaired Insulin-mediated Cytoskeleton Dynamics*

C. Welch, P. Xu, K. Reue, 1999, The Journal of Biological Chemistry.

Genes that drive the pathobiology of pediatric pulmonary arterial hypertension

W. Chung, C. Welch, E. Austin, 2020, Pediatric pulmonology.

Genetics and Genomics of Pediatric Pulmonary Arterial Hypertension

W. Chung, C. Welch, 2020, Genes.

Genetics and other omics in pediatric pulmonary arterial hypertension.

W. Chung, C. Welch, 2020, Chest.

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.

D. Accili, A. Tall, C. Welch, 2009, The Journal of clinical investigation.

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.

D. Accili, R. Haeusler, C. Welch, 2012, Cell metabolism.

Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children.

A. Tall, A. Murphy, C. Welch, 2013, Atherosclerosis.

Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

Michael C. Ostrowski, P. Libby, A. Tall, 2009, Circulation research.

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice.

A. Tall, A. Murphy, C. Welch, 2011, The Journal of clinical investigation.

Adrenocortical Lipid Depletion Gene (ald) in AKR Mice Is Associated with an Acyl-CoA:Cholesterol Acyltransferase (ACAT) Mutation*

Robert V Farese, V. Meiner, C. Welch, 1998, The Journal of Biological Chemistry.

ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis

A. Tall, J. Witztum, C. Welch, 2010, Circulation research.

Increased Atherosclerosis in Mice With Vascular ATP-Binding Cassette Transporter G1 Deficiency—Brief Report

A. Tall, C. Welch, I. Goldberg, 2010, Arteriosclerosis, thrombosis, and vascular biology.

ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet.

A. Tall, C. Welch, I. Goldberg, 2008, The Journal of clinical investigation.

Genomics of Pulmonary Hypertension

W. Chung, C. Welch, 2021, Advances in Pulmonary Hypertension.

Channelopathy Genes in Pulmonary Arterial Hypertension

W. Chung, C. Welch, 2022, Biomolecules.

Spontaneous Atherothrombosis and Medial Degradation in Apoe−/−, Npc1−/− Mice

J. D’Armiento, A. Tall, B. Arey, 2007, Circulation.

Exome Sequencing in Children With Pulmonary Arterial Hypertension Demonstrates Differences Compared With Adults

W. Chung, Yufeng Shen, F. Dewey, 2018, Circulation. Genomic and precision medicine.

Foxo1 links hyperglycemia to LDL oxidation and eNOS dysfunction in vascular endothelial cells

Alexander S. Banks, R. DePinho, D. Accili, 2009 .

Deficiency of ATP binding cassette transporter b6 in megakaryocyte progenitors accelerates atherosclerosis in mice

A. Murphy, J. Schuetz, C. Welch, 2014 .

Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development.

M. Fishbein, J. Qiao, A. Lusis, 1993, Journal of Clinical Investigation.

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

A. Tall, H. Snoeck, C. Welch, 2010, Science.

Genetic Factors in Atherosclerosis

T. Drake, J. Qiao, A. Lusis, 1998 .

Beyond Genome-Wide Association Studies: The Usefulness of Mouse Genetics in Understanding the Complex Etiology of Atherosclerosis

C. Welch, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Human-Mouse Genomic Homologies for Coronary Artery Disease – Associated Loci : Availability of Mutant Mouse Models

C. Welch, 2012 .

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages: Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions

A. Tall, C. Welch, M. Lamkanfi, 2008, Circulation.

LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.

A. Tall, R. Levine, C. Welch, 2016, Circulation research.

Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension

W. Chung, Yufeng Shen, S. Archer, 2020, Circulation.

New insights into atherosclerosis from studies with mouse models.

D. Shih, A. Lusis, C. Welch, 1995, Molecular medicine today.

Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease

W. Chung, Yufeng Shen, F. Dewey, 2018, Genome Medicine.

Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

Lisa J. Martin, Ferhaan Ahmad, W. Chung, 2019, Genome Medicine.

Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension

Lisa J. Martin, Ferhaan Ahmad, W. Chung, 2019, Genome Medicine.

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation.

D. Accili, W. Gu, L. Qiang, 2011, Cell metabolism.

Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis

A. Tall, A. Murphy, C. Welch, 2014, Circulation research.

Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

N. Sharpless, A. Tall, A. Murphy, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model

A. Tall, J. Breslow, C. Welch, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Dominantly acting KIF5B variants with pleiotropic cellular consequences cause variable clinical phenotypes

F. Del Bene, C. Compagnucci, M. Tartaglia, 2022, Human molecular genetics.

Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr −/−, Cdkn2a-Deficient Mice

A. Tall, C. Welch, Wei Wang, 2016, Circulation. Cardiovascular genetics.

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

A. Tall, A. Murphy, E. Fisher, 2013, Circulation research.

GENETIC FACTORS IN ATHEROSCLEROSIS From Humans to Mice and Back Again

T. Drake, J. Qiao, M. Mehrabian, 1996 .

Quantitative Trait Locus Mapping of Genetic Modifiers of Metabolic Syndrome and Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice: Identification of a Locus for Metabolic Syndrome and Increased Atherosclerosis on Chromosome 4

A. Tall, J. Breslow, C. Welch, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.

A. Lusis, L. Castellani, C. Welch, 1997, The Journal of clinical investigation.

Athsq1 Is an Atherosclerosis Modifier Locus With Dramatic Effects on Lesion Area and Prominent Accumulation of Versican

A. Tall, D. Teupser, J. Breslow, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain.

A. Lusis, M. Mehrabian, P. Wen, 2004, Physiological genomics.

Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice.

A. Tall, C. Welch, L. Yvan-Charvet, 2007, The Journal of clinical investigation.

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice

D. Accili, K. Tsuchiya, A. Tall, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

D. Accili, A. Tall, C. Welch, 2006, Cell metabolism.

Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells

Alexander S. Banks, R. DePinho, D. Accili, 2009, Diabetes.

Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.

D. Accili, W. Gu, L. Qiang, 2015, Cell reports.

TTC39B Deficiency Stabilizes LXR Reducing both Atherosclerosis and Steatohepatitis

Daniel J. Rader, Masahiro Koseki, D. Rader, 2016, Nature.

Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery

G. Vunjak‐Novakovic, S. Marx, C. Welch, 2023, Cell reports. Medicine.

Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation.

Robert V Farese, V. Meiner, C. Welch, 1997, The Journal of biological chemistry.

Defining the Clinical Validity of Genes Reported to Cause Pulmonary Arterial Hypertension

S. Graf, C. Welch, C. Eichstaedt, 2022, medRxiv.