M. Comb

发表

The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY

G. Sourvinos, A. Guo, P. Tsichlis, 2012, Proceedings of the National Academy of Sciences.

Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

Steven P Gygi, Ailan Guo, Judit Villén, 2010, Science Signaling.

A proteomics approach for the identification and cloning of monoclonal antibodies from serum

Sean A Beausoleil, John Rush, S. Beausoleil, 2012, Nature Biotechnology.

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

J. Rush, A. Guo, M. Comb, 2005, Nature Biotechnology.

Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer

Laura A. Sullivan, S. Gygi, J. Kornhauser, 2007, Cell.

Systematic and quantitative assessment of the ubiquitin-modified proteome.

Edward L. Huttlin, S. Gygi, M. Sowa, 2011, Molecular cell.

Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs*

P. Hornbeck, D. Alessi, M. Comb, 2002, The Journal of Biological Chemistry.

Signaling networks assembled by oncogenic EGFR and c-Met

Steven P Gygi, Ailan Guo, Judit Villén, 2008, Proceedings of the National Academy of Sciences.

A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP

S. Hyman, Young-Sun Lin, Y. S. Lin, 1988, Molecular and cellular biology.

An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

S. Hyman, M. Comb, J. Pearlberg, 1989, Molecular and cellular biology.

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

S. Richard, S. Clarke, A. Guo, 2013, Scientific Reports.

Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis

J. Minna, A. Califano, M. Bansal, 2018, bioRxiv.

Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer

M. Loda, L. Chirieac, T. Gu, 2009, Clinical Cancer Research.

study of FGFR1 fusions in acute myeloid leukemia Running Title: FGFR1OP2-FGFR1 fusion in the KG-1 cell line

J. Nardone, J. Rush, B. Druker, 2016 .

study of FGFR1 fusions in acute myeloid leukemia Phosphotyrosine profiling identifies the KG-1 cell line as a model for the

J. Nardone, J. Rush, B. Druker, 2013 .

A wide-ranging cellular response to UV damage of DNA

M. Comb, M. Stokes, 2008, Cell cycle.

Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.

J. Nardone, J. Rush, B. Druker, 2006, Blood.

The effect of depolarization on expression of the human proenkephalin gene is synergistic with cAMP and dependent upon a cAMP-inducible enhancer

S. Hyman, M. Comb, T. V. Nguyen, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture

S. Hyman, M. Ross, L. Mucke, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: A model of endogenous opioid gene regulation by exogenous opioids

S. Hyman, D. Borsook, M. Comb, 1994, Regulatory Peptides.

Use of gene transfer approaches to study regulation of neuropeptide gene expression.

M. Comb, A. Seasholtz, E. Herbert, 1987, Progress in brain research.

Gene transfer methods for studying the regulation and expression of neuropeptide genes.

M. Comb, A. Seasholtz, E. Herbert, 1986, Methods in enzymology.

Expression of Opioid Peptide Genes in Different Species

M. Comb, E. Herbert, H. Rosen, 1984 .

Regulation of expression of opioid peptide genes

N. Birnberg, M. Comb, O. Civelli, 1984, Annals of neurology.

Regulation of opioid gene expression

N. Birnberg, M. Uhler, M. Comb, 1983, Peptides.

Partial characterization of the mRNA that codes for enkephalins in bovine adrenal medulla and human pheochromocytoma.

M. Comb, R. Crea, E. Herbert, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element

M. Comb, Y. Tan, K. G. Low, 1994, Molecular and cellular biology.

cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.

M. Comb, Y. Tan, L. Kobierski, 1991, Proceedings of the National Academy of Sciences of the United States of America.

NF-I proteins from brain interact with the proenkephalin cAMP inducible enhancer.

T. Osborne, M. Comb, W. Fischer, 1991, Nucleic acids research.

Novel interactions between human T-cell leukemia virus type I Tax and activating transcription factor 3 at a cyclic AMP-responsive element

M. Comb, M. H. Melner, G. Daniels, 1994, Molecular and cellular biology.

A Mitogen-activated Protein Kinase Pathway Is Required for μ-Opioid Receptor Desensitization*

M. Comb, R. Polakiewicz, Sandra M. Schieferl, 1998, The Journal of Biological Chemistry.

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

J. Avruch, M. Comb, C. Belham, 2001, Current Biology.

A Mitotic Cascade of NIMA Family Kinases Nercc1/Nek9 ACTIVATES THE Nek6 AND Nek7 KINASES*

J. Avruch, B. Kemp, J. Roig, 2003 .

Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress.

S. Hyman, D. Borsook, M. Comb, 1994, Molecular endocrinology.

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

K. Jeang, M. Comb, L. Dorner, 1997, Journal of virology.

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions*

S. Schreiber, R. Peterson, M. Comb, 2000, The Journal of Biological Chemistry.

Expression of the human proenkephalin gene in mouse pituitary cells: accurate and efficient mRNA production and proteolytic processing.

M. Comb, E. Herbert, H. Rosen, 1985, The EMBO journal.

Phosphotyrosine proﬁling identiﬁes the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia

J. Nardone, J. Rush, B. Druker, 2006 .

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks

Avi Ma'ayan, Travis Wheeler, Alexander Lachmann, 2018, Science Signaling.

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

Peter H. Seeburg, Edward Herbert, Michael Comb, 1982, Nature.

Generation of diversity and evolution of opioid peptides.

M. Uhler, M. Comb, E. Herbert, 1983, Cold Spring Harbor symposia on quantitative biology.

new insights in ALK-mediated pathogenesis and the treatment of ALCL formyltransferase/IMP cyclohydrolase (ATIC) is enhanced by NPM-ALK: The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide

J. Nardone, O. Jensen, M. Comb, 2013 .

The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.

J. Nardone, J. Rush, G. Inghirami, 2009, Blood.

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

Ailan Guo, Hongbo Gu, J. Kornhauser, 2013, Molecular & Cellular Proteomics.

A cyclic AMP- and phorbol ester-inducible DNA element

N. Birnberg, M. Comb, H. Goodman, 1986, Nature.

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

H. Goodman, N. Mermod, M. Comb, 1988, The EMBO journal.

Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts

Mark L. Grimes, Ailan Guo, Juan Palacios-Moreno, 2015, PLoS Comput. Biol..

A common phosphotyrosine signature for the Bcr-Abl kinase.

John Rush, J. Nardone, J. Rush, 2006, Blood.

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

M. Comb, H. M. Goodman, M. Comb, 1990, Nucleic Acids Res..

Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma

Jian Yu, John Rush, Yi Wang, 2011, PloS one.

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

D. Iliopoulos, A. Guo, P. Tsichlis, 2014, Molecular cell.

Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer.

S. Beausoleil, J. Rush, T. Gu, 2012, Cancer research.

Therapeutics , Targets , and Chemical Biology Identi fi cation of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer

S. Beausoleil, J. Rush, T. Gu, 2012 .

p90RSK Blocks Bad-mediated Cell Death via a Protein Kinase C-dependent Pathway*

H. Ruan, M. Comb, Yi Tan, 1999, The Journal of Biological Chemistry.

HDAC6 Is Required for Epidermal Growth Factor-induced β-Catenin Nuclear Localization*

T. Yao, M. Comb, R. Polakiewicz, 2008, Journal of Biological Chemistry.

Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct

M. Comb, X. Jia, R. Polakiewicz, 2012, International journal of molecular sciences.

Regulation of Expression of the Human Proenkephalin Gene in Heterologous Cell Systems

M. Comb, A. Seasholtz, E. Herbert, 1986 .

Profiling of UV-induced ATM/ATR signaling pathways

S. Gygi, S. Beausoleil, J. Nardone, 2007, Proceedings of the National Academy of Sciences.

BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival*

H. Ruan, M. Comb, Yi Tan, 2000, The Journal of Biological Chemistry.

A Mitotic Cascade of NIMA Family Kinases

J. Avruch, B. Kemp, J. Roig, 2003, Journal of Biological Chemistry.

Mechanisms of trans-synaptic regulation of gene expression

S. Hyman, M. Comb, H. Goodman, 1987, Trends in Neurosciences.

PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS*

A. Guo, M. Comb, X. Jia, 2012, Molecular & Cellular Proteomics.

Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase.

J. Qin, H. Ruan, Jun Zhu, 2005, Molecular biology of the cell.

Calorie restriction alters mitochondrial protein acetylation

Damian Fermin, F. Alt, B. Schwer, 2009, Aging cell.

Primary structure of the human proenkephalin gene.

P. Seeburg, J. Adelman, M. Comb, 1983, DNA.

EXPRESSION OF THE OPIOID GENES

M. Comb, O. Civelli, J. Douglass, 1983 .

STK25 is a candidate gene for pseudopseudohypoparathyroidism.

N. Copeland, D. Gilbert, N. Jenkins, 2001, Genomics.

Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding.

Joseph Avruch, Agnieszka Bronisz, J. Avruch, 2003, Molecular biology of the cell.

μ-Opioid Receptor Activates Signaling Pathways Implicated in Cell Survival and Translational Control*

A. Gingras, N. Sonenberg, M. Comb, 1998, The Journal of Biological Chemistry.

Regulation of the p70 S6 Kinase by Phosphorylation in Vivo

Joseph Avruch, Aihua Zhang, J. Avruch, 1998, The Journal of Biological Chemistry.

A Phosphorylation State-specific Antibody Recognizes Hsp27, a Novel Substrate of Protein Kinase D*

A. Toker, P. Storz, H. Döppler, 2005, Journal of Biological Chemistry.

High Throughput Proteome Screening for Biomarker Detection*

Ning Zhang, Ruedi Aebersold, John Rush, 2005, Molecular & Cellular Proteomics.

Everything activates c-fos--how can it matter?

B. M. Cohen, S. Hyman, B. Kosofsky, 1993, NIDA research monograph.

Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice.

S. Hyman, K. Herrup, D. Borsook, 1992, Molecular Endocrinology.

A Commontrans-Acting Factor IsInvolved inTranscriptional Regulation ofNeurotransmitter GenesbyCyclic AMP

Young-Sun Lin, M. Comb, J. Pearlberg, 1988 .

Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer.

S. Beausoleil, J. Rush, T. Gu, 2012, Cancer research.

Regulation of proenkephalin expression in cultured skin mesenchymal cells.

M. Comb, R. Polakiewicz, H. Rosen, 1992, Molecular endocrinology.

Signaling networks assembled by oncogenic EGFR and c-Met

S. Gygi, J. Kornhauser, J. Nardone, 2008, Proceedings of the National Academy of Sciences.

PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS*

A. Guo, M. Comb, X. Jia, 2012, Molecular & Cellular Proteomics.

Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids

S. Hyman, D. Borsook, M. Comb, 1994 .

J. Nardone, J. Rush, G. Inghirami, 2009, Blood.

Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs*

P. Hornbeck, D. Alessi, M. Comb, 2002, The Journal of Biological Chemistry.

A proteomics approach for the identification and cloning of monoclonal antibodies from serum

S. Beausoleil, J. Rush, M. Comb, 2012, Nature Biotechnology.