Y. Okimura

K. Chihara, K. Iida, G. Iguchi, 2010, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Chemerin enhances insulin signaling and potentiates insulin‐stimulated glucose uptake in 3T3‐L1 adipocytes

R. Kitazawa, S. Kitazawa, M. Kasuga, 2008, FEBS letters.

Gene expression profile in the heart of spontaneous dwarf rat: in vivo effects of growth hormone.

K. Chihara, K. Iida, G. Iguchi, 2006, Biochemical and biophysical research communications.

Presence of growth hormone-releasing factor-like immunoreactivity in human cerebrospinal fluid.

H. Kaji, Y. Okimura, T. Fujita, 1985, The Journal of clinical endocrinology and metabolism.

Augmentation by propranolol of growth hormone-releasing hormone-(1-44)-NH2-induced growth hormone release in normal short and normal children.

H. Kaji, Y. Okimura, T. Fujita, 1985, The Journal of clinical endocrinology and metabolism.

Effects of dopamine on immunoreactive growth hormone-releasing factor and somatostatin secretion from rat hypothalamic slices perifused in vitro.

Y. Fujii, Y. Okimura, T. Fujita, 1989, Endocrinology.

A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression

Y. Sugiyama, K. Chihara, Daisuke Yamamoto, 2013, Molecular and Cellular Endocrinology.

Neuropeptide regulation of feeding in dogs.

Y. Okimura, A. Inui, K. Chihara, 1991, The American journal of physiology.

Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats

K. Chihara, Daisuke Yamamoto, K. Iida, 2007, Regulatory Peptides.

Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency.

R. Kitazawa, S. Kitazawa, K. Chihara, 2007, Gastroenterology.

Pathogenesis of Anti–PIT-1 Antibody Syndrome: PIT-1 Presentation by HLA Class I on Anterior Pituitary Cells

Kenichi Yoshida, G. Iguchi, Yutaka Takahashi, 2019, Journal of the Endocrine Society.

Spontaneous regression of diffuse large‐cell lymphoma associated with Hashimoto's thyroiditis

C. Ohbayashi, K. Chihara, T. Matsui, 1996, American journal of hematology.

Brief report: short stature caused by a mutant growth hormone.

H. Kaji, Y. Okimura, Y. Takahashi, 1996, The New England journal of medicine.

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism.

M. Kasuga, G. Iguchi, Yutaka Takahashi, 2013, Endocrine journal.

Difference Between Japanese and Caucasian Populations in the Allelic Frequency of Growth Hormone Receptor Polymorphisms

K. Chihara, K. Iida, Yutaka Takahashi, 2009, Journal of pediatric endocrinology & metabolism : JPEM.

A study of carotid intima-media thickness in GH-deficient Japanese adults during onset among adults and children.

K. Chihara, K. Iida, H. Kaji, 2003, European journal of endocrinology.

Dual Action of Eicosapentaenoic Acid in Hepatoma Cells

K. Chihara, K. Iida, H. Kaji, 2001, The Journal of Biological Chemistry.

Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro.

K. Iida, H. Kaji, Y. Okimura, 2000, Biochemical and biophysical research communications.

Unresponsiveness of GH and cortisol to insulin-hypoglycemia in a patient with sub-total pancreatectomy.

Y. Okimura, T. Fujita, K. Chihara, 1983, Endocrinologia japonica.

Discordance between growth hormone (GH) responses after GH-releasing hormone and insulin hypoglycemia in myotonic dystrophy.

Y. Okimura, T. Fujita, K. Takahashi, 1988, The Journal of clinical endocrinology and metabolism.

Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy.

R. Kitazawa, S. Kitazawa, K. Chihara, 2012, European journal of endocrinology.

Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.

K. Chihara, M. Matsuo, K. Iida, 2004, Life sciences.

Hepatic failure and enhanced oxidative stress in mitochondrial diabetes.

R. Kitazawa, S. Kitazawa, Hiroyuki Yamada, 2008, Endocrine journal.

Brain neuropeptide Y in the control of adrenocorticotropic hormone secretion in the dog

Y. Okimura, A. Inui, K. Chihara, 1990, Brain Research.

Branched Chain Amino Acids and Muscle Atrophy Protection

Y. Okimura, 2015 .

Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes.

S. Seino, K. Chihara, G. Iguchi, 2011, Endocrinology.

GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1.

K. Chihara, Daisuke Yamamoto, K. Iida, 2008, Life sciences.

The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes.

Y. Okimura, Yu Yamamoto, Ran Sawa, 2021, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects.

K. Chihara, G. Iguchi, Yutaka Takahashi, 2004, European journal of endocrinology.

Leptin stimulates basal and GHRH-induced GH release from cultured rat anterior pituitary cells in vitro.

H. Kaji, Y. Okimura, Y. Takahashi, 1999, The Kobe journal of medical sciences.

Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes.

Y. Okimura, U. Kikkawa, Yu Yamamoto, 2018, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Hormonal regulation of the human ghrelin receptor gene transcription.

Y. Yoshimoto, K. Iida, G. Iguchi, 2001, Biochemical and biophysical research communications.

Galanin stimulates immunoreactive growth hormone-releasing factor secretion from rat hypothalamic slices perifused in vitro.

Y. Okimura, H. Abe, K. Chihara, 1990, Life sciences.

Cloning and characterization of the 5(')-flanking region of the human ghrelin gene.

K. Chihara, G. Iguchi, Yutaka Takahashi, 2003, Biochemical and biophysical research communications.

Receptors for calcitonin gene-related peptide on the rat liver plasma membranes.

Y. Okimura, T. Yamatani, T. Fujita, 1988, Biochemical and biophysical research communications.

Calcitonin gene-related peptide-like immunoreactivity in the central nervous system and peripheral organs of rats

K. Chihara, T. Fujita, Y. Okimura, 1987, Regulatory Peptides.

Regional distribution of rat growth hormone releasing factor-like immunoreactivity in rat hypothalamus.

N. Ling, H. Kaji, Y. Okimura, 1985, Endocrinology.

Effect of passive immunization with antisera to vasoactive intestinal polypeptide and peptide histidine isoleucine amide on 5-hydroxy-L-tryptophan-induced prolactin release in rats.

H. Kaji, Y. Okimura, T. Fujita, 1985, Endocrinology.

L-dopa stimulates release of hypothalamic growth hormone-releasing hormone in humans.

H. Kaji, Y. Okimura, T. Fujita, 1986, The Journal of clinical endocrinology and metabolism.

Short Stature Caused by a Natural Growth Hormone Antagonist

K. Chihara, Yutaka Takahashi, H. Kaji, 1998, Hormone Research in Paediatrics.

Effect of oral glucose administration on plasma growth hormone-releasing hormone (GHRH)-like immunoreactivity levels in normal subjects and patients with idiopathic GH deficiency: evidence that GHRH is released not only from the hypothalamus but also from extrahypothalamic tissue.

Y. Okimura, S. Kadowaki, T. Fujita, 1987, The Journal of clinical endocrinology and metabolism.

Presence and release of calcitonin gene-related peptide in rat stomach.

Y. Okimura, S. Kadowaki, T. Yamatani, 1989, Life sciences.

Effect of intracerebroventricular administration of rat calcitonin gene-related peptide (CGRP), human calcitonin and [Asu1,7]-eel calcitonin on gastric acid secretion in rats.

H. Kaji, Y. Okimura, T. Fujita, 1986, Endocrinologia japonica.

The C422F mutation of the growth hormone receptor gene is not responsible for short stature.

K. Iida, H. Kaji, Y. Okimura, 1999, The Journal of clinical endocrinology and metabolism.

Growth hormone stimulates mechano growth factor expression and activates myoblast transformation in C2C12 cells.

K. Chihara, K. Iida, Yutaka Takahashi, 2008, The Kobe journal of medical sciences.

Ghrelin Modulates the Downstream Molecules of Insulin Signaling in Hepatoma Cells*

K. Chihara, K. Iida, H. Kaji, 2002, The Journal of Biological Chemistry.

Pituitary 1,25-dihydroxyvitamin D3 receptors in hyperthyroid- and hypothyroid-rats.

H. Kaji, Y. Okimura, T. Fujita, 1985, Biochemical and biophysical research communications.

The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats.

K. Chihara, K. Iida, G. Iguchi, 2003, Life sciences.

Analysis of functional cooperativity between individual transcription-stimulating elements in the proximal region of the rat prolactin gene.

Y. Okimura, R. Maurer, M. d'Emden, 1992, Molecular endocrinology.

Characterization of DNA regions mediating the ability of Ca2+/calmodulin dependent protein kinase II to stimulate prolactin promoter activity

Y. Okimura, R. Maurer, B. Nowakowski, 1997, Molecular and Cellular Endocrinology.

Low Serum IGF-I/GH Ratio Is Associated with Abnormal Glucose Tolerance in Acromegaly

K. Chihara, K. Iida, G. Iguchi, 2008, Hormone Research in Paediatrics.

Cloning of a protein binding to the most proximal Pit-1 binding element of prolactin gene from human pituitary cDNA library

K. Chihara, G. Iguchi, Yutaka Takahashi, 2003, Molecular and Cellular Endocrinology.

Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes.

Y. Okimura, Ran Sawa, Ikumi Wake, 2022, Biochimica et biophysica acta. General subjects.

Hormone replacement therapy and vascular risk disorders in adult hypopituitarism.

K. Iida, Yutaka Takahashi, H. Kaji, 2007, Endocrine journal.

Novel compound heterozygous mutations of growth hormone (GH) receptor gene in a patient with GH insensitivity syndrome.

K. Iida, Yutaka Takahashi, H. Kaji, 1997, The Journal of clinical endocrinology and metabolism.

Insulin-like growth factor I (IGF-I) production and the presence of IGF-I receptors in rat medullary thyroid carcinoma cell line 6-23 (clone 6).

Y. Okimura, H. Abe, K. Chihara, 1989, Biochemical and biophysical research communications.

Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans.

S. Seino, K. Chihara, K. Iida, 2011, The Journal of clinical investigation.

Administration of antisera to vasoactive intestinal polypeptide and peptide histidine isoleucine attenuates ether-induced prolactin secretion in rats.

H. Kaji, Y. Okimura, T. Fujita, 1985, Neuroendocrinology.

Cloning and Characterization of the 5′-Flanking Region of the Human Growth Hormone-releasing Hormone Receptor Gene*

K. Chihara, G. Iguchi, Yutaka Takahashi, 1999, The Journal of Biological Chemistry.

Kobe University Repository : Kernel タイトル Tit le Expression of mPOU Protein in the Human Pituitary Adenomas

T. Kuno, K. Chihara, G. Iguchi, 2018 .

W194XProp1 and S156insTProp1, both of which have intact DNA-binding domain, show a different DNA-binding activity to the Prop1-binding element in human Pit-1 gene

Y. Sugiyama, K. Chihara, Taiki Maki, 2010, Molecular and Cellular Endocrinology.

Identification and analysis of prophet of Pit-1-binding sites in human Pit-1 gene.

Y. Sugiyama, K. Chihara, Daisuke Yamamoto, 2008, Endocrinology.

Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL

K. Chihara, Daisuke Yamamoto, K. Iida, 2008, Molecular and Cellular Endocrinology.

Expression of mPOU protein in the human pituitary adenomas.

T. Kuno, K. Chihara, G. Iguchi, 2003, The Kobe journal of medical sciences.

Cloning and characterization of the 5'-flanking region of the human prolactin-releasing peptide receptor gene.

K. Iida, G. Iguchi, H. Kaji, 2000, Biochemical and biophysical research communications.

Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome.

G. Iguchi, Yutaka Takahashi, Y. Okimura, 2014, The Journal of clinical endocrinology and metabolism.

Growth hormone stimulates tyrosine phosphorylation of focal adhesion kinase (p125(FAK)) and actin stress fiber formation in human osteoblast-like cells, Saos2.

K. Iida, H. Kaji, Y. Okimura, 1999, Biochemical and biophysical research communications.

Physiological role of somatostatin-mediated autofeedback regulation for growth hormone: importance of growth hormone in triggering somatostatin release during a trough period of pulsatile growth hormone release in conscious male rats.

Y. Okimura, T. Fujita, K. Chihara, 1989, Neuroendocrinology.

Biologically inactive growth hormone caused by an amino acid substitution.

H. Kaji, Y. Okimura, Y. Takahashi, 1997, The Journal of clinical investigation.

Lactogenic hormone responsive element reporter gene activation assay for human growth hormone.

K. Iida, H. Kaji, Y. Okimura, 2003, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Functional characterization of truncated growth hormone (GH) receptor-(1-277) causing partial GH insensitivity syndrome with high GH-binding protein.

K. Iida, H. Kaji, Y. Okimura, 1999, The Journal of clinical endocrinology and metabolism.

Degradation kinetics and mechanisms of a new cephalosporin, cefixime, in aqueous solution.

Y. Okimura, S. Koda, Y. Namiki, 1987, Journal of pharmaceutical sciences.

Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells*

K. Chihara, K. Iida, Yutaka Takahashi, 1997, The Journal of Biological Chemistry.

Liver glycogen phosphorylase kinase. Partial purification and characterization.

Y. Nishizuka, Y. Okimura, H. Yamamura, 1979, The Journal of biological chemistry.

Multifocal fibrosclerosis as a possible cause of panhypopituitarism with central diabetes insipidus.

G. Iguchi, H. Kaji, Y. Okimura, 2000, Endocrine journal.

Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3',5'-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1.

Y. Okimura, R. Maurer, P. Howard, 1994, Molecular endocrinology.

A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome

Kenichi Yoshida, G. Iguchi, Yutaka Takahashi, 2017, Scientific Reports.

Plasma Cell MyelomaShowing Progressive Bone

T. Fujita, Y. Okimura, T. Isobe, 2007 .

Plasma cell myeloma showing progressive bone destruction during long-term clinical remission.

T. Fujita, Y. Okimura, T. Isobe, 1983, Japanese journal of medicine.

Upregulation of the klotho gene expression by thyroid hormone and during adipose differentiation in 3T3-L1 adipocytes.

H. Kaji, Y. Okimura, Y. Takahashi, 2001, Life sciences.

Hypocalcemic crisis in alcoholic fatty liver: transient hypoparathyroidism due to magnesium deficiency.

Y. Okimura, T. Fujita, T. Inatome, 1987, The American journal of gastroenterology.

McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method.

K. Chihara, K. Iida, Yutaka Takahashi, 2007, Internal medicine.

Functional Interaction of the Estrogen Receptor with the Tissue-Specific, Homeodomain Transcription Factor, PIT-1

R. Day, Y. Okimura, R. Maurer, 1994 .

Multifocal Fibroscierosis as a Possible Cause of Panhypo-pituitarism with Central Diabetes Insipidus

G. Iguchi, Yutaka Takahashi, Y. Okimura, 2006 .

Growth hormone (GH) insensitivity syndrome with high serum GH-binding protein levels caused by a heterozygous splice site mutation of the GH receptor gene producing a lack of intracellular domain.

K. Iida, H. Kaji, Y. Okimura, 1998, The Journal of clinical endocrinology and metabolism.

A novel heterozygous T51I mutation of growth hormone receptor is not associated with short stature.

K. Chihara, K. Iida, Yutaka Takahashi, 2002, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

An Observation of Plasma Cell Dyscrasia Developing to Multiple Myeloma With a Rare Association of Pituitary Adenoma and Pituitary Apoplexy

S. Maeda, S. Kitazawa, K. Chihara, 1998 .

W194XProp1 and S156insTProp1 have a different DNA-binding activity to the Prop1-binding element in human Pit-1 gene

Y. Sugiyama, Daisuke Yamamoto, Y. Okimura, 2018 .

Novel Function of the Transactivation Domain of a Pituitary-specific Transcription Factor, Pit-1*

K. Yagita, H. Okamura, K. Chihara, 2002, The Journal of Biological Chemistry.

Pathophysiology of Growth Hormone-Releasing Hormone (GHRH) Secretion in Humans

K. Chihara, T. Fujita, Y. Okimura, 1987 .

Regional distribution of growth hormone-releasing hormone (GHRH) receptor mRNA in the rat brain.

Y. Shigeyoshi, H. Kaji, Y. Okimura, 1995, Endocrinology.

Intranasal administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (growth hormone releasing peptide) increased plasma growth hormone and insulin-like growth factor-I levels in normal men.

Y. Okimura, C. Bowers, K. Chihara, 1991, Endocrinologia japonica.