J. Lennartsson

发表

the pro-apoptotic protein Bim mediated transcriptional induction and MEK regulated phosphorylation of Stem cell factor promotes mast cell survival via inactivation of FOXO3a

G. Nilsson, H. Wootz, J. Jonsson, 2012 .

Stem cell factor receptor/c-Kit: from basic science to clinical implications.

Johan Lennartsson, L. Rönnstrand, J. Lennartsson, 2012, Physiological reviews.

Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.

G. Nilsson, H. Wootz, C. Möller, 2005, Blood.

Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

C. Heldin, J. Lennartsson, M. Razmara, 2013, Cell Communication and Signaling.

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.

L. Devy, A. Luttun, P. Carmeliet, 2005, The Journal of clinical investigation.

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets

R. Nussenblatt, Yihai Cao, J. Gutkind, 2010, Proceedings of the National Academy of Sciences.

Esophageal cancer: current and emerging therapy modalities

D. Brattström, M. Bergqvist, J. Lennartsson, 2008, Expert review of anticancer therapy.

VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.

K. Becker, C. Heldin, Y. Li, 2008, The Journal of clinical investigation.

Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.

L. Rönnstrand, J. Lennartsson, K. Thömmes, 1999, The Biochemical journal.

Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.

L. Rönnstrand, J. Lennartsson, M. Carlberg, 1999, The Biochemical journal.

The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.

A. Yoshimura, L. Rönnstrand, J. Lennartsson, 2003, The Biochemical journal.

Expression of EGFR and LRIG proteins in oesophageal carcinoma with emphasis on patient survival and cellular chemosensitivity

R. Henriksson, M. Bergqvist, J. Lennartsson, 2012, Acta oncologica.

Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells.

M. Bergqvist, J. Lennartsson, S. Ekman, 2013, International journal of oncology.

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

S. Hornemann, C. Heldin, D. Kenkel, 2015, PloS one.

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)

L. Rönnstrand, J. Lennartsson, 2018 .

Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis.

C. Heldin, J. Lennartsson, A. Jurek, 2010, Cellular signalling.

RhoD Binds the Rab5 Effector Rabankyrin‐5 and has a Role in Trafficking of the Platelet‐derived Growth Factor Receptor

J. Lennartsson, P. Aspenström, O. Voytyuk, 2013, Traffic.

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis.

J. Demoulin, J. Lennartsson, F. Houssiau, 2009, Arthritis and rheumatism.

Effects of 1α,25-dihydroxyvitamin D3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells

J. Lennartsson, M. Norlin, F. Olsson, 2022, Biochemistry and biophysics reports.

The role of RhoD and RhoD-binding proteins in the regulation of cancer cell adhesion and migration

J. Lennartsson, P. Aspenström, Vishal Nehru, 2013 .

Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells

O. Larsson, P. Georgii‐Hemming, M. Axelson, 2015, Medical Oncology.

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

O. Larsson, U. Hellman, M. Axelson, 2006, Blood.

DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation

P. Lipp, M. Bootman, P. Hawkins, 2000, Current Biology.

Effects of HER2-Binding Affibody Molecules on Intracellular Signaling Pathways

J. Carlsson, J. Lennartsson, Ann-Charlott Steffen, 2006, Tumor Biology.

Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling.

J. Lennartsson, O. Söderberg, J. Heldin, 2022, Cellular signalling.

G2/M-phase accumulation and apoptosis in multiple myeloma cells IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces

O. Larsson, U. Hellman, M. Axelson, 2013 .

Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner.

C. Heldin, J. Lennartsson, Runting Yin, 2019, Biochemical and biophysical research communications.

Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.

C. Heldin, J. Lennartsson, Fatima Burovic, 2016, Cellular signalling.

The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling*

C. Heldin, J. Lennartsson, C. Rorsman, 2016, The Journal of Biological Chemistry.

Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation.

C. Heldin, J. Lennartsson, David Mazaud, 2015, Cellular signalling.

NR4A1 Promotes PDGF-BB-Induced Cell Colony Formation in Soft Agar

C. Heldin, J. Lennartsson, Natalia Papadopoulos, 2014, PloS one.

The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo*

C. Heldin, J. Lennartsson, C. Hellberg, 2013, The Journal of Biological Chemistry.

Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.

C. Heldin, J. Lennartsson, P. Wardęga, 2010, Cellular signalling.

c-Jun N-terminal Kinase Is Necessary for Platelet-derived Growth Factor-mediated Chemotaxis in Primary Fibroblasts*

C. Heldin, H. Kaneto, J. Lennartsson, 2006, Journal of Biological Chemistry.

On Metabolic Effects of Diuretics and β‐Blockers

J. Lennartsson, P. Lundberg, C. Bengtsson, 2009 .

Erythrocyte sedimentation rate in a population sample of women with special reference to its clinical and prognostic significance.

J. Lennartsson, C. Bengtsson, V. Rafnsson, 2009, Acta medica Scandinavica.

Structure-based discovery of novel small molecule inhibitors of platelet-derived growth factor-B.

C. Heldin, J. Lennartsson, Omid Zarei, 2019, Bioorganic chemistry.

Synergistic Growth of Stem Cell Factor and Granulocyte Macrophage Colony-stimulating Factor Involves Kinase-dependent and -independent Contributions from c-Kit*

J. Lennartsson, D. Linnekin, R. Shivakrupa, 2004, Journal of Biological Chemistry.

Renal stone disease--experience from a population study of women in Gothenburg, Sweden.

J. Lennartsson, C. Bengtsson, O. Lindquist, 1980, Scandinavian journal of urology and nephrology. Supplementum.

Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit

Johan Lennartsson, J. Lennartsson, D. Linnekin, 2005, Stem cells.

Structural and functional properties of platelet-derived growth factor and stem cell factor receptors.

C. Heldin, J. Lennartsson, 2013, Cold Spring Harbor perspectives in biology.

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

K. Becker, Yihai Cao, E. Wawrousek, 2009, Proceedings of the National Academy of Sciences.

A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse

M. Grabherr, K. Lindblad-Toh, C. Wade, 2008, Nature Genetics.

Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction

P. Blume-Jensen, L. Rönnstrand, J. Lennartsson, 1999, Oncogene.

SOX10 expression in superficial spreading and nodular malignant melanomas

F. Pontén, M. Uhlén, S. Strömberg, 2010, Melanoma research.

C-Kit signal transduction and involvement in cancer

E. Heiss, L. Rönnstrand, J. Lennartsson, 2005 .

Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival

F. Pontén, S. Navani, I. Alafuzoff, 2013, Medical Oncology.

Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis

C. Heldin, B. Westermark, J. Lennartsson, 2018, Journal of internal medicine.

Involvement of PDGF ligands and receptors in tumorigenesis

C. Heldin, B. Westermark, J. Lennartsson, 2017 .

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

Fan Zhang, Kevin G. Becker, Yang Li, 2010, The Journal of experimental medicine.

Alix Facilitates the Interaction between c-Cbl and Platelet-derived Growth Factor β-Receptor and Thereby Modulates Receptor Down-regulation*

U. Hellman, C. Heldin, J. Lennartsson, 2006, Journal of Biological Chemistry.

Dimeric HER2-specific affibody molecules inhibit proliferation of the SKBR-3 breast cancer cell line.

J. Carlsson, J. Lennartsson, F. Frejd, 2008, Biochemical and biophysical research communications.

The stem cell factor receptor/c-Kit as a drug target in cancer.

L. Rönnstrand, J. Lennartsson, 2006, Current cancer drug targets.

PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element–modifying factor 1

C. Heldin, J. Lennartsson, Natalia Papadopoulos, 2018, The Journal of cell biology.

The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity.

C. Heldin, J. Lennartsson, C. Hellberg, 2011, Cellular signalling.

Protein Kinase Cδ Supports Survival of MDA-MB-231 Breast Cancer Cells by Suppressing the ERK1/2 Pathway*

J. Lennartsson, C. Larsson, G. K. Lønne, 2009, The Journal of Biological Chemistry.

The PDGF/PDGFR pathway as a drug target.

Johan Lennartsson, J. Lennartsson, Natalia Papadopoulos, 2017, Molecular aspects of medicine.

Hsp90 as a therapeutic target in patients with oesophageal carcinoma

M. Bergqvist, R. Tell, J. Lennartsson, 2010, Expert opinion on therapeutic targets.

The PDGFR Receptor Family

C. Heldin, L. Rönnstrand, J. Lennartsson, 2015 .

Radiation Induced DNA-Damage/Repair and Associated Signaling Pathways

B. Stenerlöw, J. Carlsson, J. Lennartsson, 2008 .

Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin

M. Bergqvist, J. Lennartsson, S. Ekman, 2009, British Journal of Cancer.

Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

P. Löw, C. I. Smith, P. Antonsson, 2003, Biochimica et biophysica acta.

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

C. Heldin, J. Lennartsson, A. Olsson, 2020, Theranostics.

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

S. Scholl, J. Lennartsson, C. Müller-Tidow, 2012, Cell Communication and Signaling.

MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis.

C. Heldin, J. Lennartsson, M. Razmara, 2012, Cellular signalling.

Synergistic effects of combining proteasome inhibitors with chemotherapeutic drugs in lung cancer cells

M. Bergqvist, J. Lennartsson, S. Ekman, 2017, BMC Research Notes.

Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines

Claes R. Andersson, A. Isaksson, M. Bergqvist, 2013, Cancer Chemotherapy and Pharmacology.

Receptor Tyrosine Kinases and Their Ligands

J. Lennartsson, C. Heldin, 2016 .

The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines.

B. Stenerlöw, J. Lennartsson, B. Glimelius, 2011, International journal of oncology.

Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.

U. Hellman, C. Wernstedt, L. Rönnstrand, 2003, Experimental cell research.

An analysis of factors leading to a reduction in iron deficiency in Swedish women.

J. Lennartsson, L. Garby, L. Hallberg, 1979, Bulletin of the World Health Organization.

Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation.

C. Heldin, J. Lennartsson, A. Jurek, 2011, Cellular signalling.

Activation of growth factor receptors in esophageal cancer--implications for therapy.

C. Heldin, M. Bergqvist, J. Lennartsson, 2007, The oncologist.

Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation*

C. Heldin, Agnieszka Gembarska, J. Lennartsson, 2009, Journal of Biological Chemistry.

8 7 A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse Gerli

M. Grabherr, K. Lindblad-Toh, C. Wade, 2008 .

Src Family Kinases Are Involved in the Differential Signaling from Two Splice Forms of c-Kit*

L. Ashman, L. Rönnstrand, J. Lennartsson, 2003, The Journal of Biological Chemistry.

FGF2 as a potential prognostic biomarker for proneural glioma patients

F. Pontén, S. Navani, M. Bergqvist, 2015, Acta oncologica.

PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway

J. Lennartsson, K. Rubin, L. Rask, 2017, Scientific Reports.

Serum Aminotransferases after Low-Dose Heparin Treatment

J. Lennartsson, J. Waldenström, R. Olsson, 2009 .

Serum aminotransferases after low-dose heparin treatment. Short communication.

J. Lennartsson, J. Waldenström, R. Olsson, 1978, Acta medica Scandinavica.

Characteristics of anaemic women. The population study of women in Göteborg 1968-1969.

J. Lennartsson, L. Hallberg, C. Bengtsson, 2009, Scandinavian journal of haematology.

Haemoglobin concentration and peripheral blood cell counts in women. The population study of women in Göteborg 1968-1969.

J. Lennartsson, L. Hallberg, C. Bengtsson, 2009, Scandinavian journal of haematology.

Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling

C. Heldin, J. Lennartsson, C. Castillejo-López, 2022, Cellular and Molecular Life Sciences.

Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

J. Lennartsson, M. Fryknäs, Christine Dyrager, 2013, Molecular Cancer Therapeutics.

Sleep disturbances, nightmares and other possible central nervous disturbances in a population sample of women, with special reference to those on antihypertensive drugs

J. Lennartsson, C. Bengtsson, J. Sigurdsson, 2004, European Journal of Clinical Pharmacology.

Effects of an EGFR-binding affibody molecule on intracellular signaling pathways.

J. Carlsson, J. Lennartsson, B. Glimelius, 2010, International journal of oncology.

The HER2-Binding Affibody Molecule (ZHER2∶342)2 Increases Radiosensitivity in SKBR-3 Cells

J. Lennartsson, L. Gedda, L. Ekerljung, 2012, PloS one.

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

C. Heldin, A. Hamidi, J. Lennartsson, 2023, BMC Molecular and Cell Biology.

Synergistic effects of combining proteasome inhibitors with chemotherapeutic drugs in lung cancer cells

M. Bergqvist, J. Lennartsson, S. Ekman, 2017, BMC Research Notes.

154 POSTER Hsp90 is expressed and represents a novel target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxy- geldanamycin

M. Bergqvist, J. Lennartsson, S. Ekman, 2008 .

The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

C. Heldin, J. Lennartsson, Niki Sarri, 2023, International journal of molecular sciences.

PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas

F. Pontén, S. Navani, M. Bergqvist, 2014, Tumor Biology.

Src Family Kinases Are Involved in the Differential Signaling from Two Splice Forms of c-Kit*

L. Ashman, L. Rönnstrand, J. Lennartsson, 2003 .

EGF and dextran-conjugated EGF induces differential phosphorylation of the EGF receptor.

J. Carlsson, L. Rönnstrand, J. Lennartsson, 2002, International journal of molecular medicine.