N. Osman

发表

TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle

Rikang Wang, Wenhua Zheng, P. Little, 2011, Growth factors.

Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2

Wenhua Zheng, P. Little, N. Osman, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation.

P. Little, N. Osman, D. Kamato, 2018, Cellular signalling.

Smad and p38 MAP Kinase-mediated Signaling of Proteoglycan Synthesis in Vascular Smooth Muscle*

P. Little, N. Osman, Robel Getachew, 2008, Journal of Biological Chemistry.

Insulin resistance and atherosclerosis.

A. Dart, P. Little, N. Osman, 2006, Endocrine reviews.

Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation.

Wenhua Zheng, P. Little, Haitao Wang, 2012, Archives of biochemistry and biophysics.

Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes.

Wenhua Zheng, P. Little, N. Osman, 2019, Cellular signalling.

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation

P. Little, N. Osman, D. Kamato, 2019, Journal of Cell Communication and Signaling.

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle.

Wenhua Zheng, P. Little, N. Osman, 2016, Cellular signalling.

Peptidyl‐prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

Wenhua Zheng, P. Little, N. Osman, 2015, Clinical and experimental pharmacology & physiology.

Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle

P. Little, N. Osman, D. Kamato, 2012, Clinical and experimental pharmacology & physiology.

Thrombin-mediated Proteoglycan Synthesis Utilizes Both Protein-tyrosine Kinase and Serine/Threonine Kinase Receptor Transactivation in Vascular Smooth Muscle Cells*

M. Febbraio, P. Little, N. Osman, 2013, The Journal of Biological Chemistry.

G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors.

Wenhua Zheng, P. Little, N. Osman, 2012, The international journal of biochemistry & cell biology.

The Prolyl Peptidyl Isomerase Pin1 as a Potential Therapeutic Target in Atherosclerosis

P. Little, N. Osman, 2012 .

Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor*

P. Little, N. Osman, Robel Getachew, 2010, The Journal of Biological Chemistry.

Biosynthesis of Natural and Hyperelongated Chondroitin Sulfate Glycosaminoglycans: New Insights into an Elusive Process

P. Little, N. Osman, Micah L. Burch, 2008, The open biochemistry journal.

Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis.

P. Little, N. Osman, M. E. Ivey, 2008, Atherosclerosis.

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.

M. Hollenberg, Wenhua Zheng, P. Little, 2016, Cellular signalling.

Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans

Wenhua Zheng, P. Little, N. Osman, 2016, Journal of ophthalmology.

Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis

P. Little, N. Osman, M. Ballinger, 2007, Vascular health and risk management.

Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis.

P. Little, N. Osman, M. E. Ivey, 2008, Current vascular pharmacology.

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

P. Little, N. Osman, M. Ballinger, 2007, Cardiovascular diabetology.

Suramin inhibits PDGF‐stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease.

K. J. Grande-Allen, P. Little, N. Osman, 2007, Cardiovascular research.

Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL.

P. Little, N. Osman, M. Ballinger, 2009, Atherosclerosis.

Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation.

Wenhua Zheng, P. Little, Haitao Wang, 2014, Cellular signalling.

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Wenhua Zheng, P. Little, N. Osman, 2014, Cellular and Molecular Life Sciences.

Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells

Wenhua Zheng, P. Little, N. Osman, 2016, International journal of biological sciences.

Actions of Calcium Channel Blockers on Vascular Proteoglycan Synthesis: Relationship to Atherosclerosis

P. Little, N. Osman, J. Nigro, 2005, Vascular health and risk management.

Gaq proteins: molecular pharmacology and therapeutic potential

Wenhua Zheng, P. Little, N. Osman, 2017, Cellular and Molecular Life Sciences.

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis

Wenhua Zheng, P. Little, N. Osman, 2018, Pharmacology & therapeutics.

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2017, PloS one.

Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR1 signalling

M. Hollenberg, Wenhua Zheng, P. Little, 2016, British journal of pharmacology.

Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11

Wenhua Zheng, P. Little, N. Osman, 2015, Front. Cardiovasc. Med..

Therapeutic implications of endothelin and thrombin G‐protein‐coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Lipid: Extracellular Matrix Interactions as Therapeutic Targets in the Atherosclerosis of Diabetes

P. Little, N. Osman, 2014 .

Evaluation of the potential synergism of imatinib‐related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response

Wenhua Zheng, N. Osman, Robel Getachew, 2016, The Journal of pharmacy and pharmacology.

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

Wenhua Zheng, P. Little, N. Osman, 2013, Cellular signalling.

Transforming growth factor‐β regulation of proteoglycan synthesis in vascular smooth muscle: Contribution to lipid binding and accelerated atherosclerosis in diabetes

P. Little, N. Osman, Micah L. Burch, 2010, Journal of diabetes.

Combined transgenic expression of a -galactosidase and a 1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Gal a (1,3)Gal

Yiannis, N. Osman, Ioannou, 1997 .

Transforming growth factor β‐mediated site‐specific Smad linker region phosphorylation in vascular endothelial cells

Wenhua Zheng, P. Little, N. Osman, 2014, The Journal of pharmacy and pharmacology.

TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2

P. Little, N. Osman, Robel Getachew, 2010, Cellular and Molecular Life Sciences.

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.

K. J. Grande-Allen, P. Little, N. Osman, 2013, Cardiovascular pathology.

Endothelin-1 Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle is Mediated by Endothelin Receptor Transactivation of the Transforming Growth Factor-β Type I Receptor

P. Little, N. Osman, Robel Getachew, 2010, Journal of cardiovascular pharmacology.

Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma

N. Osman, T. Piva, X. Chan, 2017, International journal of molecular sciences.

A Comparison of the Interaction of Shc and the Tyrosine Kinase ZAP-70 with the T Cell Antigen Receptor ζ Chain Tyrosine-based Activation Motif (*)

H. Turner, N. Osman, D. Cantrell, 1995, The Journal of Biological Chemistry.

Methotrexate Inhibits Proliferation but not Proteoglycan Synthesis or Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells

P. Little, N. Osman, Robel Getachew, 2015 .

Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins

P. Little, N. Osman, Micah L. Burch, 2009 .

Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on Vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding

A. Wilks, P. Little, N. Osman, 2008, Journal of cardiovascular pharmacology.

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

P. Little, N. Osman, K. O’Brien, 2008, Current opinion in lipidology.

Calcific aortic valve disease and hypertension

P. Little, N. Osman, M. Ballinger, 2008 .

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

P. Little, N. Osman, M. Ballinger, 2007, Cardiovascular diabetology.

Aortic Smooth Muscle Cells from ApoE (-/-) Mice Secrete Biglycan with Hyperelongated Glycosaminoglycan Chains

P. Little, N. Osman, Robel Getachew, 2013 .

Characterisation of Ki11502 as a potent inhibitor of PDGF beta receptor-mediated proteoglycan synthesis in vascular smooth muscle cells.

P. Little, N. Osman, Robel Getachew, 2010, European journal of pharmacology.

p38 MAP kinase mediated proteoglycan synthesis as a target for the prevention of atherosclerosis.

P. Little, N. Osman, Robel Getachew, 2008, Cardiovascular & hematological disorders drug targets.

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle

Wenhua Zheng, P. Little, N. Osman, 2014, Cardiovascular Diabetology.

Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins

P. Little, N. Osman, Robel Getachew, 2015 .

The protein interactions of the immunoglobulin receptor family tyrosine‐based activation motifs present in the T cell receptor ζ subunits and the CD3 γ,δ and ϵ chains

H. Turner, N. Osman, D. Cantrell, 1996 .

PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.

P. Little, N. Osman, Robel Getachew, 2010, Endocrinology.

Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation

P. Little, N. Osman, Robel Getachew, 2009, Archives of physiology and biochemistry.

Understanding diabetes and its complications for biomedical research

P. Little, N. Osman, N. Cohen, 2013 .

(S)‐[6]‐Gingerol inhibits TGF‐β‐stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Smad and p 38 MAP Kinase-mediated Signaling of Proteoglycan Synthesis in Vascular Smooth Muscle *

P. Little, N. Osman, Robel Getachew, 2008 .

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

J. D. de Haan, J. Rutledge, P. Little, 2009, Journal of cellular and molecular medicine.

New Approaches to Regulating the Chondroitin/Dermatan Sulfate Glycosaminoglycan Component of the Vascular Extracellular Matrix

N. Osman, M. Ballinger, J. Nigro, 2005, TheScientificWorldJournal.

Androgens: New Effects on Proteoglycan Biosynthesis and Its Consequences for Atherosclerosis

P. Little, N. Osman, J. Nigro, 2005, TheScientificWorldJournal.

Assessing the role of Gαq/11 in cellular responses: an analysis of investigative tools

P. Little, N. Osman, D. Kamato, 2014 .

Recent advances in the management of diabetic retinopathy.

N. Osman, T. Thrimawithana, U. Rai, 2019, Drug discovery today.

Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells

Wenhua Zheng, P. Little, N. Osman, 2022, International journal of molecular sciences.

The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor ζ chain tyrosine‐based activation motif

N. Osman, D. Cantrell, S. Lucas, 1995, European journal of immunology.

Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling

P. Little, N. Osman, D. Kamato, 2019, Cellular and Molecular Life Sciences.

Phosphorylated Troglitazone Activates PPARγ and Inhibits Vascular Smooth Muscle Cell Proliferation and Proteoglycan Synthesis

P. Little, N. Osman, D. Bruemmer, 2008, Journal of cardiovascular pharmacology.

The Growing Promiscuity of G Protein Coupled Receptors

P. Little, N. Osman, Micah L. Burch, 2012 .

Transforming growth factor‐β regulation of proteoglycan synthesis in vascular smooth muscle: Contribution to lipid binding and accelerated atherosclerosis in diabetes

P. Little, N. Osman, Micah L. Burch, 2010, Journal of diabetes.

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.

K. J. Grande-Allen, N. Osman, Robel Getachew, 2013, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Wenhua Zheng, P. Little, N. Osman, 2014, Cellular and Molecular Life Sciences.

Therapeutic implications of endothelin and thrombin G‐protein‐coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Wenhua Zheng, P. Little, N. Osman, 2013, The Journal of pharmacy and pharmacology.

Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling

P. Little, N. Osman, D. Kamato, 2019, Cellular and Molecular Life Sciences.

Anti-Atherogenic Role of Peroxisome Proliferator-Activated Receptor Ligands

A. Dart, P. Little, N. Osman, 2005 .

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation

P. Little, N. Osman, D. Kamato, 2019, Journal of Cell Communication and Signaling.