I. Grundke‐Iqbal

发表

Diverse regulation of AKT and GSK‐3β by O‐GlcNAcylation in various types of cells

Shiliang Wu, Jianhua Shi, Chun-ling Dai, 2012, FEBS letters.

Role of protein kinase B in Alzheimer's neurofibrillary pathology

H. Braak, B. Winblad, I. Alafuzoff, 2003, Acta Neuropathologica.

Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration.

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 2002, Journal of neural transmission. Supplementum.

Alzheimer's disease, a multifactorial disorder seeking multitherapies

I. Grundke‐Iqbal, K. Iqbal, 2010, Alzheimer's & Dementia.

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Tau pathology in Alzheimer disease and other tauopathies.

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2005, Biochimica et biophysica acta.

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

I. Grundke‐Iqbal, K. Iqbal, A. Alonso, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Tau in Alzheimer disease and related tauopathies.

Fei Liu, Khadija Iqbal, I. Grundke‐Iqbal, 2010, Current Alzheimer research.

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

K. Jellinger, H. Wiśniewski, H. Budka, 1989, Brain Research.

Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies.

I. Grundke‐Iqbal, K. Iqbal, A. Alonso, 2008, Current Alzheimer research.

Post-translational modifications of tau protein in Alzheimer’s disease

F. Liu, Fei Liu, Khadija Iqbal, 2005, Journal of Neural Transmission.

Rapid Alzheimer‐like phosphorylation of tau by the synergistic actions of non‐proline‐dependent protein kinases and GSK‐3

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 1995, FEBS letters.

Neurofibrillary Pathology: An Update

H. Wiśniewski, R. Terry, I. Grundke‐Iqbal, 1977 .

Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5

I. Grundke‐Iqbal, K. Iqbal, A. Sengupta, 1997, Molecular and Cellular Biochemistry.

In vitro analysis of tau phosphorylation sites and its biological activity.

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2002, Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.

Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice.

E. Masliah, E. Rockenstein, I. Grundke‐Iqbal, 2011, Journal of Alzheimer's disease : JAD.

Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach.

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 2000, Journal of neural transmission. Supplementum.

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.

H. Braak, B. Winblad, I. Grundke‐Iqbal, 2002, Brain research. Molecular brain research.

Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats.

I. Grundke‐Iqbal, K. Iqbal, Xiaochuan Wang, 2015, Journal of Alzheimer's disease : JAD.

The carboxy‐terminal fragment of inhibitor‐2 of protein phosphatase‐2A induces Alzheimer disease pathology and cognitive impairment

R. Linden, I. Grundke‐Iqbal, K. Iqbal, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2002, Neuroscience.

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2006, Journal of Alzheimer's disease : JAD.

Inhibitors of protein phosphatase-2A: topography and subcellular localization.

I. Grundke‐Iqbal, K. Iqbal, H. Tanimukai, 2004, Brain research. Molecular brain research.

Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain

Jianhua Shi, Chun-ling Dai, Yi Li, 2011, Alzheimer's & Dementia.

Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective.

I. Grundke‐Iqbal, K. Iqbal, 2006, Journal of Alzheimer's disease : JAD.

Bovine and human tau, highly homologous but less crossreactive: implications for Alzheimer disease.

I. Grundke‐Iqbal, K. Iqbal, A. Alonso, 1995, Brain research. Molecular brain research.

Alterations of the Neuronal Cytoskeleton in Alzheimer’s Disease and Related Conditions

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1987 .

ALZHEIMER'S DISEASE, MICROTUBULE AND NEUROFILAMENT PROTEINS, AND AXOPLASMIC FLOW

I. Grundke‐Iqbal, K. Iqbal, H. Wisniewski, 1987, The Lancet.

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2010, Journal of Alzheimer's disease : JAD.

EVIDENCE THAT ALZHEIMER NEUROFIBRILLARY TANGLES ORIGINATE FROM NEUROTUBULES

R. Terry, I. Grundke‐Iqbal, K. Iqbal, 1979, The Lancet.

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease*

I. Grundke‐Iqbal, K. Iqbal, Fei Liu, 2013, The Journal of Biological Chemistry.

Phosphothreonine-212 of Alzheimer Abnormally Hyperphosphorylated Tau is a Preferred Substrate of Protein Phosphatase-1

I. Grundke‐Iqbal, K. Iqbal, Abdur Rahman, 2005, Neurochemical Research.

PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau

I. Grundke‐Iqbal, K. Iqbal, A. Rahman, 2006, Journal of Neural Transmission.

I PP2A 1 Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2A*

I. Grundke‐Iqbal, K. Iqbal, B. Li, 2008, Journal of Biological Chemistry.

I 1 PP 2 A Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2 A *

I. Grundke‐Iqbal, K. Iqbal, She. Chen, 2008 .

The organization of the microtubule associated protein tau in Alzheimer paired helical filaments

I. Grundke‐Iqbal, K. Iqbal, John E. Johnson, 1993, Brain Research.

Mechanism of neurofibrillary degeneration in Alzheimer's disease

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1994, Molecular Neurobiology.

Tau Pathology as a Target in Alzheimer's Therapeutics

I. Grundke‐Iqbal, K. Iqbal, 2007 .

Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2006, Journal of biomedicine & biotechnology.

Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage.

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2009, Journal of Alzheimer's disease : JAD.

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

I. Grundke‐Iqbal, K. Iqbal, R. Garruto, 2014, Proceedings of the National Academy of Sciences.

Cytoplasmic Retention of Protein Phosphatase 2A Inhibitor 2 (I2PP2A) Induces Alzheimer-like Abnormal Hyperphosphorylation of Tau*

I. Grundke‐Iqbal, K. Iqbal, Fei Liu, 2014, The Journal of Biological Chemistry.

Abnormal ) PP 2 A 2 Phosphatase 2 A Inhibitor 2 ( I Cytoplasmic Retention of Protein Neurobiology :

I. Grundke‐Iqbal, K. Iqbal, Fei Liu, 2014 .

Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection

J. Wegiel, T. Siddique, I. Grundke‐Iqbal, 2014, Acta Neuropathologica.

Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2012, Neurobiology of Aging.

Splicing factor SC35 promotes tau expression through stabilization of its mRNA

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2011, FEBS letters.

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial.

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2010, Biochemical Society transactions.

Phosphorylation of Tau at Thr212, Thr231, and Ser262 Combined Causes Neurodegeneration*

I. Grundke‐Iqbal, K. Iqbal, A. Alonso, 2010, The Journal of Biological Chemistry.

Central Role of Tau Protein in Alzheimer»S Disease and Related Tauopathies

I. Grundke‐Iqbal, K. Iqbal, O. Chohan, 2009 .

Anesthesia induces phosphorylation of tau.

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2009, Journal of Alzheimer's disease : JAD.

Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.

J. Wegiel, I. Grundke‐Iqbal, K. Iqbal, 2008, Journal of Alzheimer's disease : JAD.

Stratification of patients is the way to go to develop neuroprotective/disease-modifying drugs for Alzheimer's disease.

I. Grundke‐Iqbal, K. Iqbal, M. Chohan, 2008, Journal of Alzheimer's disease : JAD.

Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly.

I. Grundke‐Iqbal, K. Iqbal, A. Alonso, 2008, Journal of Alzheimer's disease : JAD.

Alzheimer subgroups: towards effective drug development

I. Grundke‐Iqbal, K. Iqbal, 2007 .

Regulation of phosphorylation of tau by cyclin‐dependent kinase 5 and glycogen synthase kinase‐3 at substrate level

I. Grundke‐Iqbal, K. Iqbal, A. Sengupta, 2006, FEBS letters.

Dephosphorylation of Tau by Protein Phosphatase 5

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2005, Journal of Biological Chemistry.

Inhibitors of protein phosphatase‐2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau

I. Grundke‐Iqbal, K. Iqbal, I. Tsujio, 2005, FEBS letters.

Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: Negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2005, Microscopy research and technique.

About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation

H. Wiśniewski, M. Barcikowska, I. Grundke‐Iqbal, 2004, Acta Neuropathologica.

Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells.

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2004 .

Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates

I. Grundke‐Iqbal, K. Iqbal, V. Chauhan, 1997, Molecular and Cellular Biochemistry.

Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases

I. Grundke‐Iqbal, K. Iqbal, J. Singh, 1994, Molecular and Cellular Biochemistry.

Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences

H. Wiśniewski, H. Budka, H. Lassmann, 1987, Acta Neuropathologica.

Young adult-form of dementia with neurofibrillary changes and lewy bodies

H. Wiśniewski, I. Grundke‐Iqbal, G. Wen, 2004, Acta Neuropathologica.

Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain

I. Grundke‐Iqbal, K. Iqbal, T. Zaidi, 1996, Molecular and Cellular Biochemistry.

Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Nonbinding Phosphatase Activities

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2001, Neurochemical Research.

Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau

A. Grover, I. Grundke‐Iqbal, K. Iqbal, 2005, Journal of Neural Transmission.

Microtubule associated protein tau binds to double-stranded but not single-stranded DNA

I. Grundke‐Iqbal, K. Iqbal, N. Haque, 2003, Cellular and Molecular Life Sciences CMLS.

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK‐3β

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2002, FEBS letters.

A pool of β‐tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain

I. Grundke‐Iqbal, K. Iqbal, E. El-Akkad, 2001, FEBS letters.

Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain.

J. Wegiel, T. Lidsky, I. Grundke‐Iqbal, 2001, Brain research. Brain research protocols.

Alzheimer disease is multifactorial and heterogeneous

I. Grundke‐Iqbal, K. Iqbal, 2000, Neurobiology of Aging.

Regulation of Phosphorylation of tau by Protein Kinases in Rat Brain

I. Grundke‐Iqbal, K. Iqbal, A. Sengupta, 2000, Neurobiology of Aging.

Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain

J. Wegiel, H. Wiśniewski, L. Zuck, 2000, Brain Research.

Hyperphosphorylated tau in SY5Y cells: similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain

I. Grundke‐Iqbal, K. Iqbal, J. Zhong, 1999, FEBS letters.

Dynamic Regulation of Expression and Phosphorylation of Tau by Fibroblast Growth Factor-2 In Neural Progenitor Cells from Adult Rat Hippocampus

I. Grundke‐Iqbal, K. Iqbal, Y. Tatebayashi, 1999, The Journal of Neuroscience.

Regulation of expression, phosphorylation and biological activity of tau during differentiation in SY5Y cells

I. Grundke‐Iqbal, K. Iqbal, N. Haque, 1999, Brain Research.

The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases

I. Grundke‐Iqbal, Toshihisa Tanaka, E. Trenkner, 1998, FEBS letters.

Role of Neurofibrillary Degeneration in Alzheimer’s Disease

I. Grundke‐Iqbal, K. Iqbal, 1998 .

Ser‐262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK

J. Sironi, I. Grundke‐Iqbal, K. Iqbal, 1998, FEBS letters.

Alzheimer disease hyperphosphorylated tau aggregates hydrophobically

I. Grundke‐Iqbal, K. Iqbal, G. Ruben, 1997, Synapse.

Alzheimer Neurofibrillary Degeneration: A Feasible and Key Target for Therapeutics

T. Kudo, I. Grundke‐Iqbal, K. Iqbal, 1997 .

Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

I. Grundke‐Iqbal, K. Iqbal, J. Wang, 1996, Brain research. Molecular brain research.

Molecular Mechanism of Alzheimer's Neurofibrillary Degeneration and Therapeutic Intervention a

I. Grundke‐Iqbal, K. Iqbal, 1996, Annals of the New York Academy of Sciences.

Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated τ by neuroleptics

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1996, Brain Research.

Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B (*)

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1995, The Journal of Biological Chemistry.

Abnormal hyperphosphorylation of tau: Participation of β-amyloid/peptide out and proline-directed protein kinases (PDPKs) and non-PDPKs in

I. Grundke‐Iqbal, K. Iqbal, 1995, Neurobiology of Aging.

Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules

I. Grundke‐Iqbal, K. Iqbal, 1995, Neurobiology of Aging.

Role of Abnormal Phosphorylation of Tau in Neurofibrillary Degeneration: Implications for Alzheimer Therapy

I. Grundke‐Iqbal, K. Iqbal, 1994 .

Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains

I. Grundke‐Iqbal, K. Iqbal, S. Khatoon, 1994, FEBS letters.

Dephosphorylation of microtubule‐associated protein tau by protein phosphatase‐1 and ‐2C and its implication in Alzheimer disease

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1994, FEBS letters.

Alzheimer paired helical filaments Restoration of the biological activity by dephosphorylation

I. Grundke‐Iqbal, K. Iqbal, C. Bancher, 1994, FEBS letters.

Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein τ: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1992, Brain Research.

Brain ubiquitin is markedly elevated in Alzheimer disease

I. Grundke‐Iqbal, K. Iqbal, S. Khatoon, 1991, Brain Research.

Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism‐dementia of guam

S. Shankar, K. Kosik, I. Grundke‐Iqbal, 1989, Annals of neurology.

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1988, Brain research.

Neuronal cytoskeleton in aging and dementia.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1986, Progress in brain research.

Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease.

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2009, The American journal of pathology.

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

Yi Li, I. Grundke‐Iqbal, K. Iqbal, 2012, PloS one.

Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Binding Phosphatases

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2004, Neurochemical Research.

Guanosine Triphosphate Binding to β‐Subunit of Tubulin in Alzheimer's Disease Brain: Role of Microtubule‐Associated Protein τ

I. Grundke‐Iqbal, K. Iqbal, S. Khatoon, 1995 .

Abnormally phosphorylated tau in SY5Y human neuroblastoma cells

I. Grundke‐Iqbal, K. Iqbal, Toshihisa Tanaka, 1995, FEBS letters.

An Antigenic Profile of Lewy Bodies: Immunocytochemical Indication for Protein Phosphorylation and Ubiquitination

H. Wiśniewski, H. Lassmann, F. Seitelberger, 1989, Journal of neuropathology and experimental neurology.

Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1995, Journal of neurochemistry.

Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein.

Khadija Iqbal, H. Barra, I. Grundke‐Iqbal, 2001, The Journal of biological chemistry.

Alzheimer neurofibrillary tangles: Antiserum and immunohistological staining

Khadija Iqbal, H. Wiśniewski, R. Terry, 1979, Annals of neurology.

Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules

H. Wiśniewski, R. Terry, I. Grundke‐Iqbal, 1978, Brain Research.

Elevated Levels of τ and Ubiquitin in Brain and Cerebrospinal Fluid in Alzheimer's Disease

I. Grundke‐Iqbal, K. Iqbal, 1997, International Psychogeriatrics.

Cerebrospinal Fluid Secretory Ca 2 -Dependent Phospholipase A 2 Activity Is Increased in

K. Blennow, T. Fladby, H. Zetterberg, 2009 .

Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease.

K. Blennow, T. Fladby, H. Zetterberg, 2009, Clinical chemistry.

Effect of Melatonin and Melatonylvalpromide on β-amyloid and Neurofilaments in N2a Cells

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2008, Neurochemical Research.

Technical Advance Levels of Nonphosphorylated and Phosphorylated Tau in Cerebrospinal Fluid of Alzheimer’s Disease Patients An Ultrasensitive Bienzyme-Substrate-Recycle Enzyme-Linked Immunosorbent Assay

I. Grundke‐Iqbal, K. Iqbal, Xiaochuan Wang, 2002 .

Novel therapeutic strategies for neurodegenerative disease

T. Kudo, M. Takeda, I. Grundke‐Iqbal, 2009, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.

Khadija Iqbal, J. Kabat, I. Grundke‐Iqbal, 1998, Archives of biochemistry and biophysics.

Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s)

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 2004, Acta Neuropathologica.

Chronic relapsing experimental allergic encephalomyelitis. Immunohistochemical studies.

H. Wiśniewski, H. Lassmann, I. Grundke‐Iqbal, 1980, Archives of neurology.

Alzheimer paired helical filaments: Identification of polypeptides with monoclonal antibodies

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 2004, Acta Neuropathologica.

Alzheimer paired helical filaments: Immunochemical identification of polypeptides

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 2004, Acta Neuropathologica.

Immunocytochemical studies on neurofibrillary changes.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1982, Experimental brain research.

Neurofibrillary degeneration: a promising target for the treatment of Alzheimer’s disease and other tauopathies K Iqbal, A del C Alonso, E El-Akkad, C-X Gong, N Haque, S Khatoon, H Tanimukai,

I. Grundke‐Iqbal, I. Tsujio, 2005 .

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

H. Braak, E. Braak, B. Winblad, 1999, Journal of neuropathology and experimental neurology.

Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1992, The American journal of pathology.

Experimental allergic encephalomyelitis Characterization of serum factors causing demyelination and swelling of myelin

C. Brosnan, I. Grundke‐Iqbal, C. Raine, 1981, Journal of the Neurological Sciences.

The solubility controversy of paired helical filaments: A commentary

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 2004, Neurochemical Research.

Studies on the encephalitogenic effects of purified preparations of human and bovine oligodendrocytes

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1977, Brain Research.

ARE DEMYELINATING SERUM FACTORS IN MS AND EAE GAMMA GLOBULINS?: 106

I. Grundke‐Iqbal, M. Bornstein, 1977 .

Neurofibrillary degeneration: a promising target for the treatment of Alzheimer’s disease and other tauopathies

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2005 .

Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration.

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2012, Journal of Alzheimer's disease : JAD.

Levels of tau phosphorylation at different sites in Alzheimer disease brain

Khadija Iqbal, T. Kudo, M. Takeda, 1998, Neuroreport.

Phosphorylation of τ Protein by Casein Kinase‐1 Converts It to an Abnormal Alzheimer‐Like State

I. Grundke‐Iqbal, K. Iqbal, T. Singh, 1995, Journal of neurochemistry.

Modulation of GSK‐3‐catalyzed phosphorylation of microtubule‐associated protein tau by non‐proline‐dependent protein kinases

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 1995, FEBS letters.

Alzheimer's Disease Abnormally Phosphorylated τ Is Dephosphorylated by Protein Phosphatase‐2B (Calcineurin)

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1994, Journal of neurochemistry.

Mechanism of Alzheimer neurofibrillary degeneration and the formation of tangles

I. Grundke‐Iqbal, K. Iqbal, 1997, Molecular Psychiatry.

Multiple sclerosis: Immunochemical studies on the demyelinating serum factor

I. Grundke‐Iqbal, M. Bornstein, 1979, Brain Research.

ON NEUROFILAMENT and NEUROTUBULE PROTEINS FROM HUMAN AUTOPSY TISSUE

H. Wiśniewski, R. Terry, R. Terry, 1977, Journal of neurochemistry.

NF-κB precursor, p105, and NF-κB inhibitor, IκBγ, are both elevated in Alzheimer disease brain

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2005, Neuroscience Letters.

Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid β-protein

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1989, Neurobiology of Aging.

Blood-brain barrier in Alzheimer dementia and in non-demented elderly

B. Winblad, I. Alafuzoff, I. Grundke‐Iqbal, 1987, Acta Neuropathologica.

Alzheimer paired helical filaments: Cross-reacting polypeptide/s normally present in brain

I. Grundke‐Iqbal, K. Iqbal, Y. Tung, 2004, Acta Neuropathologica.

Multiple sclerosis

I. Grundke‐Iqbal, M. Bornstein, 1980, Neurology.

OLIGODENDROGLIA FROM HUMAN AUTOPSIED BRAIN: BULK ISOLATION AND SOME CHEMICAL PROPERTIES 1

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1977, Journal of neurochemistry.

Cell surface immunoglobulin. VI. Dynamics on a human lymphoma line

J. Uhr, I. Grundke‐Iqbal, 1974, European journal of immunology.

Calcium/calmodulin‐dependent protein kinase II phosphorylates tau at Ser‐262 but only partially inhibits its binding to microtubules

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 1996, FEBS letters.

Phosphorylation and accumulation of tau without any concomitant increase in tubulin levels in Chinese Hamster Ovary cells stably transfected with human tau441

Khadija Iqbal, I. Grundke‐Iqbal, N. Haque, 1995, FEBS letters.

Cell surface immunoglobulin. VII. Synthesis, shedding, and secretion of immunoglobulin by lymphoid cells of germ-free mice.

J. Uhr, I. Grundke‐Iqbal, K. Holmes, 1974 .

CELL SURFACE IMMUNOGLOBULIN

J. Uhr, I. Grundke‐Iqbal, K. Holmes, 1974, The Journal of experimental medicine.

Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Overexpression of inhibitor-1 or -2 of protein phosphatase-2A causes abnormal hyperphosphorylation of tau and cognitive impairment in the rat

I. Grundke‐Iqbal, K. Iqbal, Xiaochuan Wang, 2009, Alzheimer's & Dementia.

Tau phosphatase activity as a therapeutic target for AD.

I. Grundke‐Iqbal, K. Iqbal, 1998, Drug news & perspectives.

The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer.

H. Wiśniewski, J. Johnson, I. Grundke‐Iqbal, 1991, The Journal of biological chemistry.

A SILVER IMPREGNATION METHOD SPECIFIC FOR ALZHEIMER PAIRED HELICAL FILAMENTS (PHF) STAINS MICROTUBULE ASSOCIATED PROTEIN TAU.: 4

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1987 .

Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus

H. Yamamori, I. Grundke‐Iqbal, K. Iqbal, 2008, Journal of neuropathology and experimental neurology.

PKA modulates GSK‐3β‐ and cdk5‐catalyzed phosphorylation of tau in site‐ and kinase‐specific manners

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2006, FEBS letters.

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration

B. Winblad, N. Bogdanovic, I. Grundke‐Iqbal, 1998, Brain Research.

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 1993, The Journal of biological chemistry.

Mechanisms of tau-induced neurodegeneration

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2009, Acta Neuropathologica.

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1986, The Journal of biological chemistry.

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2009, Brain : a journal of neurology.

Inhibition of PP‐2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 2001, FEBS letters.

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2007, The European journal of neuroscience.

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

Fei Liu, I. Grundke‐Iqbal, K. Iqbal, 2005, The European journal of neuroscience.

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1994, Neuroscience.

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.

B. Winblad, I. Grundke‐Iqbal, K. Iqbal, 2003, The American journal of pathology.

Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2003, Neuroscience Letters.

Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid‐treated SY5Y cells

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2001, FEBS letters.

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

H. Braak, E. Braak, B. Winblad, 2001, Journal of Alzheimer's disease : JAD.

Role of protein phosphatase‐2A and ‐1 in the regulation of GSK‐3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2000, FEBS letters.

Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain

J. Wegiel, L. Zuck, T. Lidsky, 2000, The Journal of Biological Chemistry.

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals

I. Grundke‐Iqbal, K. Iqbal, J. Pei, 1994, Brain Research.

Molecular pathology of Alzheimer neurofibrillary degeneration.

T. Kudo, I. Grundke‐Iqbal, K. Iqbal, 1993, Acta neurobiologiae experimentalis.

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Ying Liu, I. Grundke‐Iqbal, K. Iqbal, 2011, The Journal of pathology.

Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2004, The European journal of neuroscience.

Analysis of N‐glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease

I. Grundke‐Iqbal, Yuji Sato, T. Endo, 2001, FEBS letters.

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.

G. Hart, I. Grundke‐Iqbal, K. Iqbal, 2004, Proceedings of the National Academy of Sciences of the United States of America.

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

B. Winblad, I. Alafuzoff, I. Grundke‐Iqbal, 1986, The Lancet.

The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease

I. Grundke‐Iqbal, K. Iqbal, Y. Tatebayashi, 2003, Acta Neuropathologica.

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

Fei Liu, Chun-ling Dai, I. Grundke‐Iqbal, 2013, Molecular Neurobiology.

Brain Gene Expression of a Sporadic (icv-STZ Mouse) and a Familial Mouse Model (3xTg-AD Mouse) of Alzheimer’s Disease

F. LaFerla, Fei Liu, Chun-ling Dai, 2012, PloS one.

Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 1996, Nature Medicine.

Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations*

I. Grundke‐Iqbal, K. Iqbal, A. Alonso, 2004, Journal of Biological Chemistry.

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis

Bin Li, I. Grundke‐Iqbal, K. Iqbal, 2007, Neurobiology of Aging.

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau.

Khadija Iqbal, H. Barra, I. Grundke‐Iqbal, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

H. Braak, E. Braak, B. Winblad, 1999 .

Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2 PP2A/SET

I. Grundke‐Iqbal, K. Iqbal, S. Khatoon, 2011, FEBS letters.

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide

I. Grundke‐Iqbal, K. Iqbal, Xiaochuan Wang, 2011, Acta Neuropathologica.

Subcellular distribution of protein phosphatases and abnormally phosphorylated τ in the temporal cortex from Alzheimer's disease and control brains

B. Winblad, I. Grundke‐Iqbal, K. Iqbal, 1998, Journal of Neural Transmission.

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

Chun-ling Dai, I. Grundke‐Iqbal, K. Iqbal, 2015, Journal of Neural Transmission.

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

Alejandra del C. Alonso, I. Grundke‐Iqbal, K. Iqbal, 1996, Nature Medicine.

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2008, FEBS letters.

Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay.

I. Grundke‐Iqbal, K. Iqbal, Jian-Zhi Wang, 2002, The American journal of pathology.

Sera from Children with Autism Induce Autistic Features Which Can Be Rescued with a CNTF Small Peptide Mimetic in Rats

I. Grundke‐Iqbal, K. Iqbal, M. Arif, 2015, PloS one.

Molecular pathology of Alzheimer neurofibrillary

T. Kudo, I. Grundke‐Iqbal, K. Iqbal, 2009 .

Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease

I. Grundke‐Iqbal, K. Iqbal, Khalid Iqbal, 2008, Molecular Neurobiology.

Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

Khadija Iqbal, H. Wiśniewski, V. Fried, 1991, Brain Research.

Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease

V. Fried, I. Grundke‐Iqbal, K. Iqbal, 1989, Journal of neurochemistry.

τ and ubiquitin in the human hypothalamus in aging and Alzheimer's disease

R. Ravid, D. Swaab, I. Grundke‐Iqbal, 1992, Brain Research.

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1987 .

Microsoft Word-BasurtoIslas_JBC_Final_ENDNOTE

I. Grundke‐Iqbal, K. Iqbal, Fei Liu, 2013 .

Perivascular deposits of serum proteins in cerebral cortex in vascular dementia

B. Winblad, I. Alafuzoff, I. Grundke‐Iqbal, 2004, Acta Neuropathologica.

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

Hongwei Liang, Jianhua Shi, I. Grundke‐Iqbal, 2011, Nucleic acids research.

Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2011, The Journal of Biological Chemistry.

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion*

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2012, The Journal of Biological Chemistry.

Dyrk 1 A regulate the alternative splicing of tau exon 10 1 Dual-specificity tyrosine-phosphorylated and regulated kinase 1 A ( Dyrk 1 A ) modulates serine-arginine rich protein 55 ( SRp 55 )-promoted tau exon

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2012 .

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome*♦

J. Wegiel, Jianhua Shi, I. Grundke‐Iqbal, 2008, Journal of Biological Chemistry.

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

J. Wegiel, I. Grundke‐Iqbal, K. Iqbal, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers

Hilkka Soininen, Kaj Blennow, Michael Flory, 2005, Annals of neurology.

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.

I. Grundke‐Iqbal, K. Iqbal, H. Tanimukai, 2005, The American journal of pathology.

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 1993, Journal of neurochemistry.

Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain*

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2004, Journal of Biological Chemistry.

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide

I. Grundke‐Iqbal, K. Iqbal, M. Chohan, 2011, Neurobiology of Aging.

Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention

I. Grundke‐Iqbal, K. Iqbal, 2007, Journal of cellular and molecular medicine.

Developing pharmacological therapies for Alzheimer disease

I. Grundke‐Iqbal, K. Iqbal, 2007, Cellular and Molecular Life Sciences.

Role of tau phosphorylation by glycogen synthase kinase-3β in the regulation of organelle transport

I. Grundke‐Iqbal, K. Iqbal, N. Haque, 2004, Journal of Cell Science.

Inactivation of glycogen synthase kinase‐3 by protein kinase C δ: implications for regulation of τ phosphorylation

T. Kudo, M. Takeda, I. Grundke‐Iqbal, 2000 .

Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease.

K. Blennow, T. Fladby, H. Zetterberg, 2011, Journal of Alzheimer's disease : JAD.

ALZHEIMER'S DISEASE AND RELATED CONDITIONS

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1987 .

Silver Labeling of Alzheimer Neurofibrillary Changes and Brain β-Amyloid

H. Braak, E. Braak, I. Grundke‐Iqbal, 1993 .

Neurofibrillary and Synaptic Pathology in the Aged Brain

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1981 .

Neurofibrillary Pathology in Subacute Sclerosing Panencephalitis

J. Wegiel, H. Wiśniewski, I. Grundke‐Iqbal, 1991 .

Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease.

I. Grundke‐Iqbal, K. Iqbal, 2002, Journal of Alzheimer's disease : JAD.

Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1992, Biochemical and biophysical research communications.

Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels

T. Kudo, R. Ravid, D. Swaab, 1994, Brain Research.

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

Fei Liu, Fei Liu, Chun-ling Dai, 2012, Molecular Neurobiology.

Opportunities and challenges in developing Alzheimer disease therapeutics

I. Grundke‐Iqbal, K. Iqbal, 2011, Acta Neuropathologica.

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

F. LaFerla, I. Grundke‐Iqbal, K. Iqbal, 2010, Acta Neuropathologica.

Metabolic/signal transduction hypothesis of Alzheimer’s disease and other tauopathies

I. Grundke‐Iqbal, K. Iqbal, 2005, Acta Neuropathologica.

Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2002, FEBS letters.

Site‐specific effects of tau phosphorylation on its microtubule assembly activity and self‐aggregation

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2007, The European journal of neuroscience.

Brain glucose transporters, O‐GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2009, Journal of neurochemistry.

Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein

I. Grundke‐Iqbal, K. Iqbal, S. Khatoon, 1992, Journal of neurochemistry.

Rescue of Synaptic Failure and Alleviation of Learning and Memory Impairments in a Trisomic Mouse Model of Down Syndrome

I. Grundke‐Iqbal, K. Iqbal, M. Chohan, 2011, Journal of neuropathology and experimental neurology.

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer’s disease

Fei Liu, I. Grundke‐Iqbal, K. Iqbal, 2013, Nucleic acids research.

τ is phosphorylated by GSK‐3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A‐kinase

I. Grundke‐Iqbal, Qiongli Wu, Khalid Iqbal, 1998, FEBS letters.

Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

H. Braak, B. Winblad, I. Grundke‐Iqbal, 2002, Acta Neuropathologica.

Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

B. Winblad, H. Soininen, I. Alafuzoff, 2006, Neurobiology of Disease.

Down‐regulation of cAMP‐dependent protein kinase by over‐activated calpain in Alzheimer disease brain

Fei Liu, I. Grundke‐Iqbal, K. Iqbal, 2007, Journal of neurochemistry.

Truncation and Activation of Calcineurin A by Calpain I in Alzheimer Disease Brain*

K. Tomizawa, Y. Oda, I. Grundke‐Iqbal, 2005, Journal of Biological Chemistry.

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

Khadija Iqbal, H. Lassmann, I. Grundke‐Iqbal, 2004, Acta Neuropathologica.

Significance and mechanism of alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2002, Journal of Molecular Neuroscience.

Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice

I. Grundke‐Iqbal, K. Iqbal, M. Chohan, 2010, FEBS letters.

Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: A biomarker of blood–cerebrospinal fluid barrier permeability

K. Blennow, T. Fladby, H. Zetterberg, 2010, Neuroscience Letters.

Tau pathology generated by overexpression of tau.

I. Grundke‐Iqbal, K. Iqbal, 1999, The American journal of pathology.

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

H. Braak, E. Braak, I. Grundke‐Iqbal, 1986, Neuroscience Letters.

Regulation between O‐GlcNAcylation and phosphorylation of neurofilament‐M and their dysregulation in Alzheimer disease

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Pathogenesis of neuritic (senile) and amyloid plaque formation.

H. Wiśniewski, I. Grundke‐Iqbal, A. Lossinsky, 1982, Experimental brain research.

Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases.

I. Grundke‐Iqbal, K. Iqbal, T. Singh, 1996, Archives of biochemistry and biophysics.

Bilateral injection of isoproterenol into hippocampus induces Alzheimer‐like hyperphosphorylation of tau and spatial memory deficit in rat

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2005, FEBS letters.

Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

I. Grundke‐Iqbal, K. Iqbal, A. Sengupta, 2004, FEBS letters.

Targeting Tau Protein in Alzheimer’s Disease

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2010, Drugs & aging.

Distribution, Levels, and Activity of Glycogen Synthase Kinase‐3 in the Alzheimer Disease Brain

E. Braak, I. Grundke‐Iqbal, K. Iqbal, 1997, Journal of neuropathology and experimental neurology.

Rabbit IgG cross-reacts with Alzheimer neurofibrillary tangles

I. Grundke‐Iqbal, K. Iqbal, Y. Tung, 1994, Acta Neuropathologica.

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

I. Grundke‐Iqbal, K. Iqbal, A. Alonso, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Protein abnormalities in Huntington's chorea.

I. Grundke‐Iqbal, K. Iqbal, I. Tellez-Nagel, 1974, Brain research.

Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.

Khadija Iqbal, I. Grundke‐Iqbal, K. Iqbal, 1998, Journal of neural transmission. Supplementum.

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

Yi Li, I. Grundke‐Iqbal, K. Iqbal, 2009, Journal of neurochemistry.

Dephosphorylation of microtubule‐associated protein tau by protein phosphatase 5

J. Wegiel, I. Grundke‐Iqbal, K. Iqbal, 2003, Journal of neurochemistry.

Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex

B. Winblad, N. Bogdanovic, I. Grundke‐Iqbal, 2005, Journal of Neural Transmission.

Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid

H. Wiśniewski, B. Winblad, I. Grundke‐Iqbal, 2004, Acta Neuropathologica.

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau

Bin Li, I. Grundke‐Iqbal, K. Iqbal, 2007, Acta Neuropathologica.

Lewy Bodies Contain Epitopes Both Shared and Distinct from Alzheimer Neurofibrillary Tangles

I. Grundke‐Iqbal, K. Iqbal, G Perry, 1988, Journal of neuropathology and experimental neurology.

Brain iron and ferritin in Parkinson's and Alzheimer's diseases

K. Jellinger, P. Riederer, I. Grundke‐Iqbal, 1990, Journal of neural transmission. Parkinson's disease and dementia section.

Defective brain microtubule assembly in Alzheimer??s disease

Bengt Winblad, H. Wiśniewski, B. Winblad, 1987 .

Memantine Attenuates Alzheimer’s Disease-Like Pathology and Cognitive Impairment

I. Grundke‐Iqbal, K. Iqbal, Xiaochuan Wang, 2015, PloS one.

Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients

I. Grundke‐Iqbal, K. Iqbal, S. Khatoon, 2002, Neuroscience Letters.

PAIRED HELICAL FILAMENT ANTIGEN IN CSF

H. Wiśniewski, P. Mehta, I. Grundke‐Iqbal, 1985, The Lancet.

Tau in cerebrospinal fluid: A sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification

K. Blennow, H. Hampel, M. Ewers, 2007, Neuroscience Letters.

Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures

I. Grundke‐Iqbal, K. Iqbal, S. Kazim, 2013, PloS one.

Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease.

Jianhua Shi, I. Grundke‐Iqbal, K. Iqbal, 2011, Journal of Alzheimer's disease : JAD.

P3-329 I1 PP2A and I2 PP2A affect tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A

I. Grundke‐Iqbal, K. Iqbal, She. Chen, 2006, Alzheimer's & Dementia.

Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau.

I. Grundke‐Iqbal, K. Iqbal, S. Khatoon, 1995, Journal of neurochemistry.

Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice.

I. Grundke‐Iqbal, K. Iqbal, M. Chohan, 2010, Journal of Alzheimer's disease : JAD.

P2-128 Regulation of microtubule-associated proteins, protein kinases, and protein phosphatases during differentiation of SY5Y cells

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2004, Neurobiology of Aging.

MICROTUBULE ASSOCIATED PROTEIN, TAU IS A MAJOR CONSTITUENT OF ALZHEIMER PAIRED HELICAL FILAMENTS

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1986 .

109 RELATIONSHIP OF ALZHEIMER PAIRED HELICAL FILAMENTS WITH MICROTUBULES AND NEUROFILAMENTS

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1983 .

Circulating Myelinotoxic and Neuroelectric Blocking Factors in Demyelinative Disorders

I. Grundke‐Iqbal, M. Bornstein, 1982, Clinics in Immunology and Allergy.

Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation.

T. Kudo, M. Takeda, I. Grundke‐Iqbal, 2000, FEBS letters.

MULTIPLE SCLEROSIS: STUDIES ON THE IN VITRO DEMYELINATING SERUM FACTOR

I. Grundke‐Iqbal, M. Bornstein, 1978 .

NEURONAL CYTOSKELETON IN THE BIOLOGY OF ALZHEIMER DISEASE

I. Grundke‐Iqbal, 1989, Progress in clinical and biological research.

A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis

H. Braak, E. Braak, I. Grundke‐Iqbal, 1991, Neurobiology of Aging.

Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies.

I. Grundke‐Iqbal, K. Iqbal, 2004, Current drug targets.

Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia.

H. Wiśniewski, R. Terry, I. Grundke‐Iqbal, 1975, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Tau and ubiquitin in the human hypothalamus in aging and Alzheimer's disease.

R. Ravid, D. Swaab, I. Grundke‐Iqbal, 1992, Brain research.

Are Alzheimer neurofibrillary tangles insoluble polymers?

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1986, Life sciences.

TAU AND UBIQUITIN IMMUNOREACTIVITY AT DIFFERENT STAGES OF FORMATION OF ALZHEIMER NEUROFIBRILLARY TANGLES

K. Jellinger, H. Wiśniewski, H. Budka, 1989, Progress in clinical and biological research.

Pivotal Role of Neurofibrillary Degeneration in Alzheimer Disease and Therapeutic Targets

I. Grundke‐Iqbal, K. Iqbal, C. Gong, 2004 .

Ubiquitin in cerebrospinal fluid: a rapid competitive enzyme‐linked immunoflow assay

T. Kudo, R. Ravid, D. Swaab, 1994, NeuroReport.

In vitro assembly and isolation of neurofilaments and microtubules from mammalian CNS.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1987, Brain research.

CELL SURFACE IMMUNOGLOBULIN

J. Uhr, I. Grundke‐Iqbal, K. Holmes, 1974, The Journal of experimental medicine.

Alzheimer Neurofibrillary tangle: morphology and biochemistry.

H. Wiśniewski, I. Grundke‐Iqbal, K. Iqbal, 1982, Experimental brain research.

Microtubule‐associated protein tau Identification of a novel peptide from bovine brain

I. Grundke‐Iqbal, T. Zaidi, Khalid Iqbal, 1989, FEBS letters.

Restoration of the biological activity by dephosphorylation

I. Grundke‐Iqbal, T. Zaidi, Khalid IqbaP, 1994 .

Diverse regulation of AKT and GSK‐3β by O‐GlcNAcylation in various types of cells

Shiliang Wu, Jianhua Shi, Chun-ling Dai, 2012, FEBS letters.